O00468: Agrin
General Information
| Protein names | - Agrin - Agrin N-terminal 110 kDa subunit - Agrin C-terminal 110 kDa subunit - Agrin C-terminal 90 kDa fragment - C90 - Agrin C-terminal 22 kDa fragment - C22 |
|---|---|
| Gene names | AGRN |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | O00468 |
6
N-termini
4
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAGRSHPGPL RPLLPLLVVA ACVLPGAGGT CPERALERRE EEANVVLTGT VEEILNVDPV
70 80 90 100 110 120
QHTYSCKVRV WRYLKGKDLV ARESLLDGGN KVVISGFGDP LICDNQVSTG DTRIFFVNPA
130 140 150 160 170 180
PPYLWPAHKN ELMLNSSLMR ITLRNLEEVE FCVEDKPGTH FTPVPPTPPD ACRGMLCGFG
190 200 210 220 230 240
AVCEPNAEGP GRASCVCKKS PCPSVVAPVC GSDASTYSNE CELQRAQCSQ QRRIRLLSRG
250 260 270 280 290 300
PCGSRDPCSN VTCSFGSTCA RSADGLTASC LCPATCRGAP EGTVCGSDGA DYPGECQLLR
310 320 330 340 350 360
RACARQENVF KKFDGPCDPC QGALPDPSRS CRVNPRTRRP EMLLRPESCP ARQAPVCGDD
370 380 390 400 410 420
GVTYENDCVM GRSGAARGLL LQKVRSGQCQ GRDQCPEPCR FNAVCLSRRG RPRCSCDRVT
430 440 450 460 470 480
CDGAYRPVCA QDGRTYDSDC WRQQAECRQQ RAIPSKHQGP CDQAPSPCLG VQCAFGATCA
490 500 510 520 530 540
VKNGQAACEC LQACSSLYDP VCGSDGVTYG SACELEATAC TLGREIQVAR KGPCDRCGQC
550 560 570 580 590 600
RFGALCEAET GRCVCPSECV ALAQPVCGSD GHTYPSECML HVHACTHQIS LHVASAGPCE
610 620 630 640 650 660
TCGDAVCAFG AVCSAGQCVC PRCEHPPPGP VCGSDGVTYG SACELREAAC LQQTQIEEAR
670 680 690 700 710 720
AGPCEQAECG SGGSGSGEDG DCEQELCRQR GGIWDEDSED GPCVCDFSCQ SVPGSPVCGS
730 740 750 760 770 780
DGVTYSTECE LKKARCESQR GLYVAAQGAC RGPTFAPLPP VAPLHCAQTP YGCCQDNITA
790 800 810 820 830 840
ARGVGLAGCP SACQCNPHGS YGGTCDPATG QCSCRPGVGG LRCDRCEPGF WNFRGIVTDG
850 860 870 880 890 900
RSGCTPCSCD PQGAVRDDCE QMTGLCSCKP GVAGPKCGQC PDGRALGPAG CEADASAPAT
910 920 930 940 950 960
CAEMRCEFGA RCVEESGSAH CVCPMLTCPE ANATKVCGSD GVTYGNECQL KTIACRQGLQ
970 980 990 1000 1010 1020
ISIQSLGPCQ EAVAPSTHPT SASVTVTTPG LLLSQALPAP PGALPLAPSS TAHSQTTPPP
1030 1040 1050 1060 1070 1080
SSRPRTTASV PRTTVWPVLT VPPTAPSPAP SLVASAFGES GSTDGSSDEE LSGDQEASGG
1090 1100 1110 1120 1130 1140
GSGGLEPLEG SSVATPGPPV ERASCYNSAL GCCSDGKTPS LDAEGSNCPA TKVFQGVLEL
1150 1160 1170 1180 1190 1200
EGVEGQELFY TPEMADPKSE LFGETARSIE STLDDLFRNS DVKKDFRSVR LRDLGPGKSV
1210 1220 1230 1240 1250 1260
RAIVDVHFDP TTAFRAPDVA RALLRQIQVS RRRSLGVRRP LQEHVRFMDF DWFPAFITGA
1270 1280 1290 1300 1310 1320
TSGAIAAGAT ARATTASRLP SSAVTPRAPH PSHTSQPVAK TTAAPTTRRP PTTAPSRVPG
1330 1340 1350 1360 1370 1380
RRPPAPQQPP KPCDSQPCFH GGTCQDWALG GGFTCSCPAG RGGAVCEKVL GAPVPAFEGR
1390 1400 1410 1420 1430 1440
SFLAFPTLRA YHTLRLALEF RALEPQGLLL YNGNARGKDF LALALLDGRV QLRFDTGSGP
1450 1460 1470 1480 1490 1500
AVLTSAVPVE PGQWHRLELS RHWRRGTLSV DGETPVLGES PSGTDGLNLD TDLFVGGVPE
1510 1520 1530 1540 1550 1560
DQAAVALERT FVGAGLRGCI RLLDVNNQRL ELGIGPGAAT RGSGVGECGD HPCLPNPCHG
1570 1580 1590 1600 1610 1620
GAPCQNLEAG RFHCQCPPGR VGPTCADEKS PCQPNPCHGA APCRVLPEGG AQCECPLGRE
1630 1640 1650 1660 1670 1680
GTFCQTASGQ DGSGPFLADF NGFSHLELRG LHTFARDLGE KMALEVVFLA RGPSGLLLYN
1690 1700 1710 1720 1730 1740
GQKTDGKGDF VSLALRDRRL EFRYDLGKGA AVIRSREPVT LGAWTRVSLE RNGRKGALRV
1750 1760 1770 1780 1790 1800
GDGPRVLGES PKSRKVPHTV LNLKEPLYVG GAPDFSKLAR AAAVSSGFDG AIQLVSLGGR
1810 1820 1830 1840 1850 1860
QLLTPEHVLR QVDVTSFAGH PCTRASGHPC LNGASCVPRE AAYVCLCPGG FSGPHCEKGL
1870 1880 1890 1900 1910 1920
VEKSAGDVDT LAFDGRTFVE YLNAVTESEL ANEIPVPETL DSGALHSEKA LQSNHFELSL
1930 1940 1950 1960 1970 1980
RTEATQGLVL WSGKATERAD YVALAIVDGH LQLSYNLGSQ PVVLRSTVPV NTNRWLRVVA
1990 2000 2010 2020 2030 2040
HREQREGSLQ VGNEAPVTGS SPLGATQLDT DGALWLGGLP ELPVGPALPK AYGTGFVGCL
2050 2060
RDVVVGRHPL HLLEDAVTKP ELRPCPTP
Isoforms
- Isoform 2 of Agrin - Isoform 3 of Agrin - Isoform 4 of Agrin - Isoform 5 of Agrin - Isoform 6 of Agrin - Isoform 7 of Agrin - Isoform 2 of Agrin - Isoform 4 of Agrin - Isoform 7 of AgrinSequence View
10 20 30 40 50 60
MAGRSHPGPL RPLLPLLVVA ACVLPGAGGT CPERALERRE EEANVVLTGT VEEILNVDPV
70 80 90 100 110 120
QHTYSCKVRV WRYLKGKDLV ARESLLDGGN KVVISGFGDP LICDNQVSTG DTRIFFVNPA
130 140 150 160 170 180
PPYLWPAHKN ELMLNSSLMR ITLRNLEEVE FCVEDKPGTH FTPVPPTPPD ACRGMLCGFG
190 200 210 220 230 240
AVCEPNAEGP GRASCVCKKS PCPSVVAPVC GSDASTYSNE CELQRAQCSQ QRRIRLLSRG
250 260 270 280 290 300
PCGSRDPCSN VTCSFGSTCA RSADGLTASC LCPATCRGAP EGTVCGSDGA DYPGECQLLR
310 320 330 340 350 360
RACARQENVF KKFDGPCDPC QGALPDPSRS CRVNPRTRRP EMLLRPESCP ARQAPVCGDD
370 380 390 400 410 420
GVTYENDCVM GRSGAARGLL LQKVRSGQCQ GRDQCPEPCR FNAVCLSRRG RPRCSCDRVT
430 440 450 460 470 480
CDGAYRPVCA QDGRTYDSDC WRQQAECRQQ RAIPSKHQGP CDQAPSPCLG VQCAFGATCA
490 500 510 520 530 540
VKNGQAACEC LQACSSLYDP VCGSDGVTYG SACELEATAC TLGREIQVAR KGPCDRCGQC
550 560 570 580 590 600
RFGALCEAET GRCVCPSECV ALAQPVCGSD GHTYPSECML HVHACTHQIS LHVASAGPCE
610 620 630 640 650 660
TCGDAVCAFG AVCSAGQCVC PRCEHPPPGP VCGSDGVTYG SACELREAAC LQQTQIEEAR
670 680 690 700 710 720
AGPCEQAECG SGGSGSGEDG DCEQELCRQR GGIWDEDSED GPCVCDFSCQ SVPGSPVCGS
730 740 750 760 770 780
DGVTYSTECE LKKARCESQR GLYVAAQGAC RGPTFAPLPP VAPLHCAQTP YGCCQDNITA
790 800 810 820 830 840
