O00468: Agrin

General Information

Protein names	- Agrin - Agrin N-terminal 110 kDa subunit - Agrin C-terminal 110 kDa subunit - Agrin C-terminal 90 kDa fragment - C90 - Agrin C-terminal 22 kDa fragment - C22
Gene names	AGRN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00468

6 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Agrin - Isoform 3 of Agrin - Isoform 4 of Agrin - Isoform 5 of Agrin - Isoform 6 of Agrin - Isoform 7 of Agrin - Isoform 2 of Agrin - Isoform 4 of Agrin - Isoform 7 of Agrin

Sequence View

        10         20         30         40         50         60
MAGRSHPGPL RPLLPLLVVA ACVLPGAGGT CPERALERRE EEANVVLTGT VEEILNVDPV
        70         80         90        100        110        120
QHTYSCKVRV WRYLKGKDLV ARESLLDGGN KVVISGFGDP LICDNQVSTG DTRIFFVNPA
       130        140        150        160        170        180
PPYLWPAHKN ELMLNSSLMR ITLRNLEEVE FCVEDKPGTH FTPVPPTPPD ACRGMLCGFG
       190        200        210        220        230        240
AVCEPNAEGP GRASCVCKKS PCPSVVAPVC GSDASTYSNE CELQRAQCSQ QRRIRLLSRG
       250        260        270        280        290        300
PCGSRDPCSN VTCSFGSTCA RSADGLTASC LCPATCRGAP EGTVCGSDGA DYPGECQLLR
       310        320        330        340        350        360
RACARQENVF KKFDGPCDPC QGALPDPSRS CRVNPRTRRP EMLLRPESCP ARQAPVCGDD
       370        380        390        400        410        420
GVTYENDCVM GRSGAARGLL LQKVRSGQCQ GRDQCPEPCR FNAVCLSRRG RPRCSCDRVT
       430        440        450        460        470        480
CDGAYRPVCA QDGRTYDSDC WRQQAECRQQ RAIPSKHQGP CDQAPSPCLG VQCAFGATCA
       490        500        510        520        530        540
VKNGQAACEC LQACSSLYDP VCGSDGVTYG SACELEATAC TLGREIQVAR KGPCDRCGQC
       550        560        570        580        590        600
RFGALCEAET GRCVCPSECV ALAQPVCGSD GHTYPSECML HVHACTHQIS LHVASAGPCE
       610        620        630        640        650        660
TCGDAVCAFG AVCSAGQCVC PRCEHPPPGP VCGSDGVTYG SACELREAAC LQQTQIEEAR
       670        680        690        700        710        720
AGPCEQAECG SGGSGSGEDG DCEQELCRQR GGIWDEDSED GPCVCDFSCQ SVPGSPVCGS
       730        740        750        760        770        780
DGVTYSTECE LKKARCESQR GLYVAAQGAC RGPTFAPLPP VAPLHCAQTP YGCCQDNITA
       790        800        810        820        830        840
ARGVGLAGCP SACQCNPHGS YGGTCDPATG QCSCRPGVGG LRCDRCEPGF WNFRGIVTDG
       850        860        870        880        890        900
RSGCTPCSCD PQGAVRDDCE QMTGLCSCKP GVAGPKCGQC PDGRALGPAG CEADASAPAT
       910        920        930        940        950        960
CAEMRCEFGA RCVEESGSAH CVCPMLTCPE ANATKVCGSD GVTYGNECQL KTIACRQGLQ
       970        980        990       1000       1010       1020
ISIQSLGPCQ EAVAPSTHPT SASVTVTTPG LLLSQALPAP PGALPLAPSS TAHSQTTPPP
      1030       1040       1050       1060       1070       1080
SSRPRTTASV PRTTVWPVLT VPPTAPSPAP SLVASAFGES GSTDGSSDEE LSGDQEASGG
      1090       1100       1110       1120       1130       1140
GSGGLEPLEG SSVATPGPPV ERASCYNSAL GCCSDGKTPS LDAEGSNCPA TKVFQGVLEL
      1150       1160       1170       1180       1190       1200
EGVEGQELFY TPEMADPKSE LFGETARSIE STLDDLFRNS DVKKDFRSVR LRDLGPGKSV
      1210       1220       1230       1240       1250       1260
RAIVDVHFDP TTAFRAPDVA RALLRQIQVS RRRSLGVRRP LQEHVRFMDF DWFPAFITGA
      1270       1280       1290       1300       1310       1320
TSGAIAAGAT ARATTASRLP SSAVTPRAPH PSHTSQPVAK TTAAPTTRRP PTTAPSRVPG
      1330       1340       1350       1360       1370       1380
RRPPAPQQPP KPCDSQPCFH GGTCQDWALG GGFTCSCPAG RGGAVCEKVL GAPVPAFEGR
      1390       1400       1410       1420       1430       1440
SFLAFPTLRA YHTLRLALEF RALEPQGLLL YNGNARGKDF LALALLDGRV QLRFDTGSGP
      1450       1460       1470       1480       1490       1500
AVLTSAVPVE PGQWHRLELS RHWRRGTLSV DGETPVLGES PSGTDGLNLD TDLFVGGVPE
      1510       1520       1530       1540       1550       1560
DQAAVALERT FVGAGLRGCI RLLDVNNQRL ELGIGPGAAT RGSGVGECGD HPCLPNPCHG
      1570       1580       1590       1600       1610       1620
GAPCQNLEAG RFHCQCPPGR VGPTCADEKS PCQPNPCHGA APCRVLPEGG AQCECPLGRE
      1630       1640       1650       1660       1670       1680
GTFCQTASGQ DGSGPFLADF NGFSHLELRG LHTFARDLGE KMALEVVFLA RGPSGLLLYN
      1690       1700       1710       1720       1730       1740
GQKTDGKGDF VSLALRDRRL EFRYDLGKGA AVIRSREPVT LGAWTRVSLE RNGRKGALRV
      1750       1760       1770       1780       1790       1800
GDGPRVLGES PKSRKVPHTV LNLKEPLYVG GAPDFSKLAR AAAVSSGFDG AIQLVSLGGR
      1810       1820       1830       1840       1850       1860
QLLTPEHVLR QVDVTSFAGH PCTRASGHPC LNGASCVPRE AAYVCLCPGG FSGPHCEKGL
      1870       1880       1890       1900       1910       1920
VEKSAGDVDT LAFDGRTFVE YLNAVTESEL ANEIPVPETL DSGALHSEKA LQSNHFELSL
      1930       1940       1950       1960       1970       1980
RTEATQGLVL WSGKATERAD YVALAIVDGH LQLSYNLGSQ PVVLRSTVPV NTNRWLRVVA
      1990       2000       2010       2020       2030       2040
HREQREGSLQ VGNEAPVTGS SPLGATQLDT DGALWLGGLP ELPVGPALPK AYGTGFVGCL
      2050       2060
RDVVVGRHPL HLLEDAVTKP ELRPCPTP         10         20         30         40         50         60
MAGRSHPGPL RPLLPLLVVA ACVLPGAGGT CPERALERRE EEANVVLTGT VEEILNVDPV
        70         80         90        100        110        120
QHTYSCKVRV WRYLKGKDLV ARESLLDGGN KVVISGFGDP LICDNQVSTG DTRIFFVNPA
       130        140        150        160        170        180
PPYLWPAHKN ELMLNSSLMR ITLRNLEEVE FCVEDKPGTH FTPVPPTPPD ACRGMLCGFG
       190        200        210        220        230        240
AVCEPNAEGP GRASCVCKKS PCPSVVAPVC GSDASTYSNE CELQRAQCSQ QRRIRLLSRG
       250        260        270        280        290        300
PCGSRDPCSN VTCSFGSTCA RSADGLTASC LCPATCRGAP EGTVCGSDGA DYPGECQLLR
       310        320        330        340        350        360
RACARQENVF KKFDGPCDPC QGALPDPSRS CRVNPRTRRP EMLLRPESCP ARQAPVCGDD
       370        380        390        400        410        420
