TopFIND 4.0

P01326: Insulin-2

General Information

Protein names	- Insulin-2 - Insulin-2 B chain - Insulin-2 A chain
Gene names	Ins2
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P01326

2

N-termini

2

C-termini

2

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MALWMRFLPL LALLFLWESH PTQAFVKQHL CGSHLVEALY LVCGERGFFY TPMSRREVED
70 80 90 100 110
PQVAQLELGG GPGAGDLQTL ALEVAQQKRG IVDQCCTSIC SLYQLENYCN

Isoforms

Sequence View

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P01326-57-unknown	EVEDPQ...	57		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34653
P01326-90-unknown	GIVDQC...	90		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34680

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...PMSRRE	56	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34653
	...AQQKRG	89	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34680

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEC1_MOUSE	56	SRRE.\|.EVED	inferred from experiment	unknown	MEROPS	Steiner DF	Furuta M et al.:Incomplete processing of proins... (S08.072)	9452465,
NEC2_MOUSE	89	QKRG.\|.GIVD	inferred from experiment	unknown	MEROPS	Steiner DF	Furuta M et al.:Incomplete processing of proins... (S08.072)	9452465,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)