Q04592: Proprotein convertase subtilisin/kexin type 5
| Protein names | - Proprotein convertase subtilisin/kexin type 5 - 3.4.21.- - Proprotein convertase 5 - PC5 - Proprotein convertase 6 - PC6 - Subtilisin-like proprotein convertase 6 - SPC6 - Subtilisin/kexin-like protease PC5 |
|---|---|
| Gene names | Pcsk5 |
| Organism | Mus musculus |
| Protease Family | S08.076 |
| Protease ID | S08.076 |
| Chromosome location | |
| UniProt ID | Q04592 |
2
N-termini
1
C-termini
0
Cleavages
5
Substrates
Sequence
10 20 30 40 50 60
MDWDWGNRCS RPGRRDLLCV LALLAGCLLP VCRTRVYTNH WAVKIAGGFA EADRIASKYG
70 80 90 100 110 120
FINVGQIGAL KDYYHFYHSR TIKRSVLSSR GTHSFISMEP KVEWIQQQVV KKRTKRDYDL
130 140 150 160 170 180
SHAQSTYFND PKWPSMWYMH CSDNTHPCQS DMNIEGAWKR GYTGKNIVVT ILDDGIERTH
190 200 210 220 230 240
PDLMQNYDAL ASCDVNGNDL DPMPRYDASN ENKHGTRCAG EVAATANNSH CTVGIAFNAK
250 260 270 280 290 300
IGGVRMLDGD VTDMVEAKSV SYNPQHVHIY SASWGPDDDG KTVDGPAPLT RQAFENGVRM
310 320 330 340 350 360
GRRGLGSVFV WASGNGGRSK DHCSCDGYTN SIYTISISST AESGKKPWYL EECSSTLATT
370 380 390 400 410 420
YSSGESYDKK IITTDLRQRC TDNHTGTSAS APMAAGIIAL ALEANPFLTW RDVQHVIVRT
430 440 450 460 470 480
SRAGHLNAND WKTNAAGFKV SHLYGFGLMD AEAMVMEAEK WTTVPQQHVC VESTDRQIKT
490 500 510 520 530 540
IRPNSAVRSI YKASGCSDNP NHHVNYLEHV VVRITITHPR RGDLAIYLTS PSGTRSQLLA
550 560 570 580 590 600
NRLFDHSMEG FKNWEFMTIH CWGERAAGDW VLEVYDTPSQ LRNFKTPGKL KEWSLVLYGT
610 620 630 640 650 660
SVQPYSPTNE FPKVERFRYS RVEDPTDDYG AEDYAGPCDP ECSEVGCDGP GPDHCSDCLH
670 680 690 700 710 720
YYYKLKNNTR ICVSSCPPGH YHADKKRCRK CAPNCESCFG SHGNQCLSCK YGYFLNEETS
730 740 750 760 770 780
SCVTQCPDGS YEDIKKNVCG KCSENCKACI GFHNCTECKG GLSLQGSRCS VTCEDGQFFN
790 800 810 820 830 840
GHDCQPCHRF CATCSGAGAD GCINCTEGYV MEEGRCVQSC SVSYYLDHSS EGGYKSCKRC
850 860 870 880 890 900
DNSCLTCNGP GFKNCSSCPS GYLLDLGTCQ MGAICKDGEY IDDQGHCQTC EASCAKCWGP
910 920 930 940 950 960
TQEDCISCPV TRVLDDGRCV MNCPSWKFEF KKQCHPCHYT CQGCQGSGPS NCTSCRADKH
970 980 990 1000 1010 1020
GQERFLYHGE CLENCPVGHY PAKGHACLPC PDNCELCYNP HVCSRCMSGY VIIPPNHTCQ
1030 1040 1050 1060 1070 1080
KLECRQGEFQ DSEYEECMPC EEGCLGCTED DPGACTSCAT GYYMFERHCY KACPEKTFGV
1090 1100 1110 1120 1130 1140
KWECRACGTN CGSCDQHECY WCEEGFFLSG GSCVQDCGPG FHGDQELGEC KPCHRACENC
1150 1160 1170 1180 1190 1200
TGSGYNQCSS CQEGLQLWHG TCLWSTWPQV EGKDWNEAVP TEKPSLVRSL LQDRRKWKVQ
1210 1220 1230 1240 1250 1260
IKRDATSQNQ PCHSSCKTCN GSLCASCPTG MYLWLQACVP SCPQGTWPSV TSGSCEKCSE
1270 1280 1290 1300 1310 1320
DCVSCSGADL CQQCLSQPDN TLLLHEGRCY HSCPEGFYAK DGVCEHCSSP CKTCEGNATS
1330 1340 1350 1360 1370 1380
CNSCEGDFVL DHGVCWKTCP EKHVAVEGVC KHCPERCQDC IHEKTCKECM PDFFLYNDMC
