Q14C86: GTPase-activating protein and VPS9 domain-containing protein 1
Protein names | - GTPase-activating protein and VPS9 domain-containing protein 1 - GAPex-5 - Rab5-activating protein 6 |
---|---|
Gene names | GAPVD1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q14C86 |
15
N-termini
7
C-termini
6
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MVKLDIHTLA HHLKQERLYV NSEKQLIQRL NADVLKTAEK LYRTAWIAKQ QRINLDRLII
70 80 90 100 110 120
TSAEASPAEC CQHAKILEDT QFVDGYKQLG FQETAYGEFL SRLRENPRLI ASSLVAGEKL
130 140 150 160 170 180
NQENTQSVIY TVFTSLYGNC IMQEDESYLL QVLRYLIEFE LKESDNPRRL LRRGTCAFSI
190 200 210 220 230 240
LFKLFSEGLF SAKLFLTATL HEPIMQLLVE DEDHLETDPN KLIERFSPSQ QEKLFGEKGS
250 260 270 280 290 300
DRFRQKVQEM VESNEAKLVA LVNKFIGYLK QNTYCFPHSL RWIVSQMYKT LSCVDRLEVG
310 320 330 340 350 360
EVRAMCTDLL LACFICPAVV NPEQYGIISD APINEVARFN LMQVGRLLQQ LAMTGSEEGD
370 380 390 400 410 420
PRTKSSLGKF DKSCVAAFLD VVIGGRAVET PPLSSVNLLE GLSRTVVYIT YSQLITLVNF
430 440 450 460 470 480
MKSVMSGDQL REDRMALDNL LANLPPAKPG KSSSLEMTPY NTPQLSPATT PANKKNRLPI
490 500 510 520 530 540
ATRSRSRTNM LMDLHMDHEG SSQETIQEVQ PEEVLVISLG TGPQLTPGMM SENEVLNMQL
550 560 570 580 590 600
SDGGQGDVPV DENKLHGKPD KTLRFSLCSD NLEGISEGPS NRSNSVSSLD LEGESVSELG
610 620 630 640 650 660
AGPSGSNGVE ALQLLEHEQA TTQDNLDDKL RKFEIRDMMG LTDDRDISET VSETWSTDVL
670 680 690 700 710 720
GSDFDPNIDE DRLQEIAGAA AENMLGSLLC LPGSGSVLLD PCTGSTISET TSEAWSVEVL
730 740 750 760 770 780
PSDSEAPDLK QEERLQELES CSGLGSTSDD TDVREVSSRP STPGLSVVSG ISATSEDIPN
790 800 810 820 830 840
KIEDLRSECS SDFGGKDSVT SPDMDEITHG AHQLTSPPSQ SESLLAMFDP LSSHEGASAV
850 860 870 880 890 900
VRPKVHYARP SHPPPDPPIL EGAVGGNEAR LPNFGSHVLT PAEMEAFKQR HSYPERLVRS
910 920 930 940 950 960
RSSDIVSSVR RPMSDPSWNR RPGNEERELP PAAAIGATSL VAAPHSSSSS PSKDSSRGET
970 980 990 1000 1010 1020
EERKDSDDEK SDRNRPWWRK RFVSAMPKAP IPFRKKEKQE KDKDDLGPDR FSTLTDDPSP
1030 1040 1050 1060 1070 1080
RLSAQAQVAE DILDKYRNAI KRTSPSDGAM ANYESTGDNH DRDLSSKLLY HSDKEVMGDG
1090 1100 1110 1120 1130 1140
ESAHDSPRDE ALQNISADDL PDSASQAAHP QDSAFSYRDA KKKLRLALCS ADSVAFPVLT
1150 1160 1170 1180 1190 1200
HSTRNGLPDH TDPEDNEIVC FLKVQIAEAI NLQDKNLMAQ LQETMRCVCR FDNRTCRKLL
1210 1220 1230 1240 1250 1260
ASIAEDYRKR APYIAYLTRC RQGLQTTQAH LERLLQRVLR DKEVANRYFT TVCVRLLLES
1270 1280 1290 1300 1310 1320
KEKKIREFIQ DFQKLTAADD KTAQVEDFLQ FLYGAMAQDV IWQNASEEQL QDAQLAIERS
1330 1340 1350 1360 1370 1380
VMNRIFKLAF YPNQDGDILR DQVLHEHIQR LSKVVTANHR ALQIPEVYLR EAPWPSAQSE
1390 1400 1410 1420 1430 1440
IRTISAYKTP RDKVQCILRM CSTIMNLLSL ANEDSVPGAD DFVPVLVFVL IKANPPCLLS
1450 1460 1470
TVQYISSFYA SCLSGEESYW WMQFTAAVEF IKTIDDRK
Isoforms
- Isoform 2 of GTPase-activating protein and VPS9 domain-containing protein 1 - Isoform 3 of GTPase-activating protein and VPS9 domain-containing protein 1 - Isoform 4 of GTPase-activating protein and VPS9 domain-containing protein 1 - Isoform 5 of GTPase-activating protein and VPS9 domain-containing protein 1 - Isoform 6 of GTPase-activating protein and VPS9 domain-containing protein 1Sequence View
10 20 30 40 50 60
MVKLDIHTLA HHLKQERLYV NSEKQLIQRL NADVLKTAEK LYRTAWIAKQ QRINLDRLII
70 80 90 100 110 120
