Q13126: S-methyl-5'-thioadenosine phosphorylase {ECO:0000255|HAMAP-Rule:MF_03155}

General Information

Protein names	- S-methyl-5'-thioadenosine phosphorylase {ECO:0000255\|HAMAP-Rule:MF_03155} - 2.4.2.28 {ECO:0000255\|HAMAP-Rule:MF_03155} - 5'-methylthioadenosine phosphorylase {ECO:0000255\|HAMAP-Rule:MF_03155} - MTA phosphorylase {ECO:0000255\|HAMAP-Rule:MF_03155} - MTAP {ECO:0000255\|HAMAP-Rule:MF_03155} - MTAPase {ECO:0000255\|HAMAP-Rule:MF_03155}
Gene names	MTAP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13126

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of S-methyl-5'-thioadenosine phosphorylase - Isoform 3 of S-methyl-5'-thioadenosine phosphorylase - Isoform 4 of S-methyl-5'-thioadenosine phosphorylase - Isoform 5 of S-methyl-5'-thioadenosine phosphorylase - Isoform 6 of S-methyl-5'-thioadenosine phosphorylase - Isoform 7 of S-methyl-5'-thioadenosine phosphorylase

Sequence View

        10         20         30         40         50         60
MASGTTTTAV KIGIIGGTGL DDPEILEGRT EKYVDTPFGK PSDALILGKI KNVDCVLLAR
        70         80         90        100        110        120
HGRQHTIMPS KVNYQANIWA LKEEGCTHVI VTTACGSLRE EIQPGDIVII DQFIDRTTMR
       130        140        150        160        170        180
PQSFYDGSHS CARGVCHIPM AEPFCPKTRE VLIETAKKLG LRCHSKGTMV TIEGPRFSSR
       190        200        210        220        230        240
AESFMFRTWG ADVINMTTVP EVVLAKEAGI CYASIAMATD YDCWKEHEEA VSVDRVLKTL
       250        260        270        280
KENANKAKSL LLTTIPQIGS TEWSETLHNL KNMAQFSVLL PRH         10         20         30         40         50         60
MASGTTTTAV KIGIIGGTGL DDPEILEGRT EKYVDTPFGK PSDALILGKI KNVDCVLLAR
        70         80         90        100        110        120
HGRQHTIMPS KVNYQANIWA LKEEGCTHVI VTTACGSLRE EIQPGDIVII DQFIDRTTMR
       130        140        150        160        170        180
PQSFYDGSHS CARGVCHIPM AEPFCPKTRE VLIETAKKLG LRCHSKGTMV TIEGPRFSSR
       190        200        210        220        230        240
AESFMFRTWG ADVINMTTVP EVVLAKEAGI CYASIAMATD YDCWKEHEEA VSVDRVLKTL
       250        260        270        280
KENANKAKSL LLTTIPQIGS TEWSETLHNL KNMAQFSVLL PRH         10         20         30         40         50         60
MASGTTTTAV KIGIIGGTGL DDPEILEGRT EKYVDTPFGK PSDALILGKI KNVDCVLLAR
        70         80         90        100        110        120
HGRQHTIMPS KVNYQANIWA LKEEGCTHVI VTTACGSLRE EIQPGDIVII DQFIDRTTMR
       130        140        150        160        170        180
PQSFYDGSHS CARGVCHIPM AEPFCPKTRE VLIETAKKLG LRCHSKGTMV TIEGPRFSSR
       190        200        210        220        230        240
AESFMFRTWG ADVINMTTVP EVVLAKEAGI CYASIAMATD YDCWKEHEEA VSVDRVLKTL
       250        260        270        280
KENANKAKSL LLTTIPQIGS TEWSETLHNL KNMAQFSVLL PRH         10         20         30         40         50         60
MASGTTTTAV KIGIIGGTGL DDPEILEGRT EKYVDTPFGK PSDALILGKI KNVDCVLLAR
        70         80         90        100        110        120
HGRQHTIMPS KVNYQANIWA LKEEGCTHVI VTTACGSLRE EIQPGDIVII DQFIDRTTMR
       130        140        150        160        170        180
PQSFYDGSHS CARGVCHIPM AEPFCPKTRE VLIETAKKLG LRCHSKGTMV TIEGPRFSSR
       190        200        210        220        230        240
AESFMFRTWG ADVINMTTVP EVVLAKEAGI CYASIAMATD YDCWKEHEEA VSVDRVLKTL
       250        260        270        280
KENANKAKSL LLTTIPQIGS TEWSETLHNL KNMAQFSVLL PRH         10         20         30         40         50         60
MASGTTTTAV KIGIIGGTGL DDPEILEGRT EKYVDTPFGK PSDALILGKI KNVDCVLLAR
        70         80         90        100        110        120
HGRQHTIMPS KVNYQANIWA LKEEGCTHVI VTTACGSLRE EIQPGDIVII DQFIDRTTMR
       130        140        150        160        170        180
PQSFYDGSHS CARGVCHIPM AEPFCPKTRE VLIETAKKLG LRCHSKGTMV TIEGPRFSSR
       190        200        210        220        230        240
AESFMFRTWG ADVINMTTVP EVVLAKEAGI CYASIAMATD YDCWKEHEEA VSVDRVLKTL
       250        260        270        280
KENANKAKSL LLTTIPQIGS TEWSETLHNL KNMAQFSVLL PRH         10         20         30         40         50         60
MASGTTTTAV KIGIIGGTGL DDPEILEGRT EKYVDTPFGK PSDALILGKI KNVDCVLLAR
        70         80         90        100        110        120
HGRQHTIMPS KVNYQANIWA LKEEGCTHVI VTTACGSLRE EIQPGDIVII DQFIDRTTMR
       130        140        150        160        170        180
PQSFYDGSHS CARGVCHIPM AEPFCPKTRE VLIETAKKLG LRCHSKGTMV TIEGPRFSSR
       190        200        210        220        230        240
AESFMFRTWG ADVINMTTVP EVVLAKEAGI CYASIAMATD YDCWKEHEEA VSVDRVLKTL
       250        260        270        280
KENANKAKSL LLTTIPQIGS TEWSETLHNL KNMAQFSVLL PRH

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q13126-1-unknown	MASGTT...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q13126-1-unknown	MASGTT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81693
Q13126-1-unknown	MASGTT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81694
Q13126-1-unknown	MASGTT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81695
Q13126-1-unknown	MASGTT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81696
Q13126-1-unknown	MASGTT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81697
Q13126-1-unknown	MASGTT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81698
Q13126-260-unknown	STEWSE...	260	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6306

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IPQIGS	259	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6306
...IPQIGS	259	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132199
...IPQIGS	259	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132200
...IPQIGS	259	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132201
...LLPRH	283	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	259	QIGS.\|.STEW	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)