Q9WU39: Amiloride-sensitive sodium channel subunit gamma

General Information

Protein names	- Amiloride-sensitive sodium channel subunit gamma - Epithelial Na(+) channel subunit gamma - Gamma-ENaC - Gamma-NaCH - Nonvoltage-gated sodium channel 1 subunit gamma - SCNEG
Gene names	Scnn1g
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9WU39

4 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAPGEKIKAK IKKNLPVRGP QAPTIKDLMH WYCLNTNTHG CRRIVVSRGR LRRLLWIAFT
        70         80         90        100        110        120
LTAVALIIWQ CALLVFSFYT VSVSIKVHFQ KLDFPAVTIC NINPYKYSAV SDLLTDLDSE
       130        140        150        160        170        180
TKQALLSLYG VKDVLDSTPR KRREAGSMRS TWEGTPPRFL NLIPLLVFNE NEKGKARDFF
       190        200        210        220        230        240
TGRKRKISGK IIHKASNVMH VHESKKLVGF QLCSNDTSDC ATYTFSSGIN AIQEWYKLHY
       250        260        270        280        290        300
MNIMAQVPLE KKINMSYSAE ELLVTCFFDG MSCDARNFTL FHHPMYGNCY TFNNRENATI
       310        320        330        340        350        360
LSTSMGGSEY GLQVILYINE DEYNPFLVSS TGAKVLVHQQ NEYPFIEDVG TEIETAMSTS
       370        380        390        400        410        420
IGMHLTESFK LSEPYSQCTE DGSDVPVTNI YNAAYSLQIC LYSCFQTKMV EKCGCAQYSQ
       430        440        450        460        470        480
PLPPAANYCN YQQHPNWMYC YYQLYQAFVR EELGCQSVCK QSCSFKEWTL TTSLAQWPSE
       490        500        510        520        530        540
ASEKWLLNVL TWDQSQQINK KLNKTDLAKL LIFYKDLNQR SIMESPANSI EMLLSNFGGQ
       550        560        570        580        590        600
LGLWMSCSVV CVIEIIEVFF IDFFSIIARR QWQKAKDWWA RRRTPPSTET PSSQQGQDNP
       610        620        630        640        650
ALDTDDDLPT FTSAMRLPPA PEAPVPGTPP PRYNTLRLDS AFSSQLTDTQ LTNEF

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9WU39-1-unknown	MAPGEK...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9WU39-144-unknown	EAGSMR...	144	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32239
Q9WU39-187-unknown	ISGKII...	187	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34786
Q9WU39-195-unknown	ASNVMH...	195	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34783

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PRKRRE	143	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32239
...GRKRKI	186	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34786
...KIIHKA	194	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34783
...LTNEF	655	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
FURIN_MOUSE	143	KRRE.\|.EAGS	inferred from experiment	unknown	MEROPS	Kleyman TR	Hughey RP et al.:Epithelial sodium channels are ... (S08.071)	15007080,
PRSS8_MOUSE	186	KRKI.\|.ISGK	inferred from experiment	unknown	MEROPS	Kleyman TR	Bruns JB et al.:Epithelial Na+ channels are ful... (S01.159)	17199078,
PLMN_MOUSE	194	IHKA.\|.ASNV	inferred from experiment	unknown	MEROPS	Kleyman TR	Passero CJ et al.:Plasmin activates epithelial Na... (S01.131)	18981180,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)