O89023: Tripeptidyl-peptidase 1

General Information

Protein names	- Tripeptidyl-peptidase 1 - TPP-1 - 3.4.14.9 {ECO:0000269\|PubMed:28464005} - Lysosomal pepstatin-insensitive protease - LPIC - Tripeptidyl aminopeptidase - Tripeptidyl-peptidase I - TPP-I
Gene names	Tpp1
Organism	Mus musculus
Protease Family	S53.003
Protease ID	S53.003
Chromosome location
UniProt ID	O89023

6 N-termini

4 C-termini

3 Cleavages

2 Substrates

Sequence

        10         20         30         40         50         60
MGLQARLLGL LALVIAGKCT YNPEPDQRWM LPPGWVSLGR VDPEEELSLT FALKQRNLER
        70         80         90        100        110        120
LSELVQAVSD PSSPQYGKYL TLEDVAELVQ PSPLTLLTVQ KWLSAAGARN CDSVTTQDFL
       130        140        150        160        170        180
TCWLSVRQAE LLLPGAEFHR YVGGPTKTHV IRSPHPYQLP QALAPHVDFV GGLHRFPPSS
       190        200        210        220        230        240
PRQRPEPQQV GTVSLHLGVT PSVLRQRYNL TAKDVGSGTT NNSQACAQFL EQYFHNSDLT
       250        260        270        280        290        300
EFMRLFGGSF THQASVAKVV GKQGRGRAGI EASLDVEYLM SAGANISTWV YSSPGRHEAQ
       310        320        330        340        350        360
EPFLQWLLLL SNESSLPHVH TVSYGDDEDS LSSIYIQRVN TEFMKAAARG LTLLFASGDT
       370        380        390        400        410        420
GAGCWSVSGR HKFRPSFPAS SPYVTTVGGT SFKNPFLITD EVVDYISGGG FSNVFPRPPY
       430        440        450        460        470        480
QEEAVAQFLK SSSHLPPSSY FNASGRAYPD VAALSDGYWV VSNMVPIPWV SGTSASTPVF
       490        500        510        520        530        540
GGILSLINEH RILNGRPPLG FLNPRLYQQH GTGLFDVTHG CHESCLNEEV EGQGFCSGPG
       550        560
WDPVTGWGTP NFPALLKTLL NP

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 3 Cleavages - 2 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O89023-20-unmodified	TYNPEP...	20		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
O89023-20-unknown	TYNPEP...	20	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O89023-20-unknown	TYNPEP...	20	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
O89023-131-unknown	LLLPGA...	131	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33194
O89023-195-unknown	LHLGVT...	195	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O89023-195-unknown	LHLGVT...	195	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
O89023-286-unknown	ISTWVY...	286	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33195
O89023-286-unknown	ISTWVY...	286	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O89023-473-unknown	TSASTP...	473	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33196

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VRQAEL	130	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33194
...SAGANI	285	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33195
...PWVSGT	472	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33196
...TLLNP	562	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	130	QAEL.\|.LLLP	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	285	GANI.\|.ISTW	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	472	VSGT.\|.TSAS	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CCKN_MOUSE	98	DYMG.\|.GWMD	inferred from experiment	unknown	MEROPS	Bernardini F	Warburton MJ et al.:Tripeptidyl peptidase-I is esse... (S53.003)	12361850,
CCKN_MOUSE	101	GWMD.\|.DFGR	inferred from experiment	unknown	MEROPS	Bernardini F	Warburton MJ et al.:Tripeptidyl peptidase-I is esse... (S53.003)	12361850,