Q9NR30: Nucleolar RNA helicase 2 {ECO:0000305}

General Information

Protein names	- Nucleolar RNA helicase 2 {ECO:0000305} - 3.6.4.13 {ECO:0000269\|PubMed:9461305} - DEAD box protein 21 - Gu-alpha - Nucleolar RNA helicase Gu - Nucleolar RNA helicase II - RH II/Gu
Gene names	DDX21
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NR30

23 N-termini

8 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPGKLRSDAG LESDTAMKKG ETLRKQTEEK EKKEKPKSDK TEEIAEEEET VFPKAKQVKK
        70         80         90        100        110        120
KAEPSEVDMN SPKSKKAKKK EEPSQNDISP KTKSLRKKKE PIEKKVVSSK TKKVTKNEEP
       130        140        150        160        170        180
SEEEIDAPKP KKMKKEKEMN GETREKSPKL KNGFPHPEPD CNPSEAASEE SNSEIEQEIP
       190        200        210        220        230        240
VEQKEGAFSN FPISEETIKL LKGRGVTFLF PIQAKTFHHV YSGKDLIAQA RTGTGKTFSF
       250        260        270        280        290        300
AIPLIEKLHG ELQDRKRGRA PQVLVLAPTR ELANQVSKDF SDITKKLSVA CFYGGTPYGG
       310        320        330        340        350        360
QFERMRNGID ILVGTPGRIK DHIQNGKLDL TKLKHVVLDE VDQMLDMGFA DQVEEILSVA
       370        380        390        400        410        420
YKKDSEDNPQ TLLFSATCPH WVFNVAKKYM KSTYEQVDLI GKKTQKTAIT VEHLAIKCHW
       430        440        450        460        470        480
TQRAAVIGDV IRVYSGHQGR TIIFCETKKE AQELSQNSAI KQDAQSLHGD IPQKQREITL
       490        500        510        520        530        540
KGFRNGSFGV LVATNVAARG LDIPEVDLVI QSSPPKDVES YIHRSGRTGR AGRTGVCICF
       550        560        570        580        590        600
YQHKEEYQLV QVEQKAGIKF KRIGVPSATE IIKASSKDAI RLLDSVPPTA ISHFKQSAEK
       610        620        630        640        650        660
LIEEKGAVEA LAAALAHISG ATSVDQRSLI NSNVGFVTMI LQCSIEMPNI SYAWKELKEQ
       670        680        690        700        710        720
LGEEIDSKVK GMVFLKGKLG VCFDVPTASV TEIQEKWHDS RRWQLSVATE QPELEGPREG
       730        740        750        760        770        780
YGGFRGQREG SRGFRGQRDG NRRFRGQREG SRGPRGQRSG GGNKSNRSQN KGQKRSFSKA

FGQ

Isoforms

- Isoform 2 of Nucleolar RNA helicase 2

Sequence View

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Protein Neighborhood

Domains & Features

23 N-termini - 8 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NR30-1-unknown	MPGKLR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NR30-7-unknown	SDAGLE...	7	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10561
Q9NR30-7-unknown	SDAGLE...	7	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18140
Q9NR30-9-unknown	AGLESD...	9	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13386
Q9NR30-9-unknown	AGLESD...	9	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3226
Q9NR30-69-unknown	MNSPKS...	69	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72536
Q9NR30-69-unknown	MNSPKS...	69	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q9NR30-114-unknown	VTKNEE...	114	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169658
Q9NR30-114-	VTKNEE...	114		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9NR30-404-unknown	TQKTAI...	404	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169662
Q9NR30-404-	TQKTAI...	404		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9NR30-458-unknown	SAIKQD...	458	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166801
Q9NR30-458-	SAIKQD...	458		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9NR30-458-	SAIKQD...	458		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9NR30-458-	SAIKQD...	458		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q9NR30-464-unknown	AQSLHG...	464	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13387
Q9NR30-464-unknown	AQSLHG...	464	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151937
Q9NR30-585-unknown	SVPPTA...	585	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166806
Q9NR30-585-	SVPPTA...	585		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9NR30-585-	SVPPTA...	585		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9NR30-612-	AAALAH...	612		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9NR30-612-unknown	AAALAH...	612	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15021
Q9NR30-612-unknown	AAALAH...	612	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153925
Q9NR30-613-	AALAHI...	613		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9NR30-613-	AALAHI...	613		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9NR30-613-unknown	AALAHI...	613	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166804
Q9NR30-616-	AHISGA...	616		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9NR30-616-unknown	AHISGA...	616	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15023
Q9NR30-616-unknown	AHISGA...	616	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153973
Q9NR30-617-	HISGAT...	617		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9NR30-617-unknown	HISGAT...	617	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6796
Q9NR30-617-unknown	HISGAT...	617	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8099
Q9NR30-617-unknown	HISGAT...	617	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153983
Q9NR30-776-unknown	SFSKAF...	776	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169660
Q9NR30-776-	SFSKAF...	776		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...PGKLRS	6	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10561
...PGKLRS	6	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18140
...KLRSDA	8	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13386
...KLRSDA	8	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3226
...AIKQDA	463	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13387
...AIKQDA	463	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt135345
...AVEALA	611	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15021
...AVEALA	611	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt137347
...LAAALA	615	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15023
...LAAALA	615	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt137395
...AAALAH	616	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6796
...AAALAH	616	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8099
...AAALAH	616	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt137404
...KAFGQ	783		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KAFGQ	783		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KAFGQ	783	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KAFGQ	783	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt68154
...KAFGQ	783		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KAFGQ	783		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	6	KLRS.\|.SDAG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
MEP1A_HUMAN	6	KLRS.\|.SDAG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	8	RSDA.\|.AGLE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CASPE_HUMAN	8	RSDA.\|.AGLE	inferred from experiment	unknown	MEROPS		Merops CASPE_HUMAN -> DDX21_HUMAN @8
GRAB_HUMAN	463	KQDA.\|.AQSL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	611	EALA.\|.AAAL	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	615	AALA.\|.AHIS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATL1_HUMAN	616	ALAH.\|.HISG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	616	ALAH.\|.HISG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)