O00303: Eukaryotic translation initiation factor 3 subunit F {ECO:0000255|HAMAP-Rule:MF_03005}

General Information

Protein names	- Eukaryotic translation initiation factor 3 subunit F {ECO:0000255\|HAMAP-Rule:MF_03005} - eIF3f {ECO:0000255\|HAMAP-Rule:MF_03005} - Deubiquitinating enzyme eIF3f - 3.4.19.12 - Eukaryotic translation initiation factor 3 subunit 5 {ECO:0000255\|HAMAP-Rule:MF_03005} - eIF-3-epsilon {ECO:0000255\|HAMAP-Rule:MF_03005} - eIF3 p47 {ECO:0000255\|HAMAP-Rule:MF_03005}
Gene names	EIF3F
Organism	Homo sapiens
Protease Family
Protease ID	M67.974
Chromosome location
UniProt ID	O00303

7 N-termini

3 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MATPAVPVSA PPATPTPVPA AAPASVPAPT PAPAAAPVPA AAPASSSDPA AAAAATAAPG
        70         80         90        100        110        120
QTPASAQAPA QTPAPALPGP ALPGPFPGGR VVRLHPVILA SIVDSYERRN EGAARVIGTL
       130        140        150        160        170        180
LGTVDKHSVE VTNCFSVPHN ESEDEVAVDM EFAKNMYELH KKVSPNELIL GWYATGHDIT
       190        200        210        220        230        240
EHSVLIHEYY SREAPNPIHL TVDTSLQNGR MSIKAYVSTL MGVPGRTMGV MFTPLTVKYA
       250        260        270        280        290        300
YYDTERIGVD LIMKTCFSPN RVIGLSSDLQ QVGGASARIQ DALSTVLQYA EDVLSGKVSA
       310        320        330        340        350
DNTVGRFLMS LVNQVPKIVP DDFETMLNSN INDLLMVTYL ANLTQSQIAL NEKLVNL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00303-2-unknown	MATPAV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00303-2-Acetylation	ATPAVP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00303-41-unknown	AAPASS...	41		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13695
O00303-136-	SVPHNE...	136			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O00303-136-	SVPHNE...	136			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O00303-150-unknown	MEFAKN...	150		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000396929
O00303-260-unknown	NRVIGL...	260		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000434286
O00303-345-unknown	QSQIAL...	345		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6984
O00303-345-unknown	QSQIAL...	345		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5099

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...APVPAA	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13695
...LANLTQ	344	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6984
...LANLTQ	344	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5099
...KLVNL	357	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	40	VPAA.\|.AAPA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATS_HUMAN	344	NLTQ.\|.QSQI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	344	NLTQ.\|.QSQI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)