TopFIND 4.0

P09240: Cholecystokinin

General Information

Protein names	- Cholecystokinin - CCK - Cholecystokinin-33 - CCK33 - Cholecystokinin-12 - CCK12 - Cholecystokinin-8 - CCK8
Gene names	Cck
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P09240

12

N-termini

12

C-termini

15

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MKSGVCLCVV MAVLAAGALA QPVVPAEATD PVEQRAQEAP RRQLRAVLRT DGEPRARLGA
70 80 90 100 110
LLARYIQQVR KAPSGRMSVL KNLQSLDPSH RISDRDYMGW MDFGRRSAED YEYPS

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

12 N-termini - 12 C-termini - 15 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P09240-21-unknown	QPVVPA...	21		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P09240-21-unknown	QPVVPA...	21		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P09240-46-unknown	AVLRTD...	46		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34681
P09240-61-unknown	LLARYI...	61		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31488
P09240-61-unknown	LLARYI...	61		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31433
P09240-62-unknown	LARYIQ...	62		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31489
P09240-62-unknown	LARYIQ...	62		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31434
P09240-63-unknown	ARYIQQ...	63		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31435
P09240-65-unknown	YIQQVR...	65		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34654
P09240-65-unknown	YIQQVR...	65		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34682
P09240-71-unknown	KAPSGR...	71		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34655
P09240-71-unknown	KAPSGR...	71		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34683
P09240-82-unknown	NLQSLD...	82		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34684
P09240-96-unknown	DYMGWM...	96		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28012
P09240-99-unknown	GWMDFG...	99		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34817
P09240-102-unknown	DFGRRS...	102		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34818
P09240-107-unknown	SAEDYE...	107		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34685

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...RRQLRA	45	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34681
	...ARLGAL	60	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31488
	...ARLGAL	60	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31433
	...RLGALL	61	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31489
	...RLGALL	61	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31434
	...LGALLA	62	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31435
	...ALLARY	64	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34654
	...ALLARY	64	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34682
	...IQQVRK	70	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34655
	...IQQVRK	70	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34683
	...MSVLKN	81	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34684
	...RISDRD	95	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28012
	...DRDYMG	98	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34817
	...YMGWMD	101	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34818
	...DFGRRS	106	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34685
	...YEYPS	115	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEC2_MOUSE	45	QLRA.\|.AVLR	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,
CBPA6_MOUSE	60	LGAL.\|.LLAR	inferred from experiment	unknown	MEROPS	Fricker LD	Lyons PJ et al.:Substrate specificity of human ... (M14.018)	20855895,
CBPA4_MOUSE	60	LGAL.\|.LLAR	inferred from experiment	unknown	MEROPS	Fricker LD	Tanco S et al.:Characterization of the substra... (M14.017)	20385563,
CBPA6_MOUSE	61	GALL.\|.LARY	inferred from experiment	unknown	MEROPS	Fricker LD	Lyons PJ et al.:Substrate specificity of human ... (M14.018)	20855895,
CBPA4_MOUSE	61	GALL.\|.LARY	inferred from experiment	unknown	MEROPS	Fricker LD	Tanco S et al.:Characterization of the substra... (M14.017)	20385563,
CBPA4_MOUSE	62	ALLA.\|.ARYI	inferred from experiment	unknown	MEROPS	Fricker LD	Tanco S et al.:Characterization of the substra... (M14.017)	20385563,
NEC1_MOUSE	64	LARY.\|.YIQQ	inferred from experiment	unknown	MEROPS	Rehfeld JF	Rehfeld JF et al.:The endoproteolytic maturation ... (S08.072)	16680481,
NEC2_MOUSE	64	LARY.\|.YIQQ	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,
NEC1_MOUSE	70	QVRK.\|.KAPS	inferred from experiment	unknown	MEROPS	Rehfeld JF	Rehfeld JF et al.:The endoproteolytic maturation ... (S08.072)	16680481,
NEC2_MOUSE	70	QVRK.\|.KAPS	inferred from experiment	unknown	MEROPS	Rehfeld JF	Rehfeld JF et al.:The endoproteolytic maturation ... (S08.072)	16680481,
NEC2_MOUSE	81	VLKN.\|.NLQS	inferred from experiment	unknown	MEROPS	Rehfeld JF	Rehfeld JF et al.:The endoproteolytic maturation ... (S08.072)	16680481,
AMPB_MOUSE	95	SDRD.\|.DYMG	inferred from experiment	unknown	MEROPS	Hook V	Beinfeld MC et al.:Cathepsin L plays a major role ... (M01.014)	19589362,
TPP1_MOUSE	98	DYMG.\|.GWMD	inferred from experiment	unknown	MEROPS	Bernardini F	Warburton MJ et al.:Tripeptidyl peptidase-I is esse... (S53.003)	12361850,
TPP1_MOUSE	101	GWMD.\|.DFGR	inferred from experiment	unknown	MEROPS	Bernardini F	Warburton MJ et al.:Tripeptidyl peptidase-I is esse... (S53.003)	12361850,
NEC2_MOUSE	106	GRRS.\|.SAED	inferred from experiment	unknown	MEROPS	Rehfeld JF	Rehfeld JF et al.:The endoproteolytic maturation ... (S08.072)	16680481,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)