P58459: A disintegrin and metalloproteinase with thrombospondin motifs 10

General Information

Protein names	- A disintegrin and metalloproteinase with thrombospondin motifs 10 - ADAM-TS 10 - ADAM-TS10 - ADAMTS-10 - 3.4.24.-
Gene names	Adamts10
Organism	Mus musculus
Protease Family
Protease ID	M12.235
Chromosome location
UniProt ID	P58459

5 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of A disintegrin and metalloproteinase with thrombospondin motifs 10 - Isoform 3 of A disintegrin and metalloproteinase with thrombospondin motifs 10

Sequence View

        10         20         30         40         50         60
MASACQILRW ALALGLGLTF KVTHAFRSQD ELLSSLESYE IAFPTRVDHN GAMLAFSPPA
        70         80         90        100        110        120
FRRQRRGAGA TTESRLFYKV AAPSTHFLLN LTRSPRLLAG HVSVEYWTRE GLAWQRAARA
       130        140        150        160        170        180
HCLYAGHLQG QAGSSHVAVS TCGGLHGLIV ADDEEYLIEP LQGGPKGHRG PEESGPHVVY
       190        200        210        220        230        240
KRSSLRHPHL DTACGVRDEK PWKGRPWWLR TLKPPPARPL GNESERGQLG LKRSVSRERY
       250        260        270        280        290        300
VETLVVADKM MVAYHGRRDV EQYVLAIMNI VAKLFQDSSL GNIVNILVTR LILLTEDQPT
       310        320        330        340        350        360
LEITHHAGKS LDSFCKWQKS IVSHSGHGNA IPENGVANHD TAVLITRYDI CIYKNKPCGT
       370        380        390        400        410        420
LGLAPVGGMC ERERSCSINE DIGLATAFTI AHEIGHTFGM NHDGVGNGCG ARGQDPAKLM
       430        440        450        460        470        480
AAHITMKTNP FVWSSCSRDY ITSFLDSGLG LCLNNRPPRQ DFVYPTVAPG QAYDADEQCR
       490        500        510        520        530        540
FQHGVKSRQC KYGEVCSELW CLSKSNRCIT NSIPAAEGTL CQTHTIDKGW CYKRVCVPFG
       550        560        570        580        590        600
SRPEGVDGAW GPWTPWGDCS RSCGGGVSSS SRHCDSPRPT IGGKYCLGER RRHRSCNTND
       610        620        630        640        650        660
CPPGSQDFRE MQCSEFDSVP FRGKFYTWKT YRGGGVKACS LTCLAEGFNF YTERAAAVVD
       670        680        690        700        710        720
GTPCRPDTVD ICVSGECKHV GCDRVLGSDL REDKCRVCGG DGSACETIEG VFSPALPGTG
       730        740        750        760        770        780
YEDVVWIPKG SVHIFIQDLN LSLSHLALKG DQESLLLEGL PGTPQPHRLP LAGTTFHLRQ
       790        800        810        820        830        840
GPDQAQSLEA LGPINASLII MVLAQAELPA LHYRFNAPIA RDALPPYSWH YAPWTKCSAQ
       850        860        870        880        890        900
CAGGSQVQVV ECRNQLDSSA VAPHYCSGHS KLPKRQRACN TEPCPPDWVV GNWSRCSRSC
       910        920        930        940        950        960
DAGVRSRSVV CQRRVSAAEE KALDDSACPQ PRPPVLEACQ GPMCPPEWAT LDWSECTPSC
       970        980        990       1000       1010       1020
GPGLRHRVVL CKSADQRSTL PPGHCLPAAK PPSTMRCNLR RCPPARWVTS EWGECSTQCG
      1030       1040       1050       1060       1070       1080
LGQQQRTVRC TSHTGQPSRE CTEALRPSTM QQCEAKCDSV VPPGDGPEEC KDVNKVAYCP
      1090       1100
LVLKFQFCSR AYFRQMCCKT CQGR         10         20         30         40         50         60
MASACQILRW ALALGLGLTF KVTHAFRSQD ELLSSLESYE IAFPTRVDHN GAMLAFSPPA
        70         80         90        100        110        120
FRRQRRGAGA TTESRLFYKV AAPSTHFLLN LTRSPRLLAG HVSVEYWTRE GLAWQRAARA
       130        140        150        160        170        180
HCLYAGHLQG QAGSSHVAVS TCGGLHGLIV ADDEEYLIEP LQGGPKGHRG PEESGPHVVY
       190        200        210        220        230        240
KRSSLRHPHL DTACGVRDEK PWKGRPWWLR TLKPPPARPL GNESERGQLG LKRSVSRERY
       250        260        270        280        290        300
VETLVVADKM MVAYHGRRDV EQYVLAIMNI VAKLFQDSSL GNIVNILVTR LILLTEDQPT
       310        320        330        340        350        360
LEITHHAGKS LDSFCKWQKS IVSHSGHGNA IPENGVANHD TAVLITRYDI CIYKNKPCGT
       370        380        390        400        410        420