ARGVGLAGCP SACQCNPHGS YGGTCDPATG QCSCRPGVGG LRCDRCEPGF WNFRGIVTDG
850 860 870 880 890 900
RSGCTPCSCD PQGAVRDDCE QMTGLCSCKP GVAGPKCGQC PDGRALGPAG CEADASAPAT
910 920 930 940 950 960
CAEMRCEFGA RCVEESGSAH CVCPMLTCPE ANATKVCGSD GVTYGNECQL KTIACRQGLQ
970 980 990 1000 1010 1020
ISIQSLGPCQ EAVAPSTHPT SASVTVTTPG LLLSQALPAP PGALPLAPSS TAHSQTTPPP
1030 1040 1050 1060 1070 1080
SSRPRTTASV PRTTVWPVLT VPPTAPSPAP SLVASAFGES GSTDGSSDEE LSGDQEASGG
1090 1100 1110 1120 1130 1140
GSGGLEPLEG SSVATPGPPV ERASCYNSAL GCCSDGKTPS LDAEGSNCPA TKVFQGVLEL
1150 1160 1170 1180 1190 1200
EGVEGQELFY TPEMADPKSE LFGETARSIE STLDDLFRNS DVKKDFRSVR LRDLGPGKSV
1210 1220 1230 1240 1250 1260
RAIVDVHFDP TTAFRAPDVA RALLRQIQVS RRRSLGVRRP LQEHVRFMDF DWFPAFITGA
1270 1280 1290 1300 1310 1320
TSGAIAAGAT ARATTASRLP SSAVTPRAPH PSHTSQPVAK TTAAPTTRRP PTTAPSRVPG
1330 1340 1350 1360 1370 1380
RRPPAPQQPP KPCDSQPCFH GGTCQDWALG GGFTCSCPAG RGGAVCEKVL GAPVPAFEGR
1390 1400 1410 1420 1430 1440
SFLAFPTLRA YHTLRLALEF RALEPQGLLL YNGNARGKDF LALALLDGRV QLRFDTGSGP
1450 1460 1470 1480 1490 1500
AVLTSAVPVE PGQWHRLELS RHWRRGTLSV DGETPVLGES PSGTDGLNLD TDLFVGGVPE
1510 1520 1530 1540 1550 1560
DQAAVALERT FVGAGLRGCI RLLDVNNQRL ELGIGPGAAT RGSGVGECGD HPCLPNPCHG
1570 1580 1590 1600 1610 1620
GAPCQNLEAG RFHCQCPPGR VGPTCADEKS PCQPNPCHGA APCRVLPEGG AQCECPLGRE
1630 1640 1650 1660 1670 1680
GTFCQTASGQ DGSGPFLADF NGFSHLELRG LHTFARDLGE KMALEVVFLA RGPSGLLLYN
1690 1700 1710 1720 1730 1740
GQKTDGKGDF VSLALRDRRL EFRYDLGKGA AVIRSREPVT LGAWTRVSLE RNGRKGALRV
1750 1760 1770 1780 1790 1800
GDGPRVLGES PKSRKVPHTV LNLKEPLYVG GAPDFSKLAR AAAVSSGFDG AIQLVSLGGR
1810 1820 1830 1840 1850 1860
QLLTPEHVLR QVDVTSFAGH PCTRASGHPC LNGASCVPRE AAYVCLCPGG FSGPHCEKGL
1870 1880 1890 1900 1910 1920
VEKSAGDVDT LAFDGRTFVE YLNAVTESEL ANEIPVPETL DSGALHSEKA LQSNHFELSL
1930 1940 1950 1960 1970 1980
RTEATQGLVL WSGKATERAD YVALAIVDGH LQLSYNLGSQ PVVLRSTVPV NTNRWLRVVA
1990 2000 2010 2020 2030 2040
HREQREGSLQ VGNEAPVTGS SPLGATQLDT DGALWLGGLP ELPVGPALPK AYGTGFVGCL
2050 2060
RDVVVGRHPL HLLEDAVTKP ELRPCPTP
10 20 30 40 50 60
MAGRSHPGPL RPLLPLLVVA ACVLPGAGGT CPERALERRE EEANVVLTGT VEEILNVDPV
70 80 90 100 110 120
QHTYSCKVRV WRYLKGKDLV ARESLLDGGN KVVISGFGDP LICDNQVSTG DTRIFFVNPA
130 140 150 160 170 180
PPYLWPAHKN ELMLNSSLMR ITLRNLEEVE FCVEDKPGTH FTPVPPTPPD ACRGMLCGFG
190 200 210 220 230 240
AVCEPNAEGP GRASCVCKKS PCPSVVAPVC GSDASTYSNE CELQRAQCSQ QRRIRLLSRG
250 260 270 280 290 300
PCGSRDPCSN VTCSFGSTCA RSADGLTASC LCPATCRGAP EGTVCGSDGA DYPGECQLLR
310 320 330 340 350 360
RACARQENVF KKFDGPCDPC QGALPDPSRS CRVNPRTRRP EMLLRPESCP ARQAPVCGDD
370 380 390 400 410 420
GVTYENDCVM GRSGAARGLL LQKVRSGQCQ GRDQCPEPCR FNAVCLSRRG RPRCSCDRVT
430 440 450 460 470 480
CDGAYRPVCA QDGRTYDSDC WRQQAECRQQ RAIPSKHQGP CDQAPSPCLG VQCAFGATCA
490 500 510 520 530 540
VKNGQAACEC LQACSSLYDP VCGSDGVTYG SACELEATAC TLGREIQVAR KGPCDRCGQC
550 560 570 580 590 600
RFGALCEAET GRCVCPSECV ALAQPVCGSD GHTYPSECML HVHACTHQIS LHVASAGPCE
610 620 630 640 650 660
TCGDAVCAFG AVCSAGQCVC PRCEHPPPGP VCGSDGVTYG SACELREAAC LQQTQIEEAR
670 680 690 700 710 720
AGPCEQAECG SGGSGSGEDG DCEQELCRQR GGIWDEDSED GPCVCDFSCQ SVPGSPVCGS
730 740 750 760 770 780
DGVTYSTECE LKKARCESQR GLYVAAQGAC RGPTFAPLPP VAPLHCAQTP YGCCQDNITA
790 800 810 820 830 840
ARGVGLAGCP SACQCNPHGS YGGTCDPATG QCSCRPGVGG LRCDRCEPGF WNFRGIVTDG
850 860 870 880 890 900
RSGCTPCSCD PQGAVRDDCE QMTGLCSCKP GVAGPKCGQC PDGRALGPAG CEADASAPAT
910 920 930 940 950 960
CAEMRCEFGA RCVEESGSAH CVCPMLTCPE ANATKVCGSD GVTYGNECQL KTIACRQGLQ
970 980 990 1000 1010 1020
ISIQSLGPCQ EAVAPSTHPT SASVTVTTPG LLLSQALPAP PGALPLAPSS TAHSQTTPPP
1030 1040 1050 1060 1070 1080
SSRPRTTASV PRTTVWPVLT VPPTAPSPAP SLVASAFGES GSTDGSSDEE LSGDQEASGG
1090 1100 1110 1120 1130 1140
GSGGLEPLEG SSVATPGPPV ERASCYNSAL GCCSDGKTPS LDAEGSNCPA TKVFQGVLEL
1150 1160 1170 1180 1190 1200
EGVEGQELFY TPEMADPKSE LFGETARSIE STLDDLFRNS DVKKDFRSVR LRDLGPGKSV
1210 1220 1230 1240 1250 1260
RAIVDVHFDP TTAFRAPDVA RALLRQIQVS RRRSLGVRRP LQEHVRFMDF DWFPAFITGA
1270 1280 1290 1300 1310 1320
TSGAIAAGAT ARATTASRLP SSAVTPRAPH PSHTSQPVAK TTAAPTTRRP PTTAPSRVPG
1330 1340 1350 1360 1370 1380
RRPPAPQQPP KPCDSQPCFH GGTCQDWALG GGFTCSCPAG RGGAVCEKVL GAPVPAFEGR
1390 1400 1410 1420 1430 1440
SFLAFPTLRA YHTLRLALEF RALEPQGLLL YNGNARGKDF LALALLDGRV QLRFDTGSGP
1450 1460 1470 1480 1490 1500
AVLTSAVPVE PGQWHRLELS RHWRRGTLSV DGETPVLGES PSGTDGLNLD TDLFVGGVPE
1510 1520 1530 1540 1550 1560
DQAAVALERT FVGAGLRGCI RLLDVNNQRL ELGIGPGAAT RGSGVGECGD HPCLPNPCHG
1570 1580 1590 1600 1610 1620
GAPCQNLEAG RFHCQCPPGR VGPTCADEKS PCQPNPCHGA APCRVLPEGG AQCECPLGRE
1630 1640 1650 1660 1670 1680
GTFCQTASGQ DGSGPFLADF NGFSHLELRG LHTFARDLGE KMALEVVFLA RGPSGLLLYN
1690 1700 1710 1720 1730 1740
GQKTDGKGDF VSLALRDRRL EFRYDLGKGA AVIRSREPVT LGAWTRVSLE RNGRKGALRV
1750 1760 1770 1780 1790 1800
GDGPRVLGES PKSRKVPHTV LNLKEPLYVG GAPDFSKLAR AAAVSSGFDG AIQLVSLGGR
1810 1820 1830 1840 1850 1860
QLLTPEHVLR QVDVTSFAGH PCTRASGHPC LNGASCVPRE AAYVCLCPGG FSGPHCEKGL
1870 1880 1890 1900 1910 1920