TSAEASPAEC CQHAKILEDT QFVDGYKQLG FQETAYGEFL SRLRENPRLI ASSLVAGEKL
130 140 150 160 170 180
NQENTQSVIY TVFTSLYGNC IMQEDESYLL QVLRYLIEFE LKESDNPRRL LRRGTCAFSI
190 200 210 220 230 240
LFKLFSEGLF SAKLFLTATL HEPIMQLLVE DEDHLETDPN KLIERFSPSQ QEKLFGEKGS
250 260 270 280 290 300
DRFRQKVQEM VESNEAKLVA LVNKFIGYLK QNTYCFPHSL RWIVSQMYKT LSCVDRLEVG
310 320 330 340 350 360
EVRAMCTDLL LACFICPAVV NPEQYGIISD APINEVARFN LMQVGRLLQQ LAMTGSEEGD
370 380 390 400 410 420
PRTKSSLGKF DKSCVAAFLD VVIGGRAVET PPLSSVNLLE GLSRTVVYIT YSQLITLVNF
430 440 450 460 470 480
MKSVMSGDQL REDRMALDNL LANLPPAKPG KSSSLEMTPY NTPQLSPATT PANKKNRLPI
490 500 510 520 530 540
ATRSRSRTNM LMDLHMDHEG SSQETIQEVQ PEEVLVISLG TGPQLTPGMM SENEVLNMQL
550 560 570 580 590 600
SDGGQGDVPV DENKLHGKPD KTLRFSLCSD NLEGISEGPS NRSNSVSSLD LEGESVSELG
610 620 630 640 650 660
AGPSGSNGVE ALQLLEHEQA TTQDNLDDKL RKFEIRDMMG LTDDRDISET VSETWSTDVL
670 680 690 700 710 720
GSDFDPNIDE DRLQEIAGAA AENMLGSLLC LPGSGSVLLD PCTGSTISET TSEAWSVEVL
730 740 750 760 770 780
PSDSEAPDLK QEERLQELES CSGLGSTSDD TDVREVSSRP STPGLSVVSG ISATSEDIPN
790 800 810 820 830 840
KIEDLRSECS SDFGGKDSVT SPDMDEITHG AHQLTSPPSQ SESLLAMFDP LSSHEGASAV
850 860 870 880 890 900
VRPKVHYARP SHPPPDPPIL EGAVGGNEAR LPNFGSHVLT PAEMEAFKQR HSYPERLVRS
910 920 930 940 950 960
RSSDIVSSVR RPMSDPSWNR RPGNEERELP PAAAIGATSL VAAPHSSSSS PSKDSSRGET
970 980 990 1000 1010 1020
EERKDSDDEK SDRNRPWWRK RFVSAMPKAP IPFRKKEKQE KDKDDLGPDR FSTLTDDPSP
1030 1040 1050 1060 1070 1080
RLSAQAQVAE DILDKYRNAI KRTSPSDGAM ANYESTGDNH DRDLSSKLLY HSDKEVMGDG
1090 1100 1110 1120 1130 1140
ESAHDSPRDE ALQNISADDL PDSASQAAHP QDSAFSYRDA KKKLRLALCS ADSVAFPVLT
1150 1160 1170 1180 1190 1200
HSTRNGLPDH TDPEDNEIVC FLKVQIAEAI NLQDKNLMAQ LQETMRCVCR FDNRTCRKLL
1210 1220 1230 1240 1250 1260
ASIAEDYRKR APYIAYLTRC RQGLQTTQAH LERLLQRVLR DKEVANRYFT TVCVRLLLES
1270 1280 1290 1300 1310 1320
KEKKIREFIQ DFQKLTAADD KTAQVEDFLQ FLYGAMAQDV IWQNASEEQL QDAQLAIERS
1330 1340 1350 1360 1370 1380
VMNRIFKLAF YPNQDGDILR DQVLHEHIQR LSKVVTANHR ALQIPEVYLR EAPWPSAQSE
1390 1400 1410 1420 1430 1440
IRTISAYKTP RDKVQCILRM CSTIMNLLSL ANEDSVPGAD DFVPVLVFVL IKANPPCLLS
1450 1460 1470
TVQYISSFYA SCLSGEESYW WMQFTAAVEF IKTIDDRK
10 20 30 40 50 60
MVKLDIHTLA HHLKQERLYV NSEKQLIQRL NADVLKTAEK LYRTAWIAKQ QRINLDRLII
70 80 90 100 110 120
TSAEASPAEC CQHAKILEDT QFVDGYKQLG FQETAYGEFL SRLRENPRLI ASSLVAGEKL
130 140 150 160 170 180
NQENTQSVIY TVFTSLYGNC IMQEDESYLL QVLRYLIEFE LKESDNPRRL LRRGTCAFSI
190 200 210 220 230 240
LFKLFSEGLF SAKLFLTATL HEPIMQLLVE DEDHLETDPN KLIERFSPSQ QEKLFGEKGS
250 260 270 280 290 300
DRFRQKVQEM VESNEAKLVA LVNKFIGYLK QNTYCFPHSL RWIVSQMYKT LSCVDRLEVG
310 320 330 340 350 360
EVRAMCTDLL LACFICPAVV NPEQYGIISD APINEVARFN LMQVGRLLQQ LAMTGSEEGD
370 380 390 400 410 420
PRTKSSLGKF DKSCVAAFLD VVIGGRAVET PPLSSVNLLE GLSRTVVYIT YSQLITLVNF
430 440 450 460 470 480
MKSVMSGDQL REDRMALDNL LANLPPAKPG KSSSLEMTPY NTPQLSPATT PANKKNRLPI
490 500 510 520 530 540
ATRSRSRTNM LMDLHMDHEG SSQETIQEVQ PEEVLVISLG TGPQLTPGMM SENEVLNMQL
550 560 570 580 590 600
SDGGQGDVPV DENKLHGKPD KTLRFSLCSD NLEGISEGPS NRSNSVSSLD LEGESVSELG
610 620 630 640 650 660
AGPSGSNGVE ALQLLEHEQA TTQDNLDDKL RKFEIRDMMG LTDDRDISET VSETWSTDVL
670 680 690 700 710 720
