O76094: Signal recognition particle subunit SRP72

General Information

Protein names	- Signal recognition particle subunit SRP72 - SRP72 - Signal recognition particle 72 kDa protein
Gene names	SRP72
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O76094

12 N-termini

8 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASGGSGGVS VPALWSEVNR YGQNGDFTRA LKTVNKILQI NKDDVTALHC KVVCLIQNGS
        70         80         90        100        110        120
FKEALNVINT HTKVLANNSL SFEKAYCEYR LNRIENALKT IESANQQTDK LKELYGQVLY
       130        140        150        160        170        180
RLERYDECLA VYRDLVRNSQ DDYDEERKTN LSAVVAAQSN WEKVVPENLG LQEGTHELCY
       190        200        210        220        230        240
NTACALIGQG QLNQAMKILQ KAEDLCRRSL SEDTDGTEED PQAELAIIHG QMAYILQLQG
       250        260        270        280        290        300
RTEEALQLYN QIIKLKPTDV GLLAVIANNI ITINKDQNVF DSKKKVKLTN AEGVEFKLSK
       310        320        330        340        350        360
KQLQAIEFNK ALLAMYTNQA EQCRKISASL QSQSPEHLLP VLIQAAQLCR EKQHTKAIEL
       370        380        390        400        410        420
LQEFSDQHPE NAAEIKLTMA QLKISQGNIS KACLILRSIE ELKHKPGMVS ALVTMYSHEE
       430        440        450        460        470        480
DIDSAIEVFT QAIQWYQNHQ PKSPAHLSLI REAANFKLKY GRKKEAISDL QQLWKQNPKD
       490        500        510        520        530        540
IHTLAQLISA YSLVDPEKAK ALSKHLPSSD SMSLKVDVEA LENSAGATYI RKKGGKVTGD
       550        560        570        580        590        600
SQPKEQGQGD LKKKKKKKKG KLPKNYDPKV TPDPERWLPM RERSYYRGRK KGKKKDQIGK
       610        620        630        640        650        660
GTQGATAGAS SELDASKTVS SPPTSPRPGS AATVSASTSN IIPPRHQKPA GAPATKKKQQ
       670
QKKKKGGKGG W

Isoforms

- Isoform 2 of Signal recognition particle subunit SRP72

Sequence View

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Physiological Relevance:

Evidence Codes:

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Evidence Names:

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Protein Neighborhood

Domains & Features

12 N-termini - 8 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O76094-1-unknown	MASGGS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90691
O76094-2-unknown	MASGGS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O76094-2-Acetylation	ASGGSG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O76094-2-Acetylation	ASGGSG...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O76094-2-Acetylation	ASGGSG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O76094-2-Acetylation	ASGGSG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111486
O76094-103-unknown	SANQQT...	103		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5274
O76094-103-unknown	SANQQT...	103		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142563
O76094-363-unknown	EFSDQH...	363		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5276
O76094-363-unknown	EFSDQH...	363		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149931
O76094-366-unknown	DQHPEN...	366		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7072
O76094-366-unknown	DQHPEN...	366		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150006
O76094-516-unknown	VDVEAL...	516		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177373
O76094-516-	VDVEAL...	516			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
O76094-520-unknown	ALENSA...	520		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10982
O76094-520-unknown	ALENSA...	520		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152904
O76094-541-unknown	SQPKEQ...	541		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10984
O76094-541-unknown	SQPKEQ...	541		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153189
O76094-574-unknown	PERWLP...	574		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10986
O76094-574-unknown	PERWLP...	574		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153571
O76094-615-unknown	ASKTVS...	615		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1504
O76094-615-unknown	ASKTVS...	615		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154035

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LKTIES	102	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5274
...LKTIES	102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125757
...IELLQE	362	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5276
...IELLQE	362	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133322
...LQEFSD	365	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7072
...LQEFSD	365	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133398
...KVDVEA	519	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10982
...KVDVEA	519	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136329
...KVTGDS	540	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10984
...KVTGDS	540	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136615
...KVTPDP	573	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10986
...KVTPDP	573	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136993
...SSELDA	614	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1504
...SSELDA	614	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137454
...GKGGW	671	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GKGGW	671	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86309

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	102	TIES.\|.SANQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	362	LLQE.\|.EFSD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	365	EFSD.\|.DQHP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	519	DVEA.\|.ALEN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	540	TGDS.\|.SQPK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	573	TPDP.\|.PERW	inferred from experiment	unknown	MEROPS	Rosen A	Casciola-Rosen L et al.:Cleavage by granzyme B is stron... (S01.010)	10499920,
CASP3_HUMAN	614	ELDA.\|.ASKT	inferred from experiment	unknown	MEROPS	Anderson P	Utz PJ et al.:The 72-kDa component of signal ... (C14.003)	9857079,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)