VEKSAGDVDT LAFDGRTFVE YLNAVTESEL ANEIPVPETL DSGALHSEKA LQSNHFELSL
1930 1940 1950 1960 1970 1980
RTEATQGLVL WSGKATERAD YVALAIVDGH LQLSYNLGSQ PVVLRSTVPV NTNRWLRVVA
1990 2000 2010 2020 2030 2040
HREQREGSLQ VGNEAPVTGS SPLGATQLDT DGALWLGGLP ELPVGPALPK AYGTGFVGCL
2050 2060
RDVVVGRHPL HLLEDAVTKP ELRPCPTP
10 20 30 40 50 60
MAGRSHPGPL RPLLPLLVVA ACVLPGAGGT CPERALERRE EEANVVLTGT VEEILNVDPV
70 80 90 100 110 120
QHTYSCKVRV WRYLKGKDLV ARESLLDGGN KVVISGFGDP LICDNQVSTG DTRIFFVNPA
130 140 150 160 170 180
PPYLWPAHKN ELMLNSSLMR ITLRNLEEVE FCVEDKPGTH FTPVPPTPPD ACRGMLCGFG
190 200 210 220 230 240
AVCEPNAEGP GRASCVCKKS PCPSVVAPVC GSDASTYSNE CELQRAQCSQ QRRIRLLSRG
250 260 270 280 290 300
PCGSRDPCSN VTCSFGSTCA RSADGLTASC LCPATCRGAP EGTVCGSDGA DYPGECQLLR
310 320 330 340 350 360
RACARQENVF KKFDGPCDPC QGALPDPSRS CRVNPRTRRP EMLLRPESCP ARQAPVCGDD
370 380 390 400 410 420
GVTYENDCVM GRSGAARGLL LQKVRSGQCQ GRDQCPEPCR FNAVCLSRRG RPRCSCDRVT
430 440 450 460 470 480
CDGAYRPVCA QDGRTYDSDC WRQQAECRQQ RAIPSKHQGP CDQAPSPCLG VQCAFGATCA
490 500 510 520 530 540
VKNGQAACEC LQACSSLYDP VCGSDGVTYG SACELEATAC TLGREIQVAR KGPCDRCGQC
550 560 570 580 590 600
RFGALCEAET GRCVCPSECV ALAQPVCGSD GHTYPSECML HVHACTHQIS LHVASAGPCE
610 620 630 640 650 660
TCGDAVCAFG AVCSAGQCVC PRCEHPPPGP VCGSDGVTYG SACELREAAC LQQTQIEEAR
670 680 690 700 710 720
AGPCEQAECG SGGSGSGEDG DCEQELCRQR GGIWDEDSED GPCVCDFSCQ SVPGSPVCGS
730 740 750 760 770 780
DGVTYSTECE LKKARCESQR GLYVAAQGAC RGPTFAPLPP VAPLHCAQTP YGCCQDNITA
790 800 810 820 830 840
ARGVGLAGCP SACQCNPHGS YGGTCDPATG QCSCRPGVGG LRCDRCEPGF WNFRGIVTDG
850 860 870 880 890 900
RSGCTPCSCD PQGAVRDDCE QMTGLCSCKP GVAGPKCGQC PDGRALGPAG CEADASAPAT
910 920 930 940 950 960
CAEMRCEFGA RCVEESGSAH CVCPMLTCPE ANATKVCGSD GVTYGNECQL KTIACRQGLQ
970 980 990 1000 1010 1020
ISIQSLGPCQ EAVAPSTHPT SASVTVTTPG LLLSQALPAP PGALPLAPSS TAHSQTTPPP
1030 1040 1050 1060 1070 1080
SSRPRTTASV PRTTVWPVLT VPPTAPSPAP SLVASAFGES GSTDGSSDEE LSGDQEASGG
1090 1100 1110 1120 1130 1140
GSGGLEPLEG SSVATPGPPV ERASCYNSAL GCCSDGKTPS LDAEGSNCPA TKVFQGVLEL
1150 1160 1170 1180 1190 1200
EGVEGQELFY TPEMADPKSE LFGETARSIE STLDDLFRNS DVKKDFRSVR LRDLGPGKSV
1210 1220 1230 1240 1250 1260
RAIVDVHFDP TTAFRAPDVA RALLRQIQVS RRRSLGVRRP LQEHVRFMDF DWFPAFITGA
1270 1280 1290 1300 1310 1320
TSGAIAAGAT ARATTASRLP SSAVTPRAPH PSHTSQPVAK TTAAPTTRRP PTTAPSRVPG
1330 1340 1350 1360 1370 1380
RRPPAPQQPP KPCDSQPCFH GGTCQDWALG GGFTCSCPAG RGGAVCEKVL GAPVPAFEGR
1390 1400 1410 1420 1430 1440
SFLAFPTLRA YHTLRLALEF RALEPQGLLL YNGNARGKDF LALALLDGRV QLRFDTGSGP
1450 1460 1470 1480 1490 1500
AVLTSAVPVE PGQWHRLELS RHWRRGTLSV DGETPVLGES PSGTDGLNLD TDLFVGGVPE
1510 1520 1530 1540 1550 1560
DQAAVALERT FVGAGLRGCI RLLDVNNQRL ELGIGPGAAT RGSGVGECGD HPCLPNPCHG
1570 1580 1590 1600 1610 1620
GAPCQNLEAG RFHCQCPPGR VGPTCADEKS PCQPNPCHGA APCRVLPEGG AQCECPLGRE
1630 1640 1650 1660 1670 1680
GTFCQTASGQ DGSGPFLADF NGFSHLELRG LHTFARDLGE KMALEVVFLA RGPSGLLLYN
1690 1700 1710 1720 1730 1740
GQKTDGKGDF VSLALRDRRL EFRYDLGKGA AVIRSREPVT LGAWTRVSLE RNGRKGALRV
1750 1760 1770 1780 1790 1800
GDGPRVLGES PKSRKVPHTV LNLKEPLYVG GAPDFSKLAR AAAVSSGFDG AIQLVSLGGR
1810 1820 1830 1840 1850 1860
QLLTPEHVLR QVDVTSFAGH PCTRASGHPC LNGASCVPRE AAYVCLCPGG FSGPHCEKGL
1870 1880 1890 1900 1910 1920
VEKSAGDVDT LAFDGRTFVE YLNAVTESEL ANEIPVPETL DSGALHSEKA LQSNHFELSL
1930 1940 1950 1960 1970 1980
RTEATQGLVL WSGKATERAD YVALAIVDGH LQLSYNLGSQ PVVLRSTVPV NTNRWLRVVA
1990 2000 2010 2020 2030 2040
HREQREGSLQ VGNEAPVTGS SPLGATQLDT DGALWLGGLP ELPVGPALPK AYGTGFVGCL
2050 2060
RDVVVGRHPL HLLEDAVTKP ELRPCPTP
10 20 30 40 50 60
MAGRSHPGPL RPLLPLLVVA ACVLPGAGGT CPERALERRE EEANVVLTGT VEEILNVDPV
70 80 90 100 110 120
QHTYSCKVRV WRYLKGKDLV ARESLLDGGN KVVISGFGDP LICDNQVSTG DTRIFFVNPA
130 140 150 160 170 180
PPYLWPAHKN ELMLNSSLMR ITLRNLEEVE FCVEDKPGTH FTPVPPTPPD ACRGMLCGFG
190 200 210 220 230 240
AVCEPNAEGP GRASCVCKKS PCPSVVAPVC GSDASTYSNE CELQRAQCSQ QRRIRLLSRG
250 260 270 280 290 300
PCGSRDPCSN VTCSFGSTCA RSADGLTASC LCPATCRGAP EGTVCGSDGA DYPGECQLLR
310 320 330 340 350 360
RACARQENVF KKFDGPCDPC QGALPDPSRS CRVNPRTRRP EMLLRPESCP ARQAPVCGDD
370 380 390 400 410 420
GVTYENDCVM GRSGAARGLL LQKVRSGQCQ GRDQCPEPCR FNAVCLSRRG RPRCSCDRVT
430 440 450 460 470 480
CDGAYRPVCA QDGRTYDSDC WRQQAECRQQ RAIPSKHQGP CDQAPSPCLG VQCAFGATCA
490 500 510 520 530 540
VKNGQAACEC LQACSSLYDP VCGSDGVTYG SACELEATAC TLGREIQVAR KGPCDRCGQC
550 560 570 580 590 600
RFGALCEAET GRCVCPSECV ALAQPVCGSD GHTYPSECML HVHACTHQIS LHVASAGPCE
610 620 630 640 650 660
TCGDAVCAFG AVCSAGQCVC PRCEHPPPGP VCGSDGVTYG SACELREAAC LQQTQIEEAR
670 680 690 700 710 720
AGPCEQAECG SGGSGSGEDG DCEQELCRQR GGIWDEDSED GPCVCDFSCQ SVPGSPVCGS
730 740 750 760 770 780
DGVTYSTECE LKKARCESQR GLYVAAQGAC RGPTFAPLPP VAPLHCAQTP YGCCQDNITA
790 800 810 820 830 840
ARGVGLAGCP SACQCNPHGS YGGTCDPATG QCSCRPGVGG LRCDRCEPGF WNFRGIVTDG
850 860 870 880 890 900
RSGCTPCSCD PQGAVRDDCE QMTGLCSCKP GVAGPKCGQC PDGRALGPAG CEADASAPAT
910 920 930 940 950 960
CAEMRCEFGA RCVEESGSAH CVCPMLTCPE ANATKVCGSD GVTYGNECQL KTIACRQGLQ
970 980 990 1000 1010 1020