GSDFDPNIDE DRLQEIAGAA AENMLGSLLC LPGSGSVLLD PCTGSTISET TSEAWSVEVL
730 740 750 760 770 780
PSDSEAPDLK QEERLQELES CSGLGSTSDD TDVREVSSRP STPGLSVVSG ISATSEDIPN
790 800 810 820 830 840
KIEDLRSECS SDFGGKDSVT SPDMDEITHG AHQLTSPPSQ SESLLAMFDP LSSHEGASAV
850 860 870 880 890 900
VRPKVHYARP SHPPPDPPIL EGAVGGNEAR LPNFGSHVLT PAEMEAFKQR HSYPERLVRS
910 920 930 940 950 960
RSSDIVSSVR RPMSDPSWNR RPGNEERELP PAAAIGATSL VAAPHSSSSS PSKDSSRGET
970 980 990 1000 1010 1020
EERKDSDDEK SDRNRPWWRK RFVSAMPKAP IPFRKKEKQE KDKDDLGPDR FSTLTDDPSP
1030 1040 1050 1060 1070 1080
RLSAQAQVAE DILDKYRNAI KRTSPSDGAM ANYESTGDNH DRDLSSKLLY HSDKEVMGDG
1090 1100 1110 1120 1130 1140
ESAHDSPRDE ALQNISADDL PDSASQAAHP QDSAFSYRDA KKKLRLALCS ADSVAFPVLT
1150 1160 1170 1180 1190 1200
HSTRNGLPDH TDPEDNEIVC FLKVQIAEAI NLQDKNLMAQ LQETMRCVCR FDNRTCRKLL
1210 1220 1230 1240 1250 1260
ASIAEDYRKR APYIAYLTRC RQGLQTTQAH LERLLQRVLR DKEVANRYFT TVCVRLLLES
1270 1280 1290 1300 1310 1320
KEKKIREFIQ DFQKLTAADD KTAQVEDFLQ FLYGAMAQDV IWQNASEEQL QDAQLAIERS
1330 1340 1350 1360 1370 1380
VMNRIFKLAF YPNQDGDILR DQVLHEHIQR LSKVVTANHR ALQIPEVYLR EAPWPSAQSE
1390 1400 1410 1420 1430 1440
IRTISAYKTP RDKVQCILRM CSTIMNLLSL ANEDSVPGAD DFVPVLVFVL IKANPPCLLS
1450 1460 1470
TVQYISSFYA SCLSGEESYW WMQFTAAVEF IKTIDDRK
10 20 30 40 50 60
MVKLDIHTLA HHLKQERLYV NSEKQLIQRL NADVLKTAEK LYRTAWIAKQ QRINLDRLII
70 80 90 100 110 120
TSAEASPAEC CQHAKILEDT QFVDGYKQLG FQETAYGEFL SRLRENPRLI ASSLVAGEKL
130 140 150 160 170 180
NQENTQSVIY TVFTSLYGNC IMQEDESYLL QVLRYLIEFE LKESDNPRRL LRRGTCAFSI
190 200 210 220 230 240
LFKLFSEGLF SAKLFLTATL HEPIMQLLVE DEDHLETDPN KLIERFSPSQ QEKLFGEKGS
250 260 270 280 290 300
DRFRQKVQEM VESNEAKLVA LVNKFIGYLK QNTYCFPHSL RWIVSQMYKT LSCVDRLEVG
310 320 330 340 350 360
EVRAMCTDLL LACFICPAVV NPEQYGIISD APINEVARFN LMQVGRLLQQ LAMTGSEEGD
370 380 390 400 410 420
PRTKSSLGKF DKSCVAAFLD VVIGGRAVET PPLSSVNLLE GLSRTVVYIT YSQLITLVNF
430 440 450 460 470 480
MKSVMSGDQL REDRMALDNL LANLPPAKPG KSSSLEMTPY NTPQLSPATT PANKKNRLPI
490 500 510 520 530 540
ATRSRSRTNM LMDLHMDHEG SSQETIQEVQ PEEVLVISLG TGPQLTPGMM SENEVLNMQL
550 560 570 580 590 600
SDGGQGDVPV DENKLHGKPD KTLRFSLCSD NLEGISEGPS NRSNSVSSLD LEGESVSELG
610 620 630 640 650 660
AGPSGSNGVE ALQLLEHEQA TTQDNLDDKL RKFEIRDMMG LTDDRDISET VSETWSTDVL
670 680 690 700 710 720
GSDFDPNIDE DRLQEIAGAA AENMLGSLLC LPGSGSVLLD PCTGSTISET TSEAWSVEVL
730 740 750 760 770 780
PSDSEAPDLK QEERLQELES CSGLGSTSDD TDVREVSSRP STPGLSVVSG ISATSEDIPN
790 800 810 820 830 840
KIEDLRSECS SDFGGKDSVT SPDMDEITHG AHQLTSPPSQ SESLLAMFDP LSSHEGASAV
850 860 870 880 890 900
VRPKVHYARP SHPPPDPPIL EGAVGGNEAR LPNFGSHVLT PAEMEAFKQR HSYPERLVRS
910 920 930 940 950 960
RSSDIVSSVR RPMSDPSWNR RPGNEERELP PAAAIGATSL VAAPHSSSSS PSKDSSRGET
970 980 990 1000 1010 1020
EERKDSDDEK SDRNRPWWRK RFVSAMPKAP IPFRKKEKQE KDKDDLGPDR FSTLTDDPSP
1030 1040 1050 1060 1070 1080
RLSAQAQVAE DILDKYRNAI KRTSPSDGAM ANYESTGDNH DRDLSSKLLY HSDKEVMGDG
1090 1100 1110 1120 1130 1140
ESAHDSPRDE ALQNISADDL PDSASQAAHP QDSAFSYRDA KKKLRLALCS ADSVAFPVLT
1150 1160 1170 1180 1190 1200
HSTRNGLPDH TDPEDNEIVC FLKVQIAEAI NLQDKNLMAQ LQETMRCVCR FDNRTCRKLL
1210 1220 1230 1240 1250 1260
ASIAEDYRKR APYIAYLTRC RQGLQTTQAH LERLLQRVLR DKEVANRYFT TVCVRLLLES
1270 1280 1290 1300 1310 1320
KEKKIREFIQ DFQKLTAADD KTAQVEDFLQ FLYGAMAQDV IWQNASEEQL QDAQLAIERS
1330 1340 1350 1360 1370 1380
VMNRIFKLAF YPNQDGDILR DQVLHEHIQR LSKVVTANHR ALQIPEVYLR EAPWPSAQSE
1390 1400 1410 1420 1430 1440
IRTISAYKTP RDKVQCILRM CSTIMNLLSL ANEDSVPGAD DFVPVLVFVL IKANPPCLLS
1450 1460 1470
TVQYISSFYA SCLSGEESYW WMQFTAAVEF IKTIDDRK
10 20 30 40 50 60
MVKLDIHTLA HHLKQERLYV NSEKQLIQRL NADVLKTAEK LYRTAWIAKQ QRINLDRLII
70 80 90 100 110 120
TSAEASPAEC CQHAKILEDT QFVDGYKQLG FQETAYGEFL SRLRENPRLI ASSLVAGEKL
130 140 150 160 170 180
NQENTQSVIY TVFTSLYGNC IMQEDESYLL QVLRYLIEFE LKESDNPRRL LRRGTCAFSI
190 200 210 220 230 240
LFKLFSEGLF SAKLFLTATL HEPIMQLLVE DEDHLETDPN KLIERFSPSQ QEKLFGEKGS
250 260 270 280 290 300
DRFRQKVQEM VESNEAKLVA LVNKFIGYLK QNTYCFPHSL RWIVSQMYKT LSCVDRLEVG
310 320 330 340 350 360
EVRAMCTDLL LACFICPAVV NPEQYGIISD APINEVARFN LMQVGRLLQQ LAMTGSEEGD
370 380 390 400 410 420
PRTKSSLGKF DKSCVAAFLD VVIGGRAVET PPLSSVNLLE GLSRTVVYIT YSQLITLVNF
430 440 450 460 470 480
MKSVMSGDQL REDRMALDNL LANLPPAKPG KSSSLEMTPY NTPQLSPATT PANKKNRLPI
490 500 510 520 530 540
ATRSRSRTNM LMDLHMDHEG SSQETIQEVQ PEEVLVISLG TGPQLTPGMM SENEVLNMQL
550 560 570 580 590 600
SDGGQGDVPV DENKLHGKPD KTLRFSLCSD NLEGISEGPS NRSNSVSSLD LEGESVSELG
610 620 630 640 650 660
AGPSGSNGVE ALQLLEHEQA TTQDNLDDKL RKFEIRDMMG LTDDRDISET VSETWSTDVL
670 680 690 700 710 720
GSDFDPNIDE DRLQEIAGAA AENMLGSLLC LPGSGSVLLD PCTGSTISET TSEAWSVEVL
730 740 750 760 770 780
PSDSEAPDLK QEERLQELES CSGLGSTSDD TDVREVSSRP STPGLSVVSG ISATSEDIPN
790 800 810 820 830 840
KIEDLRSECS SDFGGKDSVT SPDMDEITHG AHQLTSPPSQ SESLLAMFDP LSSHEGASAV
850 860 870 880 890 900
VRPKVHYARP SHPPPDPPIL EGAVGGNEAR LPNFGSHVLT PAEMEAFKQR HSYPERLVRS
910 920 930 940 950 960
RSSDIVSSVR RPMSDPSWNR RPGNEERELP PAAAIGATSL VAAPHSSSSS PSKDSSRGET
970 980 990 1000 1010 1020
EERKDSDDEK SDRNRPWWRK RFVSAMPKAP IPFRKKEKQE KDKDDLGPDR FSTLTDDPSP
1030 1040 1050 1060 1070 1080
RLSAQAQVAE DILDKYRNAI KRTSPSDGAM ANYESTGDNH DRDLSSKLLY HSDKEVMGDG
1090 1100 1110 1120 1130 1140
ESAHDSPRDE ALQNISADDL PDSASQAAHP QDSAFSYRDA KKKLRLALCS ADSVAFPVLT
1150 1160 1170 1180 1190 1200
HSTRNGLPDH TDPEDNEIVC FLKVQIAEAI NLQDKNLMAQ LQETMRCVCR FDNRTCRKLL
1210 1220 1230 1240 1250 1260
ASIAEDYRKR APYIAYLTRC RQGLQTTQAH LERLLQRVLR DKEVANRYFT TVCVRLLLES
1270 1280 1290 1300 1310 1320
KEKKIREFIQ DFQKLTAADD KTAQVEDFLQ FLYGAMAQDV IWQNASEEQL QDAQLAIERS
1330 1340 1350 1360 1370 1380
VMNRIFKLAF YPNQDGDILR DQVLHEHIQR LSKVVTANHR ALQIPEVYLR EAPWPSAQSE
1390 1400 1410 1420 1430 1440
IRTISAYKTP RDKVQCILRM CSTIMNLLSL ANEDSVPGAD DFVPVLVFVL IKANPPCLLS
1450 1460 1470
TVQYISSFYA SCLSGEESYW WMQFTAAVEF IKTIDDRK
10 20 30 40 50 60
MVKLDIHTLA HHLKQERLYV NSEKQLIQRL NADVLKTAEK LYRTAWIAKQ QRINLDRLII
70 80 90 100 110 120
TSAEASPAEC CQHAKILEDT QFVDGYKQLG FQETAYGEFL SRLRENPRLI ASSLVAGEKL
130 140 150 160 170 180
NQENTQSVIY TVFTSLYGNC IMQEDESYLL QVLRYLIEFE LKESDNPRRL LRRGTCAFSI
190 200 210 220 230 240
LFKLFSEGLF SAKLFLTATL HEPIMQLLVE DEDHLETDPN KLIERFSPSQ QEKLFGEKGS
250 260 270 280 290 300
DRFRQKVQEM VESNEAKLVA LVNKFIGYLK QNTYCFPHSL RWIVSQMYKT LSCVDRLEVG
310 320 330 340 350 360
EVRAMCTDLL LACFICPAVV NPEQYGIISD APINEVARFN LMQVGRLLQQ LAMTGSEEGD
370 380 390 400 410 420
PRTKSSLGKF DKSCVAAFLD VVIGGRAVET PPLSSVNLLE GLSRTVVYIT YSQLITLVNF
430 440 450 460 470 480
MKSVMSGDQL REDRMALDNL LANLPPAKPG KSSSLEMTPY NTPQLSPATT PANKKNRLPI
490 500 510 520 530 540
ATRSRSRTNM LMDLHMDHEG SSQETIQEVQ PEEVLVISLG TGPQLTPGMM SENEVLNMQL
550 560 570 580 590 600
SDGGQGDVPV DENKLHGKPD KTLRFSLCSD NLEGISEGPS NRSNSVSSLD LEGESVSELG
610 620 630 640 650 660
AGPSGSNGVE ALQLLEHEQA TTQDNLDDKL RKFEIRDMMG LTDDRDISET VSETWSTDVL
670 680 690 700 710 720
GSDFDPNIDE DRLQEIAGAA AENMLGSLLC LPGSGSVLLD PCTGSTISET TSEAWSVEVL
730 740 750 760 770 780
PSDSEAPDLK QEERLQELES CSGLGSTSDD TDVREVSSRP STPGLSVVSG ISATSEDIPN
790 800 810 820 830 840
KIEDLRSECS SDFGGKDSVT SPDMDEITHG AHQLTSPPSQ SESLLAMFDP LSSHEGASAV
850 860 870 880 890 900
VRPKVHYARP SHPPPDPPIL EGAVGGNEAR LPNFGSHVLT PAEMEAFKQR HSYPERLVRS
910 920 930 940 950 960
RSSDIVSSVR RPMSDPSWNR RPGNEERELP PAAAIGATSL VAAPHSSSSS PSKDSSRGET
970 980 990 1000 1010 1020
EERKDSDDEK SDRNRPWWRK RFVSAMPKAP IPFRKKEKQE KDKDDLGPDR FSTLTDDPSP
1030 1040 1050 1060 1070 1080
RLSAQAQVAE DILDKYRNAI KRTSPSDGAM ANYESTGDNH DRDLSSKLLY HSDKEVMGDG
1090 1100 1110 1120 1130 1140
ESAHDSPRDE ALQNISADDL PDSASQAAHP QDSAFSYRDA KKKLRLALCS ADSVAFPVLT
1150 1160 1170 1180 1190 1200
HSTRNGLPDH TDPEDNEIVC FLKVQIAEAI NLQDKNLMAQ LQETMRCVCR FDNRTCRKLL
1210 1220 1230 1240 1250 1260
ASIAEDYRKR APYIAYLTRC RQGLQTTQAH LERLLQRVLR DKEVANRYFT TVCVRLLLES
1270 1280 1290 1300 1310 1320
KEKKIREFIQ DFQKLTAADD KTAQVEDFLQ FLYGAMAQDV IWQNASEEQL QDAQLAIERS
1330 1340 1350 1360 1370 1380
VMNRIFKLAF YPNQDGDILR DQVLHEHIQR LSKVVTANHR ALQIPEVYLR EAPWPSAQSE
1390 1400 1410 1420 1430 1440
IRTISAYKTP RDKVQCILRM CSTIMNLLSL ANEDSVPGAD DFVPVLVFVL IKANPPCLLS
1450 1460 1470
TVQYISSFYA SCLSGEESYW WMQFTAAVEF IKTIDDRK
Protein Neighborhood
Domains & Features
15 N-termini - 7 C-termini - 6 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q14C86-1-unknown | MVKLDI... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q14C86-1-unknown | MVKLDI... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt75697 | |||
Q14C86-1-unknown | MVKLDI... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt75698 | |||
Q14C86-1-unknown | MVKLDI... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt75699 | |||
Q14C86-1-unknown | MVKLDI... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt75700 | |||
Q14C86-1-unknown | MVKLDI... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt75701 | |||
Q14C86-62-unknown | SAEASP... | 62 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6420 | |||
Q14C86-62-unknown | SAEASP... | 62 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140056 | |||
Q14C86-62-unknown | SAEASP... | 62 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140057 | |||
Q14C86-62-unknown | SAEASP... | 62 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140058 | |||
Q14C86-62-unknown | SAEASP... | 62 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140059 | |||
Q14C86-62-unknown | SAEASP... | 62 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140060 | |||
Q14C86-608-unknown | GVEALQ... | 608 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173532 | |||
