O00308: NEDD4-like E3 ubiquitin-protein ligase WWP2

General Information

Protein names	- NEDD4-like E3 ubiquitin-protein ligase WWP2 - 2.3.2.26 {ECO:0000269\|PubMed:19274063, ECO:0000269\|PubMed:19651900} - Atrophin-1-interacting protein 2 - AIP2 - HECT-type E3 ubiquitin transferase WWP2 - WW domain-containing protein 2
Gene names	WWP2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00308

5 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of NEDD4-like E3 ubiquitin-protein ligase WWP2 - Isoform 3 of NEDD4-like E3 ubiquitin-protein ligase WWP2 - Isoform 4 of NEDD4-like E3 ubiquitin-protein ligase WWP2

Sequence View

        10         20         30         40         50         60
MASASSSRAG VALPFEKSQL TLKVVSAKPK VHNRQPRINS YVEVAVDGLP SETKKTGKRI
        70         80         90        100        110        120
GSSELLWNEI IILNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNVLKNN GGKMENMQLT
       130        140        150        160        170        180
LNLQTENKGS VVSGGELTIF LDGPTVDLGN VPNGSALTDG SQLPSRDSSG TAVAPENRHQ
       190        200        210        220        230        240
PPSTNCFGGR SRTHRHSGAS ARTTPATGEQ SPGARSRHRQ PVKNSGHSGL ANGTVNDEPT
       250        260        270        280        290        300
TATDPEEPSV VGVTSPPAAP LSVTPNPNTT SLPAPATPAE GEEPSTSGTQ QLPAAAQAPD
       310        320        330        340        350        360
ALPAGWEQRE LPNGRVYYVD HNTKTTTWER PLPPGWEKRT DPRGRFYYVD HNTRTTTWQR
       370        380        390        400        410        420
PTAEYVRNYE QWQSQRNQLQ GAMQHFSQRF LYQSSSASTD HDPLGPLPPG WEKRQDNGRV
       430        440        450        460        470        480
YYVNHNTRTT QWEDPRTQGM IQEPALPPGW EMKYTSEGVR YFVDHNTRTT TFKDPRPGFE
       490        500        510        520        530        540
SGTKQGSPGA YDRSFRWKYH QFRFLCHSNA LPSHVKISVS RQTLFEDSFQ QIMNMKPYDL
       550        560        570        580        590        600
RRRLYIIMRG EEGLDYGGIA REWFFLLSHE VLNPMYCLFE YAGKNNYCLQ INPASSINPD
       610        620        630        640        650        660
HLTYFRFIGR FIAMALYHGK FIDTGFTLPF YKRMLNKRPT LKDLESIDPE FYNSIVWIKE
       670        680        690        700        710        720
NNLEECGLEL YFIQDMEILG KVTTHELKEG GESIRVTEEN KEEYIMLLTD WRFTRGVEEQ
       730        740        750        760        770        780
TKAFLDGFNE VAPLEWLRYF DEKELELMLC GMQEIDMSDW QKSTIYRHYT KNSKQIQWFW
       790        800        810        820        830        840
QVVKEMDNEK RIRLLQFVTG TCRLPVGGFA ELIGSNGPQK FCIDKVGKET WLPRSHTCFN
       850        860        870
RLDLPPYKSY EQLREKLLYA IEETEGFGQE         10         20         30         40         50         60
MASASSSRAG VALPFEKSQL TLKVVSAKPK VHNRQPRINS YVEVAVDGLP SETKKTGKRI
        70         80         90        100        110        120
GSSELLWNEI IILNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNVLKNN GGKMENMQLT
       130        140        150        160        170        180
LNLQTENKGS VVSGGELTIF LDGPTVDLGN VPNGSALTDG SQLPSRDSSG TAVAPENRHQ
       190        200        210        220        230        240
PPSTNCFGGR SRTHRHSGAS ARTTPATGEQ SPGARSRHRQ PVKNSGHSGL ANGTVNDEPT
       250        260        270        280        290        300
TATDPEEPSV VGVTSPPAAP LSVTPNPNTT SLPAPATPAE GEEPSTSGTQ QLPAAAQAPD
       310        320        330        340        350        360
ALPAGWEQRE LPNGRVYYVD HNTKTTTWER PLPPGWEKRT DPRGRFYYVD HNTRTTTWQR
       370        380        390        400        410        420
PTAEYVRNYE QWQSQRNQLQ GAMQHFSQRF LYQSSSASTD HDPLGPLPPG WEKRQDNGRV
       430        440        450        460        470        480
YYVNHNTRTT QWEDPRTQGM IQEPALPPGW EMKYTSEGVR YFVDHNTRTT TFKDPRPGFE
       490        500        510        520        530        540
SGTKQGSPGA YDRSFRWKYH QFRFLCHSNA LPSHVKISVS RQTLFEDSFQ QIMNMKPYDL
       550        560        570        580        590        600
RRRLYIIMRG EEGLDYGGIA REWFFLLSHE VLNPMYCLFE YAGKNNYCLQ INPASSINPD
       610        620        630        640        650        660
HLTYFRFIGR FIAMALYHGK FIDTGFTLPF YKRMLNKRPT LKDLESIDPE FYNSIVWIKE
       670        680        690        700        710        720
NNLEECGLEL YFIQDMEILG KVTTHELKEG GESIRVTEEN KEEYIMLLTD WRFTRGVEEQ
       730        740        750        760        770        780