ISIQSLGPCQ EAVAPSTHPT SASVTVTTPG LLLSQALPAP PGALPLAPSS TAHSQTTPPP
1030 1040 1050 1060 1070 1080
SSRPRTTASV PRTTVWPVLT VPPTAPSPAP SLVASAFGES GSTDGSSDEE LSGDQEASGG
1090 1100 1110 1120 1130 1140
GSGGLEPLEG SSVATPGPPV ERASCYNSAL GCCSDGKTPS LDAEGSNCPA TKVFQGVLEL
1150 1160 1170 1180 1190 1200
EGVEGQELFY TPEMADPKSE LFGETARSIE STLDDLFRNS DVKKDFRSVR LRDLGPGKSV
1210 1220 1230 1240 1250 1260
RAIVDVHFDP TTAFRAPDVA RALLRQIQVS RRRSLGVRRP LQEHVRFMDF DWFPAFITGA
1270 1280 1290 1300 1310 1320
TSGAIAAGAT ARATTASRLP SSAVTPRAPH PSHTSQPVAK TTAAPTTRRP PTTAPSRVPG
1330 1340 1350 1360 1370 1380
RRPPAPQQPP KPCDSQPCFH GGTCQDWALG GGFTCSCPAG RGGAVCEKVL GAPVPAFEGR
1390 1400 1410 1420 1430 1440
SFLAFPTLRA YHTLRLALEF RALEPQGLLL YNGNARGKDF LALALLDGRV QLRFDTGSGP
1450 1460 1470 1480 1490 1500
AVLTSAVPVE PGQWHRLELS RHWRRGTLSV DGETPVLGES PSGTDGLNLD TDLFVGGVPE
1510 1520 1530 1540 1550 1560
DQAAVALERT FVGAGLRGCI RLLDVNNQRL ELGIGPGAAT RGSGVGECGD HPCLPNPCHG
1570 1580 1590 1600 1610 1620
GAPCQNLEAG RFHCQCPPGR VGPTCADEKS PCQPNPCHGA APCRVLPEGG AQCECPLGRE
1630 1640 1650 1660 1670 1680
GTFCQTASGQ DGSGPFLADF NGFSHLELRG LHTFARDLGE KMALEVVFLA RGPSGLLLYN
1690 1700 1710 1720 1730 1740
GQKTDGKGDF VSLALRDRRL EFRYDLGKGA AVIRSREPVT LGAWTRVSLE RNGRKGALRV
1750 1760 1770 1780 1790 1800
GDGPRVLGES PKSRKVPHTV LNLKEPLYVG GAPDFSKLAR AAAVSSGFDG AIQLVSLGGR
1810 1820 1830 1840 1850 1860
QLLTPEHVLR QVDVTSFAGH PCTRASGHPC LNGASCVPRE AAYVCLCPGG FSGPHCEKGL
1870 1880 1890 1900 1910 1920
VEKSAGDVDT LAFDGRTFVE YLNAVTESEL ANEIPVPETL DSGALHSEKA LQSNHFELSL
1930 1940 1950 1960 1970 1980
RTEATQGLVL WSGKATERAD YVALAIVDGH LQLSYNLGSQ PVVLRSTVPV NTNRWLRVVA
1990 2000 2010 2020 2030 2040
HREQREGSLQ VGNEAPVTGS SPLGATQLDT DGALWLGGLP ELPVGPALPK AYGTGFVGCL
2050 2060
RDVVVGRHPL HLLEDAVTKP ELRPCPTP
10 20 30 40 50 60
MAGRSHPGPL RPLLPLLVVA ACVLPGAGGT CPERALERRE EEANVVLTGT VEEILNVDPV
70 80 90 100 110 120
QHTYSCKVRV WRYLKGKDLV ARESLLDGGN KVVISGFGDP LICDNQVSTG DTRIFFVNPA
130 140 150 160 170 180
PPYLWPAHKN ELMLNSSLMR ITLRNLEEVE FCVEDKPGTH FTPVPPTPPD ACRGMLCGFG
190 200 210 220 230 240
AVCEPNAEGP GRASCVCKKS PCPSVVAPVC GSDASTYSNE CELQRAQCSQ QRRIRLLSRG
250 260 270 280 290 300
PCGSRDPCSN VTCSFGSTCA RSADGLTASC LCPATCRGAP EGTVCGSDGA DYPGECQLLR
310 320 330 340 350 360
RACARQENVF KKFDGPCDPC QGALPDPSRS CRVNPRTRRP EMLLRPESCP ARQAPVCGDD
370 380 390 400 410 420
GVTYENDCVM GRSGAARGLL LQKVRSGQCQ GRDQCPEPCR FNAVCLSRRG RPRCSCDRVT
430 440 450 460 470 480
CDGAYRPVCA QDGRTYDSDC WRQQAECRQQ RAIPSKHQGP CDQAPSPCLG VQCAFGATCA
490 500 510 520 530 540
VKNGQAACEC LQACSSLYDP VCGSDGVTYG SACELEATAC TLGREIQVAR KGPCDRCGQC
550 560 570 580 590 600
RFGALCEAET GRCVCPSECV ALAQPVCGSD GHTYPSECML HVHACTHQIS LHVASAGPCE
610 620 630 640 650 660
TCGDAVCAFG AVCSAGQCVC PRCEHPPPGP VCGSDGVTYG SACELREAAC LQQTQIEEAR
670 680 690 700 710 720
AGPCEQAECG SGGSGSGEDG DCEQELCRQR GGIWDEDSED GPCVCDFSCQ SVPGSPVCGS
730 740 750 760 770 780
DGVTYSTECE LKKARCESQR GLYVAAQGAC RGPTFAPLPP VAPLHCAQTP YGCCQDNITA
790 800 810 820 830 840
ARGVGLAGCP SACQCNPHGS YGGTCDPATG QCSCRPGVGG LRCDRCEPGF WNFRGIVTDG
850 860 870 880 890 900
RSGCTPCSCD PQGAVRDDCE QMTGLCSCKP GVAGPKCGQC PDGRALGPAG CEADASAPAT
910 920 930 940 950 960
CAEMRCEFGA RCVEESGSAH CVCPMLTCPE ANATKVCGSD GVTYGNECQL KTIACRQGLQ
970 980 990 1000 1010 1020
ISIQSLGPCQ EAVAPSTHPT SASVTVTTPG LLLSQALPAP PGALPLAPSS TAHSQTTPPP
1030 1040 1050 1060 1070 1080
SSRPRTTASV PRTTVWPVLT VPPTAPSPAP SLVASAFGES GSTDGSSDEE LSGDQEASGG
1090 1100 1110 1120 1130 1140
GSGGLEPLEG SSVATPGPPV ERASCYNSAL GCCSDGKTPS LDAEGSNCPA TKVFQGVLEL
1150 1160 1170 1180 1190 1200
EGVEGQELFY TPEMADPKSE LFGETARSIE STLDDLFRNS DVKKDFRSVR LRDLGPGKSV
1210 1220 1230 1240 1250 1260
RAIVDVHFDP TTAFRAPDVA RALLRQIQVS RRRSLGVRRP LQEHVRFMDF DWFPAFITGA
1270 1280 1290 1300 1310 1320
TSGAIAAGAT ARATTASRLP SSAVTPRAPH PSHTSQPVAK TTAAPTTRRP PTTAPSRVPG
1330 1340 1350 1360 1370 1380
RRPPAPQQPP KPCDSQPCFH GGTCQDWALG GGFTCSCPAG RGGAVCEKVL GAPVPAFEGR
1390 1400 1410 1420 1430 1440
SFLAFPTLRA YHTLRLALEF RALEPQGLLL YNGNARGKDF LALALLDGRV QLRFDTGSGP
1450 1460 1470 1480 1490 1500
AVLTSAVPVE PGQWHRLELS RHWRRGTLSV DGETPVLGES PSGTDGLNLD TDLFVGGVPE
1510 1520 1530 1540 1550 1560
DQAAVALERT FVGAGLRGCI RLLDVNNQRL ELGIGPGAAT RGSGVGECGD HPCLPNPCHG
1570 1580 1590 1600 1610 1620
GAPCQNLEAG RFHCQCPPGR VGPTCADEKS PCQPNPCHGA APCRVLPEGG AQCECPLGRE
1630 1640 1650 1660 1670 1680
GTFCQTASGQ DGSGPFLADF NGFSHLELRG LHTFARDLGE KMALEVVFLA RGPSGLLLYN
1690 1700 1710 1720 1730 1740
GQKTDGKGDF VSLALRDRRL EFRYDLGKGA AVIRSREPVT LGAWTRVSLE RNGRKGALRV
1750 1760 1770 1780 1790 1800
GDGPRVLGES PKSRKVPHTV LNLKEPLYVG GAPDFSKLAR AAAVSSGFDG AIQLVSLGGR
1810 1820 1830 1840 1850 1860
QLLTPEHVLR QVDVTSFAGH PCTRASGHPC LNGASCVPRE AAYVCLCPGG FSGPHCEKGL
1870 1880 1890 1900 1910 1920
VEKSAGDVDT LAFDGRTFVE YLNAVTESEL ANEIPVPETL DSGALHSEKA LQSNHFELSL
1930 1940 1950 1960 1970 1980
RTEATQGLVL WSGKATERAD YVALAIVDGH LQLSYNLGSQ PVVLRSTVPV NTNRWLRVVA
1990 2000 2010 2020 2030 2040
HREQREGSLQ VGNEAPVTGS SPLGATQLDT DGALWLGGLP ELPVGPALPK AYGTGFVGCL
2050 2060
RDVVVGRHPL HLLEDAVTKP ELRPCPTP
10 20 30 40 50 60