Q14C86-608-unknown | GVEALQ... | 608 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173530 | |||
Q14C86-608-unknown | GVEALQ... | 608 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173531 | |||
Q14C86-608-unknown | GVEALQ... | 608 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173533 | |||
Q14C86-608-unknown | GVEALQ... | 608 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173534 | |||
Q14C86-608- | GVEALQ... | 608 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q14C86-617-unknown | HEQATT... | 617 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6426 | |||
Q14C86-617-unknown | HEQATT... | 617 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154536 | |||
Q14C86-617-unknown | HEQATT... | 617 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154864 | |||
Q14C86-617-unknown | HEQATT... | 617 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154865 | |||
Q14C86-617-unknown | HEQATT... | 617 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154866 | |||
Q14C86-617-unknown | HEQATT... | 617 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154867 | |||
Q14C86-826-unknown | AMFDPL... | 826 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166809 | |||
Q14C86-826-unknown | AMFDPL... | 826 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166810 | |||
Q14C86-826-unknown | AMFDPL... | 826 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166811 | |||
Q14C86-826-unknown | AMFDPL... | 826 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166808 | |||
Q14C86-826- | AMFDPL... | 826 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q14C86-833-unknown | SHEGAS... | 833 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6432 | |||
Q14C86-833-unknown | SHEGAS... | 833 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156539 | |||
Q14C86-833-unknown | SHEGAS... | 833 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156616 | |||
Q14C86-833-unknown | SHEGAS... | 833 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156617 | |||
Q14C86-833-unknown | SHEGAS... | 833 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156708 | |||
Q14C86-902-unknown | SSDIVS... | 902 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10306 | |||
Q14C86-902-unknown | SSDIVS... | 902 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156765 | |||
Q14C86-902-unknown | SSDIVS... | 902 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156782 | |||
Q14C86-902-unknown | SSDIVS... | 902 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156903 | |||
Q14C86-902-unknown | SSDIVS... | 902 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156904 | |||
Q14C86-902-unknown | SSDIVS... | 902 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157002 | |||
Q14C86-1010-unknown | RFSTLT... | 1010 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12314 | |||
Q14C86-1010-unknown | RFSTLT... | 1010 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157116 | |||
Q14C86-1010-unknown | RFSTLT... | 1010 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157130 | |||
Q14C86-1010-unknown | RFSTLT... | 1010 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157171 | |||
Q14C86-1010-unknown | RFSTLT... | 1010 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157243 | |||
Q14C86-1099-unknown | DLPDSA... | 1099 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12319 | |||
Q14C86-1099-unknown | DLPDSA... | 1099 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157272 | |||
Q14C86-1099-unknown | DLPDSA... | 1099 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157281 | |||
Q14C86-1099-unknown | DLPDSA... | 1099 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157307 | |||
Q14C86-1099-unknown | DLPDSA... | 1099 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157325 | |||
Q14C86-1099-unknown | DLPDSA... | 1099 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157408 | |||
Q14C86-1103-unknown | SASQAA... | 1103 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q14C86-1103-unknown | SASQAA... | 1103 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161591 | |||
Q14C86-1103-unknown | SASQAA... | 1103 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161590 | |||
Q14C86-1103-unknown | SASQAA... | 1103 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161589 | |||
Q14C86-1103-unknown | SASQAA... | 1103 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161592 | |||
Q14C86-1103-unknown | SASQAA... | 1103 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161588 | |||
Q14C86-1103- | SASQAA... | 1103 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
Q14C86-1103- | SASQAA... | 1103 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q14C86-1103- | SASQAA... | 1103 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
Q14C86-1103- | SASQAA... | 1103 | Subtiligase Based Positive Selection | Wells | apopotic_Jurkat_FasL | 23264352 | |||
Q14C86-1103- | SASQAA... | 1103 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q14C86-1103- | SASQAA... | 1103 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q14C86-1103- | SASQAA... | 1103 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q14C86-1103- | SASQAA... | 1103 | Subtiligase Based Positive Selection | Wells | apoptotic_RPMI_Dox | 23264352 | |||
Q14C86-1103- | SASQAA... | 1103 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q14C86-1133-unknown | SVAFPV... | 1133 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166816 | |||
Q14C86-1133-unknown | SVAFPV... | 1133 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166815 | |||
Q14C86-1133-unknown | SVAFPV... | 1133 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166814 | |||
Q14C86-1133-unknown | SVAFPV... | 1133 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166817 | |||
Q14C86-1133-unknown | SVAFPV... | 1133 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt166813 | |||
Q14C86-1133- | SVAFPV... | 1133 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q14C86-1133- | SVAFPV... | 1133 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q14C86-1133- | SVAFPV... | 1133 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...RLIITS | 61 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6420 | |||
...RLIITS | 61 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt123162 | |||
