Q3U435: Matrix metalloproteinase-25
| Protein names | - Matrix metalloproteinase-25 - MMP-25 - 3.4.24.- |
|---|---|
| Gene names | Mmp25 |
| Organism | Mus musculus |
| Protease Family | M10.024 |
| Protease ID | M10.024 |
| Chromosome location | |
| UniProt ID | Q3U435 |
1
N-termini
2
C-termini
2
Cleavages
73
Substrates
Sequence
10 20 30 40 50 60
MCFPGSQISP ARLYYLVSAP WICTGSLTSS RLPRRRESGP LRVPPRSVQA ERILRLPAFG
70 80 90 100 110 120
LPLLALLLVP LLPVRAQNPD AKVVSMGVEW LTRYGYLPPA DPVHAQMQSL EKLQDAIKVM
130 140 150 160 170 180
QRFAGLPETG QMDPMTIKTM RKPRCSLPDV LGAAGLVRRR RRYSLSGSVW KKRTLTWSIR
190 200 210 220 230 240
SFSQKSQLSP QIVRTLLSYA LAVWATESGL TFQEVNSQYQ EPDIIIHFAR AYHQDSYPFD
250 260 270 280 290 300
GSGGTLAHAF FPGEHPISGD THFDDEETWT FGSTDDNGID LFAVAVHEFG HALGLGHSSA
310 320 330 340 350 360
PNSIMRPFYQ GPVGDPATYR LPQDDRDGLQ QLYGRVSQNP NARPTRKPLV PPPQPPAMPP
370 380 390 400 410 420
DSPATPVPDR CEGNFDAVAN IRGEIFLFKG PWFWRLQPSG QLVSPRPAGL HRFWEGLPTH
430 440 450 460 470 480
VKVIQAAYAR PLDGRIILFS GPQFWVFQER QLEGAARPLV EFGLPPGEDV DAVFSWPHNG
490 500 510 520 530 540
KTYLIRGQKY WRYDEVAARP DPGYPRALSL WDGAPFAPDD VTISNTGDTY FFKGTHFWRF
550 560 570 580 590 600
AEGSVKAESD SPQPIGPKWL DCPAPNSDPR VTSPPKTTSK TRSCDCHCEL NQASEQLSPL
610
LLPLLPLVAG EVFSY
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
1 N-termini - 2 C-termini - 2 Cleavages - 73 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q3U435-163-unknown | YSLSGS... | 163 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q3U435-163-unknown | YSLSGS... | 163 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34732 | |||
| Q3U435-163-unknown | YSLSGS... | 163 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32222 | |||
| Q3U435-163-unknown | YSLSGS... | 163 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...RRRRRY | 162 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34732 | |||
| ...RRRRRY | 162 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32222 | |||
| ...ELNQAS | 593 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| NEC2_MOUSE | 162 | RRRY.|.YSLS | inferred from experiment | unknown | MEROPS | Strongin AY | Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) | 18505722, |
| FURIN_MOUSE | 162 | RRRY.|.YSLS | inferred from experiment | unknown | MEROPS | Strongin AY | Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) | 18505722, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| MBP-Isoform9_MOUSE | 11 | QRSK.|.KYLA | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33068 | ||
| MBP-Isoform8_MOUSE | 11 | QRSK.|.KYLA | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33068 | ||
| MBP-Isoform7_MOUSE | 11 | QRSK.|.KYLA | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33068 | ||
| MBP-Isoform6_MOUSE | 11 | QRSK.|.KYLA | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33068 | ||
| MBP-Isoform5_MOUSE | 11 | QRSK.|.KYLA | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33068 | ||
| MBP-Isoform4_MOUSE | 11 | QRSK.|.KYLA | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33068 | ||
| MBP-Isoform14_MOUSE | 11 | QRSK.|.KYLA | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33068 | ||
| MBP-Isoform13_MOUSE | 11 | QRSK.|.KYLA | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33068 | ||
| MBP-Isoform11_MOUSE | 11 | QRSK.|.KYLA | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33068 | ||
| MBP-Isoform10_MOUSE | 11 | QRSK.|.KYLA | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33068 | ||
| MBP-Isoform9_MOUSE | 25 | ARHG.|.GFLP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33080 | ||
| MBP-Isoform8_MOUSE | 25 | ARHG.|.GFLP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33080 | ||
| MBP-Isoform7_MOUSE | 25 | ARHG.|.GFLP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33080 | ||
| MBP-Isoform6_MOUSE | 25 | ARHG.|.GFLP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33080 | ||
| MBP-Isoform5_MOUSE | 25 | ARHG.|.GFLP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33080 | ||
| MBP-Isoform4_MOUSE | 25 | ARHG.|.GFLP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33080 | ||
| MBP-Isoform14_MOUSE | 25 | ARHG.|.GFLP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33080 | ||
| MBP-Isoform13_MOUSE | 25 | ARHG.|.GFLP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33080 | ||
| MBP-Isoform11_MOUSE | 25 | ARHG.|.GFLP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33080 | ||
| MBP-Isoform10_MOUSE | 25 | ARHG.|.GFLP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33080 | ||
| MBP_MOUSE | 34 | VGKL.|.LSQT | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) | 19300513, |
| MBP-Isoform3_MOUSE | 34 | VGKL.|.LSQT | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33055 | ||
| MBP-Isoform2_MOUSE | 34 | VGKL.|.LSQT | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33055 | ||
| MBP-Isoform8_MOUSE | 70 | SLPQ.|.QKSQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33092 | ||
| MBP-Isoform7_MOUSE | 70 | SLPQ.|.QKSQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33092 | ||
| MBP-Isoform5_MOUSE | 70 | SLPQ.|.QKSQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33092 | ||
| MBP-Isoform14_MOUSE | 70 | SLPQ.|.QKSQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33092 | ||
| MBP-Isoform10_MOUSE | 70 | SLPQ.|.QKSQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33092 | ||
| MBP-Isoform8_MOUSE | 72 | PQKS.|.SQHG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33103 | ||
| MBP-Isoform7_MOUSE | 72 | PQKS.|.SQHG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33103 | ||
| MBP-Isoform5_MOUSE | 72 | PQKS.|.SQHG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33103 | ||
| MBP-Isoform14_MOUSE | 72 | PQKS.|.SQHG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33103 | ||
| MBP-Isoform10_MOUSE | 72 | PQKS.|.SQHG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33103 | ||
| MBP-Isoform2_MOUSE | 75 | PKNN.|.NWQG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33058 | ||
| MBP_MOUSE | 75 | PKNN.|.NWQG | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) | 19300513, |
| MBP-Isoform8_MOUSE | 75 | SQHG.|.GRTQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33114 | ||
| MBP-Isoform7_MOUSE | 75 | SQHG.|.GRTQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33114 | ||
| MBP-Isoform5_MOUSE | 75 | SQHG.|.GRTQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33114 | ||
| MBP-Isoform14_MOUSE | 75 | SQHG.|.GRTQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33114 | ||
| MBP-Isoform10_MOUSE | 75 | SQHG.|.GRTQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33114 | ||
| MBP-Isoform9_MOUSE | 96 | SLPQ.|.QKSQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33092 | ||
| MBP-Isoform6_MOUSE | 96 | SLPQ.|.QKSQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33092 | ||
| MBP-Isoform4_MOUSE | 96 | SLPQ.|.QKSQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33092 | ||
| MBP-Isoform13_MOUSE | 96 | SLPQ.|.QKSQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33092 | ||
| MBP-Isoform11_MOUSE | 96 | SLPQ.|.QKSQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33092 | ||
| MBP-Isoform9_MOUSE | 98 | PQKS.|.SQHG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33103 | ||
| MBP-Isoform6_MOUSE | 98 | PQKS.|.SQHG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33103 | ||
| MBP-Isoform4_MOUSE | 98 | PQKS.|.SQHG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33103 | ||
| MBP-Isoform13_MOUSE | 98 | PQKS.|.SQHG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33103 | ||
| MBP-Isoform11_MOUSE | 98 | PQKS.|.SQHG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33103 | ||
| MBP-Isoform9_MOUSE | 101 | SQHG.|.GRTQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33114 | ||
| MBP-Isoform6_MOUSE | 101 | SQHG.|.GRTQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33114 | ||
| MBP-Isoform4_MOUSE | 101 | SQHG.|.GRTQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33114 | ||
| MBP-Isoform13_MOUSE | 101 | SQHG.|.GRTQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33114 | ||
| MBP-Isoform11_MOUSE | 101 | SQHG.|.GRTQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33114 | ||
| MBP-Isoform14_MOUSE | 113 | GSPM.|.MARR | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33125 | ||
| MBP-Isoform2_MOUSE | 116 | SDEL.|.LQTI | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33060 | ||
| MBP_MOUSE | 116 | SDEL.|.LQTI | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) | 19300513, |
| MBP-Isoform2_MOUSE | 126 | PTAA.|.ASGG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33062 | ||
| MBP_MOUSE | 126 | PTAA.|.ASGG | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) | 19300513, |
| MBP-Isoform2_MOUSE | 135 | VMAS.|.SQKR | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33064 | ||
| MBP_MOUSE | 135 | VMAS.|.SQKR | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) | 19300513, |
| MBP-Isoform2_MOUSE | 136 | MASQ.|.QKRP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33066 | ||
| MBP_MOUSE | 136 | MASQ.|.QKRP | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) | 19300513, |
| MBP-Isoform13_MOUSE | 139 | GSPM.|.MARR | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33125 | ||
| MBP-Isoform2_MOUSE | 144 | QRSK.|.KYLA | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33068 | ||
| MBP_MOUSE | 144 | QRSK.|.KYLA | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) | 19300513, |
| MBP-Isoform2_MOUSE | 158 | ARHG.|.GFLP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC33080 | ||
| MBP_MOUSE | 158 | ARHG.|.GFLP | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) | 19300513, |
| MBP_MOUSE | 203 | SLPQ.|.QKSQ | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) | 19300513, |
| MBP_MOUSE | 205 | PQKS.|.SQHG | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) | 19300513, |
| MBP_MOUSE | 208 | SQHG.|.GRTQ | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) | 19300513, |
| MBP_MOUSE | 246 | GSPM.|.MARR | inferred from experiment | unknown | MEROPS | Strongin AY | Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.024) | 19300513, |