P56537: Eukaryotic translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_03132}

General Information

Protein names	- Eukaryotic translation initiation factor 6 {ECO:0000255\|HAMAP-Rule:MF_03132} - eIF-6 {ECO:0000255\|HAMAP-Rule:MF_03132} - B(2)GCN homolog - B4 integrin interactor - CAB - p27(BBP)
Gene names	EIF6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P56537

5 N-termini

4 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAVRASFENN CEIGCFAKLT NTYCLVAIGG SENFYSVFEG ELSDTIPVVH ASIAGCRIIG
        70         80         90        100        110        120
RMCVGNRHGL LVPNNTTDQE LQHIRNSLPD TVQIRRVEER LSALGNVTTC NDYVALVHPD
       130        140        150        160        170        180
LDRETEEILA DVLKVEVFRQ TVADQVLVGS YCVFSNQGGL VHPKTSIEDQ DELSSLLQVP
       190        200        210        220        230        240
LVAGTVNRGS EVIAAGMVVN DWCAFCGLDT TSTELSVVES VFKLNEAQPS TIATSMRDSL

IDSLT

Isoforms

- Isoform 2 of Eukaryotic translation initiation factor 6

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
P56537-1-unknown	MAVRAS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P56537-1-unknown	MAVRAS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77572
P56537-72-unknown	VPNNTT...	72	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6058
P56537-72-unknown	VPNNTT...	72	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7594
P56537-76-	TTDQEL...	76		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P56537-155-unknown	SNQGGL...	155	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6059
P56537-155-unknown	SNQGGL...	155	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7595
P56537-155-unknown	SNQGGL...	155	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144139
P56537-156-unknown	NQGGLV...	156	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3870
P56537-156-unknown	NQGGLV...	156	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144158

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RHGLLV	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6058
...RHGLLV	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7594
...SYCVFS	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6059
...SYCVFS	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7595
...SYCVFS	154	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127390
...YCVFSN	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3870
...YCVFSN	155	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127411
...IDSLT	245	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...IDSLT	245	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73190

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	71	GLLV.\|.VPNN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	71	GLLV.\|.VPNN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	154	CVFS.\|.SNQG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	154	CVFS.\|.SNQG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	155	VFSN.\|.NQGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)