Q9ESD1: Prostasin

General Information

Protein names	- Prostasin - 3.4.21.- - Channel-activating protease 1 - CAP1 - Serine protease 8 - Prostasin light chain - Prostasin heavy chain
Gene names	Prss8
Organism	Mus musculus
Protease Family	S01.159
Protease ID	S01.159
Chromosome location
UniProt ID	Q9ESD1

4 N-termini

2 C-termini

1 Cleavages

1 Substrates

Sequence

        10         20         30         40         50         60
MAPRVGLGLG QLEAVTILLL LGLLQSGIRA DGTEASCGAV IQPRITGGGS AKPGQWPWQV
        70         80         90        100        110        120
SITYDGNHVC GGSLVSNKWV VSAAHCFPRE HSREAYEVKL GAHQLDSYSN DTVVHTVAQI
       130        140        150        160        170        180
ITHSSYREEG SQGDIAFIRL SSPVTFSRYI RPICLPAANA SFPNGLHCTV TGWGHVAPSV
       190        200        210        220        230        240
SLQTPRPLQQ LEVPLISRET CSCLYNINAV PEEPHTIQQD MLCAGYVKGG KDACQGDSGG
       250        260        270        280        290        300
PLSCPMEGIW YLAGIVSWGD ACGAPNRPGV YTLTSTYASW IHHHVAELQP RVVPQTQESQ
       310        320        330        340
PDGHLCNHHP VFSSAAAPKL LRPVLFLPLG LTLGLLSLWL EH

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 1 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
Q9ESD1-30-unknown	ADGTEA...	30	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9ESD1-31-unmodified	DGTEAS...	31		unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
Q9ESD1-33-unknown	TEASCG...	33	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9ESD1-33-unknown	TEASCG...	33	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q9ESD1-45-unknown	ITGGGS...	45	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9ESD1-45-unknown	ITGGGS...	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34799

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VIQPRI	44	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VIQPRI	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34799
...PKLLRP	322	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ST14_MOUSE	44	QPRI.\|.ITGG	inferred from experiment	unknown	MEROPS	List K	Netzel-Arnett S et al.:Evidence for a matriptase-prost... (S01.302)	16980306,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
SCNNG_MOUSE	186	KRKI.\|.ISGK	inferred from experiment	unknown	MEROPS	Kleyman TR	Bruns JB et al.:Epithelial Na+ channels are ful... (S01.159)	17199078,