O00506: Serine/threonine-protein kinase 25

General Information

Protein names	- Serine/threonine-protein kinase 25 - 2.7.11.1 - Ste20-like kinase - Sterile 20/oxidant stress-response kinase 1 - SOK-1 - Ste20/oxidant stress response kinase 1
Gene names	STK25
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00506

4 N-termini

10 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Serine/threonine-protein kinase 25 - Isoform 3 of Serine/threonine-protein kinase 25

Sequence View

        10         20         30         40         50         60
MAHLRGFANQ HSRVDPEELF TKLDRIGKGS FGEVYKGIDN HTKEVVAIKI IDLEEAEDEI
        70         80         90        100        110        120
EDIQQEITVL SQCDSPYITR YFGSYLKSTK LWIIMEYLGG GSALDLLKPG PLEETYIATI
       130        140        150        160        170        180
LREILKGLDY LHSERKIHRD IKAANVLLSE QGDVKLADFG VAGQLTDTQI KRNTFVGTPF
       190        200        210        220        230        240
WMAPEVIKQS AYDFKADIWS LGITAIELAK GEPPNSDLHP MRVLFLIPKN SPPTLEGQHS
       250        260        270        280        290        300
KPFKEFVEAC LNKDPRFRPT AKELLKHKFI TRYTKKTSFL TELIDRYKRW KSEGHGEESS
       310        320        330        340        350        360
SEDSDIDGEA EDGEQGPIWT FPPTIRPSPH SKLHKGTALH SSQKPAEPVK RQPRSQCLST
       370        380        390        400        410        420
LVRPVFGELK EKHKQSGGSV GALEELENAF SLAEESCPGI SDKLMVHLVE RVQRFSHNRN

HLTSTR         10         20         30         40         50         60
MAHLRGFANQ HSRVDPEELF TKLDRIGKGS FGEVYKGIDN HTKEVVAIKI IDLEEAEDEI
        70         80         90        100        110        120
EDIQQEITVL SQCDSPYITR YFGSYLKSTK LWIIMEYLGG GSALDLLKPG PLEETYIATI
       130        140        150        160        170        180
LREILKGLDY LHSERKIHRD IKAANVLLSE QGDVKLADFG VAGQLTDTQI KRNTFVGTPF
       190        200        210        220        230        240
WMAPEVIKQS AYDFKADIWS LGITAIELAK GEPPNSDLHP MRVLFLIPKN SPPTLEGQHS
       250        260        270        280        290        300
KPFKEFVEAC LNKDPRFRPT AKELLKHKFI TRYTKKTSFL TELIDRYKRW KSEGHGEESS
       310        320        330        340        350        360
SEDSDIDGEA EDGEQGPIWT FPPTIRPSPH SKLHKGTALH SSQKPAEPVK RQPRSQCLST
       370        380        390        400        410        420
LVRPVFGELK EKHKQSGGSV GALEELENAF SLAEESCPGI SDKLMVHLVE RVQRFSHNRN

HLTSTR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 10 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O00506-1-unknown	MAHLRG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O00506-18-unknown	ELFTKL...	18	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10652
O00506-95-unknown	MEYLGG...	95	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt90921
O00506-95-unknown	MEYLGG...	95	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399212
O00506-95-unknown	MEYLGG...	95	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000403607
O00506-95-unknown	MEYLGG...	95	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000395104
O00506-95-unknown	MEYLGG...	95	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000404960
O00506-95-unknown	MEYLGG...	95	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000403866
O00506-95-unknown	MEYLGG...	95	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000401114
O00506-95-unknown	MEYLGG...	95	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000444886
O00506-95-unknown	MEYLGG...	95	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000446008
O00506-95-unknown	MEYLGG...	95	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt98216
O00506-159-unknown	FGVAGQ...	159	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10653
O00506-159-unknown	FGVAGQ...	159	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140310
O00506-159-unknown	FGVAGQ...	159	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141431

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RVDPEE	17	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10652
...LSQCDS	74	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000404552
...HRDIKA	142	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000401114
...HRDIKA	142	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112424
...HRDIKA	142	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112423
...LLSEQG	151	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000412617
...LLSEQG	151	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112421
...LLSEQG	151	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112420
...VKLADF	158	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10653
...VKLADF	158	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123432
...VKLADF	158	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124605
...QIKRNT	173	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000404960
...QIKRNT	173	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112418
...QIKRNT	173	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112417
...QHSKPF	242	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000395104
...QHSKPF	242	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112415
...QHSKPF	242	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112414
...KDPRFR	257	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000417020
...KDPRFR	257	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000403607
...KDPRFR	257	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112412
...KDPRFR	257	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112411
...HKFITR	271	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399212
...HKFITR	271	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112409
...HKFITR	271	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112408
...LTSTR	426	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LTSTR	426	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86539
...LTSTR	426	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86538

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	17	DPEE.\|.ELFT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	158	LADF.\|.FGVA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)