P19221: Prothrombin

General Information

Protein names	- Prothrombin - 3.4.21.5 - Coagulation factor II - Activation peptide fragment 1 - Activation peptide fragment 2 - Thrombin light chain - Thrombin heavy chain
Gene names	F2
Organism	Mus musculus
Protease Family	S01.217
Protease ID	S01.217
Chromosome location
UniProt ID	P19221

7 N-termini

5 C-termini

4 Cleavages

6 Substrates

Sequence

        10         20         30         40         50         60
MSHVRGLGLP GCLALAALVS LVHSQHVFLA PQQALSLLQR VRRANSGFLE ELRKGNLERE
        70         80         90        100        110        120
CVEEQCSYEE AFEALESPQD TDVFWAKYTV CDSVRKPRET FMDCLEGRCA MDLGVNYLGT
       130        140        150        160        170        180
VNVTHTGIQC QLWRSRYPHK PEINSTTHPG ADLKENFCRN PDSSTTGPWC YTTDPTVRRE
       190        200        210        220        230        240
ECSVPVCGQE GRTTVVMTPR SGGSKDNLSP PLGQCLTERG RLYQGNLAVT TLGSPCLPWN
       250        260        270        280        290        300
SLPAKTLSKY QDFDPEVKLV ENFCRNPDWD EEGAWCYVAG QPGDFEYCNL NYCEEAVGEE
       310        320        330        340        350        360
NYDVDESIAG RTTDAEFHTF FNEKTFGLGE ADCGLRPLFE KKSLKDTTEK ELLDSYIDGR
       370        380        390        400        410        420
IVEGWDAEKG IAPWQVMLFR KSPQELLCGA SLISDRWVLT AAHCILYPPW DKNFTENDLL
       430        440        450        460        470        480
VRIGKHSRTR YERNVEKISM LEKIYVHPRY NWRENLDRDI ALLKLKKPVP FSDYIHPVCL
       490        500        510        520        530        540
PDKQTVTSLL RAGYKGRVTG WGNLRETWTT NINEIQPSVL QVVNLPIVER PVCKASTRIR
       550        560        570        580        590        600
ITDNMFCAGF KVNDTKRGDA CEGDSGGPFV MKSPFNNRWY QMGIVSWGEG CDRKGKYGFY
       610
THVFRLKRWI QKVIDQFG

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 5 C-termini - 4 Cleavages - 6 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P19221-25-unknown	QHVFLA...	25	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P19221-44-unknown	ANSGFL...	44	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P19221-109-unknown	CAMDLG...	109	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32193
P19221-201-unknown	SGGSKD...	201	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34811
P19221-325-unknown	TFGLGE...	325	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P19221-325-unknown	TFGLGE...	325	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32194
P19221-361-unknown	IVEGWD...	361	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P19221-361-unknown	IVEGWD...	361	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32195
P19221-361-unmodified	IVEGWD...	361		unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CLEGRC	108	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32193
...VMTPRS	200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34811
...FFNEKT	324	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32194
...YIDGRI	360	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...YIDGRI	360	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32195
...IDQFG	618	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
FA10_MOUSE	108	EGRC.\|.CAMD	inferred from experiment	unknown	MEROPS	Engh RA	Brandstetter H et al.:X-ray structure of active site-... (S01.216)	8939944,
THRB_MOUSE	200	TPRS.\|.SGGS	inferred from experiment	unknown	MEROPS		Merops THRB_MOUSE -> THRB_MOUSE @200
FA10_MOUSE	324	NEKT.\|.TFGL	inferred from experiment	unknown	MEROPS		Merops FA10_MOUSE -> THRB_MOUSE @324
FA10_MOUSE	360	DGRI.\|.IVEG	inferred from experiment	unknown	MEROPS		Merops FA10_MOUSE -> THRB_MOUSE @360

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
THRB_MOUSE	200	TPRS.\|.SGGS	inferred from experiment	unknown	MEROPS		Merops THRB_MOUSE -> THRB_MOUSE @200
NID1_MOUSE	328	VPRI.\|.ILSP	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
NID1_MOUSE	349	RTRS.\|.SFQL	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,
NID1_MOUSE	1002	IGRA.\|.ASLH	inferred from experiment	unknown	MEROPS	Senior RM	Sires UI et al.:Degradation of entactin by matr... (S01.217)	8380588,
NID1_MOUSE	1031	LGRT.\|.TIFW	inferred from experiment	unknown	MEROPS	Senior RM	Sires UI et al.:Degradation of entactin by matr... (S01.217)	8380588,
NID1_MOUSE	1065	NPRG.\|.GIVT	inferred from experiment	unknown	MEROPS	Shah SV	Walker PD et al.:Meprin A, the major matrix degr... (S01.131)	9607199,