P53582: Methionine aminopeptidase 1 {ECO:0000255|HAMAP-Rule:MF_03174}

General Information

Protein names	- Methionine aminopeptidase 1 {ECO:0000255\|HAMAP-Rule:MF_03174} - MAP 1 {ECO:0000255\|HAMAP-Rule:MF_03174} - MetAP 1 {ECO:0000255\|HAMAP-Rule:MF_03174} - 3.4.11.18 {ECO:0000255\|HAMAP-Rule:MF_03174} - Peptidase M 1 {ECO:0000255\|HAMAP-Rule:MF_03174}
Gene names	METAP1
Organism	Homo sapiens
Protease Family
Protease ID	M24.017
Chromosome location
UniProt ID	P53582

7 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAVETRVCE TDGCSSEAKL QCPTCIKLGI QGSYFCSQEC FKGSWATHKL LHKKAKDEKA
        70         80         90        100        110        120
KREVSSWTVE GDINTDPWAG YRYTGKLRPH YPLMPTRPVP SYIQRPDYAD HPLGMSESEQ
       130        140        150        160        170        180
ALKGTSQIKL LSSEDIEGMR LVCRLAREVL DVAAGMIKPG VTTEEIDHAV HLACIARNCY
       190        200        210        220        230        240
PSPLNYYNFP KSCCTSVNEV ICHGIPDRRP LQEGDIVNVD ITLYRNGYHG DLNETFFVGE
       250        260        270        280        290        300
VDDGARKLVQ TTYECLMQAI DAVKPGVRYR ELGNIIQKHA QANGFSVVRS YCGHGIHKLF
       310        320        330        340        350        360
HTAPNVPHYA KNKAVGVMKS GHVFTIEPMI CEGGWQDETW PDGWTAVTRD GKRSAQFEHT
       370        380
LLVTDTGCEI LTRRLDSARP HFMSQF

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

7 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P53582-2-unknown	MAAVET...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P53582-2-Acetylation	AAVETR...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P53582-114-	GMSESE...	114			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P53582-114-	GMSESE...	114			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P53582-114-	GMSESE...	114			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P53582-173-unknown	ACIARN...	173		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000423071
P53582-223-unknown	LYRNGY...	223		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000422689
P53582-227-	GYHGDL...	227			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P53582-227-	GYHGDL...	227			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P53582-302-unknown	TAPNVP...	302		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6017

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...HKLFHT	301	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6017
	...FMSQF	386	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	301	LFHT.\|.TAPN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)