MAGRSHPGPL RPLLPLLVVA ACVLPGAGGT CPERALERRE EEANVVLTGT VEEILNVDPV
70 80 90 100 110 120
QHTYSCKVRV WRYLKGKDLV ARESLLDGGN KVVISGFGDP LICDNQVSTG DTRIFFVNPA
130 140 150 160 170 180
PPYLWPAHKN ELMLNSSLMR ITLRNLEEVE FCVEDKPGTH FTPVPPTPPD ACRGMLCGFG
190 200 210 220 230 240
AVCEPNAEGP GRASCVCKKS PCPSVVAPVC GSDASTYSNE CELQRAQCSQ QRRIRLLSRG
250 260 270 280 290 300
PCGSRDPCSN VTCSFGSTCA RSADGLTASC LCPATCRGAP EGTVCGSDGA DYPGECQLLR
310 320 330 340 350 360
RACARQENVF KKFDGPCDPC QGALPDPSRS CRVNPRTRRP EMLLRPESCP ARQAPVCGDD
370 380 390 400 410 420
GVTYENDCVM GRSGAARGLL LQKVRSGQCQ GRDQCPEPCR FNAVCLSRRG RPRCSCDRVT
430 440 450 460 470 480
CDGAYRPVCA QDGRTYDSDC WRQQAECRQQ RAIPSKHQGP CDQAPSPCLG VQCAFGATCA
490 500 510 520 530 540
VKNGQAACEC LQACSSLYDP VCGSDGVTYG SACELEATAC TLGREIQVAR KGPCDRCGQC
550 560 570 580 590 600
RFGALCEAET GRCVCPSECV ALAQPVCGSD GHTYPSECML HVHACTHQIS LHVASAGPCE
610 620 630 640 650 660
TCGDAVCAFG AVCSAGQCVC PRCEHPPPGP VCGSDGVTYG SACELREAAC LQQTQIEEAR
670 680 690 700 710 720
AGPCEQAECG SGGSGSGEDG DCEQELCRQR GGIWDEDSED GPCVCDFSCQ SVPGSPVCGS
730 740 750 760 770 780
DGVTYSTECE LKKARCESQR GLYVAAQGAC RGPTFAPLPP VAPLHCAQTP YGCCQDNITA
790 800 810 820 830 840
ARGVGLAGCP SACQCNPHGS YGGTCDPATG QCSCRPGVGG LRCDRCEPGF WNFRGIVTDG
850 860 870 880 890 900
RSGCTPCSCD PQGAVRDDCE QMTGLCSCKP GVAGPKCGQC PDGRALGPAG CEADASAPAT
910 920 930 940 950 960
CAEMRCEFGA RCVEESGSAH CVCPMLTCPE ANATKVCGSD GVTYGNECQL KTIACRQGLQ
970 980 990 1000 1010 1020
ISIQSLGPCQ EAVAPSTHPT SASVTVTTPG LLLSQALPAP PGALPLAPSS TAHSQTTPPP
1030 1040 1050 1060 1070 1080
SSRPRTTASV PRTTVWPVLT VPPTAPSPAP SLVASAFGES GSTDGSSDEE LSGDQEASGG
1090 1100 1110 1120 1130 1140
GSGGLEPLEG SSVATPGPPV ERASCYNSAL GCCSDGKTPS LDAEGSNCPA TKVFQGVLEL
1150 1160 1170 1180 1190 1200
EGVEGQELFY TPEMADPKSE LFGETARSIE STLDDLFRNS DVKKDFRSVR LRDLGPGKSV
1210 1220 1230 1240 1250 1260
RAIVDVHFDP TTAFRAPDVA RALLRQIQVS RRRSLGVRRP LQEHVRFMDF DWFPAFITGA
1270 1280 1290 1300 1310 1320
TSGAIAAGAT ARATTASRLP SSAVTPRAPH PSHTSQPVAK TTAAPTTRRP PTTAPSRVPG
1330 1340 1350 1360 1370 1380
RRPPAPQQPP KPCDSQPCFH GGTCQDWALG GGFTCSCPAG RGGAVCEKVL GAPVPAFEGR
1390 1400 1410 1420 1430 1440
SFLAFPTLRA YHTLRLALEF RALEPQGLLL YNGNARGKDF LALALLDGRV QLRFDTGSGP
1450 1460 1470 1480 1490 1500
AVLTSAVPVE PGQWHRLELS RHWRRGTLSV DGETPVLGES PSGTDGLNLD TDLFVGGVPE
1510 1520 1530 1540 1550 1560
DQAAVALERT FVGAGLRGCI RLLDVNNQRL ELGIGPGAAT RGSGVGECGD HPCLPNPCHG
1570 1580 1590 1600 1610 1620
GAPCQNLEAG RFHCQCPPGR VGPTCADEKS PCQPNPCHGA APCRVLPEGG AQCECPLGRE
1630 1640 1650 1660 1670 1680
GTFCQTASGQ DGSGPFLADF NGFSHLELRG LHTFARDLGE KMALEVVFLA RGPSGLLLYN
1690 1700 1710 1720 1730 1740
GQKTDGKGDF VSLALRDRRL EFRYDLGKGA AVIRSREPVT LGAWTRVSLE RNGRKGALRV
1750 1760 1770 1780 1790 1800
GDGPRVLGES PKSRKVPHTV LNLKEPLYVG GAPDFSKLAR AAAVSSGFDG AIQLVSLGGR
1810 1820 1830 1840 1850 1860
QLLTPEHVLR QVDVTSFAGH PCTRASGHPC LNGASCVPRE AAYVCLCPGG FSGPHCEKGL
1870 1880 1890 1900 1910 1920
VEKSAGDVDT LAFDGRTFVE YLNAVTESEL ANEIPVPETL DSGALHSEKA LQSNHFELSL
1930 1940 1950 1960 1970 1980
RTEATQGLVL WSGKATERAD YVALAIVDGH LQLSYNLGSQ PVVLRSTVPV NTNRWLRVVA
1990 2000 2010 2020 2030 2040
HREQREGSLQ VGNEAPVTGS SPLGATQLDT DGALWLGGLP ELPVGPALPK AYGTGFVGCL
2050 2060
RDVVVGRHPL HLLEDAVTKP ELRPCPTP
10 20 30 40 50 60
MAGRSHPGPL RPLLPLLVVA ACVLPGAGGT CPERALERRE EEANVVLTGT VEEILNVDPV
70 80 90 100 110 120
QHTYSCKVRV WRYLKGKDLV ARESLLDGGN KVVISGFGDP LICDNQVSTG DTRIFFVNPA
130 140 150 160 170 180
PPYLWPAHKN ELMLNSSLMR ITLRNLEEVE FCVEDKPGTH FTPVPPTPPD ACRGMLCGFG
190 200 210 220 230 240
AVCEPNAEGP GRASCVCKKS PCPSVVAPVC GSDASTYSNE CELQRAQCSQ QRRIRLLSRG
250 260 270 280 290 300
PCGSRDPCSN VTCSFGSTCA RSADGLTASC LCPATCRGAP EGTVCGSDGA DYPGECQLLR
310 320 330 340 350 360
RACARQENVF KKFDGPCDPC QGALPDPSRS CRVNPRTRRP EMLLRPESCP ARQAPVCGDD
370 380 390 400 410 420
GVTYENDCVM GRSGAARGLL LQKVRSGQCQ GRDQCPEPCR FNAVCLSRRG RPRCSCDRVT
430 440 450 460 470 480
CDGAYRPVCA QDGRTYDSDC WRQQAECRQQ RAIPSKHQGP CDQAPSPCLG VQCAFGATCA
490 500 510 520 530 540
VKNGQAACEC LQACSSLYDP VCGSDGVTYG SACELEATAC TLGREIQVAR KGPCDRCGQC
550 560 570 580 590 600
RFGALCEAET GRCVCPSECV ALAQPVCGSD GHTYPSECML HVHACTHQIS LHVASAGPCE
610 620 630 640 650 660
TCGDAVCAFG AVCSAGQCVC PRCEHPPPGP VCGSDGVTYG SACELREAAC LQQTQIEEAR
670 680 690 700 710 720
AGPCEQAECG SGGSGSGEDG DCEQELCRQR GGIWDEDSED GPCVCDFSCQ SVPGSPVCGS
730 740 750 760 770 780
DGVTYSTECE LKKARCESQR GLYVAAQGAC RGPTFAPLPP VAPLHCAQTP YGCCQDNITA
790 800 810 820 830 840
ARGVGLAGCP SACQCNPHGS YGGTCDPATG QCSCRPGVGG LRCDRCEPGF WNFRGIVTDG
850 860 870 880 890 900
RSGCTPCSCD PQGAVRDDCE QMTGLCSCKP GVAGPKCGQC PDGRALGPAG CEADASAPAT
910 920 930 940 950 960
CAEMRCEFGA RCVEESGSAH CVCPMLTCPE ANATKVCGSD GVTYGNECQL KTIACRQGLQ
970 980 990 1000 1010 1020
ISIQSLGPCQ EAVAPSTHPT SASVTVTTPG LLLSQALPAP PGALPLAPSS TAHSQTTPPP
1030 1040 1050 1060 1070 1080
SSRPRTTASV PRTTVWPVLT VPPTAPSPAP SLVASAFGES GSTDGSSDEE LSGDQEASGG
1090 1100 1110 1120 1130 1140
GSGGLEPLEG SSVATPGPPV ERASCYNSAL GCCSDGKTPS LDAEGSNCPA TKVFQGVLEL
1150 1160 1170 1180 1190 1200
