O43318: Mitogen-activated protein kinase kinase kinase 7

General Information

Protein names	- Mitogen-activated protein kinase kinase kinase 7 - 2.7.11.25 {ECO:0000269\|PubMed:10094049, ECO:0000269\|PubMed:10838074, ECO:0000269\|PubMed:12589052} - Transforming growth factor-beta-activated kinase 1 - TGF-beta-activated kinase 1
Gene names	MAP3K7
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43318

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 1A of Mitogen-activated protein kinase kinase kinase 7 - Isoform 1C of Mitogen-activated protein kinase kinase kinase 7 - Isoform 1D of Mitogen-activated protein kinase kinase kinase 7

Sequence View

        10         20         30         40         50         60
MSTASAASSS SSSSAGEMIE APSQVLNFEE IDYKEIEVEE VVGRGAFGVV CKAKWRAKDV
        70         80         90        100        110        120
AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV CLVMEYAEGG SLYNVLHGAE
       130        140        150        160        170        180
PLPYYTAAHA MSWCLQCSQG VAYLHSMQPK ALIHRDLKPP NLLLVAGGTV LKICDFGTAC
       190        200        210        220        230        240
DIQTHMTNNK GSAAWMAPEV FEGSNYSEKC DVFSWGIILW EVITRRKPFD EIGGPAFRIM
       250        260        270        280        290        300
WAVHNGTRPP LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI VKIMTHLMRY FPGADEPLQY
       310        320        330        340        350        360
PCQYSDEGQS NSATSTGSFM DIASTNTSNK SDTNMEQVPA TNDTIKRLES KLLKNQAKQQ
       370        380        390        400        410        420
SESGRLSLGA SRGSSVESLP PTSEGKRMSA DMSEIEARIA ATTAYSKPKR GHRKTASFGN
       430        440        450        460        470        480
ILDVPEIVIS GNGQPRRRSI QDLTVTGTEP GQVSSRSSSP SVRMITTSGP TSEKPTRSHP
       490        500        510        520        530        540
WTPDDSTDTN GSDNSIPMAY LTLDHQLQPL APCPNSKESM AVFEQHCKMA QEYMKVQTEI
       550        560        570        580        590        600
ALLLQRKQEL VAELDQDEKD QQNTSRLVQE HKKLLDENKS LSTYYQQCKK QLEVIRSQQQ

KRQGTS         10         20         30         40         50         60
MSTASAASSS SSSSAGEMIE APSQVLNFEE IDYKEIEVEE VVGRGAFGVV CKAKWRAKDV
        70         80         90        100        110        120
AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV CLVMEYAEGG SLYNVLHGAE
       130        140        150        160        170        180
PLPYYTAAHA MSWCLQCSQG VAYLHSMQPK ALIHRDLKPP NLLLVAGGTV LKICDFGTAC
       190        200        210        220        230        240
DIQTHMTNNK GSAAWMAPEV FEGSNYSEKC DVFSWGIILW EVITRRKPFD EIGGPAFRIM
       250        260        270        280        290        300
WAVHNGTRPP LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI VKIMTHLMRY FPGADEPLQY
       310        320        330        340        350        360
PCQYSDEGQS NSATSTGSFM DIASTNTSNK SDTNMEQVPA TNDTIKRLES KLLKNQAKQQ
       370        380        390        400        410        420
SESGRLSLGA SRGSSVESLP PTSEGKRMSA DMSEIEARIA ATTAYSKPKR GHRKTASFGN
       430        440        450        460        470        480
ILDVPEIVIS GNGQPRRRSI QDLTVTGTEP GQVSSRSSSP SVRMITTSGP TSEKPTRSHP
       490        500        510        520        530        540
WTPDDSTDTN GSDNSIPMAY LTLDHQLQPL APCPNSKESM AVFEQHCKMA QEYMKVQTEI
       550        560        570        580        590        600
ALLLQRKQEL VAELDQDEKD QQNTSRLVQE HKKLLDENKS LSTYYQQCKK QLEVIRSQQQ

KRQGTS         10         20         30         40         50         60
MSTASAASSS SSSSAGEMIE APSQVLNFEE IDYKEIEVEE VVGRGAFGVV CKAKWRAKDV
        70         80         90        100        110        120
AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV CLVMEYAEGG SLYNVLHGAE
       130        140        150        160        170        180
PLPYYTAAHA MSWCLQCSQG VAYLHSMQPK ALIHRDLKPP NLLLVAGGTV LKICDFGTAC
       190        200        210        220        230        240
DIQTHMTNNK GSAAWMAPEV FEGSNYSEKC DVFSWGIILW EVITRRKPFD EIGGPAFRIM
       250        260        270        280        290        300
WAVHNGTRPP LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI VKIMTHLMRY FPGADEPLQY
       310        320        330        340        350        360
PCQYSDEGQS NSATSTGSFM DIASTNTSNK SDTNMEQVPA TNDTIKRLES KLLKNQAKQQ
       370        380        390        400        410        420
SESGRLSLGA SRGSSVESLP PTSEGKRMSA DMSEIEARIA ATTAYSKPKR GHRKTASFGN
       430        440        450        460        470        480
ILDVPEIVIS GNGQPRRRSI QDLTVTGTEP GQVSSRSSSP SVRMITTSGP TSEKPTRSHP
       490        500        510        520        530        540
WTPDDSTDTN GSDNSIPMAY LTLDHQLQPL APCPNSKESM AVFEQHCKMA QEYMKVQTEI
       550        560        570        580        590        600
ALLLQRKQEL VAELDQDEKD QQNTSRLVQE HKKLLDENKS LSTYYQQCKK QLEVIRSQQQ

KRQGTS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O43318-1-unknown	MSTASA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43318-1-unknown	MSTASA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80173
O43318-1-unknown	MSTASA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80174
O43318-1-unknown	MSTASA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80175
O43318-464-unknown	MITTSG...	464	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172524
O43318-464-unknown	MITTSG...	464	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172526
O43318-464-unknown	MITTSG...	464	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172525
O43318-464-	MITTSG...	464		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43318-467-unknown	TSGPTS...	467	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5151
O43318-467-unknown	TSGPTS...	467	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152632
O43318-467-unknown	TSGPTS...	467	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152633
O43318-467-unknown	TSGPTS...	467	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153032

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VRMITT	466	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5151
...VRMITT	466	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136049
...VRMITT	466	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136050
...VRMITT	466	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136458
...RQGTS	606	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RQGTS	606	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75791

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	466	MITT.\|.TSGP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)