TopFIND 4.0

P21661: Neuroendocrine convertase 2

General Information

Protein names
- Neuroendocrine convertase 2
- NEC 2
- 3.4.21.94
- KEX2-like endoprotease 2
- Prohormone convertase 2
- Proprotein convertase 2
- PC2
Gene names Pcsk2
Organism Mus musculus
Protease Family S08.073
Protease ID S08.073
Chromosome location
UniProt ID P21661

2

N-termini

2

C-termini

1

Cleavages

78

Substrates

Sequence

        10         20         30         40         50         60 
MEGGCGSQWK AAGFLFCVMV FASAERPVFT NHFLVELHKD GEEEARQVAA EHGFGVRKLP 
        70         80         90        100        110        120 
FAEGLYHFYH NGLAKAKRRR SLHHKRQLER DPRIKMALQQ EGFDRKKRGY RDINEIDINM 
       130        140        150        160        170        180 
NDPLFTKQWY LFNTGQADGT PGLDLNVAEA WELGYTGKGV TIGIMDDGID YLHPDLAYNY 
       190        200        210        220        230        240 
NADASYDFSS NDPYPYPRYT DDWFNSHGTR CAGEVSAAAS NNICGVGVAY NSKVAGIRML 
       250        260        270        280        290        300 
DQPFMTDIIE ASSISHMPQL IDIYSASWGP TDNGKTVDGP RELTLQAMAD GVNKGRGGKG 
       310        320        330        340        350        360 
SIYVWASGDG GSYDDCNCDG YASSMWTISI NSAINDGRTA LYDESCSSTL ASTFSNGRKR 
       370        380        390        400        410        420 
NPEAGVATTD LYGNCTLRHS GTSAAAPEAA GVFALALEAN LDLTWRDMQH LTVLTSKRNQ 
       430        440        450        460        470        480 
LHDEVHQWRR NGVGLEFNHL FGYGVLDAGA MVKMAKDWKT VPERFHCVGG SVQNPEKIPP 
       490        500        510        520        530        540 
TGKLVLTLKT NACEGKENFV RYLEHVQAVI TVNATRRGDL NINMTSPMGT KSILLSRRPR 
       550        560        570        580        590        600 
DDDSKVGFDK WPFMTTHTWG EDARGTWTLE LGFVGSAPQK GLLKEWTLML HGTQSAPYID 
       610        620        630    
QVVRDYQSKL AMSKKQELEE ELDEAVERSL QSILRKN

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 78 Substrates

N-termini

C-termini

Cleavages

Substrates