O08663: Methionine aminopeptidase 2 {ECO:0000255|HAMAP-Rule:MF_03175}

General Information

Protein names	- Methionine aminopeptidase 2 {ECO:0000255\|HAMAP-Rule:MF_03175} - MAP 2 {ECO:0000255\|HAMAP-Rule:MF_03175} - MetAP 2 {ECO:0000255\|HAMAP-Rule:MF_03175} - 3.4.11.18 {ECO:0000255\|HAMAP-Rule:MF_03175} - Initiation factor 2-associated 67 kDa glycoprotein {ECO:0000255\|HAMAP-Rule:MF_03175} - p67 {ECO:0000255\|HAMAP-Rule:MF_03175} - p67eIF2 {ECO:0000255\|HAMAP-Rule:MF_03175} - Peptidase M {ECO:0000255\|HAMAP-Rule:MF_03175}
Gene names	Metap2
Organism	Mus musculus
Protease Family
Protease ID	M24.002
Chromosome location
UniProt ID	O08663

5 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGVEQAASF GGHLNGDLDP DDREEGTSST AEEAAKKKRR KKKKGKGAVS AVQQELDKES
        70         80         90        100        110        120
GALVDEVAKQ LESQALEEKE RDDDDEDGDG DADGATGKKK KKKKKKRGPK VQTDPPSVPI
       130        140        150        160        170        180
CDLYPNGVFP KGQECEYPPT QDGRTAAWRT TSEEKKALDQ ASEEIWNDFR EAAEAHRQVR
       190        200        210        220        230        240
KYVMSWIKPG MTMIEICEKL EDCSRKLIKE NGLNAGLAFP TGCSLNNCAA HYTPNAGDTT
       250        260        270        280        290        300
VLQYDDICKI DFGTHISGRI IDCAFTVTFN PKYDILLTAV KDATNTGIKC AGIDVRLCDV
       310        320        330        340        350        360
GEAIQEVMES YEVEIDGKTY QVKPIRNLNG HSIGPYRIHA GKTVPIVKGG EATRMEEGEV
       370        380        390        400        410        420
YAIETFGSTG KGVVHDDMEC SHYMKNFDVG HVPIRLPRTK HLLNVINENF GTLAFCRRWL
       430        440        450        460        470
DRLGESKYLM ALKNLCDLGI VDPYPPLCDI KGSYTAQFEH TILLRPTCKE VVSRGDDY

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

5 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
O08663-2-unknown	MAGVEQ...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
O08663-2-unknown	MAGVEQ...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O08663-2-Acetylation	AGVEQA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O08663-2-Acetylation	AGVEQA...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
O08663-45-unknown	GKGAVS...	45		inferred from electronic annotation	unknown	TISdb	inferred from TISdb
O08663-290-unknown	CAGIDV...	290		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000138050
O08663-338-unknown	IHAGKT...	338		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33131

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AHYTPN	234	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000137652
...AFTVTF	268	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000137911
...IGPYRI	337	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33131
...HVPIRL	395	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000138050
...RGDDY	478	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	337	PYRI.\|.IHAG	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)