Q68SA9: A disintegrin and metalloproteinase with thrombospondin motifs 7

General Information

Protein names	- A disintegrin and metalloproteinase with thrombospondin motifs 7 - ADAM-TS 7 - ADAM-TS7 - ADAMTS-7 - 3.4.24.- - COMPase
Gene names	Adamts7
Organism	Mus musculus
Protease Family
Protease ID	M12.231
Chromosome location
UniProt ID	Q68SA9

5 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MHRGPSLLLI LCALASRVLG PASGLVTEGR AGLDIVHPVR VDAGGSFLSY ELWPRVLRKR
        70         80         90        100        110        120
DVSTTQASSA FYQLQYQGRE LLFNLTTNPY LMAPGFVSEI RRHSTLGHAH IQTSVPTCHL
       130        140        150        160        170        180
LGDVQDPELE GGFAAISACD GLRGVFQLSN EDYFIEPLDG VSAQPGHAQP HVVYKHQGSR
       190        200        210        220        230        240
KQAQQGDSRP SGTCGMQVPP DLEQQREHWE QQQQKRRQQR SVSKEKWVET LVVADSKMVE
       250        260        270        280        290        300
YHGQPQVESY VLTIMNMVAG LFHDPSIGNP IHISIVRLII LEDEEKDLKI THHAEETLKN
       310        320        330        340        350        360
FCRWQKNINI KGDDHPQHHD TAILLTRKDL CASMNQPCET LGLSHVSGLC HPQLSCSVSE
       370        380        390        400        410        420
DTGMPLAFTV AHELGHSFGI QHDGTGNDCE SIGKRPFIMS PQLLYDRGIP LTWSRCSREY
       430        440        450        460        470        480
ITRFLDRGWG LCLDDRPSKD VIALPSVLPG VLYDVNHQCR LQYGSHSAYC EDMDDVCHTL
       490        500        510        520        530        540
WCSVGTTCHS KLDAAVDGTS CGKNKWCLKG ECVPEGFQPE AVDGGWSGWS AWSDCSRSCG
       550        560        570        580        590        600
VGVRSSERQC TQPVPKNRGK YCVGERKRSQ LCNLPACPPD RPSFRHTQCS QFDGMLYKGK
       610        620        630        640        650        660
LHKWVPVPND DNPCELHCRP SNSSNTEKLR DAVVDGTPCY QSRISRDICL NGICKNVGCD
       670        680        690        700        710        720
FVIDSGAEED RCGVCRGDGS TCQTVSRTFK ETEGQGYVDI GLIPAGAREI LIEEVAEAAN
       730        740        750        760        770        780
FLALRSEDPD KYFLNGGWTI QWNGDYRVAG TTFTYARKGN WENLTSPGPT SEPVWIQLLF
       790        800        810        820        830        840
QEKNPGVHYQ YTIQRDSHDQ VRPPEFSWHY GPWSKCTVTC GTGVQRQSLY CMERQAGVVA
       850        860        870        880        890        900
EEYCNTLNRP DERQRKCSEE PCPPRWWAGE WQPCSRSCGP EGLSRRAVFC IRSMGLDEQR
       910        920        930        940        950        960
ALELSACEHL PRPLAETPCN RHVICPSTWG VGNWSQCSVT CGAGIRQRSV LCINNTDVPC
       970        980        990       1000       1010       1020
DEAERPITET FCFLQPCQYP MYIVDTGASG SGSSSPELFN EVDFIPNQLA PRPSPASSPK
      1030       1040       1050       1060       1070       1080
PVSISNAIDE EELDPPGPVF VDDFYYDYNF INFHEDLSYG SFEEPHPDLV DNGGWTAPPH
      1090       1100       1110       1120       1130       1140
IRPTESPSDT PVPTAGALGA EAEDIQGSWS PSPLLSEASY SPPGLEQTSI NPLANFLTEE
      1150       1160       1170       1180       1190       1200
DTPMGAPELG FPSLPWPPAS VDDMMTPVGP GNPDELLVKE DEQSPPSTPW SDRNKLSTDG
      1210       1220       1230       1240       1250       1260
NPLGHTSPAL PQSPIPTQPS PPSISPTQAS PSPDVVEVST GWNAAWDPVL EADLKPGHGE
      1270       1280       1290       1300       1310       1320
LPSTVEVASP PLLPMATVPG IWGRDSPLEP GTPTFSSPEL SSQHLKTLTM PGTLLLTVPT
      1330       1340       1350       1360       1370       1380
DLRSPGPSGQ PQTPNLEGTQ SPGLLPTPAR ETQTNSSKDP EVQPLQPSLE EDGDPADPLP
      1390       1400       1410       1420       1430       1440
ARNASWQVGN WSQCSTTCGL GAIWRLVSCS SGNDEDCTLA SRPQPARHCH LRPCAAWRTG
      1450       1460       1470       1480       1490       1500
NWSKCSRNCG GGSSTRDVQC VDTRDLRPLR PFHCQPGPTK PPNRQLCGTQ PCLPWYTSSW
      1510       1520       1530       1540       1550       1560
RECSEACGGG EQQRLVTCPE PGLCEESLRP NNSRPCNTHP CTQWVVGPWG QCSAPCGGGV
      1570       1580       1590       1600       1610       1620
QRRLVRCVNT QTGLAEEDSD LCSHEAWPES SRPCATEDCE LVEPPRCERD RLSFNFCETL
      1630       1640       1650
RLLGRCQLPT IRAQCCRSCP PLSRGVPSRG HQRVARR

