P33176: Kinesin-1 heavy chain

General Information

Protein names	- Kinesin-1 heavy chain - Conventional kinesin heavy chain - Ubiquitous kinesin heavy chain - UKHC
Gene names	KIF5B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P33176

8 N-termini

6 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADLAECNIK VMCRFRPLNE SEVNRGDKYI AKFQGEDTVV IASKPYAFDR VFQSSTSQEQ
        70         80         90        100        110        120
VYNDCAKKIV KDVLEGYNGT IFAYGQTSSG KTHTMEGKLH DPEGMGIIPR IVQDIFNYIY
       130        140        150        160        170        180
SMDENLEFHI KVSYFEIYLD KIRDLLDVSK TNLSVHEDKN RVPYVKGCTE RFVCSPDEVM
       190        200        210        220        230        240
DTIDEGKSNR HVAVTNMNEH SSRSHSIFLI NVKQENTQTE QKLSGKLYLV DLAGSEKVSK
       250        260        270        280        290        300
TGAEGAVLDE AKNINKSLSA LGNVISALAE GSTYVPYRDS KMTRILQDSL GGNCRTTIVI
       310        320        330        340        350        360
CCSPSSYNES ETKSTLLFGQ RAKTIKNTVC VNVELTAEQW KKKYEKEKEK NKILRNTIQW
       370        380        390        400        410        420
LENELNRWRN GETVPIDEQF DKEKANLEAF TVDKDITLTN DKPATAIGVI GNFTDAERRK
       430        440        450        460        470        480
CEEEIAKLYK QLDDKDEEIN QQSQLVEKLK TQMLDQEELL ASTRRDQDNM QAELNRLQAE
       490        500        510        520        530        540
NDASKEEVKE VLQALEELAV NYDQKSQEVE DKTKEYELLS DELNQKSATL ASIDAELQKL
       550        560        570        580        590        600
KEMTNHQKKR AAEMMASLLK DLAEIGIAVG NNDVKQPEGT GMIDEEFTVA RLYISKMKSE
       610        620        630        640        650        660
VKTMVKRCKQ LESTQTESNK KMEENEKELA ACQLRISQHE AKIKSLTEYL QNVEQKKRQL
       670        680        690        700        710        720
EESVDALSEE LVQLRAQEKV HEMEKEHLNK VQTANEVKQA VEQQIQSHRE THQKQISSLR
       730        740        750        760        770        780
DEVEAKAKLI TDLQDQNQKM MLEQERLRVE HEKLKATDQE KSRKLHELTV MQDRREQARQ
       790        800        810        820        830        840
DLKGLEETVA KELQTLHNLR KLFVQDLATR VKKSAEIDSD DTGGSAAQKQ KISFLENNLE
       850        860        870        880        890        900
QLTKVHKQLV RDNADLRCEL PKLEKRLRAT AERVKALESA LKEAKENASR DRKRYQQEVD
       910        920        930        940        950        960
RIKEAVRSKN MARRGHSAQI AKPIRPGQHP AASPTHPSAI RGGGAFVQNS QPVAVRGGGG

KQV

Isoforms

Sequence View

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Directness:

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Protein Neighborhood

Domains & Features

8 N-termini - 6 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P33176-2-unknown	MADLAE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P33176-2-Acetylation	ADLAEC...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P33176-2-Acetylation	ADLAEC...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P33176-2-Acetylation	ADLAEC...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P33176-2-Acetylation	ADLAEC...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P33176-54-unknown	SSTSQE...	54		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5802
P33176-718-unknown	SLRDEV...	718		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5803
P33176-813-	KSAEID...	813			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P33176-813-	KSAEID...	813			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P33176-813-unknown	KSAEID...	813			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P33176-821-unknown	DTGGSA...	821		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11445
P33176-932-unknown	ASPTHP...	932		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5804

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...DRVFQS	53	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5802
...QKQISS	717	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5803
...EIDSDD	820	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11445
...GQHPAA	931	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5804
...GGKQV	963	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...GGKQV	963		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...GGKQV	963		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...GGKQV	963		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...GGKQV	963		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	53	VFQS.\|.SSTS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	717	QISS.\|.SLRD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	820	DSDD.\|.DTGG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATL1_HUMAN	931	HPAA.\|.ASPT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)