Q61180: Amiloride-sensitive sodium channel subunit alpha
| Protein names | - Amiloride-sensitive sodium channel subunit alpha - Alpha-NaCH - Epithelial Na(+) channel subunit alpha - Alpha-ENaC - Nonvoltage-gated sodium channel 1 subunit alpha - SCNEA |
|---|---|
| Gene names | Scnn1a |
| Organism | Mus musculus |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q61180 |
3
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MLDHTRAPEL NLDLDLDVSN SPKGSMKGNN FKEQDLCPPL PMQGLGKGDK REEQALGPEP
70 80 90 100 110 120
SEPRQPTEEE EALIEFHRSY RELFQFFCNN TTIHGAIRLV CSKHNRMKTA FWAVLWLCTF
130 140 150 160 170 180
GMMYWQFALL FEEYFSYPVS LNINLNSDKL VFPAVTVCTL NPYRYTEIKE DLEELDRITE
190 200 210 220 230 240
QTLFDLYKYN SSYTRQAGGR RRSTRDLRGA LPHPLQRLRT PPPPNPARSA RSASSSVRDN
250 260 270 280 290 300
NPQVDRKDWK IGFQLCNQNK SDCFYQTYSS GVDAVREWYR FHYINILSRL PDTSPALEEE
310 320 330 340 350 360
ALGSFIFTCR FNQAPCNQAN YSQFHHPMYG NCYTFNNKNN SNLWMSSMPG VNNGLSLTLR
370 380 390 400 410 420
TEQNDFIPLL STVTGARVMV HGQDEPAFMD DGGFNVRPGV ETSISMRKEA LDSLGGNYGD
430 440 450 460 470 480
CTENGSDVPV KNLYPSKYTQ QVCIHSCFQE NMIKKCGCAY IFYPKPKGVE FCDYLKQSSW
490 500 510 520 530 540
GYCYYKLQAA FSLDSLGCFS KCRKPCSVTN YKLSAGYSRW PSVKSQDWIF EMLSLQNNYT
550 560 570 580 590 600
INNKRNGVAK LNIFFKELNY KTNSESPSVT MVSLLSNLGS QWSLWFGSSV LSVVEMAELI
610 620 630 640 650 660
FDLLVITLIM LLHRFRSRYW SPGRGARGAR EVASTPASSF PSRFCPHPTS PPPSLPQQGT
670 680 690
TPPLALTAPP PAYATLGPSA SPLDSAVPGS SACAPAMAL
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
3 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q61180-1-unknown | MLDHTR... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q61180-206-unknown | DLRGAL... | 206 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32224 | |||
| Q61180-232-unknown | SASSSV... | 232 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32225 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...RRSTRD | 205 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32224 | |||
| ...ARSARS | 231 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32225 | |||
| ...PAMAL | 699 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| FURIN_MOUSE | 205 | STRD.|.DLRG | inferred from experiment | unknown | MEROPS | Kleyman TR | Hughey RP et al.:Distinct pools of epithelial so... (S08.071) | 15466477, |
| FURIN_MOUSE | 231 | SARS.|.SASS | inferred from experiment | unknown | MEROPS | Kleyman TR | Hughey RP et al.:Distinct pools of epithelial so... (S08.071) | 15466477, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|