O00410: Importin-5

General Information

Protein names	- Importin-5 - Imp5 - Importin subunit beta-3 - Karyopherin beta-3 - Ran-binding protein 5 - RanBP5
Gene names	IPO5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00410

8 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Importin-5 - Isoform 3 of Importin-5

Sequence View

        10         20         30         40         50         60
MAAAAAEQQQ FYLLLGNLLS PDNVVRKQAE ETYENIPGQS KITFLLQAIR NTTAAEEARQ
        70         80         90        100        110        120
MAAVLLRRLL SSAFDEVYPA LPSDVQTAIK SELLMIIQME TQSSMRKKVC DIAAELARNL
       130        140        150        160        170        180
IDEDGNNQWP EGLKFLFDSV SSQNVGLREA ALHIFWNFPG IFGNQQQHYL DVIKRMLVQC
       190        200        210        220        230        240
MQDQEHPSIR TLSARATAAF ILANEHNVAL FKHFADLLPG FLQAVNDSCY QNDDSVLKSL
       250        260        270        280        290        300
VEIADTVPKY LRPHLEATLQ LSLKLCGDTS LNNMQRQLAL EVIVTLSETA AAMLRKHTNI
       310        320        330        340        350        360
VAQTIPQMLA MMVDLEEDED WANADELEDD DFDSNAVAGE SALDRMACGL GGKLVLPMIK
       370        380        390        400        410        420
EHIMQMLQNP DWKYRHAGLM ALSAIGEGCH QQMEGILNEI VNFVLLFLQD PHPRVRYAAC
       430        440        450        460        470        480
NAVGQMATDF APGFQKKFHE KVIAALLQTM EDQGNQRVQA HAAAALINFT EDCPKSLLIP
       490        500        510        520        530        540
YLDNLVKHLH SIMVLKLQEL IQKGTKLVLE QVVTSIASVA DTAEEKFVPY YDLFMPSLKH
       550        560        570        580        590        600
IVENAVQKEL RLLRGKTIEC ISLIGLAVGK EKFMQDASDV MQLLLKTQTD FNDMEDDDPQ
       610        620        630        640        650        660
ISYMISAWAR MCKILGKEFQ QYLPVVMGPL MKTASIKPEV ALLDTQDMEN MSDDDGWEFV
       670        680        690        700        710        720
NLGDQQSFGI KTAGLEEKST ACQMLVCYAK ELKEGFVEYT EQVVKLMVPL LKFYFHDGVR
       730        740        750        760        770        780
VAAAESMPLL LECARVRGPE YLTQMWHFMC DALIKAIGTE PDSDVLSEIM HSFAKCIEVM
       790        800        810        820        830        840
GDGCLNNEHF EELGGILKAK LEEHFKNQEL RQVKRQDEDY DEQVEESLQD EDDNDVYILT
       850        860        870        880        890        900
KVSDILHSIF SSYKEKVLPW FEQLLPLIVN LICPHRPWPD RQWGLCIFDD VIEHCSPASF
       910        920        930        940        950        960
KYAEYFLRPM LQYVCDNSPE VRQAAAYGLG VMAQYGGDNY RPFCTEALPL LVRVIQSADS
       970        980        990       1000       1010       1020
KTKENVNATE NCISAVGKIM KFKPDCVNVE EVLPHWLSWL PLHEDKEEAV QTFNYLCDLI
      1030       1040       1050       1060       1070       1080
ESNHPIVLGP NNTNLPKIFS IIAEGEMHEA IKHEDPCAKR LANVVRQVQT SGGLWTECIA
      1090
QLSPEQQAAI QELLNSA         10         20         30         40         50         60
MAAAAAEQQQ FYLLLGNLLS PDNVVRKQAE ETYENIPGQS KITFLLQAIR NTTAAEEARQ
        70         80         90        100        110        120
MAAVLLRRLL SSAFDEVYPA LPSDVQTAIK SELLMIIQME TQSSMRKKVC DIAAELARNL
       130        140        150        160        170        180
IDEDGNNQWP EGLKFLFDSV SSQNVGLREA ALHIFWNFPG IFGNQQQHYL DVIKRMLVQC
       190        200        210        220        230        240
MQDQEHPSIR TLSARATAAF ILANEHNVAL FKHFADLLPG FLQAVNDSCY QNDDSVLKSL
       250        260        270        280        290        300
VEIADTVPKY LRPHLEATLQ LSLKLCGDTS LNNMQRQLAL EVIVTLSETA AAMLRKHTNI
       310        320        330        340        350        360
VAQTIPQMLA MMVDLEEDED WANADELEDD DFDSNAVAGE SALDRMACGL GGKLVLPMIK
       370        380        390        400        410        420
EHIMQMLQNP DWKYRHAGLM ALSAIGEGCH QQMEGILNEI VNFVLLFLQD PHPRVRYAAC
       430        440        450        460        470        480
NAVGQMATDF APGFQKKFHE KVIAALLQTM EDQGNQRVQA HAAAALINFT EDCPKSLLIP
       490        500        510        520        530        540
YLDNLVKHLH SIMVLKLQEL IQKGTKLVLE QVVTSIASVA DTAEEKFVPY YDLFMPSLKH
       550        560        570        580        590        600
IVENAVQKEL RLLRGKTIEC ISLIGLAVGK EKFMQDASDV MQLLLKTQTD FNDMEDDDPQ
       610        620        630        640        650        660
ISYMISAWAR MCKILGKEFQ QYLPVVMGPL MKTASIKPEV ALLDTQDMEN MSDDDGWEFV
       670        680        690        700        710        720
NLGDQQSFGI KTAGLEEKST ACQMLVCYAK ELKEGFVEYT EQVVKLMVPL LKFYFHDGVR
       730        740        750        760        770        780
VAAAESMPLL LECARVRGPE YLTQMWHFMC DALIKAIGTE PDSDVLSEIM HSFAKCIEVM
       790        800        810        820        830        840
GDGCLNNEHF EELGGILKAK LEEHFKNQEL RQVKRQDEDY DEQVEESLQD EDDNDVYILT
       850        860        870        880        890        900
KVSDILHSIF SSYKEKVLPW FEQLLPLIVN LICPHRPWPD RQWGLCIFDD VIEHCSPASF
       910        920        930        940        950        960
KYAEYFLRPM LQYVCDNSPE VRQAAAYGLG VMAQYGGDNY RPFCTEALPL LVRVIQSADS
       970        980        990       1000       1010       1020
KTKENVNATE NCISAVGKIM KFKPDCVNVE EVLPHWLSWL PLHEDKEEAV QTFNYLCDLI
      1030       1040       1050       1060       1070       1080
ESNHPIVLGP NNTNLPKIFS IIAEGEMHEA IKHEDPCAKR LANVVRQVQT SGGLWTECIA
      1090
QLSPEQQAAI QELLNSA

