O00408: cGMP-dependent 3',5'-cyclic phosphodiesterase

General Information

Protein names	- cGMP-dependent 3',5'-cyclic phosphodiesterase - 3.1.4.17 - Cyclic GMP-stimulated phosphodiesterase - CGS-PDE - cGSPDE
Gene names	PDE2A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00408

4 N-termini

8 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform PDE2A4 of cGMP-dependent 3',5'-cyclic phosphodiesterase - Isoform 5 of cGMP-dependent 3',5'-cyclic phosphodiesterase - Isoform PDE2A1 of cGMP-dependent 3',5'-cyclic phosphodiesterase - Isoform PDE2A2 of cGMP-dependent 3',5'-cyclic phosphodiesterase - Isoform 5 of cGMP-dependent 3',5'-cyclic phosphodiesterase - Isoform 6 of cGMP-dependent 3',5'-cyclic phosphodiesterase

Sequence View

        10         20         30         40         50         60
MGQACGHSIL CRSQQYPAAR PAEPRGQQVF LKPDEPPPPP QPCADSLQDA LLSLGSVIDI
        70         80         90        100        110        120
SGLQRAVKEA LSAVLPRVET VYTYLLDGES QLVCEDPPHE LPQEGKVREA IISQKRLGCN
       130        140        150        160        170        180
GLGFSDLPGK PLARLVAPLA PDTQVLVMPL ADKEAGAVAA VILVHCGQLS DNEEWSLQAV
       190        200        210        220        230        240
EKHTLVALRR VQVLQQRGPR EAPRAVQNPP EGTAEDQKGG AAYTDRDRKI LQLCGELYDL
       250        260        270        280        290        300
DASSLQLKVL QYLQQETRAS RCCLLLVSED NLQLSCKVIG DKVLGEEVSF PLTGCLGQVV
       310        320        330        340        350        360
EDKKSIQLKD LTSEDVQQLQ SMLGCELQAM LCVPVISRAT DQVVALACAF NKLEGDLFTD
       370        380        390        400        410        420
EDEHVIQHCF HYTSTVLTST LAFQKEQKLK CECQALLQVA KNLFTHLDDV SVLLQEIITE
       430        440        450        460        470        480
ARNLSNAEIC SVFLLDQNEL VAKVFDGGVV DDESYEIRIP ADQGIAGHVA TTGQILNIPD
       490        500        510        520        530        540
AYAHPLFYRG VDDSTGFRTR NILCFPIKNE NQEVIGVAEL VNKINGPWFS KFDEDLATAF
       550        560        570        580        590        600
SIYCGISIAH SLLYKKVNEA QYRSHLANEM MMYHMKVSDD EYTKLLHDGI QPVAAIDSNF
       610        620        630        640        650        660
ASFTYTPRSL PEDDTSMAIL SMLQDMNFIN NYKIDCPTLA RFCLMVKKGY RDPPYHNWMH
       670        680        690        700        710        720
AFSVSHFCYL LYKNLELTNY LEDIEIFALF ISCMCHDLDH RGTNNSFQVA SKSVLAALYS
       730        740        750        760        770        780
SEGSVMERHH FAQAIAILNT HGCNIFDHFS RKDYQRMLDL MRDIILATDL AHHLRIFKDL
       790        800        810        820        830        840
QKMAEVGYDR NNKQHHRLLL CLLMTSCDLS DQTKGWKTTR KIAELIYKEF FSQGDLEKAM
       850        860        870        880        890        900
GNRPMEMMDR EKAYIPELQI SFMEHIAMPI YKLLQDLFPK AAELYERVAS NREHWTKVSH
       910        920        930        940
KFTIRGLPSN NSLDFLDEEY EVPDLDGTRA PINGCCSLDA E         10         20         30         40         50         60
MGQACGHSIL CRSQQYPAAR PAEPRGQQVF LKPDEPPPPP QPCADSLQDA LLSLGSVIDI
        70         80         90        100        110        120
SGLQRAVKEA LSAVLPRVET VYTYLLDGES QLVCEDPPHE LPQEGKVREA IISQKRLGCN
       130        140        150        160        170        180
GLGFSDLPGK PLARLVAPLA PDTQVLVMPL ADKEAGAVAA VILVHCGQLS DNEEWSLQAV
       190        200        210        220        230        240
EKHTLVALRR VQVLQQRGPR EAPRAVQNPP EGTAEDQKGG AAYTDRDRKI LQLCGELYDL
       250        260        270        280        290        300
DASSLQLKVL QYLQQETRAS RCCLLLVSED NLQLSCKVIG DKVLGEEVSF PLTGCLGQVV
       310        320        330        340        350        360
EDKKSIQLKD LTSEDVQQLQ SMLGCELQAM LCVPVISRAT DQVVALACAF NKLEGDLFTD
       370        380        390        400        410        420
EDEHVIQHCF HYTSTVLTST LAFQKEQKLK CECQALLQVA KNLFTHLDDV SVLLQEIITE
       430        440        450        460        470        480
ARNLSNAEIC SVFLLDQNEL VAKVFDGGVV DDESYEIRIP ADQGIAGHVA TTGQILNIPD
       490        500        510        520        530        540
AYAHPLFYRG VDDSTGFRTR NILCFPIKNE NQEVIGVAEL VNKINGPWFS KFDEDLATAF
       550        560        570        580        590        600
SIYCGISIAH SLLYKKVNEA QYRSHLANEM MMYHMKVSDD EYTKLLHDGI QPVAAIDSNF
       610        620        630        640        650        660
ASFTYTPRSL PEDDTSMAIL SMLQDMNFIN NYKIDCPTLA RFCLMVKKGY RDPPYHNWMH
       670        680        690        700        710        720
AFSVSHFCYL LYKNLELTNY LEDIEIFALF ISCMCHDLDH RGTNNSFQVA SKSVLAALYS
       730        740        750        760        770        780
SEGSVMERHH FAQAIAILNT HGCNIFDHFS RKDYQRMLDL MRDIILATDL AHHLRIFKDL
       790        800        810        820        830        840
QKMAEVGYDR NNKQHHRLLL CLLMTSCDLS DQTKGWKTTR KIAELIYKEF FSQGDLEKAM
       850        860        870        880        890        900
GNRPMEMMDR EKAYIPELQI SFMEHIAMPI YKLLQDLFPK AAELYERVAS NREHWTKVSH
       910        920        930        940
KFTIRGLPSN NSLDFLDEEY EVPDLDGTRA PINGCCSLDA E         10         20         30         40         50         60
MGQACGHSIL CRSQQYPAAR PAEPRGQQVF LKPDEPPPPP QPCADSLQDA LLSLGSVIDI
        70         80         90        100        110        120
SGLQRAVKEA LSAVLPRVET VYTYLLDGES QLVCEDPPHE LPQEGKVREA IISQKRLGCN
       130        140        150        160        170        180
GLGFSDLPGK PLARLVAPLA PDTQVLVMPL ADKEAGAVAA VILVHCGQLS DNEEWSLQAV
       190        200        210        220        230        240
EKHTLVALRR VQVLQQRGPR EAPRAVQNPP EGTAEDQKGG AAYTDRDRKI LQLCGELYDL
       250        260        270        280        290        300
DASSLQLKVL QYLQQETRAS RCCLLLVSED NLQLSCKVIG DKVLGEEVSF PLTGCLGQVV
       310        320        330        340        350        360
EDKKSIQLKD LTSEDVQQLQ SMLGCELQAM LCVPVISRAT DQVVALACAF NKLEGDLFTD
       370        380        390        400        410        420
EDEHVIQHCF HYTSTVLTST LAFQKEQKLK CECQALLQVA KNLFTHLDDV SVLLQEIITE
       430        440        450        460        470        480
ARNLSNAEIC SVFLLDQNEL VAKVFDGGVV DDESYEIRIP ADQGIAGHVA TTGQILNIPD
       490        500        510        520        530        540
AYAHPLFYRG VDDSTGFRTR NILCFPIKNE NQEVIGVAEL VNKINGPWFS KFDEDLATAF
       550        560        570        580        590        600
SIYCGISIAH SLLYKKVNEA QYRSHLANEM MMYHMKVSDD EYTKLLHDGI QPVAAIDSNF
       610        620        630        640        650        660
ASFTYTPRSL PEDDTSMAIL SMLQDMNFIN NYKIDCPTLA RFCLMVKKGY RDPPYHNWMH
       670        680        690        700        710        720
AFSVSHFCYL LYKNLELTNY LEDIEIFALF ISCMCHDLDH RGTNNSFQVA SKSVLAALYS
       730        740        750        760        770        780
SEGSVMERHH FAQAIAILNT HGCNIFDHFS RKDYQRMLDL MRDIILATDL AHHLRIFKDL
       790        800        810        820        830        840
QKMAEVGYDR NNKQHHRLLL CLLMTSCDLS DQTKGWKTTR KIAELIYKEF FSQGDLEKAM
       850        860        870        880        890        900
GNRPMEMMDR EKAYIPELQI SFMEHIAMPI YKLLQDLFPK AAELYERVAS NREHWTKVSH
       910        920        930        940
KFTIRGLPSN NSLDFLDEEY EVPDLDGTRA PINGCCSLDA E         10         20         30         40         50         60
MGQACGHSIL CRSQQYPAAR PAEPRGQQVF LKPDEPPPPP QPCADSLQDA LLSLGSVIDI
        70         80         90        100        110        120
SGLQRAVKEA LSAVLPRVET VYTYLLDGES QLVCEDPPHE LPQEGKVREA IISQKRLGCN
       130        140        150        160        170        180
GLGFSDLPGK PLARLVAPLA PDTQVLVMPL ADKEAGAVAA VILVHCGQLS DNEEWSLQAV
       190        200        210        220        230        240
EKHTLVALRR VQVLQQRGPR EAPRAVQNPP EGTAEDQKGG AAYTDRDRKI LQLCGELYDL
       250        260        270        280        290        300
DASSLQLKVL QYLQQETRAS RCCLLLVSED NLQLSCKVIG DKVLGEEVSF PLTGCLGQVV
