P63239: Neuroendocrine convertase 1

General Information

Protein names	- Neuroendocrine convertase 1 - NEC 1 - 3.4.21.93 - Furin homolog - PC3 - Prohormone convertase 1 - Propeptide-processing protease - Proprotein convertase 1 - PC1
Gene names	Pcsk1
Organism	Mus musculus
Protease Family	S08.072
Protease ID	S08.072
Chromosome location
UniProt ID	P63239

4 N-termini

4 C-termini

3 Cleavages

22 Substrates

Sequence

        10         20         30         40         50         60
MEQRGWTLQC TAFAFFCVWC ALNSVKAKRQ FVNEWAAEIP GGQEAASAIA EELGYDLLGQ
        70         80         90        100        110        120
IGSLENHYLF KHKSHPRRSR RSALHITKRL SDDDRVTWAE QQYEKERSKR SVQKDSALDL
       130        140        150        160        170        180
FNDPMWNQQW YLQDTRMTAA LPKLDLHVIP VWEKGITGKG VVITVLDDGL EWNHTDIYAN
       190        200        210        220        230        240
YDPEASYDFN DNDHDPFPRY DLTNENKHGT RCAGEIAMQA NNHKCGVGVA YNSKVGGIRM
       250        260        270        280        290        300
LDGIVTDAIE ASSIGFNPGH VDIYSASWGP NDDGKTVEGP GRLAQKAFEY GVKQGRQGKG
       310        320        330        340        350        360
SIFVWASGNG GRQGDNCDCD GYTDSIYTIS ISSASQQGLS PWYAEKCSST LATSYSSGDY
       370        380        390        400        410        420
TDQRITSADL HNDCTETHTG TSASAPLAAG IFALALEANP NLTWRDMQHL VVWTSEYDPL
       430        440        450        460        470        480
ASNPGWKKNG AGLMVNSRFG FGLLNAKALV DLADPRTWRN VPEKKECVVK DNNFEPRALK
       490        500        510        520        530        540
ANGEVIVEIP TRACEGQENA IKSLEHVQFE ATIEYSRRGD LHVTLTSAVG TSTVLLAERE
       550        560        570        580        590        600
RDTSPNGFKN WDFMSVHTWG ENPVGTWTLK ITDMSGRMQN EGRIVNWKLI LHGTSSQPEH
       610        620        630        640        650        660
MKQPRVYTSY NTVQNDRRGV EKMVNVVEKR PTQKSLNGNL LVPKNSSSSN VEGRRDEQVQ
       670        680        690        700        710        720
GTPSKAMLRL LQSAFSKNAL SKQSPKKSPS AKLSIPYESF YEALEKLNKP SKLEGSEDSL
       730        740        750
YSDYVDVFYN TKPYKHRDDR LLQALMDILN EEN

Isoforms

Sequence View

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P63239-28-unknown	KRQFVN...	28	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P63239-111-unknown	SVQKDS...	111	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P63239-111-unknown	SVQKDS...	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34666
P63239-619-unknown	GVEKMV...	619	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34725
P63239-631-unknown	PTQKSL...	631	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34726

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ERSKRS	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34666
...QNDRRG	618	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34725
...VVEKRP	630	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34726
...LNEEN	753	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEC1_MOUSE	110	SKRS.\|.SVQK	inferred from experiment	unknown	MEROPS	Lazure C	Boudreault A et al.:Molecular characterization, enz... (S08.072)	9882569,
NEC2_MOUSE	618	DRRG.\|.GVEK	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,
NEC2_MOUSE	630	EKRP.\|.PTQK	inferred from experiment	unknown	MEROPS	Fricker LD	Pan H et al.:The role of prohormone converta... (S08.073)	16903874,

