O00330: Pyruvate dehydrogenase protein X component, mitochondrial

General Information

Protein names	- Pyruvate dehydrogenase protein X component, mitochondrial - Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex - E3-binding protein - E3BP - Lipoyl-containing pyruvate dehydrogenase complex component X - proX
Gene names	PDHX
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00330

4 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Pyruvate dehydrogenase protein X component, mitochondrial - Isoform 3 of Pyruvate dehydrogenase protein X component, mitochondrial

Sequence View

        10         20         30         40         50         60
MAASWRLGCD PRLLRYLVGF PGRRSVGLVK GALGWSVSRG ANWRWFHSTQ WLRGDPIKIL
        70         80         90        100        110        120
MPSLSPTMEE GNIVKWLKKE GEAVSAGDAL CEIETDKAVV TLDASDDGIL AKIVVEEGSK
       130        140        150        160        170        180
NIRLGSLIGL IVEEGEDWKH VEIPKDVGPP PPVSKPSEPR PSPEPQISIP VKKEHIPGTL
       190        200        210        220        230        240
RFRLSPAARN ILEKHSLDAS QGTATGPRGI FTKEDALKLV QLKQTGKITE SRPTPAPTAT
       250        260        270        280        290        300
PTAPSPLQAT AGPSYPRPVI PPVSTPGQPN AVGTFTEIPA SNIRRVIAKR LTESKSTVPH
       310        320        330        340        350        360
AYATADCDLG AVLKVRQDLV KDDIKVSVND FIIKAAAVTL KQMPDVNVSW DGEGPKQLPF
       370        380        390        400        410        420
IDISVAVATD KGLLTPIIKD AAAKGIQEIA DSVKALSKKA RDGKLLPEEY QGGSFSISNL
       430        440        450        460        470        480
GMFGIDEFTA VINPPQACIL AVGRFRPVLK LTEDEEGNAK LQQRQLITVT MSSDSRVVDD
       490        500
ELATRFLKSF KANLENPIRL A         10         20         30         40         50         60
MAASWRLGCD PRLLRYLVGF PGRRSVGLVK GALGWSVSRG ANWRWFHSTQ WLRGDPIKIL
        70         80         90        100        110        120
MPSLSPTMEE GNIVKWLKKE GEAVSAGDAL CEIETDKAVV TLDASDDGIL AKIVVEEGSK
       130        140        150        160        170        180
NIRLGSLIGL IVEEGEDWKH VEIPKDVGPP PPVSKPSEPR PSPEPQISIP VKKEHIPGTL
       190        200        210        220        230        240
RFRLSPAARN ILEKHSLDAS QGTATGPRGI FTKEDALKLV QLKQTGKITE SRPTPAPTAT
       250        260        270        280        290        300
PTAPSPLQAT AGPSYPRPVI PPVSTPGQPN AVGTFTEIPA SNIRRVIAKR LTESKSTVPH
       310        320        330        340        350        360
AYATADCDLG AVLKVRQDLV KDDIKVSVND FIIKAAAVTL KQMPDVNVSW DGEGPKQLPF
       370        380        390        400        410        420
IDISVAVATD KGLLTPIIKD AAAKGIQEIA DSVKALSKKA RDGKLLPEEY QGGSFSISNL
       430        440        450        460        470        480
GMFGIDEFTA VINPPQACIL AVGRFRPVLK LTEDEEGNAK LQQRQLITVT MSSDSRVVDD
       490        500
ELATRFLKSF KANLENPIRL A

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00330-1-unknown	MAASWR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83702
O00330-54-	GDPIKI...	54		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O00330-54-unknown	GDPIKI...	54	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00330-54-unknown	GDPIKI...	54	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115681
O00330-54-unknown	GDPIKI...	54	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115682
O00330-54-unknown	GDPIKI...	54	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
O00330-61-unknown	MPSLSP...	61	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000431281
O00330-61-unknown	MPSLSP...	61	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196334
O00330-61-unknown	MPSLSP...	61	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196335

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TGPRGI	209	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000432277
...TGPRGI	209	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155718
...PRGIFT	211	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000431281
...PRGIFT	211	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155736
...PIRLA	501	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PIRLA	501	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79320
...PIRLA	501	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79321

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)