Isoforms

- Isoform 2 of A disintegrin and metalloproteinase with thrombospondin motifs 7

Sequence View

        10         20         30         40         50         60
MHRGPSLLLI LCALASRVLG PASGLVTEGR AGLDIVHPVR VDAGGSFLSY ELWPRVLRKR
        70         80         90        100        110        120
DVSTTQASSA FYQLQYQGRE LLFNLTTNPY LMAPGFVSEI RRHSTLGHAH IQTSVPTCHL
       130        140        150        160        170        180
LGDVQDPELE GGFAAISACD GLRGVFQLSN EDYFIEPLDG VSAQPGHAQP HVVYKHQGSR
       190        200        210        220        230        240
KQAQQGDSRP SGTCGMQVPP DLEQQREHWE QQQQKRRQQR SVSKEKWVET LVVADSKMVE
       250        260        270        280        290        300
YHGQPQVESY VLTIMNMVAG LFHDPSIGNP IHISIVRLII LEDEEKDLKI THHAEETLKN
       310        320        330        340        350        360
FCRWQKNINI KGDDHPQHHD TAILLTRKDL CASMNQPCET LGLSHVSGLC HPQLSCSVSE
       370        380        390        400        410        420
DTGMPLAFTV AHELGHSFGI QHDGTGNDCE SIGKRPFIMS PQLLYDRGIP LTWSRCSREY
       430        440        450        460        470        480
ITRFLDRGWG LCLDDRPSKD VIALPSVLPG VLYDVNHQCR LQYGSHSAYC EDMDDVCHTL
       490        500        510        520        530        540
WCSVGTTCHS KLDAAVDGTS CGKNKWCLKG ECVPEGFQPE AVDGGWSGWS AWSDCSRSCG
       550        560        570        580        590        600
VGVRSSERQC TQPVPKNRGK YCVGERKRSQ LCNLPACPPD RPSFRHTQCS QFDGMLYKGK
       610        620        630        640        650        660
LHKWVPVPND DNPCELHCRP SNSSNTEKLR DAVVDGTPCY QSRISRDICL NGICKNVGCD
       670        680        690        700        710        720
FVIDSGAEED RCGVCRGDGS TCQTVSRTFK ETEGQGYVDI GLIPAGAREI LIEEVAEAAN
       730        740        750        760        770        780
FLALRSEDPD KYFLNGGWTI QWNGDYRVAG TTFTYARKGN WENLTSPGPT SEPVWIQLLF
       790        800        810        820        830        840
QEKNPGVHYQ YTIQRDSHDQ VRPPEFSWHY GPWSKCTVTC GTGVQRQSLY CMERQAGVVA
       850        860        870        880        890        900
EEYCNTLNRP DERQRKCSEE PCPPRWWAGE WQPCSRSCGP EGLSRRAVFC IRSMGLDEQR
       910        920        930        940        950        960
ALELSACEHL PRPLAETPCN RHVICPSTWG VGNWSQCSVT CGAGIRQRSV LCINNTDVPC
       970        980        990       1000       1010       1020
DEAERPITET FCFLQPCQYP MYIVDTGASG SGSSSPELFN EVDFIPNQLA PRPSPASSPK
      1030       1040       1050       1060       1070       1080
PVSISNAIDE EELDPPGPVF VDDFYYDYNF INFHEDLSYG SFEEPHPDLV DNGGWTAPPH
      1090       1100       1110       1120       1130       1140
IRPTESPSDT PVPTAGALGA EAEDIQGSWS PSPLLSEASY SPPGLEQTSI NPLANFLTEE
      1150       1160       1170       1180       1190       1200
DTPMGAPELG FPSLPWPPAS VDDMMTPVGP GNPDELLVKE DEQSPPSTPW SDRNKLSTDG
      1210       1220       1230       1240       1250       1260
NPLGHTSPAL PQSPIPTQPS PPSISPTQAS PSPDVVEVST GWNAAWDPVL EADLKPGHGE
      1270       1280       1290       1300       1310       1320
LPSTVEVASP PLLPMATVPG IWGRDSPLEP GTPTFSSPEL SSQHLKTLTM PGTLLLTVPT
      1330       1340       1350       1360       1370       1380
DLRSPGPSGQ PQTPNLEGTQ SPGLLPTPAR ETQTNSSKDP EVQPLQPSLE EDGDPADPLP
      1390       1400       1410       1420       1430       1440
ARNASWQVGN WSQCSTTCGL GAIWRLVSCS SGNDEDCTLA SRPQPARHCH LRPCAAWRTG
      1450       1460       1470       1480       1490       1500
NWSKCSRNCG GGSSTRDVQC VDTRDLRPLR PFHCQPGPTK PPNRQLCGTQ PCLPWYTSSW
      1510       1520       1530       1540       1550       1560
RECSEACGGG EQQRLVTCPE PGLCEESLRP NNSRPCNTHP CTQWVVGPWG QCSAPCGGGV
      1570       1580       1590       1600       1610       1620
QRRLVRCVNT QTGLAEEDSD LCSHEAWPES SRPCATEDCE LVEPPRCERD RLSFNFCETL
      1630       1640       1650
RLLGRCQLPT IRAQCCRSCP PLSRGVPSRG HQRVARR

