P10493: Nidogen-1

General Information

Protein names	- Nidogen-1 - NID-1 - Entactin
Gene names	Nid1
Organism	Mus musculus
Protease Family
Protease ID	I63.001
Chromosome location
UniProt ID	P10493

37 N-termini

34 C-termini

36 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLDASGCSWA MWTWALLQLL LLVGPGGCLN RQELFPFGPG QGDLELEAGD DVVSPSLELI
        70         80         90        100        110        120
GELSFYDRTD ITSVYVTTNG IIAMSEPPAT EYHPGTFPPS FGSVAPFLAD LDTTDGLGNV
       130        140        150        160        170        180
YYREDLSPFI IQMAAEYVQR GFPEVSFQPT SVVVVTWESV APYGGPSSSP AEEGKRNTFQ
       190        200        210        220        230        240
AVLASSNSSS YAIFLYPEDG LQFFTTFSKK DESQVPAVVG FSKGLVGFLW KSNGAYNIFA
       250        260        270        280        290        300
NDRESIENLA KSSNAGHQGV WVFEIGSPAT AKGVVSADVN LDLDDDGADY EDEDYDLVTS
       310        320        330        340        350        360
HLGLEDVATP SPSHSPRRGY PDPHNVPRIL SPGYEATERP RGVPTERTRS FQLPAERFPQ
       370        380        390        400        410        420
HHPQVIDVDE VEETGVVFSY NTGSQQTCAN NRHQCSVHAE CRDYATGFCC RCVANYTGNG
       430        440        450        460        470        480
RQCVAEGSPQ RVNGKVKGRI FVGSSQVPVV FENTDLHSYV VMNHGRSYTA ISTIPETVGY
       490        500        510        520        530        540
SLLPLAPIGG IIGWMFAVEQ DGFKNGFSIT GGEFTRQAEV TFLGHPGKLV LKQQFSGIDE
       550        560        570        580        590        600
HGHLTISTEL EGRVPQIPYG ASVHIEPYTE LYHYSSSVIT SSSTREYTVM EPDQDGAAPS
       610        620        630        640        650        660
HTHIYQWRQT ITFQECAHDD ARPALPSTQQ LSVDSVFVLY NKEERILRYA LSNSIGPVRD
       670        680        690        700        710        720
GSPDALQNPC YIGTHGCDSN AACRPGPGTQ FTCECSIGFR GDGQTCYDID ECSEQPSRCG
       730        740        750        760        770        780
NHAVCNNLPG TFRCECVEGY HFSDRGTCVA AEDQRPINYC ETGLHNCDIP QRAQCIYMGG
       790        800        810        820        830        840
SSYTCSCLPG FSGDGRACRD VDECQHSRCH PDAFCYNTPG SFTCQCKPGY QGDGFRCMPG
       850        860        870        880        890        900
EVSKTRCQLE REHILGAAGG ADAQRPTLQG MFVPQCDEYG HYVPTQCHHS TGYCWCVDRD
       910        920        930        940        950        960
GRELEGSRTP PGMRPPCLST VAPPIHQGPV VPTAVIPLPP GTHLLFAQTG KIERLPLERN
       970        980        990       1000       1010       1020
TMKKTEAKAF LHIPAKVIIG LAFDCVDKVV YWTDISEPSI GRASLHGGEP TTIIRQDLGS
      1030       1040       1050       1060       1070       1080
PEGIALDHLG RTIFWTDSQL DRIEVAKMDG TQRRVLFDTG LVNPRGIVTD PVRGNLYWTD
      1090       1100       1110       1120       1130       1140
WNRDNPKIET SHMDGTNRRI LAQDNLGLPN GLTFDAFSSQ LCWVDAGTHR AECLNPAQPG
      1150       1160       1170       1180       1190       1200
RRKVLEGLQY PFAVTSYGKN LYYTDWKTNS VIAMDLAISK EMDTFHPHKQ TRLYGITIAL
      1210       1220       1230       1240
SQCPQGHNYC SVNNGGCTHL CLPTPGSRTC RCPDNTLGVD CIERK

Isoforms

Sequence View

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P10493-29-unknown	LNRQEL...	29	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P10493-63-unknown	LSFYDR...	63	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34433
P10493-111-unknown	LDTTDG...	111	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34418
P10493-120-unknown	VYYRED...	120	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34419
P10493-232-unknown	SNGAYN...	232	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34777
P10493-249-unknown	LAKSSN...	249	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34434
P10493-304-unknown	LEDVAT...	304	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34435
P10493-329-unknown	ILSPGY...	329	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34806
P10493-350-unknown	SFQLPA...	350	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32672
P10493-350-unknown	SFQLPA...	350	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34778
P10493-350-unknown	SFQLPA...	350	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34807
P10493-377-unknown	VFSYNT...	377	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32181
P10493-379-unknown	SYNTGS...	379	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32689
P10493-380-unknown	YNTGSQ...	380	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34420
P10493-666-unknown	LQNPCY...	666	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34436
P10493-776-unknown	IYMGGS...	776	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34437
P10493-776-unknown	IYMGGS...	776	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P10493-776-unknown	IYMGGS...	776	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P10493-837-5oxothiomorpholine-3-carboxylic-acid	CMPGEV...	837		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P10493-925-unknown	IHQGPV...	925	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34421
P10493-979-unknown	IGLAFD...	979	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32182
P10493-980-unknown	GLAFDC...	980	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32183
P10493-1003-unknown	ASLHGG...	1003	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34808
P10493-1005-unknown	LHGGEP...	1005	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34422
P10493-1005-unknown	LHGGEP...	1005	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34438
P10493-1013-unknown	IIRQDL...	1013	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34423
P10493-1018-unknown	LGSPEG...	1018	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33314
P10493-1024-unknown	IALDHL...	1024	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34439
P10493-1032-unknown	TIFWTD...	1032	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34809
P10493-1033-unknown	IFWTDS...	1033	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33315
P10493-1047-unknown	KMDGTQ...	1047	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32184
P10493-1048-unknown	MDGTQR...	1048	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34440
P10493-1055-unmodified	VLFDTG...	1055		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P10493-1056-unknown	LFDTGL...	1056	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32185
P10493-1066-unknown	GIVTDP...	1066	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34810
P10493-1067-unknown	IVTDPV...	1067	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34424
P10493-1077-unknown	YWTDWN...	1077	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33316
P10493-1092-unknown	HMDGTN...	1092	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32186
P10493-1112-unknown	LTFDAF...	1112	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34441
P10493-1121-unknown	LCWVDA...	1121	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33317
P10493-1171-unknown	VIAMDL...	1171	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34425
P10493-1232-5oxothiomorpholine-3-carboxylic-acid	CPDNTL...	1232		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ELIGEL	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34433
...PFLADL	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34418
...DGLGNV	119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34419
...GFLWKS	231	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34777
...ESIENL	248	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34434
...TSHLGL	303	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34435
...HNVPRI	328	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34806
...TERTRS	349	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32672
...TERTRS	349	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34778
...TERTRS	349	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34807
...EETGVV	376	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32181
...TGVVFS	378	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32689
...GVVFSY	379	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34420
...GSPDAL	665	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34436
...QRAQCI	775	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34437
...TVAPPI	924	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34421
...PAKVII	978	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32182
...AKVIIG	979	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32183