GVTYENDCVM GRSGAARGLL LQKVRSGQCQ GRDQCPEPCR FNAVCLSRRG RPRCSCDRVT
       430        440        450        460        470        480
CDGAYRPVCA QDGRTYDSDC WRQQAECRQQ RAIPSKHQGP CDQAPSPCLG VQCAFGATCA
       490        500        510        520        530        540
VKNGQAACEC LQACSSLYDP VCGSDGVTYG SACELEATAC TLGREIQVAR KGPCDRCGQC
       550        560        570        580        590        600
RFGALCEAET GRCVCPSECV ALAQPVCGSD GHTYPSECML HVHACTHQIS LHVASAGPCE
       610        620        630        640        650        660
TCGDAVCAFG AVCSAGQCVC PRCEHPPPGP VCGSDGVTYG SACELREAAC LQQTQIEEAR
       670        680        690        700        710        720
AGPCEQAECG SGGSGSGEDG DCEQELCRQR GGIWDEDSED GPCVCDFSCQ SVPGSPVCGS
       730        740        750        760        770        780
DGVTYSTECE LKKARCESQR GLYVAAQGAC RGPTFAPLPP VAPLHCAQTP YGCCQDNITA
       790        800        810        820        830        840
ARGVGLAGCP SACQCNPHGS YGGTCDPATG QCSCRPGVGG LRCDRCEPGF WNFRGIVTDG
       850        860        870        880        890        900
RSGCTPCSCD PQGAVRDDCE QMTGLCSCKP GVAGPKCGQC PDGRALGPAG CEADASAPAT
       910        920        930        940        950        960
CAEMRCEFGA RCVEESGSAH CVCPMLTCPE ANATKVCGSD GVTYGNECQL KTIACRQGLQ
       970        980        990       1000       1010       1020
ISIQSLGPCQ EAVAPSTHPT SASVTVTTPG LLLSQALPAP PGALPLAPSS TAHSQTTPPP
      1030       1040       1050       1060       1070       1080
SSRPRTTASV PRTTVWPVLT VPPTAPSPAP SLVASAFGES GSTDGSSDEE LSGDQEASGG
      1090       1100       1110       1120       1130       1140
GSGGLEPLEG SSVATPGPPV ERASCYNSAL GCCSDGKTPS LDAEGSNCPA TKVFQGVLEL
      1150       1160       1170       1180       1190       1200
EGVEGQELFY TPEMADPKSE LFGETARSIE STLDDLFRNS DVKKDFRSVR LRDLGPGKSV
      1210       1220       1230       1240       1250       1260
RAIVDVHFDP TTAFRAPDVA RALLRQIQVS RRRSLGVRRP LQEHVRFMDF DWFPAFITGA
      1270       1280       1290       1300       1310       1320
TSGAIAAGAT ARATTASRLP SSAVTPRAPH PSHTSQPVAK TTAAPTTRRP PTTAPSRVPG
      1330       1340       1350       1360       1370       1380
RRPPAPQQPP KPCDSQPCFH GGTCQDWALG GGFTCSCPAG RGGAVCEKVL GAPVPAFEGR
      1390       1400       1410       1420       1430       1440
SFLAFPTLRA YHTLRLALEF RALEPQGLLL YNGNARGKDF LALALLDGRV QLRFDTGSGP
      1450       1460       1470       1480       1490       1500
AVLTSAVPVE PGQWHRLELS RHWRRGTLSV DGETPVLGES PSGTDGLNLD TDLFVGGVPE
      1510       1520       1530       1540       1550       1560
DQAAVALERT FVGAGLRGCI RLLDVNNQRL ELGIGPGAAT RGSGVGECGD HPCLPNPCHG
      1570       1580       1590       1600       1610       1620
GAPCQNLEAG RFHCQCPPGR VGPTCADEKS PCQPNPCHGA APCRVLPEGG AQCECPLGRE
      1630       1640       1650       1660       1670       1680
GTFCQTASGQ DGSGPFLADF NGFSHLELRG LHTFARDLGE KMALEVVFLA RGPSGLLLYN
      1690       1700       1710       1720       1730       1740
GQKTDGKGDF VSLALRDRRL EFRYDLGKGA AVIRSREPVT LGAWTRVSLE RNGRKGALRV
      1750       1760       1770       1780       1790       1800
GDGPRVLGES PKSRKVPHTV LNLKEPLYVG GAPDFSKLAR AAAVSSGFDG AIQLVSLGGR
      1810       1820       1830       1840       1850       1860
QLLTPEHVLR QVDVTSFAGH PCTRASGHPC LNGASCVPRE AAYVCLCPGG FSGPHCEKGL
      1870       1880       1890       1900       1910       1920
VEKSAGDVDT LAFDGRTFVE YLNAVTESEL ANEIPVPETL DSGALHSEKA LQSNHFELSL
      1930       1940       1950       1960       1970       1980
RTEATQGLVL WSGKATERAD YVALAIVDGH LQLSYNLGSQ PVVLRSTVPV NTNRWLRVVA
      1990       2000       2010       2020       2030       2040
HREQREGSLQ VGNEAPVTGS SPLGATQLDT DGALWLGGLP ELPVGPALPK AYGTGFVGCL
      2050       2060
RDVVVGRHPL HLLEDAVTKP ELRPCPTP         10         20         30         40         50         60
MAGRSHPGPL RPLLPLLVVA ACVLPGAGGT CPERALERRE EEANVVLTGT VEEILNVDPV
        70         80         90        100        110        120
QHTYSCKVRV WRYLKGKDLV ARESLLDGGN KVVISGFGDP LICDNQVSTG DTRIFFVNPA
       130        140        150        160        170        180
PPYLWPAHKN ELMLNSSLMR ITLRNLEEVE FCVEDKPGTH FTPVPPTPPD ACRGMLCGFG
       190        200        210        220        230        240
AVCEPNAEGP GRASCVCKKS PCPSVVAPVC GSDASTYSNE CELQRAQCSQ QRRIRLLSRG
       250        260        270        280        290        300
PCGSRDPCSN VTCSFGSTCA RSADGLTASC LCPATCRGAP EGTVCGSDGA DYPGECQLLR
       310        320        330        340        350        360
RACARQENVF KKFDGPCDPC QGALPDPSRS CRVNPRTRRP EMLLRPESCP ARQAPVCGDD
       370        380        390        400        410        420
GVTYENDCVM GRSGAARGLL LQKVRSGQCQ GRDQCPEPCR FNAVCLSRRG RPRCSCDRVT
       430        440        450        460        470        480
CDGAYRPVCA QDGRTYDSDC WRQQAECRQQ RAIPSKHQGP CDQAPSPCLG VQCAFGATCA
       490        500        510        520        530        540
VKNGQAACEC LQACSSLYDP VCGSDGVTYG SACELEATAC TLGREIQVAR KGPCDRCGQC
       550        560        570        580        590        600
RFGALCEAET GRCVCPSECV ALAQPVCGSD GHTYPSECML HVHACTHQIS LHVASAGPCE
       610        620        630        640        650        660
TCGDAVCAFG AVCSAGQCVC PRCEHPPPGP VCGSDGVTYG SACELREAAC LQQTQIEEAR
       670        680        690        700        710        720
AGPCEQAECG SGGSGSGEDG DCEQELCRQR GGIWDEDSED GPCVCDFSCQ SVPGSPVCGS
       730        740        750        760        770        780
DGVTYSTECE LKKARCESQR GLYVAAQGAC RGPTFAPLPP VAPLHCAQTP YGCCQDNITA
       790        800        810        820        830        840
ARGVGLAGCP SACQCNPHGS YGGTCDPATG QCSCRPGVGG LRCDRCEPGF WNFRGIVTDG
       850        860        870        880        890        900
RSGCTPCSCD PQGAVRDDCE QMTGLCSCKP GVAGPKCGQC PDGRALGPAG CEADASAPAT
       910        920        930        940        950        960
CAEMRCEFGA RCVEESGSAH CVCPMLTCPE ANATKVCGSD GVTYGNECQL KTIACRQGLQ
       970        980        990       1000       1010       1020
ISIQSLGPCQ EAVAPSTHPT SASVTVTTPG LLLSQALPAP PGALPLAPSS TAHSQTTPPP
      1030       1040       1050       1060       1070       1080
SSRPRTTASV PRTTVWPVLT VPPTAPSPAP SLVASAFGES GSTDGSSDEE LSGDQEASGG
      1090       1100       1110       1120       1130       1140
GSGGLEPLEG SSVATPGPPV ERASCYNSAL GCCSDGKTPS LDAEGSNCPA TKVFQGVLEL
      1150       1160       1170       1180       1190       1200
EGVEGQELFY TPEMADPKSE LFGETARSIE STLDDLFRNS DVKKDFRSVR LRDLGPGKSV
      1210       1220       1230       1240       1250       1260
RAIVDVHFDP TTAFRAPDVA RALLRQIQVS RRRSLGVRRP LQEHVRFMDF DWFPAFITGA
      1270       1280       1290       1300       1310       1320
TSGAIAAGAT ARATTASRLP SSAVTPRAPH PSHTSQPVAK TTAAPTTRRP PTTAPSRVPG
      1330       1340       1350       1360       1370       1380
RRPPAPQQPP KPCDSQPCFH GGTCQDWALG GGFTCSCPAG RGGAVCEKVL GAPVPAFEGR
      1390       1400       1410       1420       1430       1440
SFLAFPTLRA YHTLRLALEF RALEPQGLLL YNGNARGKDF LALALLDGRV QLRFDTGSGP
      1450       1460       1470       1480       1490       1500
AVLTSAVPVE PGQWHRLELS RHWRRGTLSV DGETPVLGES PSGTDGLNLD TDLFVGGVPE
      1510       1520       1530       1540       1550       1560
DQAAVALERT FVGAGLRGCI RLLDVNNQRL ELGIGPGAAT RGSGVGECGD HPCLPNPCHG
      1570       1580       1590       1600       1610       1620
GAPCQNLEAG RFHCQCPPGR VGPTCADEKS PCQPNPCHGA APCRVLPEGG AQCECPLGRE
      1630       1640       1650       1660       1670       1680
GTFCQTASGQ DGSGPFLADF NGFSHLELRG LHTFARDLGE KMALEVVFLA RGPSGLLLYN
      1690       1700       1710       1720       1730       1740
GQKTDGKGDF VSLALRDRRL EFRYDLGKGA AVIRSREPVT LGAWTRVSLE RNGRKGALRV
      1750       1760       1770       1780       1790       1800
GDGPRVLGES PKSRKVPHTV LNLKEPLYVG GAPDFSKLAR AAAVSSGFDG AIQLVSLGGR
      1810       1820       1830       1840       1850       1860
QLLTPEHVLR QVDVTSFAGH PCTRASGHPC LNGASCVPRE AAYVCLCPGG FSGPHCEKGL
      1870       1880       1890       1900       1910       1920
VEKSAGDVDT LAFDGRTFVE YLNAVTESEL ANEIPVPETL DSGALHSEKA LQSNHFELSL
      1930       1940       1950       1960       1970       1980
RTEATQGLVL WSGKATERAD YVALAIVDGH LQLSYNLGSQ PVVLRSTVPV NTNRWLRVVA
      1990       2000       2010       2020       2030       2040
HREQREGSLQ VGNEAPVTGS SPLGATQLDT DGALWLGGLP ELPVGPALPK AYGTGFVGCL
      2050       2060
RDVVVGRHPL HLLEDAVTKP ELRPCPTP         10         20         30         40         50         60
MAGRSHPGPL RPLLPLLVVA ACVLPGAGGT CPERALERRE EEANVVLTGT VEEILNVDPV
        70         80         90        100        110        120
QHTYSCKVRV WRYLKGKDLV ARESLLDGGN KVVISGFGDP LICDNQVSTG DTRIFFVNPA
       130        140        150        160        170        180
PPYLWPAHKN ELMLNSSLMR ITLRNLEEVE FCVEDKPGTH FTPVPPTPPD ACRGMLCGFG
       190        200        210        220        230        240
AVCEPNAEGP GRASCVCKKS PCPSVVAPVC GSDASTYSNE CELQRAQCSQ QRRIRLLSRG
       250        260        270        280        290        300
PCGSRDPCSN VTCSFGSTCA RSADGLTASC LCPATCRGAP EGTVCGSDGA DYPGECQLLR
       310        320        330        340        350        360
RACARQENVF KKFDGPCDPC QGALPDPSRS CRVNPRTRRP EMLLRPESCP ARQAPVCGDD
       370        380        390        400        410        420
GVTYENDCVM GRSGAARGLL LQKVRSGQCQ GRDQCPEPCR FNAVCLSRRG RPRCSCDRVT
       430        440        450        460        470        480
CDGAYRPVCA QDGRTYDSDC WRQQAECRQQ RAIPSKHQGP CDQAPSPCLG VQCAFGATCA
       490        500        510        520        530        540
VKNGQAACEC LQACSSLYDP VCGSDGVTYG SACELEATAC TLGREIQVAR KGPCDRCGQC
       550        560        570        580        590        600
RFGALCEAET GRCVCPSECV ALAQPVCGSD GHTYPSECML HVHACTHQIS LHVASAGPCE
       610        620        630        640        650        660
TCGDAVCAFG AVCSAGQCVC PRCEHPPPGP VCGSDGVTYG SACELREAAC LQQTQIEEAR
       670        680        690        700        710        720
AGPCEQAECG SGGSGSGEDG DCEQELCRQR GGIWDEDSED GPCVCDFSCQ SVPGSPVCGS
       730        740        750        760        770        780
DGVTYSTECE LKKARCESQR GLYVAAQGAC RGPTFAPLPP VAPLHCAQTP YGCCQDNITA
       790        800        810        820        830        840
ARGVGLAGCP SACQCNPHGS YGGTCDPATG QCSCRPGVGG LRCDRCEPGF WNFRGIVTDG
       850        860        870        880        890        900
RSGCTPCSCD PQGAVRDDCE QMTGLCSCKP GVAGPKCGQC PDGRALGPAG CEADASAPAT
       910        920        930        940        950        960
CAEMRCEFGA RCVEESGSAH CVCPMLTCPE ANATKVCGSD GVTYGNECQL KTIACRQGLQ
       970        980        990       1000       1010       1020
ISIQSLGPCQ EAVAPSTHPT SASVTVTTPG LLLSQALPAP PGALPLAPSS TAHSQTTPPP
      1030       1040       1050       1060       1070       1080
SSRPRTTASV PRTTVWPVLT VPPTAPSPAP SLVASAFGES GSTDGSSDEE LSGDQEASGG
      1090       1100       1110       1120       1130       1140
GSGGLEPLEG SSVATPGPPV ERASCYNSAL GCCSDGKTPS LDAEGSNCPA TKVFQGVLEL
      1150       1160       1170       1180       1190       1200
EGVEGQELFY TPEMADPKSE LFGETARSIE STLDDLFRNS DVKKDFRSVR LRDLGPGKSV
      1210       1220       1230       1240       1250       1260
RAIVDVHFDP TTAFRAPDVA RALLRQIQVS RRRSLGVRRP LQEHVRFMDF DWFPAFITGA
      1270       1280       1290       1300       1310       1320
TSGAIAAGAT ARATTASRLP SSAVTPRAPH PSHTSQPVAK TTAAPTTRRP PTTAPSRVPG
      1330       1340       1350       1360       1370       1380
RRPPAPQQPP KPCDSQPCFH GGTCQDWALG GGFTCSCPAG RGGAVCEKVL GAPVPAFEGR
      1390       1400       1410       1420       1430       1440
SFLAFPTLRA YHTLRLALEF RALEPQGLLL YNGNARGKDF LALALLDGRV QLRFDTGSGP
      1450       1460       1470       1480       1490       1500
AVLTSAVPVE PGQWHRLELS RHWRRGTLSV DGETPVLGES PSGTDGLNLD TDLFVGGVPE
      1510       1520       1530       1540       1550       1560
DQAAVALERT FVGAGLRGCI RLLDVNNQRL ELGIGPGAAT RGSGVGECGD HPCLPNPCHG
      1570       1580       1590       1600       1610       1620
GAPCQNLEAG RFHCQCPPGR VGPTCADEKS PCQPNPCHGA APCRVLPEGG AQCECPLGRE
      1630       1640       1650       1660       1670       1680
GTFCQTASGQ DGSGPFLADF NGFSHLELRG LHTFARDLGE KMALEVVFLA RGPSGLLLYN
      1690       1700       1710       1720       1730       1740
GQKTDGKGDF VSLALRDRRL EFRYDLGKGA AVIRSREPVT LGAWTRVSLE RNGRKGALRV
      1750       1760       1770       1780       1790       1800
GDGPRVLGES PKSRKVPHTV LNLKEPLYVG GAPDFSKLAR AAAVSSGFDG AIQLVSLGGR
      1810       1820       1830       1840       1850       1860
QLLTPEHVLR QVDVTSFAGH PCTRASGHPC LNGASCVPRE AAYVCLCPGG FSGPHCEKGL
      1870       1880       1890       1900       1910       1920
VEKSAGDVDT LAFDGRTFVE YLNAVTESEL ANEIPVPETL DSGALHSEKA LQSNHFELSL
      1930       1940       1950       1960       1970       1980
RTEATQGLVL WSGKATERAD YVALAIVDGH LQLSYNLGSQ PVVLRSTVPV NTNRWLRVVA
      1990       2000       2010       2020       2030       2040
HREQREGSLQ VGNEAPVTGS SPLGATQLDT DGALWLGGLP ELPVGPALPK AYGTGFVGCL
      2050       2060
RDVVVGRHPL HLLEDAVTKP ELRPCPTP         10         20         30         40         50         60
MAGRSHPGPL RPLLPLLVVA ACVLPGAGGT CPERALERRE EEANVVLTGT VEEILNVDPV
        70         80         90        100        110        120
QHTYSCKVRV WRYLKGKDLV ARESLLDGGN KVVISGFGDP LICDNQVSTG DTRIFFVNPA
       130        140        150        160        170        180
PPYLWPAHKN ELMLNSSLMR ITLRNLEEVE FCVEDKPGTH FTPVPPTPPD ACRGMLCGFG
       190        200        210        220        230        240
AVCEPNAEGP GRASCVCKKS PCPSVVAPVC GSDASTYSNE CELQRAQCSQ QRRIRLLSRG
       250        260        270        280        290        300
PCGSRDPCSN VTCSFGSTCA RSADGLTASC LCPATCRGAP EGTVCGSDGA DYPGECQLLR
       310        320        330        340        350        360
RACARQENVF KKFDGPCDPC QGALPDPSRS CRVNPRTRRP EMLLRPESCP ARQAPVCGDD
       370        380        390        400        410        420
GVTYENDCVM GRSGAARGLL LQKVRSGQCQ GRDQCPEPCR FNAVCLSRRG RPRCSCDRVT
       430        440        450        460        470        480
CDGAYRPVCA QDGRTYDSDC WRQQAECRQQ RAIPSKHQGP CDQAPSPCLG VQCAFGATCA
       490        500        510        520        530        540
VKNGQAACEC LQACSSLYDP VCGSDGVTYG SACELEATAC TLGREIQVAR KGPCDRCGQC
       550        560        570        580        590        600
RFGALCEAET GRCVCPSECV ALAQPVCGSD GHTYPSECML HVHACTHQIS LHVASAGPCE
       610        620        630        640        650        660
TCGDAVCAFG AVCSAGQCVC PRCEHPPPGP VCGSDGVTYG SACELREAAC LQQTQIEEAR
       670        680        690        700        710        720
AGPCEQAECG SGGSGSGEDG DCEQELCRQR GGIWDEDSED GPCVCDFSCQ SVPGSPVCGS
       730        740        750        760        770        780
DGVTYSTECE LKKARCESQR GLYVAAQGAC RGPTFAPLPP VAPLHCAQTP YGCCQDNITA
       790        800        810        820        830        840
ARGVGLAGCP SACQCNPHGS YGGTCDPATG QCSCRPGVGG LRCDRCEPGF WNFRGIVTDG
       850        860        870        880        890        900
RSGCTPCSCD PQGAVRDDCE QMTGLCSCKP GVAGPKCGQC PDGRALGPAG CEADASAPAT
       910        920        930        940        950        960
CAEMRCEFGA RCVEESGSAH CVCPMLTCPE ANATKVCGSD GVTYGNECQL KTIACRQGLQ
       970        980        990       1000       1010       1020
ISIQSLGPCQ EAVAPSTHPT SASVTVTTPG LLLSQALPAP PGALPLAPSS TAHSQTTPPP
      1030       1040       1050       1060       1070       1080
SSRPRTTASV PRTTVWPVLT VPPTAPSPAP SLVASAFGES GSTDGSSDEE LSGDQEASGG
      1090       1100       1110       1120       1130       1140
GSGGLEPLEG SSVATPGPPV ERASCYNSAL GCCSDGKTPS LDAEGSNCPA TKVFQGVLEL
      1150       1160       1170       1180       1190       1200
EGVEGQELFY TPEMADPKSE LFGETARSIE STLDDLFRNS DVKKDFRSVR LRDLGPGKSV
      1210       1220       1230       1240       1250       1260
RAIVDVHFDP TTAFRAPDVA RALLRQIQVS RRRSLGVRRP LQEHVRFMDF DWFPAFITGA
      1270       1280       1290       1300       1310       1320
TSGAIAAGAT ARATTASRLP SSAVTPRAPH PSHTSQPVAK TTAAPTTRRP PTTAPSRVPG
      1330       1340       1350       1360       1370       1380
RRPPAPQQPP KPCDSQPCFH GGTCQDWALG GGFTCSCPAG RGGAVCEKVL GAPVPAFEGR
      1390       1400       1410       1420       1430       1440
SFLAFPTLRA YHTLRLALEF RALEPQGLLL YNGNARGKDF LALALLDGRV QLRFDTGSGP
      1450       1460       1470       1480       1490       1500
AVLTSAVPVE PGQWHRLELS RHWRRGTLSV DGETPVLGES PSGTDGLNLD TDLFVGGVPE
      1510       1520       1530       1540       1550       1560
DQAAVALERT FVGAGLRGCI RLLDVNNQRL ELGIGPGAAT RGSGVGECGD HPCLPNPCHG
      1570       1580       1590       1600       1610       1620
GAPCQNLEAG RFHCQCPPGR VGPTCADEKS PCQPNPCHGA APCRVLPEGG AQCECPLGRE
      1630       1640       1650       1660       1670       1680
GTFCQTASGQ DGSGPFLADF NGFSHLELRG LHTFARDLGE KMALEVVFLA RGPSGLLLYN
      1690       1700       1710       1720       1730       1740
GQKTDGKGDF VSLALRDRRL EFRYDLGKGA AVIRSREPVT LGAWTRVSLE RNGRKGALRV
      1750       1760       1770       1780       1790       1800
GDGPRVLGES PKSRKVPHTV LNLKEPLYVG GAPDFSKLAR AAAVSSGFDG AIQLVSLGGR
      1810       1820       1830       1840       1850       1860
QLLTPEHVLR QVDVTSFAGH PCTRASGHPC LNGASCVPRE AAYVCLCPGG FSGPHCEKGL
      1870       1880       1890       1900       1910       1920
VEKSAGDVDT LAFDGRTFVE YLNAVTESEL ANEIPVPETL DSGALHSEKA LQSNHFELSL
      1930       1940       1950       1960       1970       1980
RTEATQGLVL WSGKATERAD YVALAIVDGH LQLSYNLGSQ PVVLRSTVPV NTNRWLRVVA
      1990       2000       2010       2020       2030       2040
HREQREGSLQ VGNEAPVTGS SPLGATQLDT DGALWLGGLP ELPVGPALPK AYGTGFVGCL
      2050       2060
RDVVVGRHPL HLLEDAVTKP ELRPCPTP         10         20         30         40         50         60
MAGRSHPGPL RPLLPLLVVA ACVLPGAGGT CPERALERRE EEANVVLTGT VEEILNVDPV
        70         80         90        100        110        120
QHTYSCKVRV WRYLKGKDLV ARESLLDGGN KVVISGFGDP LICDNQVSTG DTRIFFVNPA
       130        140        150        160        170        180
PPYLWPAHKN ELMLNSSLMR ITLRNLEEVE FCVEDKPGTH FTPVPPTPPD ACRGMLCGFG
       190        200        210        220        230        240
AVCEPNAEGP GRASCVCKKS PCPSVVAPVC GSDASTYSNE CELQRAQCSQ QRRIRLLSRG
       250        260        270        280        290        300
PCGSRDPCSN VTCSFGSTCA RSADGLTASC LCPATCRGAP EGTVCGSDGA DYPGECQLLR
       310        320        330        340        350        360
RACARQENVF KKFDGPCDPC QGALPDPSRS CRVNPRTRRP EMLLRPESCP ARQAPVCGDD
       370        380        390        400        410        420
GVTYENDCVM GRSGAARGLL LQKVRSGQCQ GRDQCPEPCR FNAVCLSRRG RPRCSCDRVT
       430        440        450        460        470        480
CDGAYRPVCA QDGRTYDSDC WRQQAECRQQ RAIPSKHQGP CDQAPSPCLG VQCAFGATCA
       490        500        510        520        530        540
VKNGQAACEC LQACSSLYDP VCGSDGVTYG SACELEATAC TLGREIQVAR KGPCDRCGQC
       550        560        570        580        590        600
RFGALCEAET GRCVCPSECV ALAQPVCGSD GHTYPSECML HVHACTHQIS LHVASAGPCE
       610        620        630        640        650        660
TCGDAVCAFG AVCSAGQCVC PRCEHPPPGP VCGSDGVTYG SACELREAAC LQQTQIEEAR
       670        680        690        700        710        720
AGPCEQAECG SGGSGSGEDG DCEQELCRQR GGIWDEDSED GPCVCDFSCQ SVPGSPVCGS
       730        740        750        760        770        780
DGVTYSTECE LKKARCESQR GLYVAAQGAC RGPTFAPLPP VAPLHCAQTP YGCCQDNITA
       790        800        810        820        830        840
ARGVGLAGCP SACQCNPHGS YGGTCDPATG QCSCRPGVGG LRCDRCEPGF WNFRGIVTDG
       850        860        870        880        890        900
RSGCTPCSCD PQGAVRDDCE QMTGLCSCKP GVAGPKCGQC PDGRALGPAG CEADASAPAT
       910        920        930        940        950        960
CAEMRCEFGA RCVEESGSAH CVCPMLTCPE ANATKVCGSD GVTYGNECQL KTIACRQGLQ
       970        980        990       1000       1010       1020
ISIQSLGPCQ EAVAPSTHPT SASVTVTTPG LLLSQALPAP PGALPLAPSS TAHSQTTPPP
      1030       1040       1050       1060       1070       1080
SSRPRTTASV PRTTVWPVLT VPPTAPSPAP SLVASAFGES GSTDGSSDEE LSGDQEASGG
      1090       1100       1110       1120       1130       1140
GSGGLEPLEG SSVATPGPPV ERASCYNSAL GCCSDGKTPS LDAEGSNCPA TKVFQGVLEL
      1150       1160       1170       1180       1190       1200
EGVEGQELFY TPEMADPKSE LFGETARSIE STLDDLFRNS DVKKDFRSVR LRDLGPGKSV
      1210       1220       1230       1240       1250       1260
RAIVDVHFDP TTAFRAPDVA RALLRQIQVS RRRSLGVRRP LQEHVRFMDF DWFPAFITGA
      1270       1280       1290       1300       1310       1320
TSGAIAAGAT ARATTASRLP SSAVTPRAPH PSHTSQPVAK TTAAPTTRRP PTTAPSRVPG
      1330       1340       1350       1360       1370       1380
RRPPAPQQPP KPCDSQPCFH GGTCQDWALG GGFTCSCPAG RGGAVCEKVL GAPVPAFEGR
      1390       1400       1410       1420       1430       1440
SFLAFPTLRA YHTLRLALEF RALEPQGLLL YNGNARGKDF LALALLDGRV QLRFDTGSGP
      1450       1460       1470       1480       1490       1500
AVLTSAVPVE PGQWHRLELS RHWRRGTLSV DGETPVLGES PSGTDGLNLD TDLFVGGVPE
      1510       1520       1530       1540       1550       1560
DQAAVALERT FVGAGLRGCI RLLDVNNQRL ELGIGPGAAT RGSGVGECGD HPCLPNPCHG
      1570       1580       1590       1600       1610       1620
GAPCQNLEAG RFHCQCPPGR VGPTCADEKS PCQPNPCHGA APCRVLPEGG AQCECPLGRE
      1630       1640       1650       1660       1670       1680
GTFCQTASGQ DGSGPFLADF NGFSHLELRG LHTFARDLGE KMALEVVFLA RGPSGLLLYN
      1690       1700       1710       1720       1730       1740
GQKTDGKGDF VSLALRDRRL EFRYDLGKGA AVIRSREPVT LGAWTRVSLE RNGRKGALRV
      1750       1760       1770       1780       1790       1800
GDGPRVLGES PKSRKVPHTV LNLKEPLYVG GAPDFSKLAR AAAVSSGFDG AIQLVSLGGR
      1810       1820       1830       1840       1850       1860
QLLTPEHVLR QVDVTSFAGH PCTRASGHPC LNGASCVPRE AAYVCLCPGG FSGPHCEKGL
      1870       1880       1890       1900       1910       1920
VEKSAGDVDT LAFDGRTFVE YLNAVTESEL ANEIPVPETL DSGALHSEKA LQSNHFELSL
      1930       1940       1950       1960       1970       1980
RTEATQGLVL WSGKATERAD YVALAIVDGH LQLSYNLGSQ PVVLRSTVPV NTNRWLRVVA
      1990       2000       2010       2020       2030       2040
HREQREGSLQ VGNEAPVTGS SPLGATQLDT DGALWLGGLP ELPVGPALPK AYGTGFVGCL
      2050       2060
RDVVVGRHPL HLLEDAVTKP ELRPCPTP         10         20         30         40         50         60
MAGRSHPGPL RPLLPLLVVA ACVLPGAGGT CPERALERRE EEANVVLTGT VEEILNVDPV
        70         80         90        100        110        120
QHTYSCKVRV WRYLKGKDLV ARESLLDGGN KVVISGFGDP LICDNQVSTG DTRIFFVNPA
       130        140        150        160        170        180
PPYLWPAHKN ELMLNSSLMR ITLRNLEEVE FCVEDKPGTH FTPVPPTPPD ACRGMLCGFG
       190        200        210        220        230        240
AVCEPNAEGP GRASCVCKKS PCPSVVAPVC GSDASTYSNE CELQRAQCSQ QRRIRLLSRG
       250        260        270        280        290        300
PCGSRDPCSN VTCSFGSTCA RSADGLTASC LCPATCRGAP EGTVCGSDGA DYPGECQLLR
       310        320        330        340        350        360
RACARQENVF KKFDGPCDPC QGALPDPSRS CRVNPRTRRP EMLLRPESCP ARQAPVCGDD
       370        380        390        400        410        420
GVTYENDCVM GRSGAARGLL LQKVRSGQCQ GRDQCPEPCR FNAVCLSRRG RPRCSCDRVT
       430        440        450        460        470        480
CDGAYRPVCA QDGRTYDSDC WRQQAECRQQ RAIPSKHQGP CDQAPSPCLG VQCAFGATCA
       490        500        510        520        530        540
VKNGQAACEC LQACSSLYDP VCGSDGVTYG SACELEATAC TLGREIQVAR KGPCDRCGQC
       550        560        570        580        590        600
RFGALCEAET GRCVCPSECV ALAQPVCGSD GHTYPSECML HVHACTHQIS LHVASAGPCE
       610        620        630        640        650        660
TCGDAVCAFG AVCSAGQCVC PRCEHPPPGP VCGSDGVTYG SACELREAAC LQQTQIEEAR
       670        680        690        700        710        720
AGPCEQAECG SGGSGSGEDG DCEQELCRQR GGIWDEDSED GPCVCDFSCQ SVPGSPVCGS
       730        740        750        760        770        780
DGVTYSTECE LKKARCESQR GLYVAAQGAC RGPTFAPLPP VAPLHCAQTP YGCCQDNITA
       790        800        810        820        830        840
ARGVGLAGCP SACQCNPHGS YGGTCDPATG QCSCRPGVGG LRCDRCEPGF WNFRGIVTDG
       850        860        870        880        890        900
RSGCTPCSCD PQGAVRDDCE QMTGLCSCKP GVAGPKCGQC PDGRALGPAG CEADASAPAT
       910        920        930        940        950        960
CAEMRCEFGA RCVEESGSAH CVCPMLTCPE ANATKVCGSD GVTYGNECQL KTIACRQGLQ
       970        980        990       1000       1010       1020
ISIQSLGPCQ EAVAPSTHPT SASVTVTTPG LLLSQALPAP PGALPLAPSS TAHSQTTPPP
      1030       1040       1050       1060       1070       1080
SSRPRTTASV PRTTVWPVLT VPPTAPSPAP SLVASAFGES GSTDGSSDEE LSGDQEASGG
      1090       1100       1110       1120       1130       1140
GSGGLEPLEG SSVATPGPPV ERASCYNSAL GCCSDGKTPS LDAEGSNCPA TKVFQGVLEL
      1150       1160       1170       1180       1190       1200
EGVEGQELFY TPEMADPKSE LFGETARSIE STLDDLFRNS DVKKDFRSVR LRDLGPGKSV
      1210       1220       1230       1240       1250       1260
RAIVDVHFDP TTAFRAPDVA RALLRQIQVS RRRSLGVRRP LQEHVRFMDF DWFPAFITGA
      1270       1280       1290       1300       1310       1320
TSGAIAAGAT ARATTASRLP SSAVTPRAPH PSHTSQPVAK TTAAPTTRRP PTTAPSRVPG
      1330       1340       1350       1360       1370       1380
RRPPAPQQPP KPCDSQPCFH GGTCQDWALG GGFTCSCPAG RGGAVCEKVL GAPVPAFEGR
      1390       1400       1410       1420       1430       1440
SFLAFPTLRA YHTLRLALEF RALEPQGLLL YNGNARGKDF LALALLDGRV QLRFDTGSGP
      1450       1460       1470       1480       1490       1500
AVLTSAVPVE PGQWHRLELS RHWRRGTLSV DGETPVLGES PSGTDGLNLD TDLFVGGVPE
      1510       1520       1530       1540       1550       1560
DQAAVALERT FVGAGLRGCI RLLDVNNQRL ELGIGPGAAT RGSGVGECGD HPCLPNPCHG
      1570       1580       1590       1600       1610       1620
GAPCQNLEAG RFHCQCPPGR VGPTCADEKS PCQPNPCHGA APCRVLPEGG AQCECPLGRE
      1630       1640       1650       1660       1670       1680
GTFCQTASGQ DGSGPFLADF NGFSHLELRG LHTFARDLGE KMALEVVFLA RGPSGLLLYN
      1690       1700       1710       1720       1730       1740
GQKTDGKGDF VSLALRDRRL EFRYDLGKGA AVIRSREPVT LGAWTRVSLE RNGRKGALRV
      1750       1760       1770       1780       1790       1800
GDGPRVLGES PKSRKVPHTV LNLKEPLYVG GAPDFSKLAR AAAVSSGFDG AIQLVSLGGR
      1810       1820       1830       1840       1850       1860
QLLTPEHVLR QVDVTSFAGH PCTRASGHPC LNGASCVPRE AAYVCLCPGG FSGPHCEKGL
      1870       1880       1890       1900       1910       1920
VEKSAGDVDT LAFDGRTFVE YLNAVTESEL ANEIPVPETL DSGALHSEKA LQSNHFELSL
      1930       1940       1950       1960       1970       1980
RTEATQGLVL WSGKATERAD YVALAIVDGH LQLSYNLGSQ PVVLRSTVPV NTNRWLRVVA
      1990       2000       2010       2020       2030       2040
HREQREGSLQ VGNEAPVTGS SPLGATQLDT DGALWLGGLP ELPVGPALPK AYGTGFVGCL
      2050       2060
RDVVVGRHPL HLLEDAVTKP ELRPCPTP         10         20         30         40         50         60
MAGRSHPGPL RPLLPLLVVA ACVLPGAGGT CPERALERRE EEANVVLTGT VEEILNVDPV
        70         80         90        100        110        120
QHTYSCKVRV WRYLKGKDLV ARESLLDGGN KVVISGFGDP LICDNQVSTG DTRIFFVNPA
       130        140        150        160        170        180
PPYLWPAHKN ELMLNSSLMR ITLRNLEEVE FCVEDKPGTH FTPVPPTPPD ACRGMLCGFG
       190        200        210        220        230        240
AVCEPNAEGP GRASCVCKKS PCPSVVAPVC GSDASTYSNE CELQRAQCSQ QRRIRLLSRG
       250        260        270        280        290        300
PCGSRDPCSN VTCSFGSTCA RSADGLTASC LCPATCRGAP EGTVCGSDGA DYPGECQLLR
       310        320        330        340        350        360
RACARQENVF KKFDGPCDPC QGALPDPSRS CRVNPRTRRP EMLLRPESCP ARQAPVCGDD
       370        380        390        400        410        420
GVTYENDCVM GRSGAARGLL LQKVRSGQCQ GRDQCPEPCR FNAVCLSRRG RPRCSCDRVT
       430        440        450        460        470        480
CDGAYRPVCA QDGRTYDSDC WRQQAECRQQ RAIPSKHQGP CDQAPSPCLG VQCAFGATCA
       490        500        510        520        530        540
VKNGQAACEC LQACSSLYDP VCGSDGVTYG SACELEATAC TLGREIQVAR KGPCDRCGQC
       550        560        570        580        590        600
RFGALCEAET GRCVCPSECV ALAQPVCGSD GHTYPSECML HVHACTHQIS LHVASAGPCE
       610        620        630        640        650        660
TCGDAVCAFG AVCSAGQCVC PRCEHPPPGP VCGSDGVTYG SACELREAAC LQQTQIEEAR
       670        680        690        700        710        720
AGPCEQAECG SGGSGSGEDG DCEQELCRQR GGIWDEDSED GPCVCDFSCQ SVPGSPVCGS
       730        740        750        760        770        780
DGVTYSTECE LKKARCESQR GLYVAAQGAC RGPTFAPLPP VAPLHCAQTP YGCCQDNITA
       790        800        810        820        830        840
ARGVGLAGCP SACQCNPHGS YGGTCDPATG QCSCRPGVGG LRCDRCEPGF WNFRGIVTDG
       850        860        870        880        890        900
RSGCTPCSCD PQGAVRDDCE QMTGLCSCKP GVAGPKCGQC PDGRALGPAG CEADASAPAT
       910        920        930        940        950        960
CAEMRCEFGA RCVEESGSAH CVCPMLTCPE ANATKVCGSD GVTYGNECQL KTIACRQGLQ
       970        980        990       1000       1010       1020
ISIQSLGPCQ EAVAPSTHPT SASVTVTTPG LLLSQALPAP PGALPLAPSS TAHSQTTPPP
      1030       1040       1050       1060       1070       1080
SSRPRTTASV PRTTVWPVLT VPPTAPSPAP SLVASAFGES GSTDGSSDEE LSGDQEASGG
      1090       1100       1110       1120       1130       1140
GSGGLEPLEG SSVATPGPPV ERASCYNSAL GCCSDGKTPS LDAEGSNCPA TKVFQGVLEL
      1150       1160       1170       1180       1190       1200
EGVEGQELFY TPEMADPKSE LFGETARSIE STLDDLFRNS DVKKDFRSVR LRDLGPGKSV
      1210       1220       1230       1240       1250       1260
RAIVDVHFDP TTAFRAPDVA RALLRQIQVS RRRSLGVRRP LQEHVRFMDF DWFPAFITGA
      1270       1280       1290       1300       1310       1320
TSGAIAAGAT ARATTASRLP SSAVTPRAPH PSHTSQPVAK TTAAPTTRRP PTTAPSRVPG
      1330       1340       1350       1360       1370       1380
RRPPAPQQPP KPCDSQPCFH GGTCQDWALG GGFTCSCPAG RGGAVCEKVL GAPVPAFEGR
      1390       1400       1410       1420       1430       1440
SFLAFPTLRA YHTLRLALEF RALEPQGLLL YNGNARGKDF LALALLDGRV QLRFDTGSGP
      1450       1460       1470       1480       1490       1500
AVLTSAVPVE PGQWHRLELS RHWRRGTLSV DGETPVLGES PSGTDGLNLD TDLFVGGVPE