EGVEGQELFY TPEMADPKSE LFGETARSIE STLDDLFRNS DVKKDFRSVR LRDLGPGKSV
1210 1220 1230 1240 1250 1260
RAIVDVHFDP TTAFRAPDVA RALLRQIQVS RRRSLGVRRP LQEHVRFMDF DWFPAFITGA
1270 1280 1290 1300 1310 1320
TSGAIAAGAT ARATTASRLP SSAVTPRAPH PSHTSQPVAK TTAAPTTRRP PTTAPSRVPG
1330 1340 1350 1360 1370 1380
RRPPAPQQPP KPCDSQPCFH GGTCQDWALG GGFTCSCPAG RGGAVCEKVL GAPVPAFEGR
1390 1400 1410 1420 1430 1440
SFLAFPTLRA YHTLRLALEF RALEPQGLLL YNGNARGKDF LALALLDGRV QLRFDTGSGP
1450 1460 1470 1480 1490 1500
AVLTSAVPVE PGQWHRLELS RHWRRGTLSV DGETPVLGES PSGTDGLNLD TDLFVGGVPE
1510 1520 1530 1540 1550 1560
DQAAVALERT FVGAGLRGCI RLLDVNNQRL ELGIGPGAAT RGSGVGECGD HPCLPNPCHG
1570 1580 1590 1600 1610 1620
GAPCQNLEAG RFHCQCPPGR VGPTCADEKS PCQPNPCHGA APCRVLPEGG AQCECPLGRE
1630 1640 1650 1660 1670 1680
GTFCQTASGQ DGSGPFLADF NGFSHLELRG LHTFARDLGE KMALEVVFLA RGPSGLLLYN
1690 1700 1710 1720 1730 1740
GQKTDGKGDF VSLALRDRRL EFRYDLGKGA AVIRSREPVT LGAWTRVSLE RNGRKGALRV
1750 1760 1770 1780 1790 1800
GDGPRVLGES PKSRKVPHTV LNLKEPLYVG GAPDFSKLAR AAAVSSGFDG AIQLVSLGGR
1810 1820 1830 1840 1850 1860
QLLTPEHVLR QVDVTSFAGH PCTRASGHPC LNGASCVPRE AAYVCLCPGG FSGPHCEKGL
1870 1880 1890 1900 1910 1920
VEKSAGDVDT LAFDGRTFVE YLNAVTESEL ANEIPVPETL DSGALHSEKA LQSNHFELSL
1930 1940 1950 1960 1970 1980
RTEATQGLVL WSGKATERAD YVALAIVDGH LQLSYNLGSQ PVVLRSTVPV NTNRWLRVVA
1990 2000 2010 2020 2030 2040
HREQREGSLQ VGNEAPVTGS SPLGATQLDT DGALWLGGLP ELPVGPALPK AYGTGFVGCL
2050 2060
RDVVVGRHPL HLLEDAVTKP ELRPCPTP
10 20 30 40 50 60
MAGRSHPGPL RPLLPLLVVA ACVLPGAGGT CPERALERRE EEANVVLTGT VEEILNVDPV
70 80 90 100 110 120
QHTYSCKVRV WRYLKGKDLV ARESLLDGGN KVVISGFGDP LICDNQVSTG DTRIFFVNPA
130 140 150 160 170 180
PPYLWPAHKN ELMLNSSLMR ITLRNLEEVE FCVEDKPGTH FTPVPPTPPD ACRGMLCGFG
190 200 210 220 230 240
AVCEPNAEGP GRASCVCKKS PCPSVVAPVC GSDASTYSNE CELQRAQCSQ QRRIRLLSRG
250 260 270 280 290 300
PCGSRDPCSN VTCSFGSTCA RSADGLTASC LCPATCRGAP EGTVCGSDGA DYPGECQLLR
310 320 330 340 350 360
RACARQENVF KKFDGPCDPC QGALPDPSRS CRVNPRTRRP EMLLRPESCP ARQAPVCGDD
370 380 390 400 410 420
GVTYENDCVM GRSGAARGLL LQKVRSGQCQ GRDQCPEPCR FNAVCLSRRG RPRCSCDRVT
430 440 450 460 470 480
CDGAYRPVCA QDGRTYDSDC WRQQAECRQQ RAIPSKHQGP CDQAPSPCLG VQCAFGATCA
490 500 510 520 530 540
VKNGQAACEC LQACSSLYDP VCGSDGVTYG SACELEATAC TLGREIQVAR KGPCDRCGQC
550 560 570 580 590 600
RFGALCEAET GRCVCPSECV ALAQPVCGSD GHTYPSECML HVHACTHQIS LHVASAGPCE
610 620 630 640 650 660
TCGDAVCAFG AVCSAGQCVC PRCEHPPPGP VCGSDGVTYG SACELREAAC LQQTQIEEAR
670 680 690 700 710 720
AGPCEQAECG SGGSGSGEDG DCEQELCRQR GGIWDEDSED GPCVCDFSCQ SVPGSPVCGS
730 740 750 760 770 780
DGVTYSTECE LKKARCESQR GLYVAAQGAC RGPTFAPLPP VAPLHCAQTP YGCCQDNITA
790 800 810 820 830 840
ARGVGLAGCP SACQCNPHGS YGGTCDPATG QCSCRPGVGG LRCDRCEPGF WNFRGIVTDG
850 860 870 880 890 900
RSGCTPCSCD PQGAVRDDCE QMTGLCSCKP GVAGPKCGQC PDGRALGPAG CEADASAPAT
910 920 930 940 950 960
CAEMRCEFGA RCVEESGSAH CVCPMLTCPE ANATKVCGSD GVTYGNECQL KTIACRQGLQ
970 980 990 1000 1010 1020
ISIQSLGPCQ EAVAPSTHPT SASVTVTTPG LLLSQALPAP PGALPLAPSS TAHSQTTPPP
1030 1040 1050 1060 1070 1080
SSRPRTTASV PRTTVWPVLT VPPTAPSPAP SLVASAFGES GSTDGSSDEE LSGDQEASGG
1090 1100 1110 1120 1130 1140
GSGGLEPLEG SSVATPGPPV ERASCYNSAL GCCSDGKTPS LDAEGSNCPA TKVFQGVLEL
1150 1160 1170 1180 1190 1200
EGVEGQELFY TPEMADPKSE LFGETARSIE STLDDLFRNS DVKKDFRSVR LRDLGPGKSV
1210 1220 1230 1240 1250 1260
RAIVDVHFDP TTAFRAPDVA RALLRQIQVS RRRSLGVRRP LQEHVRFMDF DWFPAFITGA
1270 1280 1290 1300 1310 1320
TSGAIAAGAT ARATTASRLP SSAVTPRAPH PSHTSQPVAK TTAAPTTRRP PTTAPSRVPG
1330 1340 1350 1360 1370 1380
RRPPAPQQPP KPCDSQPCFH GGTCQDWALG GGFTCSCPAG RGGAVCEKVL GAPVPAFEGR
1390 1400 1410 1420 1430 1440
SFLAFPTLRA YHTLRLALEF RALEPQGLLL YNGNARGKDF LALALLDGRV QLRFDTGSGP
1450 1460 1470 1480 1490 1500
AVLTSAVPVE PGQWHRLELS RHWRRGTLSV DGETPVLGES PSGTDGLNLD TDLFVGGVPE
1510 1520 1530 1540 1550 1560
DQAAVALERT FVGAGLRGCI RLLDVNNQRL ELGIGPGAAT RGSGVGECGD HPCLPNPCHG
1570 1580 1590 1600 1610 1620
GAPCQNLEAG RFHCQCPPGR VGPTCADEKS PCQPNPCHGA APCRVLPEGG AQCECPLGRE
1630 1640 1650 1660 1670 1680
GTFCQTASGQ DGSGPFLADF NGFSHLELRG LHTFARDLGE KMALEVVFLA RGPSGLLLYN
1690 1700 1710 1720 1730 1740
GQKTDGKGDF VSLALRDRRL EFRYDLGKGA AVIRSREPVT LGAWTRVSLE RNGRKGALRV
1750 1760 1770 1780 1790 1800
GDGPRVLGES PKSRKVPHTV LNLKEPLYVG GAPDFSKLAR AAAVSSGFDG AIQLVSLGGR
1810 1820 1830 1840 1850 1860
QLLTPEHVLR QVDVTSFAGH PCTRASGHPC LNGASCVPRE AAYVCLCPGG FSGPHCEKGL
1870 1880 1890 1900 1910 1920
VEKSAGDVDT LAFDGRTFVE YLNAVTESEL ANEIPVPETL DSGALHSEKA LQSNHFELSL
1930 1940 1950 1960 1970 1980
RTEATQGLVL WSGKATERAD YVALAIVDGH LQLSYNLGSQ PVVLRSTVPV NTNRWLRVVA
1990 2000 2010 2020 2030 2040
HREQREGSLQ VGNEAPVTGS SPLGATQLDT DGALWLGGLP ELPVGPALPK AYGTGFVGCL
2050 2060
RDVVVGRHPL HLLEDAVTKP ELRPCPTP
10 20 30 40 50 60
MAGRSHPGPL RPLLPLLVVA ACVLPGAGGT CPERALERRE EEANVVLTGT VEEILNVDPV
70 80 90 100 110 120
QHTYSCKVRV WRYLKGKDLV ARESLLDGGN KVVISGFGDP LICDNQVSTG DTRIFFVNPA
130 140 150 160 170 180
PPYLWPAHKN ELMLNSSLMR ITLRNLEEVE FCVEDKPGTH FTPVPPTPPD ACRGMLCGFG
190 200 210 220 230 240