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00410-2-unknown	MAAAAA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00410-1-unknown	MAAAAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt97298
O00410-2-Acetylation	AAAAAE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00410-2-Acetylation	AAAAAE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O00410-2-Acetylation	AAAAAE...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O00410-2-Acetylation	AAAAAE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110201
O00410-61-unknown	MAAVLL...	61		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt78010
O00410-61-unknown	MAAVLL...	61		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt106286
O00410-180-unknown	CMQDQE...	180		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6986
O00410-180-unknown	CMQDQE...	180		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143468
O00410-180-unknown	CMQDQE...	180		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146514
O00410-422-unknown	AVGQMA...	422		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164378
O00410-422-unknown	AVGQMA...	422		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164377
O00410-422-	AVGQMA...	422			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O00410-1029-unknown	GPNNTN...	1029		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5100
O00410-1029-unknown	GPNNTN...	1029		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157083
O00410-1029-unknown	GPNNTN...	1029		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157266

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RMLVQC	179	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6986
...RMLVQC	179	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126701
...RMLVQC	179	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129822
...HPIVLG	1028	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5100
...HPIVLG	1028	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140581
...HPIVLG	1028	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140765
...LLNSA	1097	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LLNSA	1097	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73628
...LLNSA	1097	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73629

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	179	LVQC.\|.CMQD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	1028	IVLG.\|.GPNN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)