       310        320        330        340        350        360
EDKKSIQLKD LTSEDVQQLQ SMLGCELQAM LCVPVISRAT DQVVALACAF NKLEGDLFTD
       370        380        390        400        410        420
EDEHVIQHCF HYTSTVLTST LAFQKEQKLK CECQALLQVA KNLFTHLDDV SVLLQEIITE
       430        440        450        460        470        480
ARNLSNAEIC SVFLLDQNEL VAKVFDGGVV DDESYEIRIP ADQGIAGHVA TTGQILNIPD
       490        500        510        520        530        540
AYAHPLFYRG VDDSTGFRTR NILCFPIKNE NQEVIGVAEL VNKINGPWFS KFDEDLATAF
       550        560        570        580        590        600
SIYCGISIAH SLLYKKVNEA QYRSHLANEM MMYHMKVSDD EYTKLLHDGI QPVAAIDSNF
       610        620        630        640        650        660
ASFTYTPRSL PEDDTSMAIL SMLQDMNFIN NYKIDCPTLA RFCLMVKKGY RDPPYHNWMH
       670        680        690        700        710        720
AFSVSHFCYL LYKNLELTNY LEDIEIFALF ISCMCHDLDH RGTNNSFQVA SKSVLAALYS
       730        740        750        760        770        780
SEGSVMERHH FAQAIAILNT HGCNIFDHFS RKDYQRMLDL MRDIILATDL AHHLRIFKDL
       790        800        810        820        830        840
QKMAEVGYDR NNKQHHRLLL CLLMTSCDLS DQTKGWKTTR KIAELIYKEF FSQGDLEKAM
       850        860        870        880        890        900
GNRPMEMMDR EKAYIPELQI SFMEHIAMPI YKLLQDLFPK AAELYERVAS NREHWTKVSH
       910        920        930        940
KFTIRGLPSN NSLDFLDEEY EVPDLDGTRA PINGCCSLDA E         10         20         30         40         50         60
MGQACGHSIL CRSQQYPAAR PAEPRGQQVF LKPDEPPPPP QPCADSLQDA LLSLGSVIDI
        70         80         90        100        110        120
SGLQRAVKEA LSAVLPRVET VYTYLLDGES QLVCEDPPHE LPQEGKVREA IISQKRLGCN
       130        140        150        160        170        180
GLGFSDLPGK PLARLVAPLA PDTQVLVMPL ADKEAGAVAA VILVHCGQLS DNEEWSLQAV
       190        200        210        220        230        240
EKHTLVALRR VQVLQQRGPR EAPRAVQNPP EGTAEDQKGG AAYTDRDRKI LQLCGELYDL
       250        260        270        280        290        300
DASSLQLKVL QYLQQETRAS RCCLLLVSED NLQLSCKVIG DKVLGEEVSF PLTGCLGQVV
       310        320        330        340        350        360
EDKKSIQLKD LTSEDVQQLQ SMLGCELQAM LCVPVISRAT DQVVALACAF NKLEGDLFTD
       370        380        390        400        410        420
EDEHVIQHCF HYTSTVLTST LAFQKEQKLK CECQALLQVA KNLFTHLDDV SVLLQEIITE
       430        440        450        460        470        480
ARNLSNAEIC SVFLLDQNEL VAKVFDGGVV DDESYEIRIP ADQGIAGHVA TTGQILNIPD
       490        500        510        520        530        540
AYAHPLFYRG VDDSTGFRTR NILCFPIKNE NQEVIGVAEL VNKINGPWFS KFDEDLATAF
       550        560        570        580        590        600
SIYCGISIAH SLLYKKVNEA QYRSHLANEM MMYHMKVSDD EYTKLLHDGI QPVAAIDSNF
       610        620        630        640        650        660
ASFTYTPRSL PEDDTSMAIL SMLQDMNFIN NYKIDCPTLA RFCLMVKKGY RDPPYHNWMH
       670        680        690        700        710        720
AFSVSHFCYL LYKNLELTNY LEDIEIFALF ISCMCHDLDH RGTNNSFQVA SKSVLAALYS
       730        740        750        760        770        780
SEGSVMERHH FAQAIAILNT HGCNIFDHFS RKDYQRMLDL MRDIILATDL AHHLRIFKDL
       790        800        810        820        830        840
QKMAEVGYDR NNKQHHRLLL CLLMTSCDLS DQTKGWKTTR KIAELIYKEF FSQGDLEKAM
       850        860        870        880        890        900
GNRPMEMMDR EKAYIPELQI SFMEHIAMPI YKLLQDLFPK AAELYERVAS NREHWTKVSH
       910        920        930        940
KFTIRGLPSN NSLDFLDEEY EVPDLDGTRA PINGCCSLDA E         10         20         30         40         50         60
MGQACGHSIL CRSQQYPAAR PAEPRGQQVF LKPDEPPPPP QPCADSLQDA LLSLGSVIDI
        70         80         90        100        110        120
SGLQRAVKEA LSAVLPRVET VYTYLLDGES QLVCEDPPHE LPQEGKVREA IISQKRLGCN
       130        140        150        160        170        180
