TopFIND 4.0

P33434: 72 kDa type IV collagenase

General Information

Protein names
- 72 kDa type IV collagenase
- 3.4.24.24 {ECO:0000250|UniProtKB:P08253}
- 72 kDa gelatinase
- Gelatinase A
- Matrix metalloproteinase-2
- MMP-2
- PEX
Gene names Mmp2
Organism Mus musculus
Protease Family M10.003
Protease ID M10.003
Chromosome location
UniProt ID P33434

5

N-termini

1

C-termini

0

Cleavages

1290

Substrates

Sequence

        10         20         30         40         50         60 
MEARVAWGAL AGPLRVLCVL CCLLGRAIAA PSPIIKFPGD VAPKTDKELA VQYLNTFYGC 
        70         80         90        100        110        120 
PKESCNLFVL KDTLKKMQKF FGLPQTGDLD QNTIETMRKP RCGNPDVANY NFFPRKPKWD 
       130        140        150        160        170        180 
KNQITYRIIG YTPDLDPETV DDAFARALKV WSDVTPLRFS RIHDGEADIM INFGRWEHGD 
       190        200        210        220        230        240 
GYPFDGKDGL LAHAFAPGTG VGGDSHFDDD ELWTLGEGQV VRVKYGNADG EYCKFPFLFN 
       250        260        270        280        290        300 
GREYSSCTDT GRSDGFLWCS TTYNFEKDGK YGFCPHEALF TMGGNADGQP CKFPFRFQGT 
       310        320        330        340        350        360 
SYNSCTTEGR TDGYRWCGTT EDYDRDKKYG FCPETAMSTV GGNSEGAPCV FPFTFLGNKY 
       370        380        390        400        410        420 
ESCTSAGRND GKVWCATTTN YDDDRKWGFC PDQGYSLFLV AAHEFGHAMG LEHSQDPGAL 
       430        440        450        460        470        480 
MAPIYTYTKN FRLSHDDIKG IQELYGPSPD ADTDTGTGPT PTLGPVTPEI CKQDIVFDGI 
       490        500        510        520        530        540 
AQIRGEIFFF KDRFIWRTVT PRDKPTGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN 
       550        560        570        580        590        600 
EYWVYSASTL ERGYPKPLTS LGLPPDVQQV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM 
       610        620        630        640        650        660 
DPGFPKLIAD SWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL 
   
GC

Isoforms

- Isoform 2 of 72 kDa type IV collagenase

Sequence View

        10         20         30         40         50         60 
MEARVAWGAL AGPLRVLCVL CCLLGRAIAA PSPIIKFPGD VAPKTDKELA VQYLNTFYGC 
        70         80         90        100        110        120 
PKESCNLFVL KDTLKKMQKF FGLPQTGDLD QNTIETMRKP RCGNPDVANY NFFPRKPKWD 
       130        140        150        160        170        180 
KNQITYRIIG YTPDLDPETV DDAFARALKV WSDVTPLRFS RIHDGEADIM INFGRWEHGD 
       190        200        210        220        230        240 
GYPFDGKDGL LAHAFAPGTG VGGDSHFDDD ELWTLGEGQV VRVKYGNADG EYCKFPFLFN 
       250        260        270        280        290        300 
GREYSSCTDT GRSDGFLWCS TTYNFEKDGK YGFCPHEALF TMGGNADGQP CKFPFRFQGT 
       310        320        330        340        350        360 
SYNSCTTEGR TDGYRWCGTT EDYDRDKKYG FCPETAMSTV GGNSEGAPCV FPFTFLGNKY 
       370        380        390        400        410        420 
ESCTSAGRND GKVWCATTTN YDDDRKWGFC PDQGYSLFLV AAHEFGHAMG LEHSQDPGAL 
       430        440        450        460        470        480 
MAPIYTYTKN FRLSHDDIKG IQELYGPSPD ADTDTGTGPT PTLGPVTPEI CKQDIVFDGI 
       490        500        510        520        530        540 
AQIRGEIFFF KDRFIWRTVT PRDKPTGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN 
       550        560        570        580        590        600 
EYWVYSASTL ERGYPKPLTS LGLPPDVQQV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM 
       610        620        630        640        650        660 
DPGFPKLIAD SWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL 
   
GC



Filter Information:


(REFRESH)

Directness:


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Protein Neighborhood

Domains & Features

5 N-termini - 1 C-termini - 0 Cleavages - 1290 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...DWLGC 662 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...DWLGC 662 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt76915

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates