O95347: Structural maintenance of chromosomes protein 2
Protein names | - Structural maintenance of chromosomes protein 2 - SMC protein 2 - SMC-2 - Chromosome-associated protein E - hCAP-E - XCAP-E homolog |
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Gene names | SMC2 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | O95347 |
4
N-termini
3
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MHIKSIILEG FKSYAQRTEV NGFDPLFNAI TGLNGSGKSN ILDSICFLLG ISNLSQVRAS
70 80 90 100 110 120
NLQDLVYKNG QAGITKASVS ITFDNSDKKQ SPLGFEVHDE ITVTRQVVIG GRNKYLINGV
130 140 150 160 170 180
NANNTRVQDL FCSVGLNVNN PHFLIMQGRI TKVLNMKPPE ILSMIEEAAG TRMYEYKKIA
190 200 210 220 230 240
AQKTIEKKEA KLKEIKTILE EEITPTIQKL KEERSSYLEY QKVMREIEHL SRLYIAYQFL
250 260 270 280 290 300
LAEDTKVRSA EELKEMQDKV IKLQEELSEN DKKIKALNHE IEELEKRKDK ETGGILRSLE
310 320 330 340 350 360
DALAEAQRVN TKSQSAFDLK KKNLACEESK RKELEKNMVE DSKTLAAKEK EVKKITDGLH
370 380 390 400 410 420
ALQEASNKDA EALAAAQQHF NAVSAGLSSN EDGAEATLAG QMMACKNDIS KAQTEAKQAQ
430 440 450 460 470 480
MKLKHAQQEL KNKQAEVKKM DSGYRKDQEA LEAVKRLKEK LEAEMKKLNY EENKEESLLE
490 500 510 520 530 540
KRRQLSRDIG RLKETYEALL ARFPNLRFAY KDPEKNWNRN CVKGLVASLI SVKDTSATTA
550 560 570 580 590 600
LELVAGERLY NVVVDTEVTG KKLLERGELK RRYTIIPLNK ISARCIAPET LRVAQNLVGP
610 620 630 640 650 660
DNVHVALSLV EYKPELQKAM EFVFGTTFVC DNMDNAKKVA FDKRIMTRTV TLGGDVFDPH
670 680 690 700 710 720
GTLSGGARSQ AASILTKFQE LKDVQDELRI KENELRALEE ELAGLKNTAE KYRQLKQQWE
730 740 750 760 770 780
MKTEEADLLQ TKLQQSSYHK QQEELDALKK TIEESEETLK NTKEIQRKAE EKYEVLENKM
790 800 810 820 830 840
KNAEAERERE LKDAQKKLDC AKTKADASSK KMKEKQQEVE AITLELEELK REHTSYKQQL
850 860 870 880 890 900
EAVNEAIKSY ESQIEVMAAE VAKNKESVNK AQEEVTKQKE VITAQDTVIK AKYAEVAKHK
910 920 930 940 950 960
EQNNDSQLKI KELDHNISKH KREAEDGAAK VSKMLKDYDW INAERHLFGQ PNSAYDFKTN
970 980 990 1000 1010 1020
NPKEAGQRLQ KLQEMKEKLG RNVNMRAMNV LTEAEERYND LMKKKRIVEN DKSKILTTIE
1030 1040 1050 1060 1070 1080
DLDQKKNQAL NIAWQKVNKD FGSIFSTLLP GANAMLAPPE GQTVLDGLEF KVALGNTWKE
1090 1100 1110 1120 1130 1140
NLTELSGGQR SLVALSLILS MLLFKPAPIY ILDEVDAALD LSHTQNIGQM LRTHFTHSQF
1150 1160 1170 1180 1190
IVVSLKEGMF NNANVLFKTK FVDGVSTVAR FTQCQNGKIS KEAKSKAKPP KGAHVEV
Isoforms
- Isoform 2 of Structural maintenance of chromosomes protein 2Sequence View
10 20 30 40 50 60
MHIKSIILEG FKSYAQRTEV NGFDPLFNAI TGLNGSGKSN ILDSICFLLG ISNLSQVRAS
70 80 90 100 110 120
NLQDLVYKNG QAGITKASVS ITFDNSDKKQ SPLGFEVHDE ITVTRQVVIG GRNKYLINGV
130 140 150 160 170 180
NANNTRVQDL FCSVGLNVNN PHFLIMQGRI TKVLNMKPPE ILSMIEEAAG TRMYEYKKIA
190 200 210 220 230 240
AQKTIEKKEA KLKEIKTILE EEITPTIQKL KEERSSYLEY QKVMREIEHL SRLYIAYQFL
250 260 270 280 290 300
LAEDTKVRSA EELKEMQDKV IKLQEELSEN DKKIKALNHE IEELEKRKDK ETGGILRSLE
310 320 330 340 350 360
DALAEAQRVN TKSQSAFDLK KKNLACEESK RKELEKNMVE DSKTLAAKEK EVKKITDGLH
