P11499: Heat shock protein HSP 90-beta

General Information

Protein names	- Heat shock protein HSP 90-beta - Heat shock 84 kDa - HSP 84 - HSP84 - Tumor-specific transplantation 84 kDa antigen - TSTA
Gene names	Hsp90ab1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P11499

12 N-termini

14 C-termini

10 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPEEVHHGEE EVETFAFQAE IAQLMSLIIN TFYSNKEIFL RELISNASDA LDKIRYESLT
        70         80         90        100        110        120
DPSKLDSGKE LKIDIIPNPQ ERTLTLVDTG IGMTKADLIN NLGTIAKSGT KAFMEALQAG
       130        140        150        160        170        180
ADISMIGQFG VGFYSAYLVA EKVVVITKHN DDEQYAWESS AGGSFTVRAD HGEPIGRGTK
       190        200        210        220        230        240
VILHLKEDQT EYLEERRVKE VVKKHSQFIG YPITLYLEKE REKEISDDEA EEEKGEKEEE
       250        260        270        280        290        300
DKEDEEKPKI EDVGSDEEDD SGKDKKKKTK KIKEKYIDQE ELNKTKPIWT RNPDDITQEE
       310        320        330        340        350        360
YGEFYKSLTN DWEDHLAVKH FSVEGQLEFR ALLFIPRRAP FDLFENKKKK NNIKLYVRRV
       370        380        390        400        410        420
FIMDSCDELI PEYLNFIRGV VDSEDLPLNI SREMLQQSKI LKVIRKNIVK KCLELFSELA
       430        440        450        460        470        480
EDKENYKKFY EAFSKNLKLG IHEDSTNRRR LSELLRYHTS QSGDEMTSLS EYVSRMKETQ
       490        500        510        520        530        540
KSIYYITGES KEQVANSAFV ERVRKRGFEV VYMTEPIDEY CVQQLKEFDG KSLVSVTKEG
       550        560        570        580        590        600
LELPEDEEEK KKMEESKAKF ENLCKLMKEI LDKKVEKVTI SNRLVSSPCC IVTSTYGWTA
       610        620        630        640        650        660
NMERIMKAQA LRDNSTMGYM MAKKHLEINP DHPIVETLRQ KAEADKNDKA VKDLVVLLFE
       670        680        690        700        710        720
TALLSSGFSL EDPQTHSNRI YRMIKLGLGI DEDEVTAEEP SAAVPDEIPP LEGDEDASRM

EEVD

Isoforms

Sequence View

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

12 N-termini - 14 C-termini - 10 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P11499-2-unknown	PEEVHH...	2	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P11499-43-unknown	LISNAS...	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33344
P11499-65-unknown	LDSGKE...	65	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33345
P11499-115-unknown	EALQAG...	115	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
P11499-185-unknown	LKEDQT...	185	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33346
P11499-208-unknown	FIGYPI...	208	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33347
P11499-344-unknown	FENKKK...	344	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29695
P11499-380-unknown	VVDSED...	380	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33348
P11499-458-unknown	HTSQSG...	458	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33349
P11499-620-unknown	MMAKKH...	620	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33350
P11499-624-unknown	KHLEIN...	624	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33351
P11499-663-unknown	LLSSGF...	663	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IFLREL	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33344
...TDPSKL	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33345
...KIDIIP	76	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000119678
...KVILHL	184	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33346
...KKHSQF	207	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33347
...APFDLF	343	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29695
...NFIRGV	379	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33348
...SKILKV	402	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000127338
...ELLRYH	457	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33349
...EYCVQQ	523	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000126239
...STMGYM	619	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33350
...YMMAKK	623	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33351
...LFETAL	662	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33352
...MEEVD	724	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	42	LREL.\|.LISN	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> HS90B_MOUSE @42
MMP2_MOUSE	64	PSKL.\|.LDSG	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP2_MOUSE	184	ILHL.\|.LKED	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> HS90B_MOUSE @184
MMP2_MOUSE	207	HSQF.\|.FIGY	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> HS90B_MOUSE @207
CATE_MOUSE	343	FDLF.\|.FENK	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HS90B_MOUSE @343
MMP2_MOUSE	379	IRGV.\|.VVDS	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> HS90B_MOUSE @379
MMP2_MOUSE	457	LRYH.\|.HTSQ	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> HS90B_MOUSE @457
MMP2_MOUSE	619	MGYM.\|.MMAK	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	623	MAKK.\|.KHLE	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> HS90B_MOUSE @623
MMP2_MOUSE	662	ETAL.\|.LLSS	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)