O14980: Exportin-1

General Information

Protein names	- Exportin-1 - Exp1 - Chromosome region maintenance 1 protein homolog
Gene names	XPO1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O14980

7 N-termini

10 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPAIMTMLAD HAARQLLDFS QKLDINLLDN VVNCLYHGEG AQQRMAQEVL THLKEHPDAW
        70         80         90        100        110        120
TRVDTILEFS QNMNTKYYGL QILENVIKTR WKILPRNQCE GIKKYVVGLI IKTSSDPTCV
       130        140        150        160        170        180
EKEKVYIGKL NMILVQILKQ EWPKHWPTFI SDIVGASRTS ESLCQNNMVI LKLLSEEVFD
       190        200        210        220        230        240
FSSGQITQVK SKHLKDSMCN EFSQIFQLCQ FVMENSQNAP LVHATLETLL RFLNWIPLGY
       250        260        270        280        290        300
IFETKLISTL IYKFLNVPMF RNVSLKCLTE IAGVSVSQYE EQFVTLFTLT MMQLKQMLPL
       310        320        330        340        350        360
NTNIRLAYSN GKDDEQNFIQ NLSLFLCTFL KEHDQLIEKR LNLRETLMEA LHYMLLVSEV
       370        380        390        400        410        420
EETEIFKICL EYWNHLAAEL YRESPFSTSA SPLLSGSQHF DVPPRRQLYL PMLFKVRLLM
       430        440        450        460        470        480
VSRMAKPEEV LVVENDQGEV VREFMKDTDS INLYKNMRET LVYLTHLDYV DTERIMTEKL
       490        500        510        520        530        540
HNQVNGTEWS WKNLNTLCWA IGSISGAMHE EDEKRFLVTV IKDLLGLCEQ KRGKDNKAII
       550        560        570        580        590        600
ASNIMYIVGQ YPRFLRAHWK FLKTVVNKLF EFMHETHDGV QDMACDTFIK IAQKCRRHFV
       610        620        630        640        650        660
QVQVGEVMPF IDEILNNINT IICDLQPQQV HTFYEAVGYM IGAQTDQTVQ EHLIEKYMLL
       670        680        690        700        710        720
PNQVWDSIIQ QATKNVDILK DPETVKQLGS ILKTNVRACK AVGHPFVIQL GRIYLDMLNV
       730        740        750        760        770        780
YKCLSENISA AIQANGEMVT KQPLIRSMRT VKRETLKLIS GWVSRSNDPQ MVAENFVPPL
       790        800        810        820        830        840
LDAVLIDYQR NVPAAREPEV LSTMAIIVNK LGGHITAEIP QIFDAVFECT LNMINKDFEE
       850        860        870        880        890        900
YPEHRTNFFL LLQAVNSHCF PAFLAIPPTQ FKLVLDSIIW AFKHTMRNVA DTGLQILFTL
       910        920        930        940        950        960
LQNVAQEEAA AQSFYQTYFC DILQHIFSVV TDTSHTAGLT MHASILAYMF NLVEEGKIST
       970        980        990       1000       1010       1020
SLNPGNPVNN QIFLQEYVAN LLKSAFPHLQ DAQVKLFVTG LFSLNQDIPA FKEHLRDFLV
      1030       1040       1050       1060       1070
QIKEFAGEDT SDLFLEEREI ALRQADEEKH KRQMSVPGIF NPHEIPEEMC D

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 10 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O14980-1-unknown	MPAIMT...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O14980-6-acetylation	TMLADH...	6	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O14980-6-acetylation	TMLADH...	6	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O14980-7-acetylation	MLADHA...	7	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O14980-7-unknown	MLADHA...	7			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O14980-7-unknown	MLADHA...	7			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O14980-7-	MLADHA...	7			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O14980-7-	MLADHA...	7			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O14980-7-	MLADHA...	7			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O14980-503-unknown	SISGAM...	503		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7010
O14980-506-unknown	GAMHEE...	506		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5135

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EHPDAW	59	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000390843
...DAWTRV	62	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000406819
...RWKILP	94	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000394951
...WKILPR	95	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000408190
...RNQCEG	100	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000393484
...GKLNMI	132	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000406428
...SEEVFD	179	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000413853
...CWAIGS	502	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7010
...IGSISG	505	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5135
...EEMCD	1071	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	502	AIGS.\|.SISG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	505	SISG.\|.GAMH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)