      1510       1520       1530       1540       1550       1560
DQAAVALERT FVGAGLRGCI RLLDVNNQRL ELGIGPGAAT RGSGVGECGD HPCLPNPCHG
      1570       1580       1590       1600       1610       1620
GAPCQNLEAG RFHCQCPPGR VGPTCADEKS PCQPNPCHGA APCRVLPEGG AQCECPLGRE
      1630       1640       1650       1660       1670       1680
GTFCQTASGQ DGSGPFLADF NGFSHLELRG LHTFARDLGE KMALEVVFLA RGPSGLLLYN
      1690       1700       1710       1720       1730       1740
GQKTDGKGDF VSLALRDRRL EFRYDLGKGA AVIRSREPVT LGAWTRVSLE RNGRKGALRV
      1750       1760       1770       1780       1790       1800
GDGPRVLGES PKSRKVPHTV LNLKEPLYVG GAPDFSKLAR AAAVSSGFDG AIQLVSLGGR
      1810       1820       1830       1840       1850       1860
QLLTPEHVLR QVDVTSFAGH PCTRASGHPC LNGASCVPRE AAYVCLCPGG FSGPHCEKGL
      1870       1880       1890       1900       1910       1920
VEKSAGDVDT LAFDGRTFVE YLNAVTESEL ANEIPVPETL DSGALHSEKA LQSNHFELSL
      1930       1940       1950       1960       1970       1980
RTEATQGLVL WSGKATERAD YVALAIVDGH LQLSYNLGSQ PVVLRSTVPV NTNRWLRVVA
      1990       2000       2010       2020       2030       2040
HREQREGSLQ VGNEAPVTGS SPLGATQLDT DGALWLGGLP ELPVGPALPK AYGTGFVGCL
      2050       2060
RDVVVGRHPL HLLEDAVTKP ELRPCPTP         10         20         30         40         50         60
MAGRSHPGPL RPLLPLLVVA ACVLPGAGGT CPERALERRE EEANVVLTGT VEEILNVDPV
        70         80         90        100        110        120
QHTYSCKVRV WRYLKGKDLV ARESLLDGGN KVVISGFGDP LICDNQVSTG DTRIFFVNPA
       130        140        150        160        170        180
PPYLWPAHKN ELMLNSSLMR ITLRNLEEVE FCVEDKPGTH FTPVPPTPPD ACRGMLCGFG
       190        200        210        220        230        240
AVCEPNAEGP GRASCVCKKS PCPSVVAPVC GSDASTYSNE CELQRAQCSQ QRRIRLLSRG
       250        260        270        280        290        300
PCGSRDPCSN VTCSFGSTCA RSADGLTASC LCPATCRGAP EGTVCGSDGA DYPGECQLLR
       310        320        330        340        350        360
RACARQENVF KKFDGPCDPC QGALPDPSRS CRVNPRTRRP EMLLRPESCP ARQAPVCGDD
       370        380        390        400        410        420
GVTYENDCVM GRSGAARGLL LQKVRSGQCQ GRDQCPEPCR FNAVCLSRRG RPRCSCDRVT
       430        440        450        460        470        480
CDGAYRPVCA QDGRTYDSDC WRQQAECRQQ RAIPSKHQGP CDQAPSPCLG VQCAFGATCA
       490        500        510        520        530        540
VKNGQAACEC LQACSSLYDP VCGSDGVTYG SACELEATAC TLGREIQVAR KGPCDRCGQC
       550        560        570        580        590        600
RFGALCEAET GRCVCPSECV ALAQPVCGSD GHTYPSECML HVHACTHQIS LHVASAGPCE
       610        620        630        640        650        660
TCGDAVCAFG AVCSAGQCVC PRCEHPPPGP VCGSDGVTYG SACELREAAC LQQTQIEEAR
       670        680        690        700        710        720
AGPCEQAECG SGGSGSGEDG DCEQELCRQR GGIWDEDSED GPCVCDFSCQ SVPGSPVCGS
       730        740        750        760        770        780
DGVTYSTECE LKKARCESQR GLYVAAQGAC RGPTFAPLPP VAPLHCAQTP YGCCQDNITA
       790        800        810        820        830        840
ARGVGLAGCP SACQCNPHGS YGGTCDPATG QCSCRPGVGG LRCDRCEPGF WNFRGIVTDG
       850        860        870        880        890        900
RSGCTPCSCD PQGAVRDDCE QMTGLCSCKP GVAGPKCGQC PDGRALGPAG CEADASAPAT
       910        920        930        940        950        960
CAEMRCEFGA RCVEESGSAH CVCPMLTCPE ANATKVCGSD GVTYGNECQL KTIACRQGLQ
       970        980        990       1000       1010       1020
ISIQSLGPCQ EAVAPSTHPT SASVTVTTPG LLLSQALPAP PGALPLAPSS TAHSQTTPPP
      1030       1040       1050       1060       1070       1080
SSRPRTTASV PRTTVWPVLT VPPTAPSPAP SLVASAFGES GSTDGSSDEE LSGDQEASGG
      1090       1100       1110       1120       1130       1140
GSGGLEPLEG SSVATPGPPV ERASCYNSAL GCCSDGKTPS LDAEGSNCPA TKVFQGVLEL
      1150       1160       1170       1180       1190       1200
EGVEGQELFY TPEMADPKSE LFGETARSIE STLDDLFRNS DVKKDFRSVR LRDLGPGKSV
      1210       1220       1230       1240       1250       1260
RAIVDVHFDP TTAFRAPDVA RALLRQIQVS RRRSLGVRRP LQEHVRFMDF DWFPAFITGA
      1270       1280       1290       1300       1310       1320
TSGAIAAGAT ARATTASRLP SSAVTPRAPH PSHTSQPVAK TTAAPTTRRP PTTAPSRVPG
      1330       1340       1350       1360       1370       1380
RRPPAPQQPP KPCDSQPCFH GGTCQDWALG GGFTCSCPAG RGGAVCEKVL GAPVPAFEGR
      1390       1400       1410       1420       1430       1440
SFLAFPTLRA YHTLRLALEF RALEPQGLLL YNGNARGKDF LALALLDGRV QLRFDTGSGP
      1450       1460       1470       1480       1490       1500
AVLTSAVPVE PGQWHRLELS RHWRRGTLSV DGETPVLGES PSGTDGLNLD TDLFVGGVPE
      1510       1520       1530       1540       1550       1560
DQAAVALERT FVGAGLRGCI RLLDVNNQRL ELGIGPGAAT RGSGVGECGD HPCLPNPCHG
      1570       1580       1590       1600       1610       1620
GAPCQNLEAG RFHCQCPPGR VGPTCADEKS PCQPNPCHGA APCRVLPEGG AQCECPLGRE
      1630       1640       1650       1660       1670       1680
GTFCQTASGQ DGSGPFLADF NGFSHLELRG LHTFARDLGE KMALEVVFLA RGPSGLLLYN
      1690       1700       1710       1720       1730       1740
GQKTDGKGDF VSLALRDRRL EFRYDLGKGA AVIRSREPVT LGAWTRVSLE RNGRKGALRV
      1750       1760       1770       1780       1790       1800
GDGPRVLGES PKSRKVPHTV LNLKEPLYVG GAPDFSKLAR AAAVSSGFDG AIQLVSLGGR
      1810       1820       1830       1840       1850       1860
QLLTPEHVLR QVDVTSFAGH PCTRASGHPC LNGASCVPRE AAYVCLCPGG FSGPHCEKGL
      1870       1880       1890       1900       1910       1920
VEKSAGDVDT LAFDGRTFVE YLNAVTESEL ANEIPVPETL DSGALHSEKA LQSNHFELSL
      1930       1940       1950       1960       1970       1980
RTEATQGLVL WSGKATERAD YVALAIVDGH LQLSYNLGSQ PVVLRSTVPV NTNRWLRVVA
      1990       2000       2010       2020       2030       2040
HREQREGSLQ VGNEAPVTGS SPLGATQLDT DGALWLGGLP ELPVGPALPK AYGTGFVGCL
      2050       2060
RDVVVGRHPL HLLEDAVTKP ELRPCPTP

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
O00468-1-unknown	MAGRSH...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66530
O00468-1-unknown	MAGRSH...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66531