AVCEPNAEGP GRASCVCKKS PCPSVVAPVC GSDASTYSNE CELQRAQCSQ QRRIRLLSRG
250 260 270 280 290 300
PCGSRDPCSN VTCSFGSTCA RSADGLTASC LCPATCRGAP EGTVCGSDGA DYPGECQLLR
310 320 330 340 350 360
RACARQENVF KKFDGPCDPC QGALPDPSRS CRVNPRTRRP EMLLRPESCP ARQAPVCGDD
370 380 390 400 410 420
GVTYENDCVM GRSGAARGLL LQKVRSGQCQ GRDQCPEPCR FNAVCLSRRG RPRCSCDRVT
430 440 450 460 470 480
CDGAYRPVCA QDGRTYDSDC WRQQAECRQQ RAIPSKHQGP CDQAPSPCLG VQCAFGATCA
490 500 510 520 530 540
VKNGQAACEC LQACSSLYDP VCGSDGVTYG SACELEATAC TLGREIQVAR KGPCDRCGQC
550 560 570 580 590 600
RFGALCEAET GRCVCPSECV ALAQPVCGSD GHTYPSECML HVHACTHQIS LHVASAGPCE
610 620 630 640 650 660
TCGDAVCAFG AVCSAGQCVC PRCEHPPPGP VCGSDGVTYG SACELREAAC LQQTQIEEAR
670 680 690 700 710 720
AGPCEQAECG SGGSGSGEDG DCEQELCRQR GGIWDEDSED GPCVCDFSCQ SVPGSPVCGS
730 740 750 760 770 780
DGVTYSTECE LKKARCESQR GLYVAAQGAC RGPTFAPLPP VAPLHCAQTP YGCCQDNITA
790 800 810 820 830 840
ARGVGLAGCP SACQCNPHGS YGGTCDPATG QCSCRPGVGG LRCDRCEPGF WNFRGIVTDG
850 860 870 880 890 900
RSGCTPCSCD PQGAVRDDCE QMTGLCSCKP GVAGPKCGQC PDGRALGPAG CEADASAPAT
910 920 930 940 950 960
CAEMRCEFGA RCVEESGSAH CVCPMLTCPE ANATKVCGSD GVTYGNECQL KTIACRQGLQ
970 980 990 1000 1010 1020
ISIQSLGPCQ EAVAPSTHPT SASVTVTTPG LLLSQALPAP PGALPLAPSS TAHSQTTPPP
1030 1040 1050 1060 1070 1080
SSRPRTTASV PRTTVWPVLT VPPTAPSPAP SLVASAFGES GSTDGSSDEE LSGDQEASGG
1090 1100 1110 1120 1130 1140
GSGGLEPLEG SSVATPGPPV ERASCYNSAL GCCSDGKTPS LDAEGSNCPA TKVFQGVLEL
1150 1160 1170 1180 1190 1200
EGVEGQELFY TPEMADPKSE LFGETARSIE STLDDLFRNS DVKKDFRSVR LRDLGPGKSV
1210 1220 1230 1240 1250 1260
RAIVDVHFDP TTAFRAPDVA RALLRQIQVS RRRSLGVRRP LQEHVRFMDF DWFPAFITGA
1270 1280 1290 1300 1310 1320
TSGAIAAGAT ARATTASRLP SSAVTPRAPH PSHTSQPVAK TTAAPTTRRP PTTAPSRVPG
1330 1340 1350 1360 1370 1380
RRPPAPQQPP KPCDSQPCFH GGTCQDWALG GGFTCSCPAG RGGAVCEKVL GAPVPAFEGR
1390 1400 1410 1420 1430 1440
SFLAFPTLRA YHTLRLALEF RALEPQGLLL YNGNARGKDF LALALLDGRV QLRFDTGSGP
1450 1460 1470 1480 1490 1500
AVLTSAVPVE PGQWHRLELS RHWRRGTLSV DGETPVLGES PSGTDGLNLD TDLFVGGVPE
1510 1520 1530 1540 1550 1560
DQAAVALERT FVGAGLRGCI RLLDVNNQRL ELGIGPGAAT RGSGVGECGD HPCLPNPCHG
1570 1580 1590 1600 1610 1620
GAPCQNLEAG RFHCQCPPGR VGPTCADEKS PCQPNPCHGA APCRVLPEGG AQCECPLGRE
1630 1640 1650 1660 1670 1680
GTFCQTASGQ DGSGPFLADF NGFSHLELRG LHTFARDLGE KMALEVVFLA RGPSGLLLYN
1690 1700 1710 1720 1730 1740
GQKTDGKGDF VSLALRDRRL EFRYDLGKGA AVIRSREPVT LGAWTRVSLE RNGRKGALRV
1750 1760 1770 1780 1790 1800
GDGPRVLGES PKSRKVPHTV LNLKEPLYVG GAPDFSKLAR AAAVSSGFDG AIQLVSLGGR
1810 1820 1830 1840 1850 1860
QLLTPEHVLR QVDVTSFAGH PCTRASGHPC LNGASCVPRE AAYVCLCPGG FSGPHCEKGL
1870 1880 1890 1900 1910 1920
VEKSAGDVDT LAFDGRTFVE YLNAVTESEL ANEIPVPETL DSGALHSEKA LQSNHFELSL
1930 1940 1950 1960 1970 1980
RTEATQGLVL WSGKATERAD YVALAIVDGH LQLSYNLGSQ PVVLRSTVPV NTNRWLRVVA
1990 2000 2010 2020 2030 2040
HREQREGSLQ VGNEAPVTGS SPLGATQLDT DGALWLGGLP ELPVGPALPK AYGTGFVGCL
2050 2060
RDVVVGRHPL HLLEDAVTKP ELRPCPTP
Protein Neighborhood
Domains & Features
6 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| O00468-1-unknown | MAGRSH... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt66530 | |||
| O00468-1-unknown | MAGRSH... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt66531 | |||
| O00468-1-unknown | MAGRSH... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt66532 | |||
| O00468-1-unknown | MAGRSH... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt66533 | |||
| O00468-1-unknown | MAGRSH... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt66534 | |||
| O00468-30-unknown | TCPERA... | 30 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| O00468-30-unknown | TCPERA... | 30 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt114662 | |||
| O00468-30-unknown | TCPERA... | 30 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt114663 | |||
| O00468-30-unknown | TCPERA... | 30 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt114664 | |||
| O00468-30-unknown | TCPERA... | 30 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt114665 | |||
| O00468-30-unknown | TCPERA... | 30 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt114666 | |||
| O00468-1103-unknown | ASCYNS... | 1103 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| O00468-1103-unknown | ASCYNS... | 1103 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116463 | |||
| O00468-1103-unknown | ASCYNS... | 1103 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116458 | |||
| O00468-1103-unknown | ASCYNS... | 1103 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116459 | |||
| O00468-1103-unknown | ASCYNS... | 1103 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116460 | |||
| O00468-1103-unknown | ASCYNS... | 1103 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116461 | |||
| O00468-1103-unknown | ASCYNS... | 1103 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116462 | |||
| O00468-1103-unknown | ASCYNS... | 1103 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
