P33993: DNA replication licensing factor MCM7
Protein names | - DNA replication licensing factor MCM7 - 3.6.4.12 - CDC47 homolog - P1.1-MCM3 |
---|---|
Gene names | MCM7 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P33993 |
13
N-termini
4
C-termini
3
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MALKDYALEK EKVKKFLQEF YQDDELGKKQ FKYGNQLVRL AHREQVALYV DLDDVAEDDP
70 80 90 100 110 120
ELVDSICENA RRYAKLFADA VQELLPQYKE REVVNKDVLD VYIEHRLMME QRSRDPGMVR
130 140 150 160 170 180
SPQNQYPAEL MRRFELYFQG PSSNKPRVIR EVRADSVGKL VTVRGIVTRV SEVKPKMVVA
190 200 210 220 230 240
TYTCDQCGAE TYQPIQSPTF MPLIMCPSQE CQTNRSGGRL YLQTRGSRFI KFQEMKMQEH
250 260 270 280 290 300
SDQVPVGNIP RSITVLVEGE NTRIAQPGDH VSVTGIFLPI LRTGFRQVVQ GLLSETYLEA
310 320 330 340 350 360
HRIVKMNKSE DDESGAGELT REELRQIAEE DFYEKLAASI APEIYGHEDV KKALLLLLVG
370 380 390 400 410 420
GVDQSPRGMK IRGNINICLM GDPGVAKSQL LSYIDRLAPR SQYTTGRGSS GVGLTAAVLR
430 440 450 460 470 480
DSVSGELTLE GGALVLADQG VCCIDEFDKM AEADRTAIHE VMEQQTISIA KAGILTTLNA
490 500 510 520 530 540
RCSILAAANP AYGRYNPRRS LEQNIQLPAA LLSRFDLLWL IQDRPDRDND LRLAQHITYV
550 560 570 580 590 600
HQHSRQPPSQ FEPLDMKLMR RYIAMCREKQ PMVPESLADY ITAAYVEMRR EAWASKDATY
610 620 630 640 650 660
TSARTLLAIL RLSTALARLR MVDVVEKEDV NEAIRLMEMS KDSLLGDKGQ TARTQRPADV
670 680 690 700 710
IFATVRELVS GGRSVRFSEA EQRCVSRGFT PAQFQAALDE YEELNVWQVN ASRTRITFV
Isoforms
- Isoform 2 of DNA replication licensing factor MCM7 - Isoform 3 of DNA replication licensing factor MCM7Sequence View
10 20 30 40 50 60
MALKDYALEK EKVKKFLQEF YQDDELGKKQ FKYGNQLVRL AHREQVALYV DLDDVAEDDP
70 80 90 100 110 120
ELVDSICENA RRYAKLFADA VQELLPQYKE REVVNKDVLD VYIEHRLMME QRSRDPGMVR
130 140 150 160 170 180
SPQNQYPAEL MRRFELYFQG PSSNKPRVIR EVRADSVGKL VTVRGIVTRV SEVKPKMVVA
190 200 210 220 230 240
TYTCDQCGAE TYQPIQSPTF MPLIMCPSQE CQTNRSGGRL YLQTRGSRFI KFQEMKMQEH
250 260 270 280 290 300
SDQVPVGNIP RSITVLVEGE NTRIAQPGDH VSVTGIFLPI LRTGFRQVVQ GLLSETYLEA
310 320 330 340 350 360
HRIVKMNKSE DDESGAGELT REELRQIAEE DFYEKLAASI APEIYGHEDV KKALLLLLVG
370 380 390 400 410 420
GVDQSPRGMK IRGNINICLM GDPGVAKSQL LSYIDRLAPR SQYTTGRGSS GVGLTAAVLR
430 440 450 460 470 480
DSVSGELTLE GGALVLADQG VCCIDEFDKM AEADRTAIHE VMEQQTISIA KAGILTTLNA
490 500 510 520 530 540
RCSILAAANP AYGRYNPRRS LEQNIQLPAA LLSRFDLLWL IQDRPDRDND LRLAQHITYV
550 560 570 580 590 600
HQHSRQPPSQ FEPLDMKLMR RYIAMCREKQ PMVPESLADY ITAAYVEMRR EAWASKDATY
610 620 630 640 650 660
TSARTLLAIL RLSTALARLR MVDVVEKEDV NEAIRLMEMS KDSLLGDKGQ TARTQRPADV
670 680 690 700 710
IFATVRELVS GGRSVRFSEA EQRCVSRGFT PAQFQAALDE YEELNVWQVN ASRTRITFV
10 20 30 40 50 60
MALKDYALEK EKVKKFLQEF YQDDELGKKQ FKYGNQLVRL AHREQVALYV DLDDVAEDDP
70 80 90 100 110 120
ELVDSICENA RRYAKLFADA VQELLPQYKE REVVNKDVLD VYIEHRLMME QRSRDPGMVR
130 140 150 160 170 180
SPQNQYPAEL MRRFELYFQG PSSNKPRVIR EVRADSVGKL VTVRGIVTRV SEVKPKMVVA
190 200 210 220 230 240
TYTCDQCGAE TYQPIQSPTF MPLIMCPSQE CQTNRSGGRL YLQTRGSRFI KFQEMKMQEH
250 260 270 280 290 300
SDQVPVGNIP RSITVLVEGE NTRIAQPGDH VSVTGIFLPI LRTGFRQVVQ GLLSETYLEA
310 320 330 340 350 360
HRIVKMNKSE DDESGAGELT REELRQIAEE DFYEKLAASI APEIYGHEDV KKALLLLLVG
370 380 390 400 410 420
GVDQSPRGMK IRGNINICLM GDPGVAKSQL LSYIDRLAPR SQYTTGRGSS GVGLTAAVLR
430 440 450 460 470 480
DSVSGELTLE GGALVLADQG VCCIDEFDKM AEADRTAIHE VMEQQTISIA KAGILTTLNA
490 500 510 520 530 540
RCSILAAANP AYGRYNPRRS LEQNIQLPAA LLSRFDLLWL IQDRPDRDND LRLAQHITYV
550 560 570 580 590 600