...RLIITS | 61 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt123164 | |||
...RLIITS | 61 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt123165 | |||
...RLIITS | 61 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt123166 | |||
...RLIITS | 61 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt123167 | |||
...LQLLEH | 616 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6426 | |||
...LQLLEH | 616 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137958 | |||
...LQLLEH | 616 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt138292 | |||
...LQLLEH | 616 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt138293 | |||
...LQLLEH | 616 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt138294 | |||
...LQLLEH | 616 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt138295 | |||
...FDPLSS | 832 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6432 | |||
...FDPLSS | 832 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140023 | |||
...FDPLSS | 832 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140101 | |||
...FDPLSS | 832 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140102 | |||
...FDPLSS | 832 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140196 | |||
...LVRSRS | 901 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10306 | |||
...LVRSRS | 901 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140257 | |||
...LVRSRS | 901 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140274 | |||
...LVRSRS | 901 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140404 | |||
...LVRSRS | 901 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140405 | |||
...LVRSRS | 901 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140493 | |||
...DLGPDR | 1009 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12314 | |||
...DLGPDR | 1009 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140616 | |||
...DLGPDR | 1009 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140630 | |||
...DLGPDR | 1009 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140672 | |||
...DLGPDR | 1009 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140741 | |||
...NISADD | 1098 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12319 | |||
...NISADD | 1098 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140771 | |||
...NISADD | 1098 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140780 | |||
...NISADD | 1098 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140806 | |||
...NISADD | 1098 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140824 | |||
...NISADD | 1098 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140907 | |||
...IDDRK | 1478 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...IDDRK | 1478 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt71316 | |||
...IDDRK | 1478 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt71317 | |||
...IDDRK | 1478 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt71318 | |||
...IDDRK | 1478 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt71315 | |||
...IDDRK | 1478 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt71319 |
Cleavages
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|