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GHRL-Isoform2_MOUSE	50	QPRA.\|.ALEG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC34667
GHRL_MOUSE	51	QPRA.\|.ALEG	inferred from experiment	unknown	MEROPS	Steiner DF	Zhu X et al.:On the processing of proghrelin... (S08.072)	17050541,
INS1_MOUSE	56	SRRE.\|.EVED	inferred from experiment	unknown	MEROPS	Steiner DF	Furuta M et al.:Incomplete processing of proins... (S08.072)	9452465,
INS2_MOUSE	56	SRRE.\|.EVED	inferred from experiment	unknown	MEROPS	Steiner DF	Furuta M et al.:Incomplete processing of proins... (S08.072)	9452465,
GAST_MOUSE	58	HRRQ.\|.QLGP	inferred from experiment	unknown	MEROPS	Friis-Hansen L	Rehfeld JF et al.:Prohormone convertases 1/3 and ... (S08.072)	18554181,
RENI2_MOUSE	63	TKRS.\|.SSLT	inferred from experiment	unknown	MEROPS	Chretien M	Seidah NG et al.:Pro-protein convertases of subt... (S08.072)	7845206,
CCKN_MOUSE	64	LARY.\|.YIQQ	inferred from experiment	unknown	MEROPS	Rehfeld JF	Rehfeld JF et al.:The endoproteolytic maturation ... (S08.072)	16680481,
CCKN_MOUSE	70	QVRK.\|.KAPS	inferred from experiment	unknown	MEROPS	Rehfeld JF	Rehfeld JF et al.:The endoproteolytic maturation ... (S08.072)	16680481,
GLUC_MOUSE	83	TKRN.\|.NRNN	inferred from experiment	unknown	MEROPS		Merops NEC1_MOUSE -> GLUC_MOUSE @83
GLUC_MOUSE	91	AKRH.\|.HDEF	inferred from experiment	unknown	MEROPS	Steiner DF	Rouille Y et al.:Differential processing of prog... (S08.072)	7592866,
GAST_MOUSE	95	GRRS.\|.SAEE	inferred from experiment	unknown	MEROPS	Friis-Hansen L	Rehfeld JF et al.:Prohormone convertases 1/3 and ... (S08.072)	18554181,
GLUC_MOUSE	97	FERH.\|.HAEG	inferred from experiment	unknown	MEROPS	Steiner DF	Rouille Y et al.:Differential processing of prog... (S08.072)	7592866,
NEC1_MOUSE	110	SKRS.\|.SVQK	inferred from experiment	unknown	MEROPS	Lazure C	Boudreault A et al.:Molecular characterization, enz... (S08.072)	9882569,
COLI_MOUSE	123	GKRS.\|.SYSM	inferred from experiment	unknown	MEROPS	Seidah NG	Benjannet S et al.:PC1 and PC2 are proprotein conv... (S08.072)	2023902,
GLUC_MOUSE	130	GRRD.\|.DFPE	inferred from experiment	unknown	MEROPS	Steiner DF	Rouille Y et al.:Differential processing of prog... (S08.072)	7592866,
GLUC_MOUSE	145	GRRH.\|.HADG	inferred from in-silico analysis	unknown	MEROPS	Steiner DF	Rouille Y et al.:Differential processing of prog... (S08.072)	7592866,
COLI_MOUSE	164	FKRE.\|.ELEG	inferred from experiment	unknown	MEROPS	Seidah NG	Benjannet S et al.:PC1 and PC2 are proprotein conv... (S08.072)	2023902,
7B2_MOUSE	181	KRRS.\|.SVNP	inferred from experiment	unknown	MEROPS	Seidah NG	De Bie I et al.:Processing specificity and bios... (S08.071)	7836354,
COLI_MOUSE	204	DKRY.\|.YGGF	inferred from experiment	unknown	MEROPS	Seidah NG	Benjannet S et al.:PC1 and PC2 are proprotein conv... (S08.072)	2023902,
COLI_MOUSE	233	HKKG.\|.GQ	inferred from experiment	unknown	MEROPS		Merops NEC1_MOUSE -> COLI_MOUSE @233
SCG1_MOUSE	574	ERRP.\|.PFSE	inferred from experiment	unknown	MEROPS	Winkler H	Laslop A et al.:Proteolytic processing of chrom... (S08.072)	9422384,
SCG1_MOUSE	587	EKRS.\|.SFAR	inferred from experiment	unknown	MEROPS	Winkler H	Laslop A et al.:Proteolytic processing of chrom... (S08.072)	9422384,

TopFIND

P63239: Neuroendocrine convertase 1

General Information

4

N-termini

4

C-termini

3

Cleavages

22

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 3 Cleavages - 22 Substrates

N-termini

C-termini

Cleavages

Substrates