GLGFSDLPGK PLARLVAPLA PDTQVLVMPL ADKEAGAVAA VILVHCGQLS DNEEWSLQAV
       190        200        210        220        230        240
EKHTLVALRR VQVLQQRGPR EAPRAVQNPP EGTAEDQKGG AAYTDRDRKI LQLCGELYDL
       250        260        270        280        290        300
DASSLQLKVL QYLQQETRAS RCCLLLVSED NLQLSCKVIG DKVLGEEVSF PLTGCLGQVV
       310        320        330        340        350        360
EDKKSIQLKD LTSEDVQQLQ SMLGCELQAM LCVPVISRAT DQVVALACAF NKLEGDLFTD
       370        380        390        400        410        420
EDEHVIQHCF HYTSTVLTST LAFQKEQKLK CECQALLQVA KNLFTHLDDV SVLLQEIITE
       430        440        450        460        470        480
ARNLSNAEIC SVFLLDQNEL VAKVFDGGVV DDESYEIRIP ADQGIAGHVA TTGQILNIPD
       490        500        510        520        530        540
AYAHPLFYRG VDDSTGFRTR NILCFPIKNE NQEVIGVAEL VNKINGPWFS KFDEDLATAF
       550        560        570        580        590        600
SIYCGISIAH SLLYKKVNEA QYRSHLANEM MMYHMKVSDD EYTKLLHDGI QPVAAIDSNF
       610        620        630        640        650        660
ASFTYTPRSL PEDDTSMAIL SMLQDMNFIN NYKIDCPTLA RFCLMVKKGY RDPPYHNWMH
       670        680        690        700        710        720
AFSVSHFCYL LYKNLELTNY LEDIEIFALF ISCMCHDLDH RGTNNSFQVA SKSVLAALYS
       730        740        750        760        770        780
SEGSVMERHH FAQAIAILNT HGCNIFDHFS RKDYQRMLDL MRDIILATDL AHHLRIFKDL
       790        800        810        820        830        840
QKMAEVGYDR NNKQHHRLLL CLLMTSCDLS DQTKGWKTTR KIAELIYKEF FSQGDLEKAM
       850        860        870        880        890        900
GNRPMEMMDR EKAYIPELQI SFMEHIAMPI YKLLQDLFPK AAELYERVAS NREHWTKVSH
       910        920        930        940
KFTIRGLPSN NSLDFLDEEY EVPDLDGTRA PINGCCSLDA E

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 8 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O00408-2-unknown	GQACGH...	2	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O00408-15-unknown	QYPAAR...	15	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6985
O00408-570-unknown	MMMYHM...	570	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000440834
O00408-570-unknown	MMMYHM...	570	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt199905
O00408-570-unknown	MMMYHM...	570	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt199904
O00408-622-unknown	MLQDMN...	622	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000388997
O00408-622-unknown	MLQDMN...	622	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt200034
O00408-622-unknown	MLQDMN...	622	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt200033

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LCRSQQ	14	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6985
...QEGKVR	107	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000443232
...QEGKVR	107	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154448
...QEGKVR	107	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154447
...VILVHC	165	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000439683
...VILVHC	165	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155190
...VILVHC	165	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155189
...HLDDVS	410	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000441322
...KNENQE	512	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000439077
...CNIFDH	747	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000440834
...KGWKTT	818	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000388997
...SLDAE	941	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SLDAE	941	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80287
...SLDAE	941	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80288

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	14	RSQQ.\|.QYPA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)