Q32P28: Prolyl 3-hydroxylase 1 {ECO:0000312|HGNC:HGNC:19316}

General Information

Protein names	- Prolyl 3-hydroxylase 1 {ECO:0000312\|HGNC:HGNC:19316} - 1.14.11.7 - Growth suppressor 1 {ECO:0000303\|PubMed:10951563} - Leucine- and proline-enriched proteoglycan 1 {ECO:0000250\|UniProtKB:Q9R1J8} - Leprecan-1 {ECO:0000250\|UniProtKB:Q9R1J8}
Gene names	LEPRE1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q32P28

6 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Prolyl 3-hydroxylase 1 - Isoform 3 of Prolyl 3-hydroxylase 1 - Isoform 4 of Prolyl 3-hydroxylase 1

Sequence View

        10         20         30         40         50         60
MAVRALKLLT TLLAVVAAAS QAEVESEAGW GMVTPDLLFA EGTAAYARGD WPGVVLSMER
        70         80         90        100        110        120
ALRSRAALRA LRLRCRTQCA ADFPWELDPD WSPSPAQASG AAALRDLSFF GGLLRRAACL
       130        140        150        160        170        180
RRCLGPPAAH SLSEEMELEF RKRSPYNYLQ VAYFKINKLE KAVAAAHTFF VGNPEHMEMQ
       190        200        210        220        230        240
QNLDYYQTMS GVKEADFKDL ETQPHMQEFR LGVRLYSEEQ PQEAVPHLEA ALQEYFVAYE
       250        260        270        280        290        300
ECRALCEGPY DYDGYNYLEY NADLFQAITD HYIQVLNCKQ NCVTELASHP SREKPFEDFL
       310        320        330        340        350        360
PSHYNYLQFA YYNIGNYTQA VECAKTYLLF FPNDEVMNQN LAYYAAMLGE EHTRSIGPRE
       370        380        390        400        410        420
SAKEYRQRSL LEKELLFFAY DVFGIPFVDP DSWTPEEVIP KRLQEKQKSE RETAVRISQE
       430        440        450        460        470        480
IGNLMKEIET LVEEKTKESL DVSRLTREGG PLLYEGISLT MNSKLLNGSQ RVVMDGVISD
       490        500        510        520        530        540
HECQELQRLT NVAATSGDGY RGQTSPHTPN EKFYGVTVFK ALKLGQEGKV PLQSAHLYYN
       550        560        570        580        590        600
VTEKVRRIME SYFRLDTPLY FSYSHLVCRT AIEEVQAERK DDSHPVHVDN CILNAETLVC
       610        620        630        640        650        660
VKEPPAYTFR DYSAILYLNG DFDGGNFYFT ELDAKTVTAE VQPQCGRAVG FSSGTENPHG
       670        680        690        700        710        720
VKAVTRGQRC AIALWFTLDP RHSERDRVQA DDLVKMLFSP EEMDLSQEQP LDAQQGPPEP
       730
AQESLSGSES KPKDEL         10         20         30         40         50         60
MAVRALKLLT TLLAVVAAAS QAEVESEAGW GMVTPDLLFA EGTAAYARGD WPGVVLSMER
        70         80         90        100        110        120
ALRSRAALRA LRLRCRTQCA ADFPWELDPD WSPSPAQASG AAALRDLSFF GGLLRRAACL
       130        140        150        160        170        180
RRCLGPPAAH SLSEEMELEF RKRSPYNYLQ VAYFKINKLE KAVAAAHTFF VGNPEHMEMQ
       190        200        210        220        230        240
QNLDYYQTMS GVKEADFKDL ETQPHMQEFR LGVRLYSEEQ PQEAVPHLEA ALQEYFVAYE
       250        260        270        280        290        300
ECRALCEGPY DYDGYNYLEY NADLFQAITD HYIQVLNCKQ NCVTELASHP SREKPFEDFL
       310        320        330        340        350        360
PSHYNYLQFA YYNIGNYTQA VECAKTYLLF FPNDEVMNQN LAYYAAMLGE EHTRSIGPRE
       370        380        390        400        410        420
SAKEYRQRSL LEKELLFFAY DVFGIPFVDP DSWTPEEVIP KRLQEKQKSE RETAVRISQE
       430        440        450        460        470        480
IGNLMKEIET LVEEKTKESL DVSRLTREGG PLLYEGISLT MNSKLLNGSQ RVVMDGVISD
       490        500        510        520        530        540
HECQELQRLT NVAATSGDGY RGQTSPHTPN EKFYGVTVFK ALKLGQEGKV PLQSAHLYYN
       550        560        570        580        590        600
VTEKVRRIME SYFRLDTPLY FSYSHLVCRT AIEEVQAERK DDSHPVHVDN CILNAETLVC
       610        620        630        640        650        660
VKEPPAYTFR DYSAILYLNG DFDGGNFYFT ELDAKTVTAE VQPQCGRAVG FSSGTENPHG
       670        680        690        700        710        720
VKAVTRGQRC AIALWFTLDP RHSERDRVQA DDLVKMLFSP EEMDLSQEQP LDAQQGPPEP
       730
AQESLSGSES KPKDEL         10         20         30         40         50         60
MAVRALKLLT TLLAVVAAAS QAEVESEAGW GMVTPDLLFA EGTAAYARGD WPGVVLSMER
