O00442: RNA 3'-terminal phosphate cyclase

General Information

Protein names	- RNA 3'-terminal phosphate cyclase - RNA cyclase - RNA-3'-phosphate cyclase - 6.5.1.4 - RNA terminal phosphate cyclase domain-containing protein 1 - RTC domain-containing protein 1
Gene names	RTCA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00442

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGPRVEVDG SIMEGGGQIL RVSTALSCLL GLPLRVQKIR AGRSTPGLRP QHLSGLEMIR
        70         80         90        100        110        120
DLCDGQLEGA EIGSTEITFT PEKIKGGIHT ADTKTAGSVC LLMQVSMPCV LFAASPSELH
       130        140        150        160        170        180
LKGGTNAEMA PQIDYTVMVF KPIVEKFGFI FNCDIKTRGY YPKGGGEVIV RMSPVKQLNP
       190        200        210        220        230        240
INLTERGCVT KIYGRAFVAG VLPFKVAKDM AAAAVRCIRK EIRDLYVNIQ PVQEPKDQAF
       250        260        270        280        290        300
GNGNGIIIIA ETSTGCLFAG SSLGKRGVNA DKVGIEAAEM LLANLRHGGT VDEYLQDQLI
       310        320        330        340        350        360
VFMALANGVS RIKTGPVTLH TQTAIHFAEQ IAKAKFIVKK SEDEEDAAKD TYIIECQGIG

MTNPNL

Isoforms

- Isoform 2 of RNA 3'-terminal phosphate cyclase

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00442-1-unknown	MAGPRV...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00442-1-unknown	MAGPRV...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88316
O00442-10-unknown	GSIMEG...	10	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10641
O00442-10-unknown	GSIMEG...	10	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194869
O00442-65-unknown	GQLEGA...	65	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175694
O00442-65-	GQLEGA...	65		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O00442-65-	GQLEGA...	65		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RVEVDG	9	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10641
...TNPNL	366	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TNPNL	366	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83934

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	9	EVDG.\|.GSIM	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)