Q9ULT8: E3 ubiquitin-protein ligase HECTD1

General Information

Protein names	- E3 ubiquitin-protein ligase HECTD1 - 2.3.2.26 {ECO:0000250\|UniProtKB:Q69ZR2} - E3 ligase for inhibin receptor - EULIR - HECT domain-containing protein 1 - HECT-type E3 ubiquitin transferase HECTD1
Gene names	HECTD1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9ULT8

6 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI
        70         80         90        100        110        120
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA
       130        140        150        160        170        180
EQCVKVLELI CTRESGAVFE AGGLNCVLTF IRDSGHLVHK DTLHSAMAVV SRLCGKMEPQ
       190        200        210        220        230        240
DSSLEICVES LSSLLKHEDH QVSDGALRCF ASLADRFTRR GVDPAPLAKH GLTEELLSRM
       250        260        270        280        290        300
AAAGGTVSGP SSACKPGRST TGAPSTTADS KLSNQVSTIV SLLSTLCRGS PVVTHDLLRS
       310        320        330        340        350        360
ELPDSIESAL QGDERCVLDT MRLVDLLLVL LFEGRKALPK SSAGSTGRIP GLRRLDSSGE
       370        380        390        400        410        420
RSHRQLIDCI RSKDTDALID AIDTGAFEVN FMDDVGQTLL NWASAFGTQE MVEFLCERGA
       430        440        450        460        470        480
DVNRGQRSSS LHYAACFGRP QVAKTLLRHG ANPDLRDEDG KTPLDKARER GHSEVVAILQ
       490        500        510        520        530        540
SPGDWMCPVN KGDDKKKKDT NKDEEECNEP KGDPEMAPIY LKRLLPVFAQ TFQQTMLPSI
       550        560        570        580        590        600
RKASLALIRK MIHFCSEALL KEVCDSDVGH NLPTILVEIT ATVLDQEDDD DGHLLALQII
       610        620        630        640        650        660
RDLVDKGGDI FLDQLARLGV ISKVSTLAGP SSDDENEEES KPEKEDEPQE DAKELQQGKP
       670        680        690        700        710        720
YHWRDWSIIR GRDCLYIWSD AAALELSNGS NGWFRFILDG KLATMYSSGS PEGGSDSSES
       730        740        750        760        770        780
RSEFLEKLQR ARGQVKPSTS SQPILSAPGP TKLTVGNWSL TCLKEGEIAI HNSDGQQATI
       790        800        810        820        830        840
LKEDLPGFVF ESNRGTKHSF TAETSLGSEF VTGWTGKRGR KLKSKLEKTK QKVRTMARDL
       850        860        870        880        890        900
YDDHFKAVES MPRGVVVTLR NIATQLESSW ELHTNRQCIE SENTWRDLMK TALENLIVLL
       910        920        930        940        950        960
KDENTISPYE MCSSGLVQAL LTVLNNSMDL DMKQDCSQLV ERINVFKTAF SENEDDESRP
       970        980        990       1000       1010       1020
AVALIRKLIA VLESIERLPL HLYDTPGSTY NLQILTRRLR FRLERAPGET ALIDRTGRML
      1030       1040       1050       1060       1070       1080
KMEPLATVES LEQYLLKMVA KQWYDFDRSS FVFVRKLREG QNFIFRHQHD FDENGIIYWI
      1090       1100       1110       1120       1130       1140
GTNAKTAYEW VNPAAYGLVV VTSSEGRNLP YGRLEDILSR DNSALNCHSN DDKNAWFAID
      1150       1160       1170       1180       1190       1200
LGLWVIPSAY TLRHARGYGR SALRNWVFQV SKDGQNWTSL YTHVDDCSLN EPGSTATWPL
      1210       1220       1230       1240       1250       1260
DPPKDEKQGW RHVRIKQMGK NASGQTHYLS LSGFELYGTV NGVCEDQLGK AAKEAEANLR
      1270       1280       1290       1300       1310       1320
RQRRLVRSQV LKYMVPGARV IRGLDWKWRD QDGSPQGEGT VTGELHNGWI DVTWDAGGSN
      1330       1340       1350       1360       1370       1380
SYRMGAEGKF DLKLAPGYDP DTVASPKPVS STVSGTTQSW SSLVKNNCPD KTSAAAGSSS
      1390       1400       1410       1420       1430       1440
RKGSSSSVCS VASSSDISLG STKTERRSEI VMEHSIVSGA DVHEPIVVLS SAENVPQTEV
      1450       1460       1470       1480       1490       1500