1390 1400 1410 1420 1430 1440
HRSCPKSFYP DMRQCVPCHK NCLECNGPKE DDCKVCADTS KALHNGLCLD ECPEGTYKEE
1450 1460 1470 1480 1490 1500
ENDECRDCPE SCLICSSAWT CLACREGFTV VHDVCTAPKE CAAVEYWDEG SHRCQPCHKK
1510 1520 1530 1540 1550 1560
CSRCSGPSED QCYTCPRETF LLNTTCVKEC PEGYHTDKDS QQCVLCHSSC RTCEGPHSMQ
1570 1580 1590 1600 1610 1620
CLSCRPGWFQ LGKECLLQCR DGYYGESTSG RCEKCDKSCK SCRGPRPTDC QSCDTFFFLL
1630 1640 1650 1660 1670 1680
RSKGQCHRAC PEHYYADQHA QTCERCHPTC DKCSGKEAWS CLSCVWSYHL LKGICIPECI
1690 1700 1710 1720 1730 1740
VGEYREGKGE NFNCKKCHES CMECKGPGSK NCTGCSAGLL LDMDDNRCLH CCNASHSRRS
1750 1760 1770 1780 1790 1800
QDCCDCQSST DECILPAREA EFYEHTKTAL LVTSGAMLLL LLGAAAVVWR KSRSRPVAKG
1810 1820 1830 1840 1850 1860
RYEKLAEPTV SYSSYRSSYL DEDQVIEYRD RDYDEDDEDD IVYMGQDGTV YRKFKYGLLD
1870
ETEDDELEYD DESYSYQ
Isoforms
- Isoform PC5A of Proprotein convertase subtilisin/kexin type 5Sequence View
10 20 30 40 50 60
MDWDWGNRCS RPGRRDLLCV LALLAGCLLP VCRTRVYTNH WAVKIAGGFA EADRIASKYG
70 80 90 100 110 120
FINVGQIGAL KDYYHFYHSR TIKRSVLSSR GTHSFISMEP KVEWIQQQVV KKRTKRDYDL
130 140 150 160 170 180
SHAQSTYFND PKWPSMWYMH CSDNTHPCQS DMNIEGAWKR GYTGKNIVVT ILDDGIERTH
190 200 210 220 230 240
PDLMQNYDAL ASCDVNGNDL DPMPRYDASN ENKHGTRCAG EVAATANNSH CTVGIAFNAK
250 260 270 280 290 300
IGGVRMLDGD VTDMVEAKSV SYNPQHVHIY SASWGPDDDG KTVDGPAPLT RQAFENGVRM
310 320 330 340 350 360
GRRGLGSVFV WASGNGGRSK DHCSCDGYTN SIYTISISST AESGKKPWYL EECSSTLATT
370 380 390 400 410 420
YSSGESYDKK IITTDLRQRC TDNHTGTSAS APMAAGIIAL ALEANPFLTW RDVQHVIVRT
430 440 450 460 470 480
SRAGHLNAND WKTNAAGFKV SHLYGFGLMD AEAMVMEAEK WTTVPQQHVC VESTDRQIKT
490 500 510 520 530 540
IRPNSAVRSI YKASGCSDNP NHHVNYLEHV VVRITITHPR RGDLAIYLTS PSGTRSQLLA
550 560 570 580 590 600
NRLFDHSMEG FKNWEFMTIH CWGERAAGDW VLEVYDTPSQ LRNFKTPGKL KEWSLVLYGT
610 620 630 640 650 660
SVQPYSPTNE FPKVERFRYS RVEDPTDDYG AEDYAGPCDP ECSEVGCDGP GPDHCSDCLH
670 680 690 700 710 720
YYYKLKNNTR ICVSSCPPGH YHADKKRCRK CAPNCESCFG SHGNQCLSCK YGYFLNEETS
730 740 750 760 770 780
SCVTQCPDGS YEDIKKNVCG KCSENCKACI GFHNCTECKG GLSLQGSRCS VTCEDGQFFN
790 800 810 820 830 840
GHDCQPCHRF CATCSGAGAD GCINCTEGYV MEEGRCVQSC SVSYYLDHSS EGGYKSCKRC
850 860 870 880 890 900
DNSCLTCNGP GFKNCSSCPS GYLLDLGTCQ MGAICKDGEY IDDQGHCQTC EASCAKCWGP
910 920 930 940 950 960
TQEDCISCPV TRVLDDGRCV MNCPSWKFEF KKQCHPCHYT CQGCQGSGPS NCTSCRADKH
970 980 990 1000 1010 1020
GQERFLYHGE CLENCPVGHY PAKGHACLPC PDNCELCYNP HVCSRCMSGY VIIPPNHTCQ
1030 1040 1050 1060 1070 1080
KLECRQGEFQ DSEYEECMPC EEGCLGCTED DPGACTSCAT GYYMFERHCY KACPEKTFGV
1090 1100 1110 1120 1130 1140
