Q9Y6D6: Brefeldin A-inhibited guanine nucleotide-exchange protein 1

General Information

Protein names	- Brefeldin A-inhibited guanine nucleotide-exchange protein 1 - Brefeldin A-inhibited GEP 1 - ADP-ribosylation factor guanine nucleotide-exchange factor 1 - p200 ARF guanine nucleotide exchange factor - p200 ARF-GEP1
Gene names	ARFGEF1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y6D6

8 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MYEGKKTKNM FLTRALEKIL ADKEVKKAHH SQLRKACEVA LEEIKAETEK QSPPHGEAKA
        70         80         90        100        110        120
GSSTLPPVKS KTNFIEADKY FLPFELACQS KCPRIVSTSL DCLQKLIAYG HLTGNAPDST
       130        140        150        160        170        180
TPGKKLIDRI IETICGCFQG PQTDEGVQLQ IIKALLTAVT SQHIEIHEGT VLQAVRTCYN
       190        200        210        220        230        240
IYLASKNLIN QTTAKATLTQ MLNVIFARME NQALQEAKQM EKERHRQHHH LLQSPVSHHE
       250        260        270        280        290        300
PESPQLRYLP PQTVDHISQE HEGDLDLHTN DVDKSLQDDT EPENGSDISS AENEQTEADQ
       310        320        330        340        350        360
ATAAETLSKN EVLYDGENHD CEEKPQDIVQ NIVEEMVNIV VGDMGEGTTI NASADGNIGT
       370        380        390        400        410        420
IEDGSDSENI QANGIPGTPI SVAYTPSLPD DRLSVSSNDT QESGNSSGPS PGAKFSHILQ
       430        440        450        460        470        480
KDAFLVFRSL CKLSMKPLSD GPPDPKSHEL RSKILSLQLL LSILQNAGPI FRTNEMFINA
       490        500        510        520        530        540
IKQYLCVALS KNGVSSVPEV FELSLSIFLT LLSNFKTHLK MQIEVFFKEI FLYILETSTS
       550        560        570        580        590        600
SFDHKWMVIQ TLTRICADAQ SVVDIYVNYD CDLNAANIFE RLVNDLSKIA QGRGSQELGM
       610        620        630        640        650        660
SNVQELSLRK KGLECLVSIL KCMVEWSKDQ YVNPNSQTTL GQEKPSEQEM SEIKHPETIN
       670        680        690        700        710        720
RYGSLNSLES TSSSGIGSYS TQMSGTDNPE QFEVLKQQKE IIEQGIDLFN KKPKRGIQYL
       730        740        750        760        770        780
QEQGMLGTTP EDIAQFLHQE ERLDSTQVGE FLGDNDKFNK EVMYAYVDQH DFSGKDFVSA
       790        800        810        820        830        840
LRMFLEGFRL PGEAQKIDRL MEKFAARYLE CNQGQTLFAS ADTAYVLAYS IIMLTTDLHS
       850        860        870        880        890        900
PQVKNKMTKE QYIKMNRGIN DSKDLPEEYL SAIYNEIAGK KISMKETKEL TIPTKSSKQN
       910        920        930        940        950        960
VASEKQRRLL YNLEMEQMAK TAKALMEAVS HVQAPFTSAT HLEHVRPMFK LAWTPFLAAF
       970        980        990       1000       1010       1020
SVGLQDCDDT EVASLCLEGI RCAIRIACIF SIQLERDAYV QALARFTLLT VSSGITEMKQ
      1030       1040       1050       1060       1070       1080
KNIDTIKTLI TVAHTDGNYL GNSWHEILKC ISQLELAQLI GTGVKPRYIS GTVRGREGSL
      1090       1100       1110       1120       1130       1140
TGTKDQAPDE FVGLGLVGGN VDWKQIASIQ ESIGETSSQS VVVAVDRIFT GSTRLDGNAI
      1150       1160       1170       1180       1190       1200
VDFVRWLCAV SMDELLSTTH PRMFSLQKIV EISYYNMGRI RLQWSRIWEV IGDHFNKVGC
      1210       1220       1230       1240       1250       1260
NPNEDVAIFA VDSLRQLSMK FLEKGELANF RFQKDFLRPF EHIMKRNRSP TIRDMVVRCI
      1270       1280       1290       1300       1310       1320
AQMVNSQAAN IRSGWKNIFS VFHLAASDQD ESIVELAFQT TGHIVTLVFE KHFPATIDSF
      1330       1340       1350       1360       1370       1380
QDAVKCLSEF ACNAAFPDTS MEAIRLIRHC AKYVSDRPQA FKEYTSDDMN VAPEDRVWVR
      1390       1400       1410       1420       1430       1440
GWFPILFELS CIINRCKLDV RTRGLTVMFE IMKTYGHTYE KHWWQDLFRI VFRIFDNMKL
      1450       1460       1470       1480       1490       1500
PEQQTEKAEW MTTTCNHALY AICDVFTQYL EVLSDVLLDD IFAQLYWCVQ QDNEQLARSG
      1510       1520       1530       1540       1550       1560
TNCLENVVIL NGEKFTLEIW DKTCNCTLDI FKTTIPHALL TWRPNSGETA PPPPSPVSEK
      1570       1580       1590       1600       1610       1620
PLDTISQKSV DIHDSIQPRS VDNRPQAPLV SASAVNEEVS KIKSTAKFPE QKLFAALLIK
      1630       1640       1650       1660       1670       1680
CVVQLELIQT IDNIVFFPAT SKKEDAENLA AAQRDAVDFD VRVDTQDQGM YRFLTSQQLF
      1690       1700       1710       1720       1730       1740
KLLDCLLESH RFAKAFNSNN EQRTALWKAG FKGKSKPNLL KQETSSLACG LRILFRMYMD
      1750       1760       1770       1780       1790       1800
ESRVSAWEEV QQRLLNVCSE ALSYFLTLTS ESHREAWTNL LLLFLTKVLK ISDNRFKAHA
      1810       1820       1830       1840
SFYYPLLCEI MQFDLIPELR AVLRRFFLRI GVVFQISQPP EQELGINKQ

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y6D6-1-unknown	MYEGKK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y6D6-1-acetylation	MYEGKK...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9Y6D6-10-unknown	MFLTRA...	10		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q9Y6D6-114-unknown	GNAPDS...	114		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6959
Q9Y6D6-547-unknown	MVIQTL...	547		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000428429
Q9Y6D6-1152-unknown	MDELLS...	1152		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000429138
Q9Y6D6-1163-unknown	MFSLQK...	1163		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000430891
Q9Y6D6-1670-unknown	MYRFLT...	1670		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000429560

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YGHLTG	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6959
...GNAPDS	118	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000429002
...ANIRSG	1273	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000429138
...RAVLRR	1824	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000429560
...GINKQ	1849	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	113	HLTG.\|.GNAP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)