| O00468-1216-unknown | APDVAR... | 1216 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10644 | |||
| O00468-1216-unknown | APDVAR... | 1216 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157428 | |||
| O00468-1216-unknown | APDVAR... | 1216 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157723 | |||
| O00468-1216-unknown | APDVAR... | 1216 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157724 | |||
| O00468-1216-unknown | APDVAR... | 1216 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157725 | |||
| O00468-1216-unknown | APDVAR... | 1216 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157726 | |||
| O00468-1216-unknown | APDVAR... | 1216 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157727 | |||
| O00468-1860-unknown | LVEKSA... | 1860 | unknown | Wildes D. et al: Sampling the N-terminal proteome of human blood | 20173099 | ||||
| O00468-1860-unknown | LVEKSA... | 1860 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt180049 | |||
| O00468-1860-unknown | LVEKSA... | 1860 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt180044 | |||
| O00468-1860-unknown | LVEKSA... | 1860 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt180045 | |||
| O00468-1860-unknown | LVEKSA... | 1860 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt180046 | |||
| O00468-1860-unknown | LVEKSA... | 1860 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt180047 | |||
| O00468-1860-unknown | LVEKSA... | 1860 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt180048 | |||
| O00468-1864-unknown | SAGDVD... | 1864 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| O00468-1864-unknown | SAGDVD... | 1864 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116517 | |||
| O00468-1864-unknown | SAGDVD... | 1864 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116512 | |||
| O00468-1864-unknown | SAGDVD... | 1864 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116513 | |||
| O00468-1864-unknown | SAGDVD... | 1864 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116514 | |||
| O00468-1864-unknown | SAGDVD... | 1864 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116515 | |||
| O00468-1864-unknown | SAGDVD... | 1864 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116516 | |||
| O00468-1864-unknown | SAGDVD... | 1864 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...PPVERA | 1102 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...PPVERA | 1102 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
| ...PPVERA | 1102 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93659 | |||
| ...PPVERA | 1102 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93654 | |||
| ...PPVERA | 1102 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93655 | |||
| ...PPVERA | 1102 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93656 | |||
| ...PPVERA | 1102 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93657 | |||
| ...PPVERA | 1102 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93658 | |||
| ...TTAFRA | 1215 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10644 | |||
| ...TTAFRA | 1215 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140926 | |||
| ...TTAFRA | 1215 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt141222 | |||
| ...TTAFRA | 1215 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt141223 | |||
| ...TTAFRA | 1215 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt141224 | |||
| ...TTAFRA | 1215 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt141225 | |||
| ...TTAFRA | 1215 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt141226 | |||
| ...GLVEKS | 1863 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...GLVEKS | 1863 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
| ...GLVEKS | 1863 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93793 | |||
| ...GLVEKS | 1863 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93788 | |||
| ...GLVEKS | 1863 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93789 | |||
| ...GLVEKS | 1863 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93790 | |||
| ...GLVEKS | 1863 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93791 | |||
| ...GLVEKS | 1863 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93792 | |||
| ...RPCPTP | 2067 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...RPCPTP | 2067 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt62147 | |||
| ...RPCPTP | 2067 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt62151 | |||
| ...RPCPTP | 2067 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt62148 | |||
| ...RPCPTP | 2067 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt62150 | |||
| ...RPCPTP | 2067 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt62149 | |||
| ...RPCPTP | 2067 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt62152 |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| GRAB_HUMAN | 1215 | AFRA.|.APDV | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|