LGLAPVGGMC ERERSCSINE DIGLATAFTI AHEIGHTFGM NHDGVGNGCG ARGQDPAKLM
       430        440        450        460        470        480
AAHITMKTNP FVWSSCSRDY ITSFLDSGLG LCLNNRPPRQ DFVYPTVAPG QAYDADEQCR
       490        500        510        520        530        540
FQHGVKSRQC KYGEVCSELW CLSKSNRCIT NSIPAAEGTL CQTHTIDKGW CYKRVCVPFG
       550        560        570        580        590        600
SRPEGVDGAW GPWTPWGDCS RSCGGGVSSS SRHCDSPRPT IGGKYCLGER RRHRSCNTND
       610        620        630        640        650        660
CPPGSQDFRE MQCSEFDSVP FRGKFYTWKT YRGGGVKACS LTCLAEGFNF YTERAAAVVD
       670        680        690        700        710        720
GTPCRPDTVD ICVSGECKHV GCDRVLGSDL REDKCRVCGG DGSACETIEG VFSPALPGTG
       730        740        750        760        770        780
YEDVVWIPKG SVHIFIQDLN LSLSHLALKG DQESLLLEGL PGTPQPHRLP LAGTTFHLRQ
       790        800        810        820        830        840
GPDQAQSLEA LGPINASLII MVLAQAELPA LHYRFNAPIA RDALPPYSWH YAPWTKCSAQ
       850        860        870        880        890        900
CAGGSQVQVV ECRNQLDSSA VAPHYCSGHS KLPKRQRACN TEPCPPDWVV GNWSRCSRSC
       910        920        930        940        950        960
DAGVRSRSVV CQRRVSAAEE KALDDSACPQ PRPPVLEACQ GPMCPPEWAT LDWSECTPSC
       970        980        990       1000       1010       1020
GPGLRHRVVL CKSADQRSTL PPGHCLPAAK PPSTMRCNLR RCPPARWVTS EWGECSTQCG
      1030       1040       1050       1060       1070       1080
LGQQQRTVRC TSHTGQPSRE CTEALRPSTM QQCEAKCDSV VPPGDGPEEC KDVNKVAYCP
      1090       1100
LVLKFQFCSR AYFRQMCCKT CQGR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P58459-1-unknown	MASACQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67966
P58459-1-unknown	MASACQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67967
P58459-26-unknown	FRSQDE...	26	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P58459-26-unknown	FRSQDE...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114026
P58459-26-unknown	FRSQDE...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114027
P58459-67-unknown	GAGATT...	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32210
P58459-67-unknown	GAGATT...	67	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140463
P58459-97-unknown	LLAGHV...	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32213
P58459-97-unknown	LLAGHV...	97	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142260
P58459-234-unknown	SVSRER...	234	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P58459-234-unknown	SVSRER...	234	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32215
P58459-234-unknown	SVSRER...	234	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116084
P58459-234-unknown	SVSRER...	234	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RRQRRG	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32210
...RRQRRG	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123589
...RRQRRG	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123590
...TRSPRL	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32213
...TRSPRL	96	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125449
...LGLKRS	233	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32215
...LGLKRS	233	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128765
...TCQGR	1104	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
FURIN_MOUSE	66	QRRG.\|.GAGA	inferred from experiment	unknown	MEROPS	Apte SS	Somerville RP et al.:Discovery and characterization ... (S08.071)	15355968,
FURIN_MOUSE	96	SPRL.\|.LLAG	inferred from experiment	unknown	MEROPS	Apte SS	Somerville RP et al.:Discovery and characterization ... (S08.071)	15355968,
FURIN_MOUSE	233	LKRS.\|.SVSR	inferred from experiment	unknown	MEROPS	Apte SS	Somerville RP et al.:Discovery and characterization ... (S08.071)	15355968,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)