Q60813: Disintegrin and metalloproteinase domain-containing protein 1a
| Protein names | - Disintegrin and metalloproteinase domain-containing protein 1a - ADAM 1a - 3.4.24.- - Fertilin subunit alpha-a |
|---|---|
| Gene names | Adam1a |
| Organism | Mus musculus |
| Protease Family | |
| Protease ID | M12.202 |
| Chromosome location | |
| UniProt ID | Q60813 |
3
N-termini
2
C-termini
5
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSVAAAGRGF ASSLSSPQIR RIALKEAKLT PHIWAALHWN LGLRLVPSVR VGILVLLIFL
70 80 90 100 110 120
PSTFCDIGSV YNSSYETVIP ERLPGKGGKD PGGKVSYMLL MQGQKQLLHL EVKGHYPENN
130 140 150 160 170 180
FPVYSYHNGI LRQEMPLLSQ DCHYEGYMEG VPGSFVSVNI CSGLRGVLIK EETSYGIEPM
190 200 210 220 230 240
LSSKNFEHVL YTMEHQPVVS CSVTPKDSPG DTSHPPRSRK PDDLLVLTDW WSHTKYVEMF
250 260 270 280 290 300
VVVNHQRFQM WGSNINETVQ AVMDIIALAN SFTRGINTEV VLVGLEIWTE GDPIEVPVDL
310 320 330 340 350 360
QTTLRNFNFW RQEKLVGRVR HDVAHLIVGH RPGENEGQAF LRGACSGEFA AAVEAFHHED
370 380 390 400 410 420
VLLFAALMAH ELGHNLGIQH DHPTCTCGPK HFCLMGEKIG KDSGFSNCSS DHFLRFLHDH
430 440 450 460 470 480
RGACLLDEPG RQSRMRRAAN CGNGVVEDLE ECDCGSDCDS HPCCSPTCTL KEGAQCSEGL
490 500 510 520 530 540
CCYNCTFKKK GSLCRPAEDV CDLPEYCDGS TQECPANSYM QDGTQCDRIY YCLGGWCKNP
550 560 570 580 590 600
DKQCSRIYGY PARSAPEECY ISVNTKANRF GNCGHPTSAN FRYETCSDED VFCGKLVCTD
610 620 630 640 650 660
VRYLPKVKPL HSLLQVPYGE DWCWSMDAYN ITDVPDDGDV QSGTFCAPNK VCMEYICTGR
670 680 690 700 710 720
GVLQYNCEPQ EMCHGNGVCN NFKHCHCDAG FAPPDCSSPG NGGSVDSGPV GKPADRHLSL
730 740 750 760 770 780
SFLAEESPDD KMEDEEVNLK VMVLVVPIFL VVLLCCLMLI AYLWSEVQEV VSPPSSSESS
790
SSSSWSDSDS Q
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
3 N-termini - 2 C-termini - 5 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q60813-0-unknown | QMSVAA... | 0 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q60813-66-unknown | DIGSVY... | 66 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q60813-221-unknown | PDDLLV... | 221 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34733 | |||
| Q60813-221-unknown | PDDLLV... | 221 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34757 | |||
| Q60813-221-unknown | PDDLLV... | 221 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34761 | |||
| Q60813-221-unknown | PDDLLV... | 221 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34772 | |||
| Q60813-221-unknown | PDDLLV... | 221 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32223 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...PRSRKP | 220 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34733 | |||
| ...PRSRKP | 220 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34757 | |||
| ...PRSRKP | 220 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34761 | |||
| ...PRSRKP | 220 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34772 | |||
| ...PRSRKP | 220 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32223 | |||
| ...DSDSQ | 791 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| NEC2_MOUSE | 220 | SRKP.|.PDDL | inferred from experiment | unknown | MEROPS | Strongin AY | Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) | 18505722, |
| PCSK4_MOUSE | 220 | SRKP.|.PDDL | inferred from experiment | unknown | MEROPS | Strongin AY | Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) | 18505722, |
| PCSK5_MOUSE | 220 | SRKP.|.PDDL | inferred from experiment | unknown | MEROPS | Strongin AY | Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) | 18505722, |
| PCSK7_MOUSE | 220 | SRKP.|.PDDL | inferred from experiment | unknown | MEROPS | Strongin AY | Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) | 18505722, |
| FURIN_MOUSE | 220 | SRKP.|.PDDL | inferred from experiment | unknown | MEROPS | Strongin AY | Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) | 18505722, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|