TKAFLDGFNE VAPLEWLRYF DEKELELMLC GMQEIDMSDW QKSTIYRHYT KNSKQIQWFW
       790        800        810        820        830        840
QVVKEMDNEK RIRLLQFVTG TCRLPVGGFA ELIGSNGPQK FCIDKVGKET WLPRSHTCFN
       850        860        870
RLDLPPYKSY EQLREKLLYA IEETEGFGQE         10         20         30         40         50         60
MASASSSRAG VALPFEKSQL TLKVVSAKPK VHNRQPRINS YVEVAVDGLP SETKKTGKRI
        70         80         90        100        110        120
GSSELLWNEI IILNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNVLKNN GGKMENMQLT
       130        140        150        160        170        180
LNLQTENKGS VVSGGELTIF LDGPTVDLGN VPNGSALTDG SQLPSRDSSG TAVAPENRHQ
       190        200        210        220        230        240
PPSTNCFGGR SRTHRHSGAS ARTTPATGEQ SPGARSRHRQ PVKNSGHSGL ANGTVNDEPT
       250        260        270        280        290        300
TATDPEEPSV VGVTSPPAAP LSVTPNPNTT SLPAPATPAE GEEPSTSGTQ QLPAAAQAPD
       310        320        330        340        350        360
ALPAGWEQRE LPNGRVYYVD HNTKTTTWER PLPPGWEKRT DPRGRFYYVD HNTRTTTWQR
       370        380        390        400        410        420
PTAEYVRNYE QWQSQRNQLQ GAMQHFSQRF LYQSSSASTD HDPLGPLPPG WEKRQDNGRV
       430        440        450        460        470        480
YYVNHNTRTT QWEDPRTQGM IQEPALPPGW EMKYTSEGVR YFVDHNTRTT TFKDPRPGFE
       490        500        510        520        530        540
SGTKQGSPGA YDRSFRWKYH QFRFLCHSNA LPSHVKISVS RQTLFEDSFQ QIMNMKPYDL
       550        560        570        580        590        600
RRRLYIIMRG EEGLDYGGIA REWFFLLSHE VLNPMYCLFE YAGKNNYCLQ INPASSINPD
       610        620        630        640        650        660
HLTYFRFIGR FIAMALYHGK FIDTGFTLPF YKRMLNKRPT LKDLESIDPE FYNSIVWIKE
       670        680        690        700        710        720
NNLEECGLEL YFIQDMEILG KVTTHELKEG GESIRVTEEN KEEYIMLLTD WRFTRGVEEQ
       730        740        750        760        770        780
TKAFLDGFNE VAPLEWLRYF DEKELELMLC GMQEIDMSDW QKSTIYRHYT KNSKQIQWFW
       790        800        810        820        830        840
QVVKEMDNEK RIRLLQFVTG TCRLPVGGFA ELIGSNGPQK FCIDKVGKET WLPRSHTCFN
       850        860        870
RLDLPPYKSY EQLREKLLYA IEETEGFGQE

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00308-1-unknown	MASASS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00308-1-unknown	MASASS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt94692
O00308-117-unknown	MQLTLN...	117	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt94690
O00308-117-unknown	MQLTLN...	117	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000445616
O00308-117-unknown	MQLTLN...	117	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108493
O00308-160-	GSQLPS...	160		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O00308-160-	GSQLPS...	160		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O00308-160-	GSQLPS...	160		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O00308-160-unknown	GSQLPS...	160	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168307
O00308-160-unknown	GSQLPS...	160	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168306
O00308-440-unknown	MIQEPA...	440	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt94691
O00308-440-unknown	MIQEPA...	440	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000456216
O00308-440-unknown	MIQEPA...	440	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108560

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GKRIGS	61	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000455347
...GKRIGS	61	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153938
...LSNVLK	107	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000456451
...LSNVLK	107	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154454
...PLPPGW	335	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt90310
...PLPPGW	335	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000455311
...PLPPGW	335	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92439
...GFGQE	870	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GFGQE	870	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt90309
...GFGQE	870	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt90308

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)