O95373: Importin-7

General Information

Protein names	- Importin-7 - Imp7 - Ran-binding protein 7 - RanBP7
Gene names	IPO7
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O95373

6 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDPNTIIEAL RGTMDPALRE AAERQLNEAH KSLNFVSTLL QITMSEQLDL PVRQAGVIYL
        70         80         90        100        110        120
KNMITQYWPD RETAPGDISP YTIPEEDRHC IRENIVEAII HSPELIRVQL TTCIHHIIKH
       130        140        150        160        170        180
DYPSRWTAIV DKIGFYLQSD NSACWLGILL CLYQLVKNYE YKKPEERSPL VAAMQHFLPV
       190        200        210        220        230        240
LKDRFIQLLS DQSDQSVLIQ KQIFKIFYAL VQYTLPLELI NQQNLTEWIE ILKTVVNRDV
       250        260        270        280        290        300
PNETLQVEED DRPELPWWKC KKWALHILAR LFERYGSPGN VSKEYNEFAE VFLKAFAVGV
       310        320        330        340        350        360
QQVLLKVLYQ YKEKQYMAPR VLQQTLNYIN QGVSHALTWK NLKPHIQGII QDVIFPLMCY
       370        380        390        400        410        420
TDADEELWQE DPYEYIRMKF DVFEDFISPT TAAQTLLFTA CSKRKEVLQK TMGFCYQILT
       430        440        450        460        470        480
EPNADPRKKD GALHMIGSLA EILLKKKIYK DQMEYMLQNH VFPLFSSELG YMRARACWVL
       490        500        510        520        530        540
HYFCEVKFKS DQNLQTALEL TRRCLIDDRE MPVKVEAAIA LQVLISNQEK AKEYITPFIR
       550        560        570        580        590        600
PVMQALLHII RETENDDLTN VIQKMICEYS EEVTPIAVEM TQHLAMTFNQ VIQTGPDEEG
       610        620        630        640        650        660
SDDKAVTAMG ILNTIDTLLS VVEDHKEITQ QLEGICLQVI GTVLQQHVLE FYEEIFSLAH
       670        680        690        700        710        720
SLTCQQVSPQ MWQLLPLVFE VFQQDGFDYF TDMMPLLHNY VTVDTDTLLS DTKYLEMIYS
       730        740        750        760        770        780
MCKKVLTGVA GEDAECHAAK LLEVIILQCK GRGIDQCIPL FVEAALERLT REVKTSELRT
       790        800        810        820        830        840
MCLQVAIAAL YYNPHLLLNT LENLRFPNNV EPVTNHFITQ WLNDVDCFLG LHDRKMCVLG
       850        860        870        880        890        900
LCALIDMEQI PQVLNQVSGQ ILPAFILLFN GLKRAYACHA EHENDSDDDD EAEDDDETEE
       910        920        930        940        950        960
LGSDEDDIDE DGQEYLEILA KQAGEDGDDE DWEEDDAEET ALEGYSTIID DEDNPVDEYQ
       970        980        990       1000       1010       1020
IFKAIFQTIQ NRNPVWYQAL THGLNEEQRK QLQDIATLAD QRRAAHESKM IEKHGGYKFS
      1030
APVVPSSFNF GGPAPGMN

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O95373-1-Acetylation	MDPNTI...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O95373-1-Acetylation	MDPNTI...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O95373-1-Acetylation	MDPNTI...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O95373-1-Acetylation	MDPNTI...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O95373-1-Acetylation	MDPNTI...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O95373-41-unknown	QITMSE...	41		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
O95373-63-unknown	MITQYW...	63		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000435235
O95373-328-unknown	YINQGV...	328		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13876
O95373-728-unknown	GVAGED...	728		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7077
O95373-728-unknown	GVAGED...	728		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5289
O95373-729-unknown	VAGEDA...	729		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3302

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LLSDQS	192	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435235
...QQTLNY	327	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13876
...KKVLTG	727	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7077
...KKVLTG	727	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5289
...KVLTGV	728	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3302
...APGMN	1038	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	327	TLNY.\|.YINQ	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATS_HUMAN	727	VLTG.\|.GVAG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	727	VLTG.\|.GVAG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	728	LTGV.\|.VAGE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)