        70         80         90        100        110        120
ALRSRAALRA LRLRCRTQCA ADFPWELDPD WSPSPAQASG AAALRDLSFF GGLLRRAACL
       130        140        150        160        170        180
RRCLGPPAAH SLSEEMELEF RKRSPYNYLQ VAYFKINKLE KAVAAAHTFF VGNPEHMEMQ
       190        200        210        220        230        240
QNLDYYQTMS GVKEADFKDL ETQPHMQEFR LGVRLYSEEQ PQEAVPHLEA ALQEYFVAYE
       250        260        270        280        290        300
ECRALCEGPY DYDGYNYLEY NADLFQAITD HYIQVLNCKQ NCVTELASHP SREKPFEDFL
       310        320        330        340        350        360
PSHYNYLQFA YYNIGNYTQA VECAKTYLLF FPNDEVMNQN LAYYAAMLGE EHTRSIGPRE
       370        380        390        400        410        420
SAKEYRQRSL LEKELLFFAY DVFGIPFVDP DSWTPEEVIP KRLQEKQKSE RETAVRISQE
       430        440        450        460        470        480
IGNLMKEIET LVEEKTKESL DVSRLTREGG PLLYEGISLT MNSKLLNGSQ RVVMDGVISD
       490        500        510        520        530        540
HECQELQRLT NVAATSGDGY RGQTSPHTPN EKFYGVTVFK ALKLGQEGKV PLQSAHLYYN
       550        560        570        580        590        600
VTEKVRRIME SYFRLDTPLY FSYSHLVCRT AIEEVQAERK DDSHPVHVDN CILNAETLVC
       610        620        630        640        650        660
VKEPPAYTFR DYSAILYLNG DFDGGNFYFT ELDAKTVTAE VQPQCGRAVG FSSGTENPHG
       670        680        690        700        710        720
VKAVTRGQRC AIALWFTLDP RHSERDRVQA DDLVKMLFSP EEMDLSQEQP LDAQQGPPEP
       730
AQESLSGSES KPKDEL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q32P28-1-unknown	MAVRAL...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84027
Q32P28-1-unknown	MAVRAL...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84028
Q32P28-1-unknown	MAVRAL...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84029
Q32P28-19-	ASQAEV...	19		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q32P28-19-unknown	ASQAEV...	19	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171312
Q32P28-19-unknown	ASQAEV...	19	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171313
Q32P28-19-unknown	ASQAEV...	19	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171314
Q32P28-23-unknown	EVESEA...	23	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q32P28-23-unknown	EVESEA...	23	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt113331
Q32P28-23-unknown	EVESEA...	23	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt113332
Q32P28-23-unknown	EVESEA...	23	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt113333
Q32P28-37-unknown	LLFAEG...	37	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12433
Q32P28-37-unknown	LLFAEG...	37	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138118
Q32P28-37-unknown	LLFAEG...	37	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138119
Q32P28-37-unknown	LLFAEG...	37	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138120
Q32P28-653-unknown	SGTENP...	653	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6504
Q32P28-653-unknown	SGTENP...	653	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155357
Q32P28-653-unknown	SGTENP...	653	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155358

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MVTPDL	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12433
...MVTPDL	36	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121143
...MVTPDL	36	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121144
...MVTPDL	36	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121145
...CEGPYD	250	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000361604
...AVGFSS	652	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6504
...AVGFSS	652	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138790
...AVGFSS	652	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138791
...PKDEL	736	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	36	TPDL.\|.LLFA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	652	GFSS.\|.SGTE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)