O00468-1-unknown	MAGRSH...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66532
O00468-1-unknown	MAGRSH...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66533
O00468-1-unknown	MAGRSH...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66534
O00468-30-unknown	TCPERA...	30	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O00468-30-unknown	TCPERA...	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114662
O00468-30-unknown	TCPERA...	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114663
O00468-30-unknown	TCPERA...	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114664
O00468-30-unknown	TCPERA...	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114665
O00468-30-unknown	TCPERA...	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114666
O00468-1103-unknown	ASCYNS...	1103	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O00468-1103-unknown	ASCYNS...	1103	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116463
O00468-1103-unknown	ASCYNS...	1103	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116458
O00468-1103-unknown	ASCYNS...	1103	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116459
O00468-1103-unknown	ASCYNS...	1103	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116460
O00468-1103-unknown	ASCYNS...	1103	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116461
O00468-1103-unknown	ASCYNS...	1103	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116462
O00468-1103-unknown	ASCYNS...	1103	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
O00468-1216-unknown	APDVAR...	1216	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10644
O00468-1216-unknown	APDVAR...	1216	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157428
O00468-1216-unknown	APDVAR...	1216	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157723
O00468-1216-unknown	APDVAR...	1216	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157724
O00468-1216-unknown	APDVAR...	1216	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157725
O00468-1216-unknown	APDVAR...	1216	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157726
O00468-1216-unknown	APDVAR...	1216	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157727
O00468-1860-unknown	LVEKSA...	1860		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
O00468-1860-unknown	LVEKSA...	1860	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180049
O00468-1860-unknown	LVEKSA...	1860	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180044
O00468-1860-unknown	LVEKSA...	1860	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180045
O00468-1860-unknown	LVEKSA...	1860	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180046
O00468-1860-unknown	LVEKSA...	1860	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180047
O00468-1860-unknown	LVEKSA...	1860	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180048
O00468-1864-unknown	SAGDVD...	1864	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O00468-1864-unknown	SAGDVD...	1864	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116517
O00468-1864-unknown	SAGDVD...	1864	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116512
O00468-1864-unknown	SAGDVD...	1864	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116513
O00468-1864-unknown	SAGDVD...	1864	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116514
O00468-1864-unknown	SAGDVD...	1864	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116515
O00468-1864-unknown	SAGDVD...	1864	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116516
O00468-1864-unknown	SAGDVD...	1864	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PPVERA	1102	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PPVERA	1102	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
...PPVERA	1102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93659
...PPVERA	1102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93654
...PPVERA	1102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93655
...PPVERA	1102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93656
...PPVERA	1102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93657
...PPVERA	1102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93658
...TTAFRA	1215	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10644
...TTAFRA	1215	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140926
...TTAFRA	1215	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141222
...TTAFRA	1215	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141223
...TTAFRA	1215	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141224
...TTAFRA	1215	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141225
...TTAFRA	1215	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141226
...GLVEKS	1863	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GLVEKS	1863	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
...GLVEKS	1863	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93793
...GLVEKS	1863	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93788
...GLVEKS	1863	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93789
...GLVEKS	1863	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93790
...GLVEKS	1863	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93791
...GLVEKS	1863	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93792
...RPCPTP	2067	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RPCPTP	2067	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62147
...RPCPTP	2067	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62151
...RPCPTP	2067	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62148
...RPCPTP	2067	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62150
...RPCPTP	2067	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62149
...RPCPTP	2067	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62152

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	1215	AFRA.\|.APDV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)