O88839: Disintegrin and metalloproteinase domain-containing protein 15

General Information

Protein names	- Disintegrin and metalloproteinase domain-containing protein 15 - ADAM 15 - 3.4.24.- - AD56 - Metalloprotease RGD disintegrin protein - Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15 - MDC-15 - Metargidin
Gene names	Adam15
Organism	Mus musculus
Protease Family
Protease ID	M12.215
Chromosome location
UniProt ID	O88839

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Disintegrin and metalloproteinase domain-containing protein 15 - Isoform 3 of Disintegrin and metalloproteinase domain-containing protein 15 - Isoform 4 of Disintegrin and metalloproteinase domain-containing protein 15

Sequence View

        10         20         30         40         50         60
MRLALLWALG LLGAGSPRPS PPLPNIGGTE EEQQASPERT LSGSMESRVV QDSPPMSLAD
        70         80         90        100        110        120
VLQTGLPEAL RISLELDSES HVLELLQNRD LIPGRPTLVW YQPDGTRMVS EGYSLENCCY
       130        140        150        160        170        180
RGRVQGHPSS WVSLCACSGI RGLIVLSPER GYTLELGPGD LQRPVISRIQ DHLLLGHTCA
       190        200        210        220        230        240
PSWHASVPTR AGPDLLLEQH HAHRLKRDVV TETKIVELVI VADNSEVRKY PDFQQLLNRT
       250        260        270        280        290        300
LEAALLLDTF FQPLNVRVAL VGLEAWTQHN LIEMSSNPAV LLDNFLRWRR TDLLPRLPHD
       310        320        330        340        350        360
SAQLVTVTSF SGPMVGMAIQ NSICSPDFSG GVNMDHSTSI LGVASSIAHE LGHSLGLDHD
       370        380        390        400        410        420
SPGHSCPCPG PAPAKSCIME ASTDFLPGLN FSNCSRQALE KALLEGMGSC LFERQPSLAP
       430        440        450        460        470        480
MSSLCGNMFV DPGEQCDCGF PDECTDPCCD HFTCQLRPGA QCASDGPCCQ NCKLHPAGWL
       490        500        510        520        530        540
CRPPTDDCDL PEFCPGDSSQ CPSDIRLGDG EPCASGEAVC MHGRCASYAR QCQSLWGPGA
       550        560        570        580        590        600
QPAAPLCLQT ANTRGNAFGS CGRSPGGSYM PCAPRDVMCG QLQCQWGRSQ PLLGSVQDRL
       610        620        630        640        650        660
SEVLEANGTQ LNCSWVDLDL GNDVAQPLLA LPGTACGPGL VCIGHRCQPV DLLGAQECRR
       670        680        690        700        710        720
KCHGHGVCDS SGHCRCEEGW APPDCMTQLK ATSSLTTGLL LSLLLLLVLV LLGASYWHRA
       730        740        750        760        770        780
RLHQRLCQLK GSSCQYRAPQ SCPPERPGPP QRAQQMTGTK QASVVSFPVP PSRPLPPNPV
       790        800        810        820        830        840
PKKLQAALAD RSNPPTRPLP ADPVVRRPKS QGPTKPPPPR KPLPANPQGQ HPPGDLPGPG
       850        860
DGSLPLVVPS RPAPPPPAAS SLYL         10         20         30         40         50         60
MRLALLWALG LLGAGSPRPS PPLPNIGGTE EEQQASPERT LSGSMESRVV QDSPPMSLAD
        70         80         90        100        110        120
VLQTGLPEAL RISLELDSES HVLELLQNRD LIPGRPTLVW YQPDGTRMVS EGYSLENCCY
       130        140        150        160        170        180
RGRVQGHPSS WVSLCACSGI RGLIVLSPER GYTLELGPGD LQRPVISRIQ DHLLLGHTCA
       190        200        210        220        230        240
PSWHASVPTR AGPDLLLEQH HAHRLKRDVV TETKIVELVI VADNSEVRKY PDFQQLLNRT
       250        260        270        280        290        300
LEAALLLDTF FQPLNVRVAL VGLEAWTQHN LIEMSSNPAV LLDNFLRWRR TDLLPRLPHD
       310        320        330        340        350        360
SAQLVTVTSF SGPMVGMAIQ NSICSPDFSG GVNMDHSTSI LGVASSIAHE LGHSLGLDHD
       370        380        390        400        410        420
SPGHSCPCPG PAPAKSCIME ASTDFLPGLN FSNCSRQALE KALLEGMGSC LFERQPSLAP
       430        440        450        460        470        480
MSSLCGNMFV DPGEQCDCGF PDECTDPCCD HFTCQLRPGA QCASDGPCCQ NCKLHPAGWL
       490        500        510        520        530        540
CRPPTDDCDL PEFCPGDSSQ CPSDIRLGDG EPCASGEAVC MHGRCASYAR QCQSLWGPGA
       550        560        570        580        590        600
QPAAPLCLQT ANTRGNAFGS CGRSPGGSYM PCAPRDVMCG QLQCQWGRSQ PLLGSVQDRL
       610        620        630        640        650        660
SEVLEANGTQ LNCSWVDLDL GNDVAQPLLA LPGTACGPGL VCIGHRCQPV DLLGAQECRR
       670        680        690        700        710        720
KCHGHGVCDS SGHCRCEEGW APPDCMTQLK ATSSLTTGLL LSLLLLLVLV LLGASYWHRA
       730        740        750        760        770        780
RLHQRLCQLK GSSCQYRAPQ SCPPERPGPP QRAQQMTGTK QASVVSFPVP PSRPLPPNPV
       790        800        810        820        830        840
PKKLQAALAD RSNPPTRPLP ADPVVRRPKS QGPTKPPPPR KPLPANPQGQ HPPGDLPGPG
       850        860
DGSLPLVVPS RPAPPPPAAS SLYL         10         20         30         40         50         60
MRLALLWALG LLGAGSPRPS PPLPNIGGTE EEQQASPERT LSGSMESRVV QDSPPMSLAD
        70         80         90        100        110        120
VLQTGLPEAL RISLELDSES HVLELLQNRD LIPGRPTLVW YQPDGTRMVS EGYSLENCCY
       130        140        150        160        170        180
RGRVQGHPSS WVSLCACSGI RGLIVLSPER GYTLELGPGD LQRPVISRIQ DHLLLGHTCA
       190        200        210        220        230        240
PSWHASVPTR AGPDLLLEQH HAHRLKRDVV TETKIVELVI VADNSEVRKY PDFQQLLNRT
       250        260        270        280        290        300
LEAALLLDTF FQPLNVRVAL VGLEAWTQHN LIEMSSNPAV LLDNFLRWRR TDLLPRLPHD
       310        320        330        340        350        360
SAQLVTVTSF SGPMVGMAIQ NSICSPDFSG GVNMDHSTSI LGVASSIAHE LGHSLGLDHD
       370        380        390        400        410        420
SPGHSCPCPG PAPAKSCIME ASTDFLPGLN FSNCSRQALE KALLEGMGSC LFERQPSLAP
       430        440        450        460        470        480
MSSLCGNMFV DPGEQCDCGF PDECTDPCCD HFTCQLRPGA QCASDGPCCQ NCKLHPAGWL
       490        500        510        520        530        540
CRPPTDDCDL PEFCPGDSSQ CPSDIRLGDG EPCASGEAVC MHGRCASYAR QCQSLWGPGA
       550        560        570        580        590        600
QPAAPLCLQT ANTRGNAFGS CGRSPGGSYM PCAPRDVMCG QLQCQWGRSQ PLLGSVQDRL
       610        620        630        640        650        660
SEVLEANGTQ LNCSWVDLDL GNDVAQPLLA LPGTACGPGL VCIGHRCQPV DLLGAQECRR
       670        680        690        700        710        720
KCHGHGVCDS SGHCRCEEGW APPDCMTQLK ATSSLTTGLL LSLLLLLVLV LLGASYWHRA
       730        740        750        760        770        780
RLHQRLCQLK GSSCQYRAPQ SCPPERPGPP QRAQQMTGTK QASVVSFPVP PSRPLPPNPV
       790        800        810        820        830        840
PKKLQAALAD RSNPPTRPLP ADPVVRRPKS QGPTKPPPPR KPLPANPQGQ HPPGDLPGPG
       850        860
DGSLPLVVPS RPAPPPPAAS SLYL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O88839-1-unknown	MRLALL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66265
O88839-1-unknown	MRLALL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66266
O88839-1-unknown	MRLALL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66267
O88839-18-unknown	RPSPPL...	18	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O88839-18-unknown	RPSPPL...	18	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111963
O88839-18-unknown	RPSPPL...	18	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111964
O88839-18-unknown	RPSPPL...	18	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111965
O88839-208-unknown	DVVTET...	208	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O88839-208-unknown	DVVTET...	208	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32198
O88839-208-unknown	DVVTET...	208	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116034
O88839-208-unknown	DVVTET...	208	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116035
O88839-208-unknown	DVVTET...	208	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116036

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HRLKRD	207	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32198
...HRLKRD	207	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130186
...HRLKRD	207	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130187
...HRLKRD	207	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130188
...SSLYL	864	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SSLYL	864	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61885
...SSLYL	864	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61884
...SSLYL	864	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61883

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
FURIN_MOUSE	207	LKRD.\|.DVVT	inferred from experiment	unknown	MEROPS	Blobel CP	Lum L et al.:Intracellular maturation of the... (S08.071)	9748307,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)