P56818: Beta-secretase 1 {ECO:0000305}
| Protein names | - Beta-secretase 1 {ECO:0000305} - 3.4.23.46 - Aspartyl protease 2 - ASP2 - Asp 2 - Beta-site amyloid precursor protein cleaving enzyme 1 - Beta-site APP cleaving enzyme 1 - Memapsin-2 - Membrane-associated aspartic protease 2 |
|---|---|
| Gene names | Bace1 |
| Organism | Mus musculus |
| Protease Family | A01.004 |
| Protease ID | A01.004 |
| Chromosome location | |
| UniProt ID | P56818 |
2
N-termini
2
C-termini
1
Cleavages
6
Substrates
Sequence
10 20 30 40 50 60
MAPALHWLLL WVGSGMLPAQ GTHLGIRLPL RSGLAGPPLG LRLPRETDEE SEEPGRRGSF
70 80 90 100 110 120
VEMVDNLRGK SGQGYYVEMT VGSPPQTLNI LVDTGSSNFA VGAAPHPFLH RYYQRQLSST
130 140 150 160 170 180
YRDLRKGVYV PYTQGKWEGE LGTDLVSIPH GPNVTVRANI AAITESDKFF INGSNWEGIL
190 200 210 220 230 240
GLAYAEIARP DDSLEPFFDS LVKQTHIPNI FSLQLCGAGF PLNQTEALAS VGGSMIIGGI
250 260 270 280 290 300
DHSLYTGSLW YTPIRREWYY EVIIVRVEIN GQDLKMDCKE YNYDKSIVDS GTTNLRLPKK
310 320 330 340 350 360
VFEAAVKSIK AASSTEKFPD GFWLGEQLVC WQAGTTPWNI FPVISLYLMG EVTNQSFRIT
370 380 390 400 410 420
ILPQQYLRPV EDVATSQDDC YKFAVSQSST GTVMGAVIME GFYVVFDRAR KRIGFAVSAC
430 440 450 460 470 480
HVHDEFRTAA VEGPFVTADM EDCGYNIPQT DESTLMTIAY VMAAICALFM LPLCLMVCQW
490 500
RCLRCLRHQH DDFADDISLL K
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
2 N-termini - 2 C-termini - 1 Cleavages - 6 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| P56818-22-unknown | THLGIR... | 22 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P56818-46-unknown | ETDEES... | 46 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P56818-46-unknown | ETDEES... | 46 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32209 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...LRLPRE | 45 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32209 | |||
| ...ISLLK | 501 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| FURIN_MOUSE | 45 | LPRE.|.ETDE | inferred from experiment | unknown | MEROPS | De Strooper B | Creemers JW et al.:Processing of beta-secretase by... (S08.071) | 11071887, |