...PSIGRA	1002	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34808
...IGRASL	1004	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34422
...IGRASL	1004	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34438
...GEPTTI	1012	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34423
...IIRQDL	1017	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33314
...GSPEGI	1023	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34439
...DHLGRT	1031	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34809
...HLGRTI	1032	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33315
...RIEVAK	1046	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32184
...IEVAKM	1047	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34440
...TQRRVL	1055	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32185
...LVNPRG	1065	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34810
...VNPRGI	1066	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34424
...VRGNLY	1076	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33316
...KIETSH	1091	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32186
...GLPNGL	1111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34441
...AFSSQL	1120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33317
...WKTNSV	1170	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34425
...CIERK	1245	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP7_MOUSE	62	IGEL.\|.LSFY	inferred from experiment	unknown	MEROPS	Senior RM	Sires UI et al.:Degradation of entactin by matr... (M10.008)	8380588,
MMP3_MOUSE	110	LADL.\|.LDTT	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
MMP3_MOUSE	119	LGNV.\|.VYYR	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
PLMN_MOUSE	231	LWKS.\|.SNGA	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
MMP7_MOUSE	248	IENL.\|.LAKS	inferred from experiment	unknown	MEROPS	Murphy G	Mayer U et al.:Sites of nidogen cleavage by pr... (M10.008)	8223643,
MMP7_MOUSE	303	HLGL.\|.LEDV	inferred from experiment	unknown	MEROPS	Murphy G	Mayer U et al.:Sites of nidogen cleavage by pr... (M10.008)	8223643,
THRB_MOUSE	328	VPRI.\|.ILSP	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
KLKB1_MOUSE	349	RTRS.\|.SFQL	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
PLMN_MOUSE	349	RTRS.\|.SFQL	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
THRB_MOUSE	349	RTRS.\|.SFQL	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
ELNE_MOUSE	376	TGVV.\|.VFSY	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
MCPT3_MOUSE	378	VVFS.\|.SYNT	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
MMP3_MOUSE	379	VFSY.\|.YNTG	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
MMP7_MOUSE	665	PDAL.\|.LQNP	inferred from experiment	unknown	MEROPS	Senior RM	Sires UI et al.:Degradation of entactin by matr... (M10.008)	8380588,
MMP7_MOUSE	775	AQCI.\|.IYMG	inferred from experiment	unknown	MEROPS	Senior RM	Sires UI et al.:Degradation of entactin by matr... (M10.008)	8380588,
MMP3_MOUSE	924	APPI.\|.IHQG	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
ELNE_MOUSE	978	KVII.\|.IGLA	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
ELNE_MOUSE	979	VIIG.\|.GLAF	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
THRB_MOUSE	1002	IGRA.\|.ASLH	inferred from experiment	unknown	MEROPS	Senior RM	Sires UI et al.:Degradation of entactin by matr... (S01.217)	8380588,
MMP3_MOUSE	1004	RASL.\|.LHGG	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
MMP7_MOUSE	1004	RASL.\|.LHGG	inferred from experiment	unknown	MEROPS	Murphy G	Mayer U et al.:Sites of nidogen cleavage by pr... (M10.008)	8223643,
MMP3_MOUSE	1012	PTTI.\|.IIRQ	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
MMP2_MOUSE	1017	RQDL.\|.LGSP	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP7_MOUSE	1023	PEGI.\|.IALD	inferred from experiment	unknown	MEROPS	Murphy G	Mayer U et al.:Sites of nidogen cleavage by pr... (M10.008)	8223643,
THRB_MOUSE	1031	LGRT.\|.TIFW	inferred from experiment	unknown	MEROPS	Senior RM	Sires UI et al.:Degradation of entactin by matr... (S01.217)	8380588,
MMP2_MOUSE	1032	GRTI.\|.IFWT	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
ELNE_MOUSE	1046	EVAK.\|.KMDG	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
MMP7_MOUSE	1047	VAKM.\|.MDGT	inferred from experiment	unknown	MEROPS	Murphy G	Mayer U et al.:Sites of nidogen cleavage by pr... (M10.008)	8223643,
ELNE_MOUSE	1055	RRVL.\|.LFDT	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
THRB_MOUSE	1065	NPRG.\|.GIVT	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
MMP3_MOUSE	1066	PRGI.\|.IVTD	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
MMP2_MOUSE	1076	GNLY.\|.YWTD	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
ELNE_MOUSE	1091	ETSH.\|.HMDG	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
MMP7_MOUSE	1111	PNGL.\|.LTFD	inferred from experiment	unknown	MEROPS	Murphy G	Mayer U et al.:Sites of nidogen cleavage by pr... (M10.008)	8223643,
MMP2_MOUSE	1120	SSQL.\|.LCWV	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP3_MOUSE	1170	TNSV.\|.VIAM	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,

TopFIND

P10493: Nidogen-1

General Information

37

N-termini

34

C-termini

36

Cleavages

0

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

37 N-termini - 34 C-termini - 36 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates