P10148: C-C motif chemokine 2

General Information

Protein names	- C-C motif chemokine 2 - Monocyte chemoattractant protein 1 - Monocyte chemotactic protein 1 - MCP-1 - Platelet-derived growth factor-inducible protein JE - Small-inducible cytokine A2
Gene names	Ccl2
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P10148

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQVPVMLLGL LFTVAGWSIH VLAQPDAVNA PLTCCYSFTS KMIPMSRLES YKRITSSRCP
        70         80         90        100        110        120
KEAVVFVTKL KREVCADPKK EWVQTYIKNL DRNQMRSEPT TLFKTASALR SSAPLNVKLT
       130        140
RKSEANASTT FSTTTSSTSV GVTSVTVN

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P10148-24-Pyrrolidone carboxylic acid	QPDAVN...	24	pyrrolidone carboxylic acid-		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P10148-24-unknown	QPDAVN...	24		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P10148-24-unknown	QPDAVN...	24		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P10148-59-5oxothiomorpholine-3-carboxylic-acid	CPKEAV...	59			N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P10148-105-unknown	TASALR...	105		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34776

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...TTLFKT	104	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34776
	...SVTVN	148	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PLMN_MOUSE	104	LFKT.\|.TASA	inferred from experiment	unknown	MEROPS	Tsirka SE	Sheehan JJ et al.:Proteolytic activation of monoc... (S01.233)	17301181,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)