TopFIND 4.0

P23188: Furin

General Information

Protein names
- Furin
- 3.4.21.75 {ECO:0000250|UniProtKB:P09958}
- Dibasic-processing enzyme
- Paired basic amino acid residue-cleaving enzyme
- PACE
- Prohormone convertase 3
Gene names Furin
Organism Mus musculus
Protease Family S08.071
Protease ID S08.071
Chromosome location
UniProt ID P23188

4

N-termini

6

C-termini

3

Cleavages

44

Substrates

Sequence

        10         20         30         40         50         60 
MELRSWLLWV VAAAGAVVLL AADAQGQKIF TNTWAVHIPG GPAVADRVAQ KHGFHNLGQI 
        70         80         90        100        110        120 
FGDYYHFWHR AVTKRSLSPH RPRHSRLQRE PQVKWLEQQV AKRRAKRDVY QEPTDPKFPQ 
       130        140        150        160        170        180 
QWYLSGVTQR DLNVKEAWAQ GFTGHGIVVS ILDDGIEKNH PDLAGNYDPG ASFDVNDQDP 
       190        200        210        220        230        240 
DPQPRYTQMN DNRHGTRCAG EVAAVANNGV CGVGVAYNAR IGGVRMLDGE VTDAVEARSL 
       250        260        270        280        290        300 
GLNPNHIHIY SASWGPEDDG KTVDGPARLA EEAFFRGVSQ GRGGLGSIFV WASGNGGREH 
       310        320        330        340        350        360 
DSCNCDGYTN SIYTLSISSA TQFGNVPWYS EACSSTLATT YSSGNQNEKQ IVTTDLRQKC 
       370        380        390        400        410        420 
TESHTGTSAS APLAAGIIAL TLEANKNLTW RDMQHLVVQT SKPAHLNADD WATNGVGRKV 
       430        440        450        460        470        480 
SHSYGYGLLD AGAMVALAQN WTTVAPQRKC IVEILVEPKD IGKRLEVRKA VTACLGEPNH 
       490        500        510        520        530        540 
ITRLEHVQAR LTLSYNRRGD LAIHLISPMG TRSTLLAARP HDYSADGFND WAFMTTHSWD 
       550        560        570        580        590        600 
EDPAGEWVLE IENTSEANNY GTLTKFTLVL YGTAPEGLST PPESSGCKTL TSSQACVVCE 
       610        620        630        640        650        660 
EGYSLHQKSC VQHCPPGFIP QVLDTHYSTE NDVEIIRASV CTPCHASCAT CQGPAPTDCL 
       670        680        690        700        710        720 
SCPSHASLDP VEQTCSRQSQ SSRESRPQQQ PPALRPEVEM EPRLQAGLAS HLPEVLAGLS 
       730        740        750        760        770        780 
CLIIVLIFGI VFLFLHRCSG FSFRGVKVYT MDRGLISYKG LPPEAWQEEC PSDSEEDEGR 
       790    
GERTAFIKDQ SAL

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

4 N-termini - 6 C-termini - 3 Cleavages - 44 Substrates

N-termini

C-termini

Cleavages

Substrates