O00458: Interferon-related developmental regulator 1

General Information

Protein names	- Interferon-related developmental regulator 1 - Nerve growth factor-inducible protein PC4
Gene names	IFRD1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00458

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPKNKKRNTP HRGSSAGGGG SGAAAATAAT AGGQHRNVQP FSDEDASIET MSHCSGYSDP
        70         80         90        100        110        120
SSFAEDGPEV LDEEGTQEDL EYKLKGLIDL TLDKSAKTRQ AALEGIKNAL ASKMLYEFIL
       130        140        150        160        170        180
ERRMTLTDSI ERCLKKGKSD EQRAAAALAS VLCIQLGPGI ESEEILKTLG PILKKIICDG
       190        200        210        220        230        240
SASMQARQTC ATCFGVCCFI ATDDITELYS TLECLENIFT KSYLKEKDTT VICSTPNTVL
       250        260        270        280        290        300
HISSLLAWTL LLTICPINEV KKKLEMHFHK LPSLLSCDDV NMRIAAGESL ALLFELARGI
       310        320        330        340        350        360
ESDFFYEDME SLTQMLRALA TDGNKHRAKV DKRKQRSVFR DVLRAVEERD FPTETIKFGP
       370        380        390        400        410        420
ERMYIDCWVK KHTYDTFKEV LGSGMQYHLQ SNEFLRNVFE LGPPVMLDAA TLKTMKISRF
       430        440        450
ERHLYNSAAF KARTKARSKC RDKRADVGEF F

Isoforms

- Isoform 2 of Interferon-related developmental regulator 1

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00458-1-unknown	MPKNKK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00458-2-unknown	PKNKKR...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O00458-2-unknown	PKNKKR...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O00458-51-unknown	MSHCSG...	51	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt77603
O00458-409-unknown	AATLKT...	409	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10642
O00458-409-unknown	AATLKT...	409	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151144

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PVMLDA	408	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10642
...PVMLDA	408	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134546
...VGEFF	451	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VGEFF	451	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73221

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	408	MLDA.\|.AATL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)