Q01130: Serine/arginine-rich splicing factor 2

General Information

Protein names	- Serine/arginine-rich splicing factor 2 - Protein PR264 - Splicing component, 35 kDa - Splicing factor SC35 - SC-35 - Splicing factor, arginine/serine-rich 2
Gene names	SRSF2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q01130

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSYGRPPPDV EGMTSLKVDN LTYRTSPDTL RRVFEKYGRV GDVYIPRDRY TKESRGFAFV
        70         80         90        100        110        120
RFHDKRDAED AMDAMDGAVL DGRELRVQMA RYGRPPDSHH SRRGPPPRRY GGGGYGRRSR
       130        140        150        160        170        180
SPRRRRRSRS RSRSRSRSRS RSRYSRSKSR SRTRSRSRST SKSRSARRSK SKSSSVSRSR
       190        200        210        220
SRSRSRSRSR SPPPVSKRES KSRSRSKSPP KSPEEEGAVS S

Isoforms

- Isoform 2 of Serine/arginine-rich splicing factor 2

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q01130-2-unknown	MSYGRP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q01130-2-Acetylation	SYGRPP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q01130-2-Acetylation	SYGRPP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q01130-2-Acetylation	SYGRPP...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q01130-2-Acetylation	SYGRPP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q01130-5-unknown	RPPPDV...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6205
Q01130-71-	AMDAMD...	71			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q01130-74-	AMDGAV...	74			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...SRSKSR	149	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463317
	...GAVSS	221	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	4	SYGR.\|.RPPP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)