HQHSRQPPSQ FEPLDMKLMR RYIAMCREKQ PMVPESLADY ITAAYVEMRR EAWASKDATY
610 620 630 640 650 660
TSARTLLAIL RLSTALARLR MVDVVEKEDV NEAIRLMEMS KDSLLGDKGQ TARTQRPADV
670 680 690 700 710
IFATVRELVS GGRSVRFSEA EQRCVSRGFT PAQFQAALDE YEELNVWQVN ASRTRITFV
Protein Neighborhood
Domains & Features
13 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P33993-2-unknown | MALKDY... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P33993-1-unknown | MALKDY... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt80628 | |||
P33993-2-Acetylation | ALKDYA... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
P33993-2-Acetylation | ALKDYA... | 2 | acetylation- | other | CNRS/ISV | Large_scale_NTA_Human | |||
P33993-2-Acetylation | ALKDYA... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110062 | ||
P33993-16-unknown | FLQEFY... | 16 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177864 | |||
P33993-16- | FLQEFY... | 16 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P33993-19-unknown | EFYQDD... | 19 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5808 | |||
P33993-19-unknown | EFYQDD... | 19 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt136794 | |||
P33993-177-unknown | MVVATY... | 177 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt80629 | |||
P33993-177-unknown | MVVATY... | 177 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt109483 | |||
P33993-358-unknown | LVGGVD... | 358 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3773 | |||
P33993-358-unknown | LVGGVD... | 358 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt145978 | |||
P33993-439-unknown | QGVCCI... | 439 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11451 | |||
P33993-439-unknown | QGVCCI... | 439 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt148929 | |||
P33993-500-unknown | SLEQNI... | 500 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt168595 | |||
P33993-500- | SLEQNI... | 500 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P33993-500- | SLEQNI... | 500 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P33993-621- | MVDVVE... | 621 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P33993-621- | MVDVVE... | 621 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P33993-621-unknown | MVDVVE... | 621 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt174374 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...KKFLQE | 18 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5808 | |||
...ALLLLL | 357 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3773 | |||
...ALLLLL | 357 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt129277 | |||
...LVLADQ | 438 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11451 | |||
...LVLADQ | 438 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt132309 | |||
...RITFV | 719 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...RITFV | 719 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt76246 | |||
...RITFV | 719 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt76247 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATL1_HUMAN | 18 | FLQE.|.EFYQ | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
CATB_HUMAN | 357 | LLLL.|.LVGG | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
GRAB_HUMAN | 438 | LADQ.|.QGVC | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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