370 380 390 400 410 420
ALQEASNKDA EALAAAQQHF NAVSAGLSSN EDGAEATLAG QMMACKNDIS KAQTEAKQAQ
430 440 450 460 470 480
MKLKHAQQEL KNKQAEVKKM DSGYRKDQEA LEAVKRLKEK LEAEMKKLNY EENKEESLLE
490 500 510 520 530 540
KRRQLSRDIG RLKETYEALL ARFPNLRFAY KDPEKNWNRN CVKGLVASLI SVKDTSATTA
550 560 570 580 590 600
LELVAGERLY NVVVDTEVTG KKLLERGELK RRYTIIPLNK ISARCIAPET LRVAQNLVGP
610 620 630 640 650 660
DNVHVALSLV EYKPELQKAM EFVFGTTFVC DNMDNAKKVA FDKRIMTRTV TLGGDVFDPH
670 680 690 700 710 720
GTLSGGARSQ AASILTKFQE LKDVQDELRI KENELRALEE ELAGLKNTAE KYRQLKQQWE
730 740 750 760 770 780
MKTEEADLLQ TKLQQSSYHK QQEELDALKK TIEESEETLK NTKEIQRKAE EKYEVLENKM
790 800 810 820 830 840
KNAEAERERE LKDAQKKLDC AKTKADASSK KMKEKQQEVE AITLELEELK REHTSYKQQL
850 860 870 880 890 900
EAVNEAIKSY ESQIEVMAAE VAKNKESVNK AQEEVTKQKE VITAQDTVIK AKYAEVAKHK
910 920 930 940 950 960
EQNNDSQLKI KELDHNISKH KREAEDGAAK VSKMLKDYDW INAERHLFGQ PNSAYDFKTN
970 980 990 1000 1010 1020
NPKEAGQRLQ KLQEMKEKLG RNVNMRAMNV LTEAEERYND LMKKKRIVEN DKSKILTTIE
1030 1040 1050 1060 1070 1080
DLDQKKNQAL NIAWQKVNKD FGSIFSTLLP GANAMLAPPE GQTVLDGLEF KVALGNTWKE
1090 1100 1110 1120 1130 1140
NLTELSGGQR SLVALSLILS MLLFKPAPIY ILDEVDAALD LSHTQNIGQM LRTHFTHSQF
1150 1160 1170 1180 1190
IVVSLKEGMF NNANVLFKTK FVDGVSTVAR FTQCQNGKIS KEAKSKAKPP KGAHVEV
Protein Neighborhood
Domains & Features
4 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
O95347-1-unknown | MHIKSI... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
O95347-1-unknown | MHIKSI... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt90004 | |||
O95347-146-unknown | MQGRIT... | 146 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000414999 | |||
O95347-146-unknown | MQGRIT... | 146 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt197600 | |||
O95347-612-unknown | YKPELQ... | 612 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5287 | |||
O95347-612-unknown | YKPELQ... | 612 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154781 | |||
O95347-1117- | AALDLS... | 1117 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
O95347-1117- | AALDLS... | 1117 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
O95347-1117- | AALDLS... | 1117 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
O95347-1117- | AALDLS... | 1117 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...KRKDKE | 290 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000414999 | |||
...LSLVEY | 611 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5287 | |||
...LSLVEY | 611 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt138207 | |||
...AHVEV | 1197 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATL1_HUMAN | 611 | LVEY.|.YKPE | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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