Q99627: COP9 signalosome complex subunit 8

General Information

Protein names	- COP9 signalosome complex subunit 8 - SGN8 - Signalosome subunit 8 - COP9 homolog - hCOP9 - JAB1-containing signalosome subunit 8
Gene names	COPS8
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99627

3 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPVAVMAESA FSFKKLLDQC ENQELEAPGG IATPPVYGQL LALYLLHNDM NNARYLWKRI
        70         80         90        100        110        120
PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE TVQPIMEALR DATRRRAFAL
       130        140        150        160        170        180
VSQAYTSIIA DDFAAFVGLP VEEAVKGILE QGWQADSTTR MVLPRKPVAG ALDVSFNKFI
       190        200
PLSEPAPVPP IPNEQQLARL TDYVAFLEN

Isoforms

- Isoform 2 of COP9 signalosome complex subunit 8

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q99627-2-unknown	PVAVMA...	2	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q99627-50-unknown	MNNARY...	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt71915
Q99627-170-unknown	GALDVS...	170	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6711
Q99627-170-unknown	GALDVS...	170	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143512

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...RKPVAG	169	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6711
...RKPVAG	169	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt126752
...AFLEN	209		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...AFLEN	209		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...AFLEN	209	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...AFLEN	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt67533
...AFLEN	209		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...AFLEN	209		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	169	PVAG.\|.GALD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)