P20918: Plasminogen

General Information

Protein names	- Plasminogen - 3.4.21.7 - Plasmin heavy chain A - Activation peptide - Angiostatin - Plasmin heavy chain A, short form - Plasmin light chain B
Gene names	Plg
Organism	Mus musculus
Protease Family	S01.233
Protease ID	S01.233
Chromosome location
UniProt ID	P20918

4 N-termini

4 C-termini

1 Cleavages

8 Substrates

Sequence

        10         20         30         40         50         60
MDHKEVILLF LLLLKPGQGD SLDGYISTQG ASLFSLTKKQ LAAGGVSDCL AKCEGETDFV
        70         80         90        100        110        120
CRSFQYHSKE QQCVIMAENS KTSSIIRMRD VILFEKRVYL SECKTGIGNG YRGTMSRTKS
       130        140        150        160        170        180
GVACQKWGAT FPHVPNYSPS THPNEGLEEN YCRNPDNDEQ GPWCYTTDPD KRYDYCNIPE
       190        200        210        220        230        240
CEEECMYCSG EKYEGKISKT MSGLDCQAWD SQSPHAHGYI PAKFPSKNLK MNYCRNPDGE
       250        260        270        280        290        300
PRPWCFTTDP TKRWEYCDIP RCTTPPPPPS PTYQCLKGRG ENYRGTVSVT VSGKTCQRWS
       310        320        330        340        350        360
EQTPHRHNRT PENFPCKNLE ENYCRNPDGE TAPWCYTTDS QLRWEYCEIP SCESSASPDQ
       370        380        390        400        410        420
SDSSVPPEEQ TPVVQECYQS DGQSYRGTSS TTITGKKCQS WAAMFPHRHS KTPENFPDAG
       430        440        450        460        470        480
LEMNYCRNPD GDKGPWCYTT DPSVRWEYCN LKRCSETGGS VVELPTVSQE PSGPSDSETD
       490        500        510        520        530        540
CMYGNGKDYR GKTAVTAAGT PCQGWAAQEP HRHSIFTPQT NPRAGLEKNY CRNPDGDVNG
       550        560        570        580        590        600
PWCYTTNPRK LYDYCDIPLC ASASSFECGK PQVEPKKCPG RVVGGCVANP HSWPWQISLR
       610        620        630        640        650        660
TRFTGQHFCG GTLIAPEWVL TAAHCLEKSS RPEFYKVILG AHEEYIRGLD VQEISVAKLI
       670        680        690        700        710        720
LEPNNRDIAL LKLSRPATIT DKVIPACLPS PNYMVADRTI CYITGWGETQ GTFGAGRLKE
       730        740        750        760        770        780
AQLPVIENKV CNRVEYLNNR VKSTELCAGQ LAGGVDSCQG DSGGPLVCFE KDKYILQGVT
       790        800        810
SWGLGCARPN KPGVYVRVSR FVDWIEREMR NN

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 1 Cleavages - 8 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P20918-20-unknown	DSLDGY...	20	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P20918-98-unknown	VYLSEC...	98	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P20918-98-unknown	VYLSEC...	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32665
P20918-582-unknown	VVGGCV...	582	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P20918-583-unmodified	VGGCVA...	583		unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LFEKRV	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32665
...DKGPWC	436	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KCPGRV	581	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EMRNN	812	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
K1KB9_MOUSE	97	EKRV.\|.VYLS	inferred from experiment	unknown	MEROPS		Merops K1KB9_MOUSE -> PLMN_MOUSE @97

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CCL2_MOUSE	104	LFKT.\|.TASA	inferred from experiment	unknown	MEROPS	Tsirka SE	Sheehan JJ et al.:Proteolytic activation of monoc... (S01.233)	17301181,
UPAR_MOUSE	107	GARG.\|.GRAF	inferred from experiment	unknown	MEROPS	Sidenius N	Andolfo A et al.:Metalloproteases cleave the uro... (S01.131)	12195704,
UPAR-Isoform2_MOUSE	107	GARG.\|.GRAF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC34779
UPAR_MOUSE	109	RGRA.\|.AFPQ	inferred from experiment	unknown	MEROPS	Sidenius N	Andolfo A et al.:Metalloproteases cleave the uro... (S01.131)	12195704,
UPAR-Isoform2_MOUSE	109	RGRA.\|.AFPQ	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC34781
SCNNG_MOUSE	194	IHKA.\|.ASNV	inferred from experiment	unknown	MEROPS	Kleyman TR	Passero CJ et al.:Plasmin activates epithelial Na... (S01.131)	18981180,
NID1_MOUSE	231	LWKS.\|.SNGA	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
NID1_MOUSE	349	RTRS.\|.SFQL	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,