GSSSSASTST LTAETGSENA ERKLGPDSSV RTPGESSAIS MGIVSVSSPD VSSVSELTNK
      1510       1520       1530       1540       1550       1560
EAASQRPLSS SASNRLSVSS LLAAGAPMSS SASVPNLSSR ETSSLESFVR RVANIARTNA
      1570       1580       1590       1600       1610       1620
TNNMNLSRSS SDNNTNTLGR NVMSTATSPL MGAQSFPNLT TPGTTSTVTM STSSVTSSSN
      1630       1640       1650       1660       1670       1680
VATATTVLSV GQSLSNTLTT SLTSTSSESD TGQEAEYSLY DFLDSCRAST LLAELDDDED
      1690       1700       1710       1720       1730       1740
LPEPDEEDDE NEDDNQEDQE YEEVMILRRP SLQRRAGSRS DVTHHAVTSQ LPQVPAGAGS
      1750       1760       1770       1780       1790       1800
RPIGEQEEEE YETKGGRRRT WDDDYVLKRQ FSALVPAFDP RPGRTNVQQT TDLEIPPPGT
      1810       1820       1830       1840       1850       1860
PHSELLEEVE CTPSPRLALT LKVTGLGTTR EVELPLTNFR STIFYYVQKL LQLSCNGNVK
      1870       1880       1890       1900       1910       1920
SDKLRRIWEP TYTIMYREMK DSDKEKENGK MGCWSIEHVE QYLGTDELPK NDLITYLQKN
      1930       1940       1950       1960       1970       1980
ADAAFLRHWK LTGTNKSIRK NRNCSQLIAA YKDFCEHGTK SGLNQGAIST LQSSDILNLT
      1990       2000       2010       2020       2030       2040
KEQPQAKAGN GQNSCGVEDV LQLLRILYIV ASDPYSRISQ EDGDEQLQFT FPPDEFTSKK
      2050       2060       2070       2080       2090       2100
ITTKILQQIE EPLALASGAL PDWCEQLTSK CPFLIPFETR QLYFTCTAFG ASRAIVWLQN
      2110       2120       2130       2140       2150       2160
RREATVERTR TTSSVRRDDP GEFRVGRLKH ERVKVPRGES LMEWAENVMQ IHADRKSVLE
      2170       2180       2190       2200       2210       2220
VEFLGEEGTG LGPTLEFYAL VAAEFQRTDL GAWLCDDNFP DDESRHVDLG GGLKPPGYYV
      2230       2240       2250       2260       2270       2280
QRSCGLFTAP FPQDSDELER ITKLFHFLGI FLAKCIQDNR LVDLPISKPF FKLMCMGDIK
      2290       2300       2310       2320       2330       2340
SNMSKLIYES RGDRDLHCTE SQSEASTEEG HDSLSVGSFE EDSKSEFILD PPKPKPPAWF
      2350       2360       2370       2380       2390       2400
NGILTWEDFE LVNPHRARFL KEIKDLAIKR RQILSNKGLS EDEKNTKLQE LVLKNPSGSG
      2410       2420       2430       2440       2450       2460
PPLSIEDLGL NFQFCPSSRI YGFTAVDLKP SGEDEMITMD NAEEYVDLMF DFCMHTGIQK
      2470       2480       2490       2500       2510       2520
QMEAFRDGFN KVFPMEKLSS FSHEEVQMIL CGNQSPSWAA EDIINYTEPK LGYTRDSPGF
      2530       2540       2550       2560       2570       2580
LRFVRVLCGM SSDERKAFLQ FTTGCSTLPP GGLANLHPRL TVVRKVDATD ASYPSVNTCV
      2590       2600       2610
HYLKLPEYSS EEIMRERLLA ATMEKGFHLN

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9ULT8-1-unknown	MADVDP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9ULT8-2-acetylation	ADVDPD...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9ULT8-249-unknown	GPSSAC...	249		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6865
Q9ULT8-527-unknown	VFAQTF...	527		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451860
Q9ULT8-1493-	SVSELT...	1493			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9ULT8-2313-	SLSVGS...	2313			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GGTVSG	248	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6865
...TVLNNS	926	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452015
...SVGQSL	1633	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452233
...DEFTSK	2038	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000451860
...GFHLN	2610	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	248	TVSG.\|.GPSS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)