O00746: Nucleoside diphosphate kinase, mitochondrial

General Information

Protein names	- Nucleoside diphosphate kinase, mitochondrial - NDK - NDP kinase, mitochondrial - 2.7.4.6 - Nucleoside diphosphate kinase D - NDPKD - nm23-H4
Gene names	NME4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00746

4 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGGLFWRSAL RGLRCGPRAP GPSLLVRHGS GGPSWTRERT LVAVKPDGVQ RRLVGDVIQR
        70         80         90        100        110        120
FERRGFTLVG MKMLQAPESV LAEHYQDLRR KPFYPALIRY MSSGPVVAMV WEGYNVVRAS
       130        140        150        160        170        180
RAMIGHTDSA EAAPGTIRGD FSVHISRNVI HASDSVEGAQ REIQLWFQSS ELVSWADGGQ

HSSIHPA

Isoforms

- Isoform 2 of Nucleoside diphosphate kinase, mitochondrial

Sequence View

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Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00746-29-	GSGGPS...	29		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O00746-29-	GSGGPS...	29		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O00746-29-	GSGGPS...	29		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O00746-29-unknown	GSGGPS...	29		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O00746-29-unknown	GSGGPS...	29		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O00746-29-unknown	GSGGPS...	29	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00746-34-unknown	SWTRER...	34	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00746-71-unknown	MKMLQA...	71	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82471
O00746-71-unknown	MKMLQA...	71	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000380834
O00746-71-unknown	MKMLQA...	71	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000406317
O00746-71-unknown	MKMLQA...	71	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000389048

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SGPVVA	107	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000406317
...SGPVVA	107	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt110035
...SIHPA	187	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SIHPA	187	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78089

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)