KWECRACGTN CGSCDQHECY WCEEGFFLSG GSCVQDCGPG FHGDQELGEC KPCHRACENC
1150 1160 1170 1180 1190 1200
TGSGYNQCSS CQEGLQLWHG TCLWSTWPQV EGKDWNEAVP TEKPSLVRSL LQDRRKWKVQ
1210 1220 1230 1240 1250 1260
IKRDATSQNQ PCHSSCKTCN GSLCASCPTG MYLWLQACVP SCPQGTWPSV TSGSCEKCSE
1270 1280 1290 1300 1310 1320
DCVSCSGADL CQQCLSQPDN TLLLHEGRCY HSCPEGFYAK DGVCEHCSSP CKTCEGNATS
1330 1340 1350 1360 1370 1380
CNSCEGDFVL DHGVCWKTCP EKHVAVEGVC KHCPERCQDC IHEKTCKECM PDFFLYNDMC
1390 1400 1410 1420 1430 1440
HRSCPKSFYP DMRQCVPCHK NCLECNGPKE DDCKVCADTS KALHNGLCLD ECPEGTYKEE
1450 1460 1470 1480 1490 1500
ENDECRDCPE SCLICSSAWT CLACREGFTV VHDVCTAPKE CAAVEYWDEG SHRCQPCHKK
1510 1520 1530 1540 1550 1560
CSRCSGPSED QCYTCPRETF LLNTTCVKEC PEGYHTDKDS QQCVLCHSSC RTCEGPHSMQ
1570 1580 1590 1600 1610 1620
CLSCRPGWFQ LGKECLLQCR DGYYGESTSG RCEKCDKSCK SCRGPRPTDC QSCDTFFFLL
1630 1640 1650 1660 1670 1680
RSKGQCHRAC PEHYYADQHA QTCERCHPTC DKCSGKEAWS CLSCVWSYHL LKGICIPECI
1690 1700 1710 1720 1730 1740
VGEYREGKGE NFNCKKCHES CMECKGPGSK NCTGCSAGLL LDMDDNRCLH CCNASHSRRS
1750 1760 1770 1780 1790 1800
QDCCDCQSST DECILPAREA EFYEHTKTAL LVTSGAMLLL LLGAAAVVWR KSRSRPVAKG
1810 1820 1830 1840 1850 1860
RYEKLAEPTV SYSSYRSSYL DEDQVIEYRD RDYDEDDEDD IVYMGQDGTV YRKFKYGLLD
1870
ETEDDELEYD DESYSYQ
Protein Neighborhood
Domains & Features
2 N-termini - 1 C-termini - 0 Cleavages - 5 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q04592-1-unknown | MDWDWG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt84598 | |||
| Q04592-117-unknown | DYDLSH... | 117 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q04592-117-unknown | DYDLSH... | 117 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt115903 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...SYSYQ | 1877 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| SLIB_MOUSE | 73 | LSRQ.|.QEDS | inferred from experiment | unknown | MEROPS | Steiner DF | Dey A et al.:Furin and prohormone convertase... (S08.073) | 14684599, |
| MMP15_MOUSE | 127 | RKRY.|.YTLT | inferred from experiment | unknown | MEROPS | Strongin AY | Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) | 18505722, |
| ADM1A_MOUSE | 220 | SRKP.|.PDDL | inferred from experiment | unknown | MEROPS | Strongin AY | Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) | 18505722, |
| GDF11_MOUSE | 296 | SRRN.|.NLGL | inferred from experiment | unknown | MEROPS | Prat A | Essalmani R et al.:In vivo functions of the propro... (S08.076) | 18378898, |
| L1CAM_MOUSE | 863 | SKRH.|.HIHK | inferred from experiment | unknown | MEROPS | Schachner M | Kalus I et al.:The proprotein convertase PC5A ... (S08.076) | 12529374, |