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q68SA9-1-unknown	MHRGPS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67987
Q68SA9-21-unknown	PASGLV...	21	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q68SA9-21-unknown	PASGLV...	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112778
Q68SA9-59-unknown	KRDVST...	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32226
Q68SA9-59-unknown	KRDVST...	59	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139856
Q68SA9-61-unknown	DVSTTQ...	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32228
Q68SA9-61-unknown	DVSTTQ...	61	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140038
Q68SA9-221-unknown	SVSKEK...	221	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q68SA9-221-unknown	SVSKEK...	221	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32230
Q68SA9-221-unknown	SVSKEK...	221	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116052

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PRVLRK	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32226
...PRVLRK	58	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122956
...VLRKRD	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32228
...VLRKRD	60	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123144
...RRQQRS	220	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32230
...RRQQRS	220	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130756
...RVARR	1657	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RVARR	1657	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63605

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
FURIN_MOUSE	58	VLRK.\|.KRDV	inferred from experiment	unknown	MEROPS	Apte SS	Somerville RP et al.:ADAMTS7B, the full-length produ... (S08.071)	15192113,
FURIN_MOUSE	60	RKRD.\|.DVST	inferred from experiment	unknown	MEROPS	Apte SS	Somerville RP et al.:ADAMTS7B, the full-length produ... (S08.071)	15192113,
FURIN_MOUSE	220	QQRS.\|.SVSK	inferred from experiment	unknown	MEROPS	Apte SS	Somerville RP et al.:ADAMTS7B, the full-length produ... (S08.071)	15192113,

TopFIND

Q68SA9: A disintegrin and metalloproteinase with thrombospondin motifs 7

General Information

